31,092 results match your criteria: "Aortic Regurgitation"

Treponema Pallidum: A Forgotten Pathogen With Major Cardiovascular Consequence.

JACC Case Rep

November 2024

Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.

Article Synopsis
  • The rate of syphilis cases has risen significantly over the past 20 years.
  • This case study discusses a 43-year-old man who presented with an aortic aneurysm and aortic regurgitation, initially thought to be a congenital issue.
  • Eventually, it was confirmed that the aortic problems were due to tertiary syphilis, highlighting the importance of considering syphilis as a potential cause of heart-related conditions.
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Article Synopsis
  • * The J-Valve device, developed by JC Medical, shows promising outcomes, particularly in patients with complex anatomical challenges.
  • * Two successful cases of transcatheter aortic valve replacement using the J-Valve were reported in patients who had significant aortic angulation.
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Evolving Concern: Late Outcomes after Repair of Transposition of the Great Arteries.

J Thorac Cardiovasc Surg

November 2024

Division of Cardiovascular Surgery, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Article Synopsis
  • - The study evaluated the survival rates and need for re-operation in children who had surgery for transposition of great arteries (TGA) from 1990 to 2019, finding a strong 30-year survival rate of 92% and a low in-hospital death rate of 3.8%.
  • - Most patients (94%) underwent arterial switch operations, with 82% being free from cardiac re-operations 30 years post-surgery. Re-operation rates were highest in the first 2 years, then decreased for 18 years, followed by an increase after 20 years.
  • - Late complications were noted, particularly a concerning rise in neo-aortic valve and root re-operations after 17 years,
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Echocardiographic estimates of stroke volume in healthy dogs: comparability, reference intervals, and reproducibility.

J Vet Cardiol

November 2024

James L. Voss Veterinary Teaching Hospital, College of Veterinary Medicine & Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.

Article Synopsis
  • This study compared stroke volume estimates from various anatomical sites in healthy dogs and aimed to create reference intervals for specific volume indices like shunt volume and regurgitant volume.
  • Ninety healthy dogs underwent echocardiography to assess stroke volume at different valve levels, with repeat tests for consistency, using methods like Bland-Altman plots for analysis.
  • Results indicated that different echocardiographic methods for measuring stroke volume produced significant variations, highlighting the need for unique reference intervals to evaluate heart conditions in dogs effectively.
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Article Synopsis
  • * The use of this approach significantly increased from 18.7% in 2019 to 97.8% by 2023, with a mean procedure time of 127 minutes and no intraoperative deaths reported.
  • * Thirty-day adverse events included a 1.9% rate of major complications, with factors like intraoperative conversion and respiratory failure being linked to higher risks of complications and mortality.
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Article Synopsis
  • * A case is presented of a patient who arrived at the emergency department with only worsening pitting edema and subtle physical examination findings, ultimately leading to the discovery of severe heart conditions linked to infective endocarditis.
  • * The case highlights the significance of thorough physical examinations and clinical judgment, emphasizing the role of tubular adenomas in causing bacteremia and the necessity for a more comprehensive approach in patient assessment.
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Functional Mitral Regurgitation Post-Isolated Aortic Valve Replacement.

J Clin Med

November 2024

Department of Cardiology and Internal Medicine, Vascular Surgery Clinic, Institute for Cardiovascular Diseases Dedinje, 11000 Belgrade, Serbia.

Article Synopsis
  • * A study involving 108 patients revealed that 63% experienced improvement in mitral regurgitation after isolated aortic valve replacement, with variances in outcomes based on patient-prosthesis mismatch.
  • * Results indicate that avoiding patient-prosthesis mismatch leads to better hemodynamic outcomes and reduces the chance of persistent mitral regurgitation, potentially minimizing the necessity for further mitral valve surgery.
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Article Synopsis
  • The Myval is a transcatheter heart valve developed by Meril Life Sciences that features an operator-friendly design for easier delivery and precise deployment.
  • It has shown effectiveness and safety in clinical studies, making it suitable for various complex heart valve procedures, including aortic valve implantation and pulmonary valve replacement.
  • The advancement of Myval signifies a step forward in cardiology, with a need for further long-term studies to confirm its benefits in improving patient outcomes and quality of life.*
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Article Synopsis
  • * Out of 44 patients, the procedure was successful in 43 cases (97.7%), with minimal complications, although one patient required surgery due to device embolization and significant tissue damage.
  • * Over a follow-up period of 43 months, AR worsened in only 1 patient, while it improved in several others, showing that transcatheter closure is a safe and effective treatment method for these conditions.
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Despite offering several potential benefits over standard prosthetic aortic valve replacement, the use of the pulmonary autograft has been limited to date due to concerns over the risk of pulmonary autograft expansion and the need for reintervention. Several techniques using materials with biomimetic potential have been developed to reduce this complication. The incidence, risk factors, and pathophysiology of pulmonary autograft dilatation are discussed in this article.

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Endo-Aortic Clamp for Minimally Invasive Redo Mitral Valve Surgery: Early Outcome.

J Cardiovasc Dev Dis

November 2024

Division of Cardiac Surgery, Cardiovascular and Thoracic Department, Città della Salute e della Scienza, University of Turin, 10126 Turin, Italy.

Objective: Redo mitral valve surgery still represents a challenging and high-risk procedure in cardiac surgery. The incidence of cardiac structural injuries during re-sternotomy remains consistent and is reported to be an independent risk factor for hospital mortality. Minimally invasive cardiac surgery with retrograde femoral arterial perfusion and endo-aortic clamping avoids re-entry injuries and reduces the requirement for dissection of adhesions and the risk of damage to cardiac structures.

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Article Synopsis
  • The LANDMARK trial compared the balloon-expandable Myval transcatheter heart valve (THV) series to the SAPIEN and Evolut THV series in 768 patients to evaluate safety and effectiveness.
  • Results showed that Myval achieved non-inferiority to SAPIEN (24.7% vs 24.1%) and Evolut (24.7% vs 30.0%) regarding a primary composite safety endpoint.
  • Additionally, while Myval had better pressure gradient metrics compared to SAPIEN, Evolut showed slightly higher rates of prosthetic valve regurgitation compared to Myval but no significant difference between Myval and SAPIEN.
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The absence of a Food and Drug Administration-approved percutaneous valve technology for the treatment of severe aortic regurgitation (AR) presents a challenge for high-risk patients. In this report, we describe the successful treatment of an 84-year-old male patient suffering from severe symptomatic AR and concomitant cardiorenal syndrome with renal failure using a 34 mm Evolut R (Medtronic) self-expanding transcatheter aortic valve replacement. This intervention resulted in the resolution of AR, cardiorenal syndrome, and congestive heart failure symptoms.

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Background: Data on the incidence of infective endocarditis (IE) in patients with hypertrophic cardiomyopathy (HCM) is sparse. This study evaluated a HCM cohort with aim to study the incidence of IE in these patients.

Methods: All patients entering the HCM cohort from May 2003 to June 2022 of a tertiary care hospital with at least one follow-up visit were included and followed up till June 2023.

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