SETD2 regulates SLC family transporter-mediated sodium and glucose reabsorptions in renal tubule.

A regulatory mechanism for SLC family transporters, critical transporters for sodium and glucose reabsorptions in renal tubule, is incompletely understood. Here, we report an important regulation of SLC family transporter by SETD2, a chromatin remodeling gene whose alterations have been found in a subset of kidney cancers. Kidney-specific inactivation of Setd2 resulted in hypovolemia with excessive urine excretion in mouse and interestingly, RNA-sequencing analysis of Setd2-deficient murine kidney exhibited decreased expressions of SLC family transporters, critical transporters for sodium and glucose reabsorptions in renal tubule.

Retrospective analysis of treatment-positioning accuracy and dose error in boron neutron capture therapy using a sitting-position treatment system for head and neck cancer.

The neutron beam in boron neutron capture therapy (BNCT) exhibits poor directionality and significantly decreasing neutron flux with increasing distance. Therefore, the treatment site must be close to the irradiation aperture. Some patients with head and neck cancer may benefit from a sitting-position setup.

Radiation research trends by young scientists and the future tasks in Northern Japan: report on 'the 10th educational symposium on radiation and health (ESRAH) by young scientists in 2023'.

Purpose: Since 2014, an educational activity on radiation and health in northern Japan has been carried out by young scientists, the so-called 'Educational Symposium on Radiation and Health (ESRAH)'. Close cooperation has been continued in preparing for any possible emergency response to radiation accidents because several facilities, e.g.

Enhancement of liquid/gas production during co-pyrolysis of vacuum residue and plastics due to synergistic interactions.

Vacuum residue (VR) was copyrolysed with polyethylene (PE) or polystyrene (PS) in a batch reactor to investigate the corresponding synergistic pyrolytic interactions. The synergistic interactions between VR and plastic pyrolysates enhanced liquid and gas production while reducing coke formation, as compared with VR-only and plastic-only pyrolysis. The pyrolysis of 9:1 w/w VR: PE (PE with M = 3 MDa) and 9:1 w/w VR/PS (PS with M ≈ 350 kDa) mixtures produced oil in yields of 28.

Fecundity difference is related to the production of reproductive pheromones in rats.

In Brief: Social and reproductive behaviors in mammals are regulated by pheromones. This study shows the possibility that male extraorbital lacrimal gland-derived pheromones are involved in reproductive efficiency in rats.

Abstract: In rodents, male-derived pheromones play fundamental roles in reproduction.

Nasojejunal Tube Placement for Levodopa-carbidopa Intestinal Gel Treatment by Neurologists in Patients with Advanced Parkinson's Disease: A Retrospective Observational Study.

Introduction Short-term levodopa-carbidopa intestinal gel (LCIG) treatment using nasojejunal (NJ) tubes (NJ-LCIG test) is recommended for patients with advanced Parkinson's disease to ensure compatibility with this treatment system prior to permanent percutaneous endoscopic gastrojejunostomy. However, there have been no studies on NJ tube insertion by neurologists or on possible differences in treatment efficacy based on the NJ tube insertion method or tube tip position. We therefore investigated the effects of LCIG with NJ tube placement performed by a neurologist.

Creating a diagnostic assessment model for autism spectrum disorder by differentiating lexicogrammatical choices through machine learning.

This study explores the challenge of differentiating autism spectrum (AS) from non-AS conditions in adolescents and adults, particularly considering the heterogeneity of AS and the limitations ofssss diagnostic tools like the ADOS-2. In response, we advocate a multidimensional approach and highlight lexicogrammatical analysis as a key component to improve diagnostic accuracy. From a corpus of spoken language we developed, interviews and story-recounting texts were extracted for 64 individuals diagnosed with AS and 71 non-AS individuals, all aged 14 and above.

Artificial intelligence detection of cognitive impairment in older adults during walking.

Introduction: To detect early cognitive impairment in community-dwelling older adults, this study explored the viability of artificial intelligence (AI)-assisted linear acceleration and angular velocity analysis during walking.

Methods: This cross-sectional study included 879 participants without dementia (female, 60.6%; mean age, 73.

The Impact of Spinopelvic and Hip Mobility on Passive Hip Flexion Range of Motion Assessment.

Background: Measuring passive hip flexion range of motion (ROM) is challenging due to compensatory movements. Despite the interest in using functional lateral radiographs for assessing hip mobility, the relationship with passive hip flexion ROM remains unclear. This study aims to elucidate this relationship and clarify spinopelvic parameters and mobility factors influencing variations in passive and radiographic hip flexion ROM.

Impact of an education intervention focusing on comprehensive mindful eating and chewing habits on daily eating practices: A mobile tool-based randomized controlled trial.

Background: Mindful eating (ME) emphasizes full awareness of food consumption, incorporating the practice of eating slowly. Traditional interventions targeting slower eating rates often concentrate on chewing behavior, leaving the impact of ME largely unexplored. The objective of this study was to evaluate the effectiveness of the ME program in improving eating rates and mindful eating compared to conventional education centered solely on chewing.

Riboswitch Design Using MODENA.

In silico design of artificial riboswitches is a challenging and intriguing task. Since experimental approaches such as in vitro selection are time-consuming processes, computational tools that guide riboswitch design are desirable to accelerate the design process. In this chapter, we describe the usage of the MODENA web server to design ON riboswitches on the basis of a multi-objective genetic algorithm and RNA secondary structure prediction.

Effects of Psychogenic Stress Frequency during the Growth Stage on Oxidative Stress, Organ and Bone Development.

Background: This study aimed to examine the effects of psychogenic stress (PS) frequency on oxidative stress and organ development during growth and to gain fundamental insights into developmental processes during this period.

Methods: Four-week-old male Wistar rats were randomly assigned to a control and three PS groups according to PS frequencies. PS was induced using restraint and water immersion techniques once daily for 3 hr at a time for a period of 4 weeks.

Usefulness of bilateral cerebral regional oxygen saturation measurements in determining selective cerebral perfusion flow rate in a pediatric patient with aortic arch stenosis: a case report.

Background: We report a pediatric case where bilateral regional oxygen saturation (rSO) measurements were useful in determining the selective cerebral perfusion (SCP) flow rate.

Case Presentation: A 9-year-old Japanese boy, 128 cm tall and weighing 25.6 kg, was scheduled for aortic arch reconstruction due to a 90-100 mmHg pressure gradient.