Silencing of gene represses cell proliferation and induces apoptosis in human skin fibroblasts.

Estrogen‑related receptor (ERR) is an orphan nuclear receptor structurally akin to the estrogen receptor. ERR is expressed in tissues with active energy metabolism and regulates intracellular metabolic functions. Additionally, ERRs are known to be strongly expressed in the epidermis of skin tissue, but their functions are unknown.

Evaluation of Nudge-Based Notification for Follow-Up Examinations in Health Check-Ups Targeting Occupational Health Staff and Undiagnosed Workers: A Randomized Controlled Trial.

Purpose Follow-up examinations after health check-ups are important for early detection of noncommunicable diseases among workers. Nudging can serve as an effective intervention for individuals who avoid follow-up examinations due to cognitive biases. This study aims to evaluate the interest in nudge-based notification for follow-up examinations, targeting occupational health staff and undiagnosed workers in a randomized controlled trial.

Multifaceted effects of variable biotic interactions on population stability in complex interaction webs.

Recent studies have revealed that biotic interactions in ecological communities vary over time, possibly mediating community responses to anthropogenic disturbances. This study investigated the heterogeneity of such variability within a real community and its impact on population stability in the face of pesticide application, particularly focusing on density-dependence of the interaction effect. Using outdoor mesocosms with a freshwater community, we found considerable heterogeneity in density-dependent interaction variability among links in the same community.

Mid-term patient-reported outcomes are inferior in opening-wedge high tibial osteotomy patients with untreated medial meniscus posterior root tear.

Purpose: The impact of untreated medial meniscus posterior root (MMPR) tear (MMPRT) during opening-wedge high tibial osteotomy (OWHTO) on patient-reported outcomes (PROs) remains poorly understood. This retrospective cohort study aimed to investigate the association between the presence of MMPRT and post-operative PROs in patients who underwent OWHTO.

Methods: A total of 83 knees that underwent OWHTO that were followed up for 6.

D-aspartate stimulates growth hormone secretion in wethers.

Growth hormone (GH) is an essential factor in enhancing the productivity of animals. In ruminants, L-aspartate (L-Asp) stimulates the secretion of GH; however, the effect of D-Asp on GH remains unknown. Here, we examined the effect of D-Asp on GH secretion in wethers.

Maternal Broccoli Powder Intake Ameliorates Insulin Resistance and Inflammation via AMPK/mTOR Pathway in the Livers of High-Fructose-Fed Male Rat Offspring Exposed to Maternal Protein Restriction.

Scope: Sub-optimal prenatal conditions such as maternal undernutrition during pregnancy and lactation posit high risks of adult metabolic diseases. High fructose intake causes insulin resistance and liver inflammation contributing to metabolic diseases. However, food-based preventive measure for these metabolic diseases in the offspring is under-researched.

Nanoscale Structures of Tough Microparticle-Based Films Investigated by Synchrotron X-Ray Scattering and All-Atom Molecular-Dynamics Simulation.

In this study, the nanoscale structures of microparticle-based films are revealed by synchrotron small-angle X-ray scattering (SAXS) and all-atom molecular-dynamics (AA-MD) simulations. The microparticle-based films consisting of the simplest acrylate polymer microparticles are applied as a model because the films are formed without additives and organic solvents and exhibit high toughness properties. The characteristic interfacial thickness () obtained from the SAXS analysis reflects the mixing degree of polymer chains on the microparticle surface in the film.

Effects of Motor and Cognitive Dual-Task Demands on Ankle Dorsiflexor and Plantarflexor Force Control in Older Adults.

Background: Force steadiness can be impaired under dual-task conditions in older adults. Since this impairment is attributed to their limited attentional resources, we hypothesized that the degree of cortical activity involved in muscle contraction would affect force steadiness under dual-task conditions. To test this hypothesis, based on the premise that dorsiflexion requires more cortical resources than plantarflexion, we compared the effects of additional motor and cognitive task demands on force steadiness between dorsiflexion and plantarflexion contractions in young and older adults.

Color-induced cognitive conflicts affect muscle activity prior to gait initiation in the Go/No-go task.

Introduction: In traffic rule, green/blue means go, and red means stop. It has been shown that this prior knowledge about traffic signal colors can affect reaction times (RTs). For example, RTs are longer when responding to a red "Go" signal and withholding the response to a blue "No-go" signal (Red Go/Blue No-go task) than when responding to a blue "Go" signal and withholding the response to a red "No-go" signal (Blue Go/Red No-go task), when responses are provided by button press.

Synchronous Oligometastasis and Oligoprogression as a Prognostic Marker in Patients With Extensive-Stage SCLC Treated With a Combination of Immune-Checkpoint Inhibitor and Chemotherapy (HOT2301).

Introduction: Oligometastasis and oligoprogression (OP) has not been adequately defined in extensive-stage SCLC (ES-SCLC) and may be a good indication for adding local treatment. Therefore, this multicenter study aimed to investigate the prognostic impact of oligometastasis and OP in ES-SCLC.

Methods: We enrolled patients who received chemoimmunotherapy between September 2019 and June 2022.

Reduction in the incidence of cognitive impairment and related costs through an innovative health awareness programme in rural Japan.

Objectives: This study examined the impact of the Center of Healthy Aging Program (CHAP) on the cognitive function and economic burden associated with dementia.

Methods: This observational study utilised Iwaki cohort data. We included participants with mini-mental state examination (MMSE) scores and categorised them into pre- and post-CHAP groups based on their year of entry into the cohort (before 2013 or after) (index year).

Triantaspirols A-C and Paraphaeolactone Cs from sp. KT4192: Sensitivity of CP3 in Distinguishing Close NMR Signals.

Hybridized spirobisnaphthalene derivatives, triantaspirols A-C (-) and paraphaeolactones C1 and C2 ( and ), were identified from the culture broth of the fungus sp. KT4192. The NMR spectra of and , as well as and , closely resembled each other, indicating that these were pairs of diastereomers.