83 results match your criteria: "Antwerp University Hospital-University of Antwerp[Affiliation]"

Angiotensin receptor blockers: a panacea for Marfan syndrome and related disorders?

Drug Discov Today

February 2015

Center for Medical Genetics, Antwerp University Hospital/University of Antwerp, Prins Boudewijnlaan 43, 2650 Antwerp, Belgium. Electronic address:

The study of mouse models for Marfan syndrome, an autosomal dominant connective tissue disorder caused by mutations in fibrillin-1 (FBN1), has shifted our understanding of the pathogenesis of thoracic aortic aneurysm significantly. Multiple lines of evidence support the notion that dysregulation of canonical and noncanonical transforming growth factor (TGF)β signaling is the responsible pathway in this and related thoracic aortic aneurysm conditions. This exciting knowledge has opened numerous new treatment options, including antagonism of the angiotensin II receptor blocker type 1 (AT1R).

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Traumatic intracranial hypertension.

N Engl J Med

May 2014

From the Department of Pathophysiology and Transplantation, Milan University, and Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Cà Granda-Ospedale Maggiore Policlinico - both in Milan (N.S.); and the Department of Neurosurgery, Antwerp University Hospital-University of Antwerp, Edegem, Belgium (A.I.R.M.).

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Loeys-Dietz syndrome.

Adv Exp Med Biol

May 2014

Center for Medical Genetics, Faculty of Medicine and Health Sciences, Antwerp University Hospital/University of Antwerp, Prins Boudewijnlaan 43, 2650, Antwerp, Belgium.

Loeys-Dietz syndrome is an autosomal dominant aortic aneurysm syndrome characterized by multisystemic involvement. The most typical clinical triad includes hypertelorism, bifid uvula or cleft palate and aortic aneurysm with tortuosity. Natural history is significant for aortic dissection at smaller aortic diameter and arterial aneurysms throughout the arterial tree.

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Objective: The adult petromastoid canal (PMC) is a thin anatomical structure, but in young children, it can be wide on high resolution CT (HRCT) scans. We performed this study to evaluate the year-by-year change in width and shape of the PMC in the young child.

Materials And Methods: We retrospectively reviewed temporal bone HRCT scans, performed between 2007 and 2012.

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Objective: To describe the postgraduate surgical skills training programme of the Flemish Society of Obstetrics and Gynaecology (VVOG*). Laparoscopic surgical techniques and indications have increased substantially during the past two decades. From surgeons it is expected that they keep up with all techniques and should be able to perform all relevant procedures.

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The broadening of imaging capabilities and the increasing capacity of imaging to quantitate biologic processes has increased industry interest in using imaging methods in new drug development. Investigators participating in industry-sponsored trials should be aware of how such trials differ from investigator-initiated, grant-funded research. In particular, investigators should be cognizant of possible ethical conflicts in the care of patients, the development and analysis of data, and issues related to the dissemination of results.

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