CSF1-R inhibition attenuates posttraumatic osteoarthritis and quadriceps atrophy following ligament injury.

Knee osteoarthritis contributes substantially to worldwide disability. Post-traumatic osteoarthritis (PTOA) develops secondary to joint injury, such as ligament rupture, and there is increasing evidence suggesting a key role for inflammation in the aetiology of PTOA and associated functional deficits. Colony stimulating factor 1 receptor (CSF1-R) has been implicated in the pathogenesis of musculoskeletal degeneration following anterior cruciate ligament (ACL) injury.

Increased Lateral Femoral Condyle Ratio Is Associated With A Higher Risk Of Anterior Cruciate Ligament Injury and Concomitant Anterolateral Ligament and Meniscus Injuries.

Purpose: To investigate whether lateral femoral condyle ratio (LFCR) and lateral femoral condyle index (LFCI) were associated with a higher risk of anterior cruciate ligament (ACL) injury and concomitant injuries.

Methods: This systematic review followed the PRISMA guidelines and was registered on PROSPERO. PubMed, Web of Science, Embase, and the Cochrane Library were searched from inception to April 1, 2024.

Diagnostic performance of self-reported knee crepitus using a Knee injury and Osteoarthritis Outcome Score item.

Objective: To assess the diagnostic performance of a single Knee injury and Osteoarthritis Outcome Score (KOOS) item in evaluating the presence of knee crepitus.

Design: All 184 participants aged 18-40 years with a symptomatic knee, 9-36 months following anterior cruciate ligament reconstruction (ACLR) who were prospectively enrolled in a post-traumatic knee osteoarthritis trial (ACTRN12620001164987) were included. Participants completed the KOOS and underwent physical examination for knee crepitus at baseline.

Injury prevention programmes (IPPs) for preventing anterior cruciate ligament injuries.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To determine the benefits and harms of injury prevention programmes on anterior cruciate ligament injuries.

Lack of association between revision ACL reconstruction and preoperative, intraoperative and post-operative factors at primary ACL reconstruction in children and adolescents.

Purpose: To evaluate factors associated with revision anterior cruciate ligament reconstruction (ACLR) within 5 years of primary ACLR in children and adolescents.

Methods: Children and adolescents (age <20 years at surgery) who underwent primary hamstring tendon ACLR at the Capio Artro Clinic, Stockholm, Sweden, between January 2005 and December 2018 were identified. Revision ACLR within 5 years of primary ACLR was captured in the Swedish National Knee Ligament Registry.

Posteromedial corner injuries result in the same posterior translation as posterolateral corner injuries in PCL ruptures.

Purpose: Ruptures of the posterior cruciate ligament (PCL) are often accompanied by posterolateral corner (PLC) and posteromedial corner (PMC) injuries. This study investigates the incidence and impact of PMC and PLC injuries on posterior tibial translation (PTT). It was hypothesized that PMC injuries are more common and impactful than previously reported.

Joint Effusion at 3 Months After Anterior Cruciate Ligament Reconstruction: Its Risk Factors and Association With Subsequent Muscle Strength and Graft Remodeling.

Background: Joint effusion at 3 months after anterior cruciate ligament (ACL) reconstruction is a risk factor for ACL reinjury. However, factors associated with joint effusion at 3 months postoperatively and the effect of joint effusion on subsequent quadriceps muscle strength and graft remodeling remain unknown.

Purposes: To identify factors associated with joint effusion and investigate the association between joint effusion and quadriceps muscle strength and graft remodeling in the postoperative period.

Return to Soccer After Anterior Cruciate Ligament Reconstruction: An Outcome or a Decision?

Background: The return-to-sports rate is often used as an outcome measure after anterior cruciate ligament (ACL) reconstruction (ACLR). Although most soccer players want to return to sports after their ACL injury, up to 40% do not believe they will return to soccer after their ACL injury.

Purpose: To investigate whether self-reported presurgical beliefs regarding return to soccer correspond to registered official match participation after ACLR.

Validity and reliability study of the Turkish version of KOOS-ACL questionnaire.

Background: This study aimed to adapt the Knee injury and Osteoarthritis Outcome Score- Anterior Cruciate Ligament (KOOS-ACL) into Turkish and to assess its validity and reliability.

Methods: The adaptation process involved translation, back-translation, and cultural adaptation of the questionnaire. Totally 133 patients who had a diagnosis of anterior cruciate ligament tear was recruited.

Simultaneous patellar tendon and anterior cruciate ligament rupture: a systematic review, meta-analysis and algorithmic approach.

Introduction: Isolated patellar tendon (PT) or anterior cruciate ligament (ACL) ruptures are common injuries, yet the co-occurrence of both presents a rare challenge for clinicians. The objectives of the study are to document diagnostic and therapeutic approaches, outcomes, and complications of combined PT and ACL injuries and to develop an algorithm to guide clinicians in decision-making.

Methods: The systematic review und metanalysis was conducted according to the PRISMA guidelines.

Efficacy and safety of quadriceps tendon autograft versus bone-patellar tendon-bone and hamstring tendon autografts for anterior cruciate ligament reconstruction: a systematic review and meta-analysis.

Background: Quadriceps tendon (QT), bone-patellar tendon-bone (BPTB), and hamstring tendon (HT) autografts are widely used for anterior cruciate ligament reconstruction (ACLR), but the optimal autograft choice remains controversial. This study assessed the treatment effects of QT versus BPTB and HT autografts for ACLR.

Methods: The PubMed, Embase, and Cochrane Library databases were systematically searched for eligible studies published from inception until July 2022.

Preoperative Physical Therapy Is Protective From Construct Failure in Anterior Cruciate Ligament Reconstruction.

Background: Risk factors for anterior cruciate ligament reconstruction (ACLR) construct failure have been studied extensively. However, while some studies account for variables such as activity level, construct types, preoperative physical therapy, or patient demographics individually, comprehensive studies that control for all these factors simultaneously are scarce.

Hypothesis: By utilizing a robust multivariable analysis, the factors associated with an increased risk of ACLR construct failure can be determined.

Associated Medial Meniscal Injury with ACL Reconstruction Results in Poorer Strength and Jump Tests Outcomes: A 6-Month Analysis of 504 Patients from the MERIScience Cohort.

: After anterior cruciate ligament reconstruction (ACLR), a 6-month composite test is recommended during rehabilitation before the return to sport, and the influence of a meniscal tear is not known. The hypothesis was that the location and treatment of meniscus injuries could influence the results of the composite test. : A retrospective single-center study was carried out of prospectively collected data involving 504 patients who performed a composite test 6 months after ACLR.

Lateral Extraarticular Tenodesis in Revision Anterior Cruciate Ligament Reconstruction: An Analysis of Clinical Outcomes and Failure Rates.

: Lateral extraarticular tenodesis (LET) has been advocated in revision anterior cruciate ligament reconstruction (ACLR) to improve knee stability and furthermore, decrease failure rates. The aim of this study was to compare clinical outcomes, knee laxity, and failure rates after revision ACLR with LET (ACLR + LET) versus without LET. It was hypothesized that ACLR + LET improves clinical outcomes and reduces the failure rate.

Needleless graft preparation for anterior cruciate ligament reconstruction with 4-strand semitendinosus autograft: a biomechanical in vitro study using a porcine model.

Background: Ruptures of the anterior cruciate ligament (ACL) are common injuries. Reconstruction using autologous grafts is recommended to prevent further damage and functional impairment. Grafts are usually prepared with stabilizing sutures.

Comparison of Clinical Results Using Hamstring Versus Quadriceps Tendon Graft Versus Bone Patella Tendon in Anterior Cruciate Ligament Reconstruction Surgery: A Randomized Clinical Trial.

Background: Anterior cruciate ligament (ACL) reconstruction is pivotal for restoring knee stability and function in individuals with ACL injuries. While bone-patellar tendon-bone (PT), hamstring tendon (HT), and quadriceps tendon (QT) autografts are commonly employed, their comparative effectiveness remains a subject of ongoing research. This study aims to comprehensively compare the functional outcomes, knee stability, revision rates, and incidence of anterior knee pain associated with these autografts.

Anterior Cruciate Ligament Reconstruction Graft Options.

Anterior cruciate ligament reconstruction is one of the most common orthopaedic sports medicine surgeries. Its prevalence in the sports medicine sphere is matched by the numerous options of different techniques. Chief among these is graft selection, which most commonly falls into 1 of 4 options: bone-patellar tendon-bone (BPTB) autograft, hamstring tendon autograft (HT), quadriceps tendon autograft, and allografts.

Delivery of FBXO6 with highly branched poly(β-amino ester)s to modulate the inflammatory environment for the treatment of osteoarthritis.

Osteoarthritis (OA) is a chronic joint disease characterized by the progressive degradation of articular cartilage. Delivering functional genes to chondrocytes to modulate the inflammatory environment offers a promising approach to treating OA. However, the dense extracellular matrix (ECM) in the OA microenvironment and the rapid clearance of naked nucleic acids from synovial fluid present significant challenges.

Allograft versus autograft ACL reconstruction in skeletally immature patients: a systematic review.

Introduction: Anterior cruciate ligament (ACL) injuries in children and adolescents with open physes are common.

Areas Of Agreement: Evidence of ACL reconstruction using allografts in children with open physes is limited.

Areas Of Controversy: Whether the outcomes of ACL allograft reconstruction in children and adolescents with open physes are superior to autograft ACL reconstruction is unclear, with contrasting evidence.

Evaluating the Impact of Adjustable- and Fixed-Loop Femoral Endobuttons on Intraoperative Surgeon Satisfaction and Postoperative Patient Functional Outcomes in Anterior Cruciate Ligament (ACL) Reconstruction.

Introduction: This study aims to evaluate the effects of adjustable- and fixed-loop femoral endobuttons on intraoperative surgeon satisfaction and postoperative patient functional outcomes in anterior cruciate ligament (ACL) reconstruction. The use of cortical suspensory devices, either fixed-loop or adjustable-loop, is common in ACL reconstruction surgeries for femoral tunnel fixation. Fixed-loop devices, although effective, often require additional tunnel drilling, potentially leading to tunnel widening.

Does Tibial Plateau Slope and Depth Influence ACL Strain In Vivo?

Background: The anterior cruciate ligament (ACL) is loaded under tension when the tibia translates anteriorly relative to the femur. The shape of the articular surfaces of the tibiofemoral joint may influence the amount of anterior tibial translation under compressive loading. Thus, a steep lateral tibial plateau and a shallow medial plateau are thought to be risk factors for ACL injury.

Fifteen-Year Radiographic Follow-up Comparison of Early Versus Delayed ACL Reconstruction: A Retrospective Review of a Previous Prospective Randomized Clinical Trial.

Background: Posttraumatic osteoarthritis (PTOA) after anterior cruciate ligament injury and reconstruction (ACLR) is a prevalent cause of long-term disability. Few studies have compared the effect of ACLR timing on the development of PTOA.

Purpose/hypothesis: The purpose of this study was to compare the rate of PTOA at a long-term follow-up between patients who underwent early ACLR (<21 days after injury) versus delayed ACLR (>6 weeks after injury).

A Study on Clinical and Functional Outcomes of Arthroscopic Anterior Cruciate Ligament Reconstruction Using Hamstring versus Peroneus graft.

Introduction: Anterior cruciate ligament (ACL) injury is the most common for athletes.

Materials And Methods: ACL injury reconstruction is a pivotal surgical intervention aimed at restoring knee stability and function following ligamentous trauma.

Surgical Technique: Advances in surgical techniques and rehabilitation protocols have significantly improved outcomes and patient recovery rates.

Patellofemoral Arthritis after Conservative Management for Post-operative Arthrofibrosis: A Case Report.

Introduction: Arthrofibrosis of the knee is an adverse outcome after anterior cruciate ligament (ACL) reconstruction. Definitions and classifications vary widely based on extension and flexion losses, patellar mobility, and location. In general, it is understood as a restricted range of motion (ROM) due to scar tissue, and it is often defined as symptomatic limitation in knee ROM compared to the opposite knee.

Physical functions assessed by lower limb performance-based and self-reported outcome measures for knee musculoskeletal conditions: A scoping review.

Background: Physical function assessment is key for the management of knee musculoskeletal conditions. There are a wide variety of self-reported outcome measures (SROMs) and performance-based outcome measures (PBOMs) to assess physical function of individuals with knee conditions. However, the content of these measures has not been explored.