6,070 results match your criteria: "Anterior Circulation Stroke"

Introduction: Mechanical thrombectomy is a highly effective treatment for acute ischemic stroke (AIS) caused by large vessel occlusions (LVO). However, our understanding of the pathophysiology of AIS is still limited, particularly regarding the ischemic microenvironment distal to the occlusion.

Aim: To investigate the relationship between the intracerebral blood pressure (BP) distal to an LVO and clinical and imaging parameters.

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Background: We aimed to clarify the association between intraoperative P2Y inhibitor administration during EVT and clinical outcomes in patients with anterior circulation TO stroke.

Methods: Among consecutive patients with acute ischemic stroke (AIS) enrolled in the Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolic and Atherothrombotic Stroke with Large Vessel Occlusion Registry from 2016 to 2019, those with anterior circulation TOs who underwent EVT were analyzed. These patients were categorized into the following groups: those who received P2Y inhibitors during the perioperative period and those who did not receive P2Y inhibitors.

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Effectiveness and Safety of Mechanical Thrombectomy in Large-Vessel-Occlusion Mild Stroke: Insights from the ASSIST Registry.

AJNR Am J Neuroradiol

December 2024

From the Department of Department of Neuroradiology, University Hospital Heidelberg (S.H.; D. F. V.; M. A. M.); Neuroradiology, Hospital Son Espases, Mallorca, Spain (S.M.); Interventional Neurology, McLaren Regional Medical Center, Flint, Michigan, USA (B.N.); Interventional Neurology, McLaren Regional Medical Center, Macomb, Michigan, USA (B.N.); Neurosurgery, Medical University of South Carolina, Charleston, SC, USA (A.S.); Radiology and Neuroradiology, Klinikum Vest Recklinghausen, Recklinghausen, Germany (C.L.); Interventional Neuroradiology/Endovascular Neurosurgery, Hospital Clínico Universitario de Valladolid, Valladolid, Spain (M.M.G.); Interventional Neuroradiology, Rhode Island Hospital, Providence, Rhode Island, USA (R.M.T.); Vascular and Interventional Radiology, Ghent University Hospital, Ghent, Belgium (L.D.); Radiology, Hospital Universitario Central de Asturias-HUCA, Oviedo, Spain (P.V.); Neuroscience Department, Bon Secours Mercy Health St. Vincent Medical Center, Toledo, Ohio, USA (O.O.Z); Stryker Neurovascular, Fremont, California, USA (P.J.); Neuroradiology Unit, Radiology Department, University Hospital "G. Martino" Messina, Messina, Italy (S.L.V., A.T.); Department of Neurology and Comprehensive Stroke Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA (D.S.L.); Wellstar Medical Group, Neurosurgery, WellStar Health System, Marietta, Georgia, USA (R.G.).

Background And Purpose: Mechanical thrombectomy (MT) is effective for acute ischemic stroke, yet its indication in mild stroke remains unclear. This study evaluates MT's effectiveness and safety in low NIHSS patients and assesses different MT strategies' impact on procedural success and clinical outcomes.

Materials And Methods: Data from the ASSIST Registry were analyzed, categorizing patients with large vessel occlusion of the anterior circulation into mild (NIHSS≤5) and moderate-severe (NIHSS>5) stroke groups.

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Background And Purpose: Acute ischemic stroke due to anterior circulation large-vessel occlusion (AIS-LVO) remains a leading cause of disability despite successful reperfusion therapies. Prolonged venous transit (PVT) has emerged as a potential prognostic imaging biomarker in AIS-LVO. We aimed to investigate whether PVT is associated with a decreased likelihood of excellent functional outcome (modified Rankin Scale [mRS] score of 0-1 at 90 days) after successful reperfusion.

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Article Synopsis
  • Post-recanalization target vessel re-occlusion (TVR) is a known complication after endovascular thrombectomy (EVT), linked to poor long-term outcomes, but its causes and incidence right after the procedure are not well understood.
  • A multicenter study examined 167 patients undergoing EVT for large vessel occlusion, measuring changes in the TICI score immediately after the procedure and 10 minutes later, revealing that 16.2% experienced a score change, with 70% of those worsening.
  • The study suggests that neurointerventionalists should conduct angiographic assessments 10 minutes post-EVT to better manage the risk of TVR, considering that only 31% of the entire cohort achieved functional independence at
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Rationale: Neuroprotective strategies based on reperfusion therapy hold substantial promise for acute ischaemic stroke (AIS). Preclinical research indicates that tocilizumab, an interleukin-6 receptor antagonist, can attenuate ischaemia-reperfusion damage by exerting anti-inflammatory and neuroprotective effects.

Aim: To determine tocilizumab's efficacy and safety when combined with endovascular thrombectomy (EVT) in patients with acute anterior circulation large vessel occlusion (LVO).

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[Midterm and long-term angiographic outcomes and efficacy analysis of the Pipeline Embolization Device in the treatment of intracranial aneurysms].

Zhonghua Wai Ke Za Zhi

December 2024

Department of Neurosurgery, People's Hospital of Ningxia Hui Autonomous Region(People's Hospital of Autonomous Region, Ningxia Medical University), Yinchuan750002, China.

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Article Synopsis
  • - A systematic review and meta-analysis were conducted to determine factors affecting leptomeningeal collateral status in patients with acute ischemic stroke, analyzing 81 studies with over 17,000 participants.
  • - The analysis identified that older age, male sex, hypertension, diabetes, atrial fibrillation, cardioembolic stroke, internal carotid artery occlusion, and high admission blood glucose negatively impacted collateral status.
  • - The study suggests that hypertension and diabetes could be modified to improve outcomes in stroke patients, while older age and male sex are inherent risk factors that cannot be changed; further studies are recommended to explore treatment strategies.
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Prolonged Venous Transit on Perfusion Imaging is Associated with Longer Lengths of Stay in Acute Large Vessel Occlusions.

AJNR Am J Neuroradiol

November 2024

From the Department of Radiology (M.K.), Cooper Medical School of Rowan University, Camden, NJ, USA; Department of Radiology (J.Y.M., H.A.S., M.S., H.L., V.S.Y), Department of Neurosurgery (R.X.), and Department of Neurology (V.C.U., E.B.M., R.L., M.B., R.H.L, A.E.H), Johns Hopkins Hospital, Baltimore, MD, USA; Department of Radiology (D.A.L.), West Virginia University Medicine, Morgantown, WV, USA; Department of Neuroradiology (A.A.D.), Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA; Department of Radiology (A.G.), Universite Libre De Bruxelles Hospital, Erasme, Belgium; Department of Radiology (J.J.H., B.P.), Department of Neurology (G.W.A.), Stanford University School of Medicine, Stanford, CA, USA; Department of Radiology (D.W.), Brown University/Rhode Island Hospital, Providence, RI, USA; Department of Radiology (T.D.F.), University Medical Center Munster, Munster, Germany; Department of Radiology (V.V.), Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA; Department of Radiology (A.S.), Department of Neurology (Y.A.), University of Cincinnati, Cincinnati, OH, USA; Department of Radiology and Biomedical Imaging (K.N.), University of California San Francisco, San Francisco, CA, USA.

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Background: Intensive blood pressure (BP) management within 24 hours after successful reperfusion following endovascular thrombectomy (EVT) is associated with worse functional outcomes than conventional BP management in Asian randomized controlled trials. Given the high prevalence of intracranial atherosclerotic stenosis (ICAS) in Asia, ICAS may influence these outcomes.

Aims: We aimed to assess whether ICAS affects the outcomes of intensive BP management after successful EVT.

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Prognostic Prediction Model for Endovascular Treatment of Acute Anterior Circulation Ischemic Stroke Based on Rapid Processing of PerfusIon and Diffusion Software.

World Neurosurg

December 2024

Department of Cardiology, Affiliated Hospital 6 of Nantong University, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng Third People's Hospital, Yancheng, China. Electronic address:

Objective: To construct a universally applicable nomogram using computed tomography perfusion parameters based on Rapid processing of PerfusIon and Diffusion software for evaluating the prognosis of acute anterior circulation large vessel occlusion treated by endovascular therapy.

Methods: A total of 130 patients were divided into 2 groups: a group with a good prognosis [Rankin Rating Scale (mRS) score ≤2 points] and a group with a poor prognosis (mRS score >2 points). The least absolute shrinkage and selection operator logistic regression method was used to screen the predictive factors, and a nomogram chart prediction model was established.

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Article Synopsis
  • Carotid plaques may play a significant role in causing ischemic strokes, and this study evaluated their characteristics in relation to strokes that occur on either side of the affected carotid artery.
  • Researchers analyzed data from the ESCAPE-NA1 trial, focusing on patients with embolic stroke of undetermined source (ESUS) who underwent thrombectomy, and looked for "vulnerable carotid plaques" using various imaging criteria.
  • The findings revealed that vulnerable plaques, characterized by surface irregularity and significant stenosis, were significantly more common in the carotid arteries on the same side as the stroke, highlighting the importance of monitoring these plaques for better stroke risk assessment.
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Background: Mechanical thrombectomy (MT) is an established therapy for acute ischemic stroke (AIS), but recanalization is not always achieved. Common reasons are inadequate removal at the thrombus site and difficulties with the access route. In order to identify risk factors for MT failure we conducted a retrospective study on a high-volume comprehensive stroke center.

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Long-Term Outcome of Rescue Stenting for Acute Intracranial Atherosclerotic Stenosis Related Large Vessel Occlusion in Anterior Circulation.

AJNR Am J Neuroradiol

November 2024

From the Department of Neurology (H.P.), Keimyung University School of Medicine, Daegue, Korea; Department of Radiology (B.M.K., D.J.K.), Interventional Neuroradiology, Department of Radiology, Severance Stroke Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; Department of Radiology (J-W.K.), Yonging Severance Hospital, Yonsei University College of Medicine, Yongin, Korea; Department of Radiology (J.W.K), Yonsei University Wonju Christian Hospital, Wonju, Korea; Department of Neurology (J-H.B), Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Neurosurgery (M.J.K), Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea; Department of Neurosurgery (S.Y), Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea; Department of Neurosurgery (C.K.J), Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea; Department of Neurosurgery (S.K), Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea; Department of Neurology (JN.H), Chung-Ang University, Gwangmeyong Hospital, Gwangmyeong, Korea; Department of Neurosurgery (J-K.K), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; Department of Neurology (I.H.L), Wonkwang University School of Medicine, Iksan, Korea; Department of Neurology (J.H.H., H.S.N., Y.D.K.), Yonsei University College of Medicine, Seoul, Korea.

Background And Purpose: Rescue stent (RS) is an accepted rescue option after failed mechanical thrombectomy (MT) for acute ischemic stroke due to intracranial atherosclerotic stenosis (ICAS)-related large vessel occlusion (LVO). However, the long-term outcomes (≥ 12 months) of RS have not yet been elucidated.

Materials And Methods: We retrospectively analyzed the data of 154 patients with RS for ICAS-related LVO, which were identified from prospectively maintained multicenter database of RS after MT failure, to assess good outcome (mRS 0-2), mortality, stroke recurrence, symptomatic intracranial hemorrhage (SICH) and stent patency.

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The cortical vein opacification score (COVES) is independently associated with DSA ASITN collateral score.

AJNR Am J Neuroradiol

November 2024

From the Department of Radiology and Radiological Sciences (D.A.L., A.B.B., H.S., R.W., J.M., V.Y.), and Department of Neurology (A.E.H.), Johns Hopkins University, Baltimore, MD, USA; Department of Neuroradiology (D.A.L., S.A., M.K., A.T.R.), and Department of Biostatistics (S.W.), West Virginia University, Morgantown, WV, USA; Cooper Medical School of Rowan University (M.K.), Camden, NJ, USA; Department of Neurology (J.J.H., G.W.A.), Stanford University, Stanford, CA, USA; Department of Radiology (A.A.D.), Harvard Medical School, Boston, MA, USA; Department of Radiology, Neuroendovascular Division (T.D.F.), University Medical Center Münster, Germany; Department of Neuroradiology (M.W.), MD Anderson Medical Center, Houston, TX, USA; Department of Radiology (K.N.), University of California San Francisco, CA, USA.

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Background: Symptomatic intracranial hemorrhage (sICH) after mechanical thrombectomy (MT) is associated with worse outcomes. We sought to develop and internally validate a machine learning (ML) model to predict sICH prior to MT in patients with anterior circulation large vessel occlusion.

Methods: Consecutive adults who underwent MT for internal carotid artery/M1/M2 occlusions at a single institution were reviewed.

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