Cyclophosphamide treatment with a comparison in both pediatric rheumatology and pediatric nephrology practices.

Background: Cyclophosphamide (CYC) is an inactive alkylating agent that transforms the alkyl radicals into other molecules and is used in combination with systemic corticosteroids in the treatment of many childhood rheumatic diseases, such as systemic lupus erythematosus (SLE), and ANCA-associated vasculitis (AAV). In recent years, rituximab (RTX), a B-cell-targeting anti-CD20 monoclonal antibody, has emerged as a new alternative treatment modality over CYC for induction therapy of childhood-onset rheumatic diseases. Clinicians adopt different practices for using CYC particularly in relation to indications, posology, pre-treatment laboratory work-up, post-treatment follow-up, and screening pre- and post-treatment vaccination status.

Use of the Hounsfield unit scale in differentiating transudate and exudate in pleural effusion in the emergency department.

Attenuation values in computed tomography (CT) are used as a diagnostic aid in certain clinical conditions. In our study, we investigated the effectiveness of attenuation values, obtained through the noninvasive method of CT, in determining the type of pleural effusions in the emergency department. Patients who presented to the emergency department with a diagnosis of pleural effusion and underwent thoracentesis within 48 hours between January 1, 2023, and January 1, 2024, were included in the study.

Preoperative hemoglobin A1c as a predictor of lymph node metastasis in diabetic women with endometrial cancer.

Background: Glycated hemoglobin A1c (HbA1c) is a well-established marker for glycemic control; recent studies suggest its potential role in cancer prognosis. Understanding the relationship between preoperative HbA1c levels and lymph node metastasis (LNM) in diabetic women with endometrial cancer (EC) can enhance prognostic assessments and treatment strategies.

Objectives: This study aimed to evaluate the predictive value of preoperative HbA1c levels for LNM in diabetic women with EC.

Assessment of inflammatory status in long-term night shift workers using the CRP-albumin ratio and neutrophil-lymphocyte ratio.

Long-term night shift (NS) work is known to affect the body's circadian rhythm, leading to chronic low-level inflammation. We aimed to evaluate this information for the first time through CRP-Albumin Ratio [CAR] and Neutrophil-Lymphocyte Ratio [NLR] levels. Design is descriptive, cross-sectional.

Systemic effect of sympathectomy in the treatment of localized hyperhidrosis.

Hyperhidrosis is thought to result from excessive stimulation of sweat glands due to increased sympathetic activity; however, data on systemic responses following bilateral thoracic sympathectomy as the definitive treatment have not yet been sufficiently evaluated. This study, designed as a prospective cohort investigation, included 24 patients who underwent sympathectomy for palmar and axillary hyperhidrosis at our center in 2023, along with an age-matched control group of equal size. In the sympathectomy group, pupillometry measurements were performed 1 day before surgery and on the 7th postoperative day, while the control group underwent measurements at corresponding intervals.

Good response rates and predictors during the first year of cabergoline treatment in large invasive prolactinomas.

Purpose: The factors predicting the long-term response to cabergoline are not well known, particularly in more invasive prolactinomas. This study aimed to evaluate the rate of good response (GR) (normoprolactinemia and ≥ 50% tumor shrinkage) at the one-year follow-up and to identify predictors of GR in patients with large invasive prolactinomas.

Methods: This retrospective single-center study included 38 patients (32 males, 6 females; mean age 41.

An exceptional presentation of nephrotic syndrome: bilateral massive pulmonary embolism.

Venous thromboembolism (TE) and arterial TE are rare in children, but can cause severe morbidity and mortality. The incidence of TE is 8.6-57 per 100 000 among hospitalized children and 0.

Predictive factors of mortality in patients with abdominal trauma.

Background: Traumatic injuries, particularly abdominal trauma, are a major cause of mortality worldwide. This study aimed to evaluate predictive factors for mortality and morbidity in abdominal trauma patients using simple, rapid, and accessible clinical and laboratory parameters, with a focus on developing scoring systems for emergency department decision-making.

Methods: A retrospective cohort study was conducted in a Level 1 Trauma Center between October 2022 and March 2024.

A Wide QRS Complex Tachycardia with Variation of Ventriculoatrial Interval: What is the Mechanism?

The differential diagnosis for wide complex tachycardia includes all causes of narrow complex tachycardia with bundle branch block, all causes of narrow complex tachycardia with antegrade pre-excitation, ventricular tachycardia, and antidromic and other pre-excited reciprocating tachycardias. The variation in a specific intracardiac interval that causes a subsequent change in the tachycardia cycle length or another intracardiac interval can be diagnostic in these arrhythmias.

Expanding the Genetic Spectrum of PPM1K-Related Maple Syrup Urine Disease: A Novel Mutation.

Maple syrup urine disease (MSUD) is a rare inborn error of metabolism caused by impaired catabolism of branched-chain amino acids (BCAAs). The genes BCKDHA, BCKDHB, DBT, and DLD encode the subunits of the branched-chain α-ketoacid dehydrogenase (BCKDH) complex, which is essential for BCAA metabolism. Catalytic subunits are BCKDHA, BCKDHB, DBT, and DLD, whereas the regulator subunits are PPM1K and BCKDK.

Posterior tibial slope after total knee arthroplasty is not reproducible or consistent.

Background: Our aim was to compare posterior tibial slope (PTS) values, distribution, deviation from manufacturer's recommended value and restoration of this value in total knee arthroplasty (TKA) with tibial component placement using intramedullary (IM) and extramedullary (EM) methods, and to analyze factors affecting these values.

Methods: A total of 151 knees operated with Zimmer-Biomet NexGen® LPS Fixed Bearing Knee TKA between 2022 and 2024 were retrospectively investigated. Knees were grouped by method of tibial component placement (IM or EM).

Compliance Evaluation with ChatGPT for diagnosis and treatment in patients brought to the ED with a Preliminary Diagnosis of Stroke.

Objectives: Chat Generative Pre-trained Transformer (ChatGPT) is a natural language processing product developed by OpenAI. Recently, the use of ChatGPT has gained attention in the field of healthcare, particularly for its potential applications in diagnostic and decision-making support. While its utility is still being explored, it shows promise as a supplementary tool in these contexts.

Allogeneic Hematopoietic Stem Cell Transplantation in Relapsed Refractory Multiple Myeloma.

Objectives: Allo-Hematopoietic Stem Cell Transplantation (HSCT) offers a curative option for relapsed and refractory multiple myeloma in younger aged and fit patients with high-risk cytogenetic properties.

Material And Methods: This study retrospectively enrolled the medical data of 30 patients who had undergone allogeneic stem cell transplantation at the Gazi University Adult Stem Cell Transplant Unit between 2005 and 2020.

Results: Before allo-SCT, 6 (20.

The Relationship Between Cognitive Disengagement Syndrome in Children and Cognitive Disengagement Syndrome, Depression, and Anxiety Levels in Their Parents.

Objective: This study aimed to investigate the relationship between Cognitive Disengagement Syndrome (CDS) symptoms in children/adolescents and their parents within the Turkish population, examining the association with co-occurring ADHD symptoms, peer/social relationships, and total difficulties.

Method: The study included 229 parents aged 18 to 50 with children aged 6 to 18 from the staff of Karabuk Training and Research Hospital. Data collection occurred from April to September 2022.

Frequency of central sensitization and nociplastic pain in patients with plantar fasciitis : Central sensitization and nociplastic pain in plantar fasciitis.

Purpose: If the pain persists for a long time in the treatment of plantar fasciitis (PF) or if there is no response to treatment, central sensitization (CS) may develop and the pain may transform into nociplastic pain (NP). This study aimed to evaluate the frequency of CS and NP in patients with PF.

Methods: This cross-sectional study was undertaken between November 2023 and March 2024.

Aetiological distribution and clinical features in children with large pericardial effusion who underwent pericardiocentesis.

Background: We aimed to evaluate the clinical and laboratory characteristics and aetiological factors of patients who underwent pericardiocentesis for moderate to large pericardial effusion.

Method: A total of 38 patients who underwent pericardiocentesis due to moderate-severe pericardial effusion and not related to cardiac surgery were included in the study.

Results: The male-to-female ratio was 2.

Psycho-Oncological Issues in a Pediatric Sample: Two Years Follow-Up Data of Consultation Liaison Psychiatry.

Background: Pediatric oncology patients encounter substantial psychosocial and psychiatric challenges alongside physical illness and treatment burdens. Consultation-Liaison Psychiatry (CLP) is critical for addressing these young patients' mental health needs within a broader healthcare framework. Socioeconomic disparities, family dynamics, and educational interruptions further complicate the psychiatric landscape in pediatric oncology.

Maternal Recognition of Formula Food Brand Logos and Its Association with Breastfeeding.

Despite many well-documented benefits of breastfeeding, only 44% of babies worldwide are exclusively breastfed for the first 6 months. The aggressive marketing of formula food companies may be contributing to why mothers are choosing artificial feeding over breastfeeding. To identify when and how mothers become aware of infant formula food and the impact it has on breastfeeding.

18F-FDG PET/CT Findings in Idiopathic Hypertrophic Pachymeningitis with Cranial Nerves Dysfunction.

Hypertrophic pachymeningitis is an uncommon inflammatory process with thickening of the dura mater and may be idiopathic or secondary to various conditions such as vasculitis, Sjögren syndrome, rheumatoid arthritis, sarcoidosis, and infections. A 67-year-old man who presented with bilateral hearing loss, vision loss in the left eye, right-sided facial paralysis, and right-side headache underwent 18F-FDG PET/CT for further evaluation. Herein, we have presented a patient who showed diffuse increased radiotracer uptake in the cranial nerves and intracranial dura mater on 18F-FDG PET/CT and was diagnosed as idiopathic hypertrophic pachymeningitis based on laboratory and MRI findings.

Clarithromycin-resistant Helicobacter pylori in Ankara, Turkey: Detection by real-time PCR in formalin-fixed paraffin-embedded gastric biopsy samples.

Choosing the appropriate treatment regimen for Helicobacter pylori (Hp) depends on knowing or predicting regional antibiotic resistance rates. In this study, we aimed to determine the frequency of Hp and clarithromycin (Cla) resistance rates by PCR analysis in formalin-fixed paraffin-embedded (FFPE) gastric biopsies of patients diagnosed with gastritis. Hp DNA and Hp Cla resistance (ClaR) were analyzed by PCR method.

Eyelid and Parotid Gland Metastasis of Colorectal Cancer Demonstrated by 18F-FDG PET/CT.

A 67-year-old man underwent a sigmoid colectomy and received 4 cycles of capecitabine and oxaliplatin. 18F-FDG was performed for the treatment response evaluation. It revealed increased radiotracer uptake both in the nodular lesion of the left parotid gland and in the subcutaneous density of the left eyelid.

Factors Predicting Incidentally Found Appendiceal Tumors Following Appendectomy: Propensity Score Matching Analysis.

Purpose: The factors that predict coincidental appendiceal neoplasms in patients who underwent appendectomy due to appendicitis were investigated.

Methods: 5829 patients diagnosed with appendicitis and underwent appendectomy in the department of surgery were examined. Among these patients, patients with appendiceal neoplasia and benign pathology were selected by propensity score matching analysis in a ratio of 1:4.