822 results match your criteria: "Ankara Bilkent City Hospital.[Affiliation]"

Background And Hypothesis: Schizophrenia is a complex disorder thought to have neurodevelopmental and neurodegenerative aspects. Optical coherence tomography (OCT) measurements of schizophrenia patients revealed that the retinal layers of these patients were thinner than those of healthy controls. This study aimed to examine retinal changes in first-episode psychosis patients treated with electroconvulsive therapy (ECT) via OCT.

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  • The study assessed the effectiveness of hybrid aortic surgery in 24 patients with complex aortic conditions, focusing on technical success and postoperative outcomes like morbidity and mortality.
  • Different surgical strategies were utilized based on the location of the aortic issue, with notable findings that the femoral incision approach resulted in shorter hospital stays despite higher infection rates in some areas.
  • Overall, the results suggest that hybrid aortic surgery is both a safe and effective method for treating complex cases where standard procedures may not be adequate.
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Background: Pain and sedation management is an integral part of pediatric intensive care practice. Sedoanalgesia management must be balanced in order to optimize comfort and avoid complications. In order to achieve this balance, sedoanalgesia management needs to be clarified in pediatric intensive care units (PICU).

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Outcomes by Retrospective Eligibility for Maintenance Therapy of Patients With Advanced Urothelial Carcinoma: Post Hoc Analysis of the Phase 3 KEYNOTE-361 Trial.

Clin Genitourin Cancer

February 2025

Barts Cancer Centre, St Bartholomew's Hospital, London United Kingdom; Barts Cancer Institute, Barts Health NHS Trust, Queen Mary University of London, London, United Kingdom.

Introduction: The phase 3 KEYNOTE-361 trial of first-line pembrolizumab with or without chemotherapy versus chemotherapy alone in patients with locally advanced or metastatic urothelial carcinoma (la/mUC) completed enrollment before the approval of postchemotherapy maintenance avelumab for patients without progressive disease. This post hoc analysis evaluated the outcomes of patients who received chemotherapy alone in KEYNOTE-361 by retrospective eligibility for subsequent maintenance therapy.

Patients And Methods: Patients in the chemotherapy alone arm were retrospectively categorized as maintenance eligible (received ≥4 cycles of chemotherapy and did not die or experience disease progression within 10 weeks of chemotherapy completion), maintenance ineligible (received <4 cycles of chemotherapy or had progressive disease or died within 0-10 weeks after completion of ≥4 cycles of chemotherapy), and indeterminate eligibility for maintenance therapy (if neither maintenance eligible or ineligible).

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We studied a family with three male individuals across two generations affected by common variable immune deficiency (CVID). We identified a novel missense heterozygous variant (c.2602T>A:p.

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Secondary lymphoid organs (SLOs) provide the confined microenvironment required for stromal cells to interact with immune cells to initiate adaptive immune responses resulting in B cell differentiation. Here, we studied three patients from two families with functional hyposplenism, absence of tonsils, and complete lymph node aplasia, leading to recurrent bacterial and viral infections. We identified biallelic loss-of-function mutations in encoding the lymphotoxin beta receptor (LTβR), primarily expressed on stromal cells.

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  • Researchers investigated the effectiveness of combining exoskeleton training (FreeGait®) with traditional therapy for improving walking abilities in patients with incomplete spinal cord injuries.
  • The study involved 14 participants split into two groups, where one received standard therapy while the other also underwent additional exoskeleton training three times a week.
  • Results showed significant improvements in walking and mobility measures for the group using the exoskeleton (RBCT), indicating that this method enhances rehabilitation, though overall quality of life scores did not differ significantly between the groups.
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Behavioral feeding problems and parenting stress in toddlers with food protein-induced allergic proctocolitis.

Ann Allergy Asthma Immunol

November 2024

Division of Pediatric Allergy and Immunology, Department of Pediatrics, University of Health Sciences Türkiye, Ankara Bilkent City Hospital, Ankara, Turkey.

Background: Food protein-induced allergic proctocolitis (FPIAP) typically develops in infancy, a critical period for taste preference and feeding skill development. Eliminating culprit foods, along with limited food options and the child's distressing symptoms, can significantly impact the mothers' parenting roles. However, research on behavioral feeding problems and parenting stress in toddlers with FPIAP is lacking.

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Introduction: The natural history, the progression of a disease process in an individual over time, has not yet been fully elucidated in hidradenitis suppurativa (HS). In this large multicenter study, we aimed to investigate the natural history of HS and its gender differences.

Methods: This cross-sectional study included 827 patients.

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Development and evaluation of an antigen targeting lateral flow test for Crimean-Congo Haemorrhagic Fever.

EBioMedicine

December 2024

Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom; Global Access Diagnostics, Thurleigh, Bedfordshire, United Kingdom.

Background: Crimean-Congo Haemorrhagic Fever (CCHF) is a viral haemorrhagic fever with a case fatality rate of 5-25% that has been prioritised for research and development by the World Health Organisation. There are no CCHF rapid diagnostic tests (RDTs) commercially available. We describe the development and evaluation of an antigen-targeting lateral flow immunoassay RDT for CCHF.

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Introduction: This report describes a rare occurrence of corneal epithelial keratopathy associated with ribociclib, a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor widely used in breast cancer treatment.

Case Report: An 83-year-old female with a recent breast cancer diagnosis presented with blurred vision during the third cycle of ribociclib treatment. Ocular examination revealed corneal epitheliopathy and fluorescein staining findings.

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Objective: According to the Tokyo 2018 guidelines, white blood cells (WBCs) are the only markers used in the staging of acute cholecystitis. We aimed to investigate the role of thiol-disulfide and ischemia-modified albumin (IMA), which are used in the diagnosis of inflammatory diseases, in the diagnosis, and severity of acute cholecystitis.

Materials And Methods: A total of 108 patients hospitalized with acute cholecystitis and 42 healthy volunteers were included in the study.

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Background: Our study aims to reveal the relationship between autistic traits and repetitive behaviors in adolescents diagnosed with obsessive-compulsive disorder and trichotillomania and to compare them to healthy controls.

Method: A total of 100 adolescents, 33 of whom were diagnosed with obsessive-compulsive disorder, 32 of whom were diagnosed with trichotillomania and 35 healthy controls, aged 11-18 years, who applied to a Child and Adolescent Psychiatry Outpatient Clinic between February 2023 and July 2023, were included in the study. Participants were evaluated with the Autism Spectrum Quotient (AQ)-Adolescent, Repetitive Behavior Scale-Revised (RBS-R), Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS), and Clinical Global Impression Scale-Severity (CGI-S).

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The clinical policy of the Emergency Medicine Association of Türkiye (EMAT) provides guidance on the use of tranexamic acid (TXA) in emergency settings. TXA, an antifibrinolytic drug, is used to control bleeding by inhibiting plasminogen. Its applications have expanded from hemophilia and severe menstrual bleeding to include various forms of trauma and surgery-related bleeding.

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Introduction: Beta-lactam antibiotics (BLAs) are the most common cause of drug hypersensitivity reactions in children, and it is important to find safe alternative antibiotics for these children. This study evaluates the selection, safety to alternative antibiotics in patients with confirmed BLA allergies based on diagnostic tests.

Methods: At the Pediatric Immunology and Allergy Clinic of Ankara Bilkent City Hospital, a retrospective evaluation of diagnostic tests (including skin prick, intradermal, and drug provocation tests) was conducted to identify alternative antibiotics for patients with confirmed BLA.

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  • The study explores a new type of heart rhythm issue called pseudo-RNRVAS that occurs when atrial stimulation stops while there is continued communication between the ventricles and atrium during certain heart phases.
  • Researchers investigated 21 patients with cardiac devices, finding that 20 experienced pseudo-RNRVAS, particularly at lower heart rates and specific timing intervals after losing atrial capture.
  • The findings suggest that pseudo-RNRVAS can happen without the usual risk factors and are more likely in scenarios that increase atrial pacing, especially soon after pacemaker implantation, indicating a possible link to pacemaker syndrome and heart failure risk.
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Unlabelled: The aim of this study was to evaluate the cutaneous manifestations of immunoglobulin A vasculitis (IgAV) in terms of skin lesion type, distribution and persistence and to investigate the relationship between cutaneous manifestations and system involvement and treatment needs. This retrospective observational study was conducted with 489 IgAV patients who were followed-up for at least 6 months between 2013 and 2024. Demographic characteristics, detailed cutaneous manifestations, clinical findings and treatments were retrieved from electronic medical records.

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Objective: To evaluate immunoglobulin A vasculitis (IgAV) patients with gastrointestinal (GI) tract involvement and to reveal the relationship between the location and extent of the affected intestinal segment detected on the initial abdominal ultrasound (US) and GI tract bleeding.

Methods: This medical record review study was conducted on 117 IgAV patients with GI tract involvement between January 2016- June 2023. Patients were divided into two groups as those with (n=28) and without (n=89) GI tract bleeding.

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  • The study analyzed oxidative stress in the blood of obese and nonobese pregnant women and their babies, involving 30 obese and 35 nonobese participants aged 18-40.
  • Significant findings showed higher levels of oxidative stress markers like disulfide and catalase in obese mothers and their newborns, indicating increased oxidative stress compared to nonobese counterparts.
  • The study highlights the importance of weight management before and during pregnancy to reduce oxidative stress and associated health risks for both mothers and infants.
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Lyme serology in non-endemic countries: Why do we request it and what do we find?

BMC Infect Dis

November 2024

Division of Pediatric Infectious Disease, Department of Pediatrics, Ankara Bilkent City Hospital, Yildirim Beyazit University, Bilkent, Ankara, 06800, Turkey.

Background: The primary objectives of our research were to analyze Lyme serology results from pediatric patients, identify the clinical reasons for ordering these tests, and assess the clinical relevance of the serology results in the context of Lyme disease.

Methods: Our study, conducted at a reference pediatric hospital in a non-endemic region for Lyme disease, included all pediatric patients for whom Lyme serology was requested. ELISA and Western blot results were documented.

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Securing long-term immunity: The possible necessity of supplementary measles vaccination.

BMC Infect Dis

November 2024

Division of Pediatric Infectious Disease, Department of Pediatrics, Ankara Bilkent City Hospital, Yildirim Beyazit University, Bilkent, Ankara, 06800, Turkey.

Background: The global initiative to eliminate measles, spearheaded by the World Health Organization, has yet to achieve its intended goals. In Turkey, despite robust vaccination strategies, recent increases in measles cases have been attributed to vaccine hesitancy and irregular migration. This study evaluates measles serology within a pediatric population to determine the impact of vaccination regimens on immunity.

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