Climate change impact on green spaces planning in an urban area using a hybrid approach.

This study presents a hybrid methodology for planning green spaces to enhance urban sustainability and livability, evaluating the impacts of climate change on cities. Cities, once accommodating a small population, have become major centers of migration and development since the eighteenth century. Rapid urban growth intensifies infrastructure, environmental, and social challenges.

An Autoethnographic Account of Familial Mediterranean Fever: A Turkish Patient's Discovery of Spiritual Meaning.

Familial Mediterranean Fever (FMF) is a genetic autoinflammatory disorder characterized by recurrent febrile episodes that are accompanied by pain in the abdomen, chest, or joints caused by peritonitis, pleuritis, skin lesions, arthritis, and pericarditis. This original article aims to provide an analytic autoethnographic account of a Turkish patient's experience of FMF, with a focus on the discovery of spiritual meaning. In addition to discussing the grief reactions to a loss of health, the article uses self-reflexive discourse and narrative-based analysis to explore four stages of discovery of spiritual meaning through FMF: "omnipotent me," "God's punishment," "God's test," and "God's mercy.

Computer simulation approaches to evaluate the interaction between analytical performance characteristics and clinical (mis)classification: a complementary tool for setting indirect outcome-based analytical performance specifications.

Simulation-based approaches for setting indirect outcome-based analytical performance specifications (APS) predominantly involve test repetition through analytical reruns or resampling. These methodologies assess the agreement between original and simulated measurement results, determining the APS corresponding to pre-established performance thresholds. For APS related to imprecision and bias, both analytical performance characteristics (APCs) are typically considered in simulations, whereas for APS regarding measurement uncertainty, bias is excluded in alignment with traceability standards.

Prokaryotic and eukaryotic periphyton responses to warming, nutrient enrichment and small omnivorous fish: a shallow lake mesocosms experiment.

Global change stressors, including climate warming, eutrophication, and small-sized omnivorous fish, may exert interactive effects on the food webs and functioning of shallow lakes. Periphyton plays a central role in the primary production and nutrient cycling of shallow lakes but constitutes a complex community composed of eukaryotes and prokaryotes that may exhibit different responses to multiple environmental stressors with implications for the projections of the effects of global change on shallow lakes. We analyzed the effects of warming, nutrient enrichment, small omnivorous fish and their interactions on eukaryotic and prokaryotic periphyton structures in shallow lake mesocosms.

Analysis of glipizide and pravastatin sodium drug molecules at trace level by using magnetic solid phase extraction and HPLC-DAD system.

An easy applicable and selective sample preparation technique has been developed for trace and simultaneously analysis of Glipizide (GLP) and Pravastatin (PST) molecules in biological matrices based on magnetic solid phase extraction (MSPE) and high-performance liquid chromatography (HPLC). A new magnetic adsorbent including FeO@TEOS-Melamine has been synthetized and characterized for extraction studies. Experimental variables of MSPE were examined and optimized step by step such as pH, adsorption and desorption conditions, time effect, etc.

The prevalence and related factors of social frailty in older adults: A low- and middle-income country perspective.

Objectives: There are no studies examining the prevalence of social frailty and associated factors in low- and middle-income countries. This study aimed to assess the prevalence of social frailty and identify the contributing factors among older adults in Türkiye.

Methods: This cross-sectional study included 570 participants aged 65 and older, all outpatients at a geriatric clinic.

Kidney Replacement Therapies and Outcomes in Children With Crush Syndrome-Associated Kidney Injury.

Importance: This study addresses the characteristics, kidney replacement therapy (KRT) modalities, and outcomes in children diagnosed with crush syndrome following an earthquake in Turkey.

Objective: To analyze the associations of different KRT modalities with long-term dialysis dependency and length of stay (LOS) in the pediatric intensive care unit (PICU).

Design, Setting, And Participants: This multicenter, prospective, and retrospective cohort study was conducted across 20 PICUs in Turkey.

Real-World Efficacy and Safety of Escalation to Weekly Adalimumab for Chronic Non-Infectious Uveitis: A Multicenter Study Involving Pediatric and Adult Patients.

Purpose: To evaluate the efficacy and safety of weekly adalimumab (ADA) treatment in non-infectious uveitis (NIU) patients, including both pediatric and adult populations, and identify factors influencing treatment efficacy.

Methods: A retrospective cohort study at two hospitals in Türkiye included 51 NIU patients (29 children, 22 adults) who escalated from bi-weekly to weekly ADA due to inadequate disease control. Data on six clinical parameters (anterior chamber reaction, vitreous haze, visual acuity, central macular thickness [CMT], prednisone use, uveitis flare-up frequency), adverse effects, and treatment-related factors were collected.

New approaches in childhood IgE-mediated food allergy treatment.

Purpose Of Review: This review aims to provide an overview of the current and future treatment options for children with food allergies (FAs), highlighting the latest research findings and the potential impact of these new approaches on improving patients' and caregivers' quality of life.

Recent Findings: In the last decade, many promising approaches have emerged as an alternative to the standard avoidance of the culprit food with the risk of severe accidental reactions. Desensitization through oral immunotherapy has been introduced in clinical settings as a therapeutic approach, and more recently also omalizumab.

Properties of encapsulated raspberry powder and its efficacy for improving the color stability and amino acid composition of pastırma cemen pastes with different pH during long term cold-storage.

Unlabelled: In this study, the changes in the physicochemical properties, color stability, and amino acid composition of cemen paste (CP) produced by adjusting to different pH levels (3.0, 4.0, 5.

Relationship between oxidative stress and endometrial polyps in pre-and postmenopausal women.

Objective: This study aimed to investigate the relationship between oxidative stress (OS) and endometrial polyps (EP) in pre- versus postmenopausal women with abnormal uterine bleeding.

Methods: This prospective case control study was conducted in the Gynecology Department of Ankara Bilkent City Hospital between January and December 2019. In this study, the EP and control groups included 45 participants each (30 pre- and 15 postmenopausal women).

Evaluating SCUBE-1 as Predictive Biomarker for Hypertension-Mediated Organ Damage: A Comparative Study.

Background: Hypertension-mediated organ damage (HMOD) is a critical complication of hypertension that can present with cardiac, retinal, and renal manifestations and affect patient outcomes. Serum signal peptide, CUB (complement C1r/C1s, Uegf, and Bmp1) domain, and epidermal growth factor-like domain-containing protein 1 (SCUBE-1), a novel biomarker implicated in vascular pathology, shows promise for detecting HMOD. This study aims to explore the relation between SCUBE-1 levels and HMOD in hypertensive patients.

Characterizing the pan-cancer role of exosomal miRNAs in metastasis across cancers.

Exosomal microRNAs (exomiRs) play a critical role in intercellular communication, especially in cancer, where they regulate key cellular processes like proliferation, angiogenesis, and metastasis, highlighting their significance as potential diagnostic and therapeutic targets. Here, we aimed to characterize the role of exomiRs, derived from seven cancer types (four cell lines and three tumors), in influencing the pre-metastatic niche (PMN). In each cancer type we extracted high confidence exomiRs (LogFC >= 2 in exosomes relative to control), their experimentally validated targets, and the enriched pathways among those targets.

Treatment Inertia and Symptom Burden in Anemia of CKD: Insights from the SATISFY Survey in the Middle East, South Africa, and Türkiye.

Introduction: Limited data exist regarding treatment patterns and symptom burden of patients with anemia of chronic kidney disease (CKD) in the Middle East, South Africa, and Türkiye.

Methods: This real-world study explored clinical characteristics, symptom burden, and treatment patterns of patients with anemia of CKD living in the Middle East, South Africa, and Türkiye. Physician and patient perceptions of treatment were captured via cross-sectional surveys; patients' clinical characteristics were recorded by retrospective review of medical records.

Chemical reactions with Liesegang rings: generation of non-permanent thermal patterns.

Patterns are encountered and employed in nature, such as in the communication or growth of organisms and sophisticated behaviors such as camouflage. Artificial patterns are not rare, either. They can also be used in sensing, recording information, and manipulating material properties.

Phytosomes-unraveling the Unique Properties of Plant-derived Nanotechnological Drug Delivery Systems: A Review.

Phytosomes are innovative compounds that enhance the bioavailability of plant-derived compounds, making them more effective in pharmaceuticals and nutraceuticals. By improving cellular absorption, phytosomes allow lower doses of plant extracts to achieve therapeutic effects, which may reduce both cost and the risk of potential side effects. The incorporation of phospholipids in phytosomes not only stabilizes the active compounds but also protects them from degradation in the gastrointestinal tract, potentially increasing their shelf life and efficacy.

Epidemiology, treatment, and mortality of femoral neck fractures in patients over the age of 65 years: a nationwide retrospective cohort study of 83,789 cases in Turkey.

Background: A population-based study delineating the epidemiologic, clinical, and treatment characteristics of femoral neck fractures (FNFs) in elderly patients has not yet been conducted in Turkey. In this nationwide study, the epidemiologic, clinical, and treatment characteristics of patients aged ⩾65 years with FNFs who underwent osteosynthesis, hemiarthroplasty (HA), or total hip arthroplasty (THA) were examined.

Methods: Patients aged ⩾65 years with FNFs were identified in this retrospective, nationwide study.

Endovascular management of carotid blowout syndrome.

Objectives: To evaluate success, complications and efficacy for endovascular management for carotid blowout syndrome.

Methods: Images were evaluated for contrast extravasation, vessel wall irregularity, pseudoaneurysm/aneurysm formation. Hemostatic results in the immediate postprocedural period and procedure related infarcts were assessed.

The effect of nutrition education intervention for caregivers on the nutrition status of the elderly receiving home care: A 1-year follow-up interventional trial.

Background: The high prevalence of malnutrition among those of older age and the lack of nutrition knowledge among the elderly and their caregivers underscore the need for a nutrition education intervention (NEI) for caregivers.

Materials And Methods: Patients enrolled in the "home care program" who were dependent, were >65 years of age, and had caregivers (n = 94) were included in the study. A nutritionist conducted initial NEI sessions for caregivers and subsequently monitored them monthly at home for 12 months.

Development and implementation of a Sezer gastrostomy care bundle using the Knowledge to Action framework.

Background: This project aimed to develop an evidence-based nursing care bundle after gastrostomy feeding tube insertion and implement it into clinical practice using the Knowledge to Action (KTA) framework.

Methods: This mixed-method design project was conducted in a university hospital between December 2021 and June 2022. The project was carried out in four phases: (1) development of an evidence-based care bundle, (2) education for care bundle training, (3) implementation of the care bundle, (4) evaluation of the care bundle.

Socioeconomic status has direct impact on asthma control: Turkish adult asthma registry.

Background: Asthma is one of the most common causes of chronic respiratory disease, and countries with low socioeconomic status have both a high prevalence of asthma and asthma-related death.

Objective: In this study, we aimed to determine socioeconomic levels of asthmatic patients according to a national database and investigate the effects of social markers on disease control in our region.

Methods: This is an analysis of data from 2053 adult asthma patients from a multicentre chart study in Turkey.

The Effects of Cosmic Radiation Exposure on Pregnancy During a Probable Manned Mission to Mars.

Space missions have revealed certain disincentive factors of this unique environment, such as microgravity, cosmic radiation, etc., as the aerospace industry has made substantial progress in exploring deep space and its impacts on human body. Galactic cosmic radiation (GCR), a form of ionizing radiation, is one of those environmental factors that has potential health implications and, as a result, may limit the duration - and possibly the occurrence - of deep-space missions.