Citrus bliss: potassium, sodium, and calcium silicates secrets for post-harvest diseases of fruit defense.

Biotic stress significantly challenges the global citrus industry. Major post-harvest issues include diseases caused by , and . The negative impact of chemical fungicides on the environment and health necessitates eco-friendly alternatives.

What is it like to be a lizard? Directed attention and the flow of sensory experience in lizards and birds.

While the content of subjective (personal) experience is inaccessible to external observers, behavioral proxies can frame the nature of that experience and suggest its cognitive requirements. Directed attention is widely recognized as a feature of animal awareness. This descriptive study used the frequency of gaze shifts in lizards and birds as an indicator of the rate at which the animals change the perceptual segmentation of their ongoing experience.

Aspirin-triggered resolvin D1 modulates pulmonary and neurological inflammation in an IL-22 knock-out organic dust exposure mouse model.

Agriculture dust contains many organic immunogenic compounds, and organic dust exposure is strongly associated with the development of immune-mediated chronic pulmonary diseases such as chronic obstructive pulmonary disease (COPD). Chronic organic dust exposure from agriculture sources induces chronic lung inflammatory diseases and organic dust exposure has recently been linked to an increased risk of developing dementia. The cytokine interleukin-22 (IL-22) has been established as an important mediator in the resolution and repair of lung tissues.

Computational modeling of fear and stress responses: validation using consolidated fear and stress protocols.

Dysfunction in fear and stress responses is intrinsically linked to various neurological diseases, including anxiety disorders, depression, and Post-Traumatic Stress Disorder. Previous studies using in vivo models with Immediate-Extinction Deficit (IED) and Stress Enhanced Fear Learning (SEFL) protocols have provided valuable insights into these mechanisms and aided the development of new therapeutic approaches. However, assessing these dysfunctions in animal subjects using IED and SEFL protocols can cause significant pain and suffering.

Vascularized tumor on a microfluidic chip to study mechanisms promoting tumor neovascularization and vascular targeted therapies.

The cascade of events leading to tumor formation includes induction of a tumor supporting neovasculature, as a primary hallmark of cancer. Developing vasculature is difficult to evaluate but can be captured using microfluidic chip technology and patient derived cells. Herein, we established an approach to investigate the mechanisms promoting tumor vascularization and vascular targeted therapies via co-culture of cancer spheroids and endothelial cells in a three dimensional environment.

A general strategy towards activatable nanophotosensitizer for phototoxicity-free photodynamic therapy.

Photodynamic therapy (PDT) has gained widespread attention in cancer treatment, but it still faces clinical problems such as skin phototoxicity. Activatable photosensitizers offer a promising approach to addressing this issue. However, several significant hurdles need to be overcome, including developing effective activation strategies and achieving the optimal balance between photodynamic effects and related side effects.

Millisecond-level transient heating and temperature monitoring technique for ultrasound-induced thermal strain imaging.

Ultrasound-induced thermal strain imaging (US-TSI) is a promising ultrasound imaging modality that has been demonstrated in preclinical studies to identify a lipid-rich necrotic core of an atherosclerotic plaque. However, human physiological motion, e.g.

A Rare Q-Fever Infection Diagnosed Using Metagenomic Next-Generation Sequencing in Liver Transplantation Patient: A Case Report and Literature Review.

Q fever is a zoonotic disease caused by the Gram-negative bacterium , typically transmitted through exposure to infected animal secretions. As the clinical signs of Q-fever are largely non-specific in humans, a definitive diagnosis can often be overlooked, particularly when physicians fail to consider on the list of differentials. This case report describes Q-fever in a male patient who had previously undergone orthotopic liver transplantation.

Challenges in establishing small animal models for : Host specificity and resistance to infection in rodent hosts.

This study explores potential small animal models for the dog hookworm, , a parasitic nematode which has repeatedly exhibited the ability to develop resistance to a range of anthelmintics. Immunomodulated hamsters, gerbils, rats, and mice were infected with Despite varying degrees of immunosuppression, and in some cases, total adaptive immunodeficiency, no adult worms were recovered, and larval arrest (L3 stage) occurred in muscle tissue of mice and hamsters. This highlights the strict host specificity of and emphasizes the challenges of developing rodent models usable for anthelmintic testing with a strict specialist parasite.

Decoding Inflammation: Predicting Sepsis in the ICU.

Background: Sepsis is a life-threatening condition arising from a dysregulated host response to infection leading to organ dysfunction. Traditional clinical signs are often unreliable for detecting sepsis, necessitating the exploration of more accurate biomarkers. Furthermore, currently, recommended screening scores perform poorly, necessitating more effective biomarkers to identify sepsis.

Periodontitis in Patients Undergoing Coronary Angiography: A Cross-Sectional Study.

Background Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, with coronary artery disease (CAD) being the primary contributor. Periodontitis, a common non-communicable disease, has been associated with an increased risk of CVD. Previous studies have suggested a link between the severity of periodontitis and the degree of coronary artery obstruction.

Standardized Neonatal ICU Progress Note Template and Feedback System: A Clinical Documentation Improvement Initiative.

Introduction This quality improvement (QI) initiative aimed to improve the clinical documentation of daily progress notes in the neonatal intensive care unit (NICU) by applying a standardized documentation template and conducting regular cycles of audit and feedback to ensure compliance and improvement. Methods Firstly, to better assess documentation practices impacting patient care, members of the NICU auditing team identified seven key points in medical records. These points were then used for the audit of 30 randomly selected "progress notes" for infants admitted to the NICU between January and June 2022.

Evaluating and Improving the Quality of the Follow-Up Checklist at Dongola Specialised Hospital: A Clinical Audit.

Background: Clinical notes are essential for patient care, guiding treatment decisions, and supporting research. This study explores how structured documentation impacts the quality of clinical notes in resource-limited settings like Sudan.

Materials And Methods: This retrospective-prospective clinical audit was conducted in the Internal Medicine Department at Dongola Specialised Hospital.

Health and Oral Health-Related Quality of Life and the Associated Factors in Diabetic Patients.

Background: Diabetes mellitus, a chronic multi-systemic disease affecting various organs, may negatively influence health-related quality of life (HRQoL) and oral health-related quality of life (OHRQoL). This study aimed to investigate this association in a cross-sectional sample of Iraqi Kurdish diabetic patients.

Methods: Two hundred eighty-five type 2 diabetic patients participated in the survey.

Upper Limb Deep Venous Thrombosis Associated With Peripherally Inserted Central Catheters in Hospitalised Surgical Patients.

Introduction Surgical inpatients frequently require peripherally inserted central catheters (PICCs) for parenteral feeding and administration of medication. PICCs may cause upper limb deep venous thrombosis (ULDVT), which impacts patient morbidity. We investigated the risk and prevention of PICC-ULDVT in hospitalised surgical inpatients.

Partitioning for Enhanced Statistical Power and Noise Reduction: Comparing One-Way and Repeated Measures Analysis of Variance (ANOVA).

Using simulated data with duplicate observational data points, this research aims to highlight the notable efficiency of repeated measures analysis of variance (ANOVA) compared to one-way ANOVA as a more powerful statistical model. One of the principal advantages of repeated measures ANOVA is its design, in which each subject acts as their own control. This methodology allows for the statistical mitigation of individual differences among subjects, thereby reducing extraneous variability (noise) that can obscure the effects of the experimental conditions under investigation.

Assessing Training Needs and Self-Efficacy of Hospital Administrators in Western India.

Introduction: Effective training is required to enhance hospital administrators' abilities and improve performance. This study evaluates the training needs and their association with the self-efficacy of hospital administrators in public and private hospitals in Western India.

Methodology: This study evaluated the training needs of hospital administrators using a survey-based methodology and a descriptive cross-sectional design.

Impact of Body Mass Index and Anthropometric Measures on Cardiorespiratory Fitness in Non-obese Adult Males: A Cross-Sectional Observational Study.

Introduction Cardiorespiratory fitness (CRF) is a key health indicator for assessing optimal physical function and overall well-being. Exploring the early impact of body mass index (BMI) and anthropometric measures on CRF in non-obese individuals is essential for identifying risk factors and guiding preventive strategies to address weight-related health challenges. This study aims to investigate the impact of BMI and anthropometric measures on CRF, focusing on maximal oxygen uptake (VO2max) and metabolic equivalents (METs) in non-obese adult males.

The Etiology of Intraocular Lens Dislocation and Changes in Intraocular Pressure After Intrascleral Intraocular Lens Fixation Surgery.

Objectives This study aimed to identify the etiology and the direction of dislocation of the natural crystalline lens or intraocular lens (IOL) in IOL intrascleral fixation surgery and to determine the change in intraocular pressure (IOP) after surgery. Methods We retrospectively investigated the diagnosis, direction of lens and IOL dislocation, and IOP before and after surgery (preoperatively and one day, one week, and one month postoperatively) in 236 eyes from 228 patients who underwent IOL intrascleral fixation at Chiba University Hospital between February 2015 and September 2020. Results IOL intrascleral fixation was performed in 48 (20.

Low-Dose Acyclovir Reduces the Reactivation of Herpes Simplex and Varicella Zoster Viruses After Allogeneic Stem Cell Transplantation.

Introduction: Reactivation of herpes simplex virus (HSV) and varicella zoster virus (VZV) is a potential complication following allogeneic stem cell transplantation (alloSCT). Since different doses and durations of acyclovir prophylaxis may be utilized across transplant centers, this study aimed to evaluate the effectiveness of a lower dose of acyclovir in preventing HSV and VZV reactivation in alloSCT recipients within our institution.

Methods: A retrospective chart review was conducted for patients who underwent alloSCT between April 2016 and May 2023.

Impact of Timing Surgical Fixation on Complications and Functional Outcomes in Ankle Fractures.

Introduction: This study aimed to assess whether adherence to the British Orthopaedic Association Standards for Trauma (BOAST) and National Institute for Health and Care Excellence (NICE) guidelines for ankle fractures is associated with reduced complication rates and improved functional outcomes.  Methods: A retrospective analysis was conducted of all patients who underwent surgical fixation for ankle fractures in August 2023 to January 2024 from an acute hospital. Statistical analyses were performed using IBM SPSS Statistics software, version 29 (IBM Corp.

A Comparison of the Efficacy of High-Dose Vitamin C Infusion and Thiamine (Vitamin B1) Infusion in Patients With Sepsis: A Prospective Randomized Controlled Trial.

Background and objective Vitamin C and thiamine possess properties that may mitigate the harmful effects of sepsis. However, there is a dearth of studies in the literature comparing these two vitamins with each other and with a placebo regarding their efficacy against sepsis. This study aimed to investigate the outcomes associated with high-dose infusions of vitamin C and thiamine in septic patients, thereby seeking to contribute valuable insights into the optimal management of sepsis.

Optimizing Home Visit Records as a Way of Improving Quality of Care: A Quality Improvement Study.

Introduction Home visits are a key component of primary care in Portugal, designed for patients unable to visit medical facilities. However, logistical constraints often lead to incomplete real-time clinical records, impacting care quality and safety. This study aimed to improve the quality of home visit records through structural interventions and a continuous quality improvement approach.

Factors Associated With Nutritional Status in Patients With Removable Dentures: A Cross-Sectional Study.

Background Tooth loss can impair masticatory function and may subsequently result in malnutrition. This study aimed to investigate the factors associated with controlling nutritional status (CONUT) scores, which assess malnutrition risk, in patients with removable dentures. Materials and methods In this cross-sectional study, data were obtained from a consecutive sampling of 192 patients (mean age 72.

Tranexamic Acid in Pregnant Women With Placenta Previa: A Double-Blind, Multicenter Randomized Clinical Trial.

Aims: To determine the effectiveness of tranexamic acid (TXA) in reducing vaginal bleeding, extending pregnancy duration, and enhancing perinatal outcomes in pregnant women with placenta previa.

Methods: A multicenter, randomized, double-blind clinical trial was conducted at three maternity teaching hospitals in Iraq's Kurdistan region, Azadi Hospital in the north of Iraq, and Al-Azhar University Hospital in Egypt on 146 women with placenta previa. Participants were randomly assigned to two interventional groups in a 1:1 ratio to receive either TXA or Dextrose 5% water (D5W).