Application of "Internet+" cognitive-behavioral intervention in caregivers of children with congenital heart disease undergoing elective surgery during the COVID-19 pandemic.

Objective: To explore the effects of cognitive and behavioral interventions for caregivers of children undergoing interventional surgery for congenital heart disease (CHD) during COVID-19.

Methods: A prospective study was conducted on 140 children with CHD who were hospitalized in the Department of Cardiology in a children's hospital from March 2020 to March 2022. The children were randomly divided into an intervention group and a control group, with 70 cases in each group.

Controllable synthesis of variable-sized magnetic nanocrystals self-assembled into porous nanostructures for enhanced cancer chemo-ferroptosis therapy and MR imaging.

Magnetic-based nanomaterials are promising for cancer diagnosis and treatment. Herein, we develop a self-assembled approach for the preparation of a porous magnetic nanosystem, DOX/Mn(0.25)-FeO-III NPs, which can simultaneously achieve chemotherapy, ferroptosis therapy and MRI to improve the therapeutic efficacy.

Expression of miR-141 and YAP1 in gastric carcinoma and modulation of cancer cell proliferation and apoptosis.

Yes-associated protein 1 (YAP1) plays important roles in facilitating cell proliferation and decreasing apoptosis and is related to gastric cancer. Abnormal down-regulation of miR-141 is associated with gastric cancer pathogenesis, suggesting a potentially tumor suppressor role. Bioinformatics analysis found complementary binding sites between miR-141 and YP1.

[The effect of shifting of estrogen level on the expression of estrogen receptor and morphology of condyle in rat].

Purpose: To evaluate the possible role and mechanism of estrogen in the morphologic alteration process of mandibular condyle.

Methods: Forty healthy non-pregnant female 6-week-old Sprague-Dawley rats were randomly divided into control group, contraceptive group (intragastric administration with contraceptive), contraceptive + normal saline (intragastric administration with contraceptive and normal saline) and contraceptive +estradiol group(intragastric administration with contraceptive and estradiol) equally. The serum levels of estradiol were detected respectively before the experiment, on the twelfth week and sixteenth week.

[The effect of lowered serum levels of estrogen on the expression of ERα, ERβ, OPG and RANKL in rat mandibular condylar cartilage].

Purpose: To investigate lowered serum estrogen on the expression of ERα, ERβ, OPG and RANKL of rat condyle and explore the possible mechanisms of idiopathic condylar resorption(ICR).

Methods: Thirty female SD rats were randomly divided into control group, oral contraceptives group and tripterygium glycosides tablets group. The model of lowered serum estrogen level and model of premature ovarian were established by gastric gavage with oral contraceptives pills and tripterygium wilfordii glycosides tablets, respectively.