Large-scale production of MXenes as nanoknives for antibacterial application.

Antimicrobial resistance of existing antibacterial agents has become a pressing issue for human health and demands effective antimicrobials beyond conventional antibacterial mechanisms. Two-dimensional (2D) nanomaterials have attracted considerable interest for this purpose. However, obtaining a high yield of 2D nanomaterials with a designed morphology for effective antibacterial activity remains exceptionally challenging.

Near-infrared spectroscopy bioprobe estimation of metabolites' responses to Pb in Cladophora rupestris.

Near-infrared (NIR) spectroscopy was used as a bioprobe to estimation chlorophyll, total sugar, proline, and metallothionein (MT) response to Pb (0, 1, 2.5, 5, 7.5, 10, and 20 mg/l) in Cladophora rupestris.

Improving the anti-tumor effect of EGCG in colorectal cancer cells by blocking EGCG-induced YAP activation.

(-)-Epigallocatechin-3-gallate (EGCG) is the primary active ingredient in green tea and has been used for cancer prevention in clinical trials. The anti-tumor effects of EGCG stem from its ability to inhibit the activities of many oncoproteins, such as AKT, VEGFR, STAT3, and mutant p53. However, the clinical efficacy of EGCG is unsatisfactory.

Rapid SERS identification of methicillin-susceptible and methicillin-resistant aptamer recognition and deep learning.

Here, we report a label-free surface-enhanced Raman scattering (SERS) method for the rapid and accurate identification of methicillin-susceptible (MSSA) and methicillin-resistant (MRSA) based on aptamer-guided AgNP enhancement and convolutional neural network (CNN) classification. Sixty clinical isolates of (), comprising 30 strains of MSSA and 30 strains of MRSA were used to build the CNN classification model. The developed method exhibited 100% identification accuracy for MSSA and MRSA, and is thus a promising tool for the rapid detection of drug-sensitive and drug-resistant bacterial strains.

Recent advances in the conversion of furfural into bio-chemicals through chemo- and bio-catalysis.

Furfural is a promising renewable platform molecule derived from hemi-cellulose, which can be further converted to fossil fuel alternatives and valuable chemicals due to its highly functionalized molecular structure. This mini-review summarizes the recent progress in the chemo-catalytic and/or bio-catalytic conversion of furfural into high-value-added chemicals, including furfurylamine, C carboxylic acid, , furandicarboxylic acid, furfural alcohol, aromatics, levulinic acid, maleic acid, succinic acid, furoic acid, and cyclopentanone, particularly the advances in the catalytic valorization of furfural into useful chemicals in the last few years. The possible reaction mechanisms for the conversion of furfural into bio-chemicals are summarized and discussed.

Dual-signal lateral flow assay using vancomycin-modified nanotags for rapid and sensitive detection of .

This paper reports a colorimetric-fluorescent dual-signal lateral flow assay (LFA) based on vancomycin (Van)-modified SiO-Au-QD tags for sensitive and quantitative detection of (). The combination of high-performance Van-tags and detection antibodies integrated into the LFA system produced assays with high sensitivity and specificity. The visualization limit of the colorimetric signal and the detection limit of the fluorescence signal of the proposed method for can reach 10 and 100 cells mL, respectively.

Highly rapid and non-enzymatic detection of cholesterol based on carbon nitride quantum dots as fluorescent nanoprobes.

In this work, we reported a highly rapid and non-enzymatic method for cholesterol measuring based on carbon nitride quantum dots (CNQDs) as fluorescent nanoprobes, which were synthesized through chemical oxidation. The obtained CNQDs displayed high quantum yield up to 35% as well as excellent photostability, water solubility and low toxicity. We found that the fluorescence of CNQDs could be quenched more than 90% within 30 seconds by cholesterol through the formation of hydrogen bonds between -NH, -NH on the surface of CNQDs and cholesterol containing -OH.

Lactic--glycolic acid-coated methylene blue nanoparticles with enhanced antibacterial activity for efficient wound healing.

Effective wound healing has been demonstrated using lactic--glycolic acid (PLGA)-coated methylene blue nanoparticles (MPNPs) as a novel susceptible agent for photodynamic antibacterial therapy. Compared with methylene blue (MB) solution, MPNPs have a significantly improved antibacterial effect and . The enhanced antibacterial effect is achieved through increased singlet oxygen generation in MPNPs compared to that of MB solution, as a result of the decreased aggregation-induced quenching (ACQ) effect of the MPNPs.

The characterization and evaluation of the synthesis of large-ring cyclodextrins (CD-CD) and α-tocopherol with enhanced thermal stability.

Large-ring cyclodextrins LR-CDs (CD-CD) were obtained from rice starch using cyclodextrin glycosyltransferase (CGTase), and were used as a wall material for embedding α-tocopherol. Complexes of α-tocopherol and LR-CDs were prepared by co-precipitation. A molar ratio of α-tocopherol/LR-CD of 1 : 2 showed the highest encapsulation efficiency.

Palladium-catalyzed intermolecular transthioetherification of aryl halides with thioethers and thioesters.

Functional group transfer reactions are an important synthetic tool in modern organic synthesis. Herein, we developed a new palladium-catalyzed intermolecular transthioetherification reaction of aryl halides with thioethers and thioesters. The synthetic utility and practicality of this catalytic protocol are demonstrated in a wide range of successful transformations (>70 examples).

Polyethyleneimine-interlayered silica-core quantum dot-shell nanocomposites for sensitive detection of a lateral flow immunoassay.

Herein, we synthesized high-performance SiO-core quantum dot (QD)-shell nanocomposites (SiO@PEI-QDs) using the polyethyleneimine (PEI)-mediated adsorption method. Cationic PEI was used to form a positively charged interlayer on the SiO core, which achieved a dense adsorption of carboxylated QDs to form a shell of QDs and maintained a good dispersibility of the nanocomposite. The SiO@PEI-QDs showed excellent stability and high luminescence, and served as high-performance fluorescent labels for the detection of bacteria when used with the lateral flow immunoassay (LFA) technique.

Rapid, quantitative and ultra-sensitive detection of cancer biomarker by a SERRS-based lateral flow immunoassay using bovine serum albumin coated Au nanorods.

Early diagnosis of cancer biomarkers is the key to guiding treatments and improving the survival rate of patients. Herein, we report a novel surface-enhanced resonance Raman scattering (SERRS)-based lateral flow immunoassay (LFIA) for quantitative and ultra-sensitive analysis of alpha-fetoprotein (AFP). Gold nanorods (AuNRs) were fabricated to be in resonance with 785 nm laser excitation, that is, the excitation level that can maximize SERRS activity.

Construction of a phosphate-rich polyacrylonitrile fiber surface microenvironment for efficient purification of crystal violet wastewater.

Wastewater purification using fibrous adsorbents has received much attention due to their high efficiency, low cost, and recyclability. In this work, phosphate modified polyacrylonitrile fiber (B-PANF) was prepared and used to remove cationic dyes. The B-PANF showed the best adsorption capacity for crystal violet (CV) when compared with rhodamine B, methyl green, Victoria blue B, methylene blue, and neutral red.

Preparation, identification and molecular docking study of novel osteoblast proliferation-promoting peptides from yak () bones.

The aim of this study was to isolate and identify osteogenic bioactive peptides from yak bones collagen, while simultaneously investigating their underlying mechanisms for promoting osteoblast proliferation. Response surface methodology (RSM) was employed to investigate the effect of hydrolysis variables on the production of peptides with osteoblast proliferation-promoting activity (OPPA). The concentration of soluble peptides reached 0.

Facile synthesis of high-performance SiO@Au core-shell nanoparticles with high SERS activity.

This study proposes a facile and general method for fabricating a wide range of high-performance SiO@Au core-shell nanoparticles (NPs). The thicknesses of Au shells can be easily controlled, and the process of Au shell formation was completed within 5 min through sonication. The fabricated SiO@Au NPs with highly uniform size and SERS activity could be ideal SERS tags for SERS-based immunoassay.

Improvement of hairy root induction and development of a mycorrhizal symbiosis system.

Premise Of The Study: We describe a highly efficient in vitro hairy root transformation system that is useful for the investigation of mycorrhizal symbiosis.

Methods And Results: The -mediated transformation method was improved based on the binary plasmid (pCAMBIA ) harboring green fluorescent protein and β-glucuronidase genes for rapid detection. Transgenic hairy roots were grown within 13 days.