2,685 results match your criteria: "Angola; H&TRC - Health & Technology Research Center[Affiliation]"

In contemporary society, depression has emerged as a prominent mental disorder that exhibits exponential growth and exerts a substantial influence on premature mortality. Although numerous research applied machine learning methods to forecast signs of depression. Nevertheless, only a limited number of research have taken into account the severity level as a multiclass variable.

View Article and Find Full Text PDF

Purpose: To analyse factors affecting the ability to use the digital asthma monitoring application Mask-Air in old-age individuals living in inland Portugal.

Patients And Methods: In this observational study, patients with medically confirmed asthma who agreed to participate were interviewed and subdivided into Non-users Group: those who could not use the application and Users Group: those who could. Sociodemographic and psychological data, comorbidities, and asthma status were compared between groups.

View Article and Find Full Text PDF

An island in a sea of sand: a first checklist of the herpetofauna of the Serra da Neve inselberg, southwestern Angola.

Zookeys

May 2024

CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Campus de Vairão, Universidade do Porto, 4485-661 Vairão, Portugal Universidade do Porto Vairão Portugal.

The Serra da Neve inselberg in Namibe Province, southwestern Angola is the second highest peak of Angola with an elevation of 2489 m. It remains one of the least explored regions in the country, despite several endemic species having been recently described from this inselberg. Here we provide an inventory of the amphibian and reptile species ocurring in Serra da Neve and compare its fauna with that of the surrounding habitats at lower elevations.

View Article and Find Full Text PDF

Rheumatic heart disease (RHD) is a chronic complication arising from acute rheumatic fever (ARF), an autoimmune response triggered by group A streptococcal infection. It primarily affects children and young adults in developing countries. RHD continues to show substantial global heterogeneity.

View Article and Find Full Text PDF

The SARS-CoV-2 genome occupies a unique place in infection biology - it is the most highly sequenced genome on earth (making up over 20% of public sequencing datasets) with fine scale information on sampling date and geography, and has been subject to unprecedented intense analysis. As a result, these phylogenetic data are an incredibly valuable resource for science and public health. However, the vast majority of the data was sequenced by tiling amplicons across the full genome, with amplicon schemes that changed over the pandemic as mutations in the viral genome interacted with primer binding sites.

View Article and Find Full Text PDF

From pole to pole, life-long research of sleep in extreme environments.

Sleep Adv

May 2024

Invited Scientist (ret), Malaria Research Unit, UMR 5246 CNRS, Claude-Bernard Lyon-1 University, Villeurbanne, France.

In November 1965, Michel Jouvet accepted me into his laboratory in Lyon as a medical student at a time when sleep research was an adventure. After 4 years of investigations in cats, I obtained my medical doctorate. Being a military physician, I was posted to Antarctica for wintering over and was initiated by Jean Rivolier into the psychology of small isolated human groups.

View Article and Find Full Text PDF

Background: Intimate partner violence (IPV) is high among women of reproductive age in sub-Saharan Africa (SSA). However, empowering women enables them to confront and mitigate IPV. In this study, we examined the association between the survey-based women's empowerment index (SWPER) and IPV in SSA.

View Article and Find Full Text PDF

Risk Factors for Eating Disorders in University Students: The RUNEAT Study.

Healthcare (Basel)

May 2024

Research Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, 39011 Santander, Spain.

The purpose of the study is to assess the risk of developing general eating disorders (ED), anorexia nervosa (AN), and bulimia nervosa (BN), as well as to examine the effects of gender, academic year, place of residence, faculty, and diet quality on that risk. Over two academic years, 129 first- and fourth-year Uneatlántico students were included in an observational descriptive study. The self-administered tests SCOFF, EAT-26, and BITE were used to determine the participants' risk of developing ED.

View Article and Find Full Text PDF

Thermostability study of virulent Newcastle disease viruses isolated in Southern Angola.

Onderstepoort J Vet Res

April 2024

Laboratory of Virology, National Institute of Agricultural and Veterinary Research, Oeiras, Portugal Laboratory for the Production of Veterinary Vaccines, Veterinary Research Institute, Lubango.

Newcastle disease (ND) is endemic in Angola. Several outbreaks of ND occurred in small backyard flocks and village chickens with high mortality in the southern provinces of the country, Cunene, Namibe and Huíla, in 2016 and 2018. In those years, 15 virulent ND virus (NDV) strains were isolated and grouped within subgenotype 2 of genotype VII (subgenotype VII.

View Article and Find Full Text PDF

Like many Sub-Saharan countries, Angola struggles with a shortage of trained health professionals, especially for primary care. In 2021, the Angolan Ministry of Health in collaboration with the Angolan Medical Council launched the National Program for the Expansion of Family Medicine as a long-term strategy for the provision, fixation and training of family physicians in community health centres. Of the 425 residents 411 (96.

View Article and Find Full Text PDF

Hydroxyurea dose optimisation for children with sickle cell anaemia in sub-Saharan Africa (REACH): extended follow-up of a multicentre, open-label, phase 1/2 trial.

Lancet Haematol

June 2024

Division of Hematology, Cincinnati Children's Hospital, Cincinnati, OH, USA; Global Health Center, Cincinnati Children's Hospital, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Background: Realizing Effectiveness Across Continents with Hydroxyurea (REACH) is an open-label non-randomised trial of hydroxyurea (hydroxycarbamide) in children with sickle cell anaemia in sub-Saharan Africa. The short-term results of REACH on safety, feasibility, and effectiveness of hydroxyurea were published previously. In this paper we report results from extended hydroxyurea treatment in the REACH cohort up to 8 years.

View Article and Find Full Text PDF

Oncology Education in Angola: Current Status and Recommendations for Improvement.

J Cancer Educ

December 2024

Experimental Pathology and Therapeutics Group, Surgical Oncology Department, Portuguese Institute of Oncology, Porto, Portugal.

Angola, a country grappling with prevalent tropical diseases such as malaria, is witnessing an alarming rise in cancer-related deaths. Despite the escalating significance of cancer globally and in Angola, the nation's medical schools lack compulsory oncology disciplines in their curricula. This absence compromises the comprehensive training of medical students, preventing the development of integrated perspectives and skills crucial for addressing the growing cancer burden.

View Article and Find Full Text PDF

[Marburg virus disease in travellers].

Rev Med Suisse

May 2024

Service de médecine tropicale et humanitaire, Département de médecine de premier recours, Hôpitaux universitaires de Genève, 1211 Genève 14.

Marburg virus disease (MVD) is a dreadful but exceptional disease. Formerly mainly identified in Uganda, Angola and the Democratic Republic of Congo, it has recently appeared in the Republic of Guinea, Ghana, Equatorial Guinea and Tanzania, adding West Africa to the affected regions. Humans become infected through exposure to bats Roussettus aegyptiacus or during unprotected care of infected people.

View Article and Find Full Text PDF
Article Synopsis
  • qPCR is emerging as a significant method for diagnosing soil-transmitted helminths (STHs), especially for differentiating species like Strongyloides stercoralis and hookworms, but its effectiveness can be impacted by how samples are preserved and DNA is extracted.
  • In a study involving 3,063 schoolchildren in Angola, qPCR's results were compared to the traditional Kato-Katz technique, showing comparable prevalence for some infections while qPCR identified a higher prevalence of hookworms.
  • The agreement between the methods varied, being very good for Ascaris lumbricoides, moderate for Trichuris trichiura, and fair for hookworm, indicating a need for further research on preservation and extraction techniques to
View Article and Find Full Text PDF

Introduction: Introduction: Malaria continues to be the leading cause of hospitalization and death in Angola, a country in sub- Saharan Africa. In 2023, in the first quarter, 2,744,682 cases were registered, and of these 2,673 patients died due to malaria disease. Previous studies have shown that the ABO blood group can affect the progression of malaria to severe conditions after P.

View Article and Find Full Text PDF

Application of Goat and Lamb Lipases on the Development of New Immobilized Biocatalysts Aiming at Fish Oil Hydrolysis.

Appl Biochem Biotechnol

November 2024

Departamento de Biotecnología y Microbiología de los Alimentos, Instituto de Investigación en Ciencias de La Alimentación, CIAL-CSIC, Calle Nicolás Cabrera 9, Campus UAM, Cantoblanco, 28049, Madrid, Spain.

The use of lipases from animal sources for the synthesis of new biocatalysts is barely studied in the literature. The present work focused on the immobilization of lipases from kid goat's and lamb's epiglottis in different ionic supports. For this, anionic supports (monoaminoethyl-N-aminoethyl-agarose (MANAE) and diethylaminoethyl-agarose (DEAE)) and cationic supports (carboxymethyl-agarose and sulfopropyl-agarose) were used.

View Article and Find Full Text PDF

To explore the opinions of Brazilian National School Feeding Program (NSFP) nutritionists concerning the benefits and difficulties of implementing family-farming food purchases for the school feeding program. Exploratory and descriptive qualitative study conducted through the analysis of inductive content of open interviews carried out with technically responsible nutritionists of the School Feeding Program of 21 municipalities in Southern Brazil. The qualitative analysis of the interviews resulted in 17 codes grouped into four categories that show the opinion of nutritionists on the benefits and difficulties of purchasing family-farming food: 1.

View Article and Find Full Text PDF

Applying Next-Generation Sequencing to Track HIV-1 Drug Resistance Mutations Circulating in Portugal.

Viruses

April 2024

Laboratório de Biologia Molecular, Serviço de Patologia Clínica, Unidade Local de Saúde Lisboa Ocidental, Hospital Egas Moniz, 1349-019 Lisbon, Portugal.

Article Synopsis
  • The study examines drug resistance patterns in HIV-1 patients in Portugal, focusing on both transmitted drug resistance (TDR) and acquired drug resistance (ADR) among a sample of 1,050 cases.
  • Findings reveal that about 20% of the patients had drug resistance mutations, with TDR at 12.6% and ADR at 41.1%, particularly noting several specific mutations prevalent in both ART-naive and experienced patients.
  • The research also identifies risk factors associated with higher rates of drug resistance, including age over 50, origin from Portuguese-speaking African countries, specific HIV-1 subtypes, and low CD4 counts, while men and patients with high viral loads showed lower chances of resistance mutations.
View Article and Find Full Text PDF

Genetic Modifiers of Sickle Cell Anemia Phenotype in a Cohort of Angolan Children.

Genes (Basel)

April 2024

H&TRC-Health & Technology Research Center, ESTeSL-Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, 1990-096 Lisbon, Portugal.

Article Synopsis
  • * Researchers analyzed samples from 192 patients, discovering over 5 million high-quality genetic variants and identifying specific genes associated with worsening vaso-occlusive crises (VOC) and lower fetal hemoglobin (HbF) levels.
  • * This research highlights the complex genetic factors influencing SCA symptoms and represents the first detailed investigation of its clinical variations in Angola, suggesting potential genetic modifiers related to patient phenotypes.
View Article and Find Full Text PDF

African spitting cobra, Naja nigricincta nigricincta (Zebra snake), envenomation is an important cause of snakebite morbidity and mortality in Namibia. The snake is endemic to central and northern Namibia as well as southern Angola. The venom is mainly cytotoxic, resulting in aggressive dermo-necrosis and often accompanied by severe systemic complications.

View Article and Find Full Text PDF

As microbes are developing resistance to antibiotics, natural, botanical drugs or traditional herbal medicine are presently being studied with an eye of great curiosity and hope. Hence, complementary and alternative treatments for uncomplicated pelvic inflammatory disease (uPID) are explored for their efficacy. Therefore, this study determined the therapeutic efficacy and safety of Linn seeds with Mill Oil in uPID with standard control.

View Article and Find Full Text PDF

Background: Improving women's access to and use of modern contraceptives is a key global strategy for improving the sexual and reproductive health of women. However, the use of modern contraceptives among adolescent girls and young women in sub-Saharan Africa (SSA) remains relatively low, despite the numerous interventions to increase patronage. This study examined adolescent girls and young women's receipt of quality contraceptive counselling and its associated factors in SSA.

View Article and Find Full Text PDF

Health workforce strategies during COVID-19 response: insights from 15 countries in the WHO Africa Region.

BMC Health Serv Res

April 2024

Health Workforce Unit, Universal Health Coverage - Life Course Cluster, World Health Organization Regional Office for Africa, Brazzaville, Congo.

Introduction: The COVID-19 pandemic unveiled huge challenges in health workforce governance in the context of public health emergencies in Africa. Several countries applied several measures to ensure access to qualified and skilled health workers to respond to the pandemic and provide essential health services. However, there has been limited documentation of these measures.

View Article and Find Full Text PDF

Toxicity Mechanisms of Gadolinium and Gadolinium-Based Contrast Agents-A Review.

Int J Mol Sci

April 2024

Associate Laboratory i4HB-Institute for Health and Bioeconomy, Department of Biological Sciences, Faculdade de Farmácia da Universidade do Porto, 4050-313 Porto, Portugal.

Gadolinium-based contrast agents (GBCAs) have been used for more than 30 years to improve magnetic resonance imaging, a crucial tool for medical diagnosis and treatment monitoring across multiple clinical settings. Studies have shown that exposure to GBCAs is associated with gadolinium release and tissue deposition that may cause short- and long-term toxicity in several organs, including the kidney, the main excretion organ of most GBCAs. Considering the increasing prevalence of chronic kidney disease worldwide and that most of the complications following GBCA exposure are associated with renal dysfunction, the mechanisms underlying GBCA toxicity, especially renal toxicity, are particularly important.

View Article and Find Full Text PDF

Folk medicine is widely used in Angola, even for human African trypanosomiasis (sleeping sickness) in spite of the fact that the reference treatment is available for free. Aiming to validate herbal remedies in use, we selected nine medicinal plants and assessed their antitrypanosomal activity. A total of 122 extracts were prepared using different plant parts and solvents.

View Article and Find Full Text PDF