1,399 results match your criteria: "Anemia and Thrombocytopenia in Pregnancy"
Incidental identification of neonatal babesiosis: a case report.
BMC Pediatr
November 2024
Division of Infectious Diseases, Department of Pediatrics, New York Presbyterian-Columbia University Irving Medical Center, 650 W 168TH St, New York, NY, 10032, USA.
Article Synopsis
- - This text discusses a case of neonatal babesiosis, a rare condition caused by a parasite transmitted by ticks, which was discovered during a typical evaluation for suspected sepsis in a newborn.
- - A full-term male neonate presenting with fever was found to have Babesia microti parasites in his blood, and maternal history showed prior signs of thrombocytopenia and anemia linked to the same parasite.
- - The case emphasizes the need for healthcare providers to consider babesiosis as a possible diagnosis in feverish neonates, especially in areas where the disease is common, and to review maternal health records and blood tests thoroughly.
Management of Myelodysplastic Syndrome in Pregnant Patients: Treatment Approaches and Considerations.
Semin Hematol
December 2024
Tampa General Hospital Cancer Institute, Tampa, FL, USA. Electronic address:
Article Synopsis
- Myelodysplastic Syndromes (MDS) during pregnancy is uncommon, leading to a lack of specific treatment guidelines for affected patients.
- The paper discusses two clinical cases to illustrate potential management strategies for pregnant patients with MDS, drawing on expert opinions and existing research.
- It highlights important considerations and necessary evaluations to assist healthcare providers in effectively navigating the challenges of managing pregnancy in patients with this condition.
Persistent hypoglycemia in congenital syphilis: hyperinsulinemic hypoglycemia with a focal pancreatic lesion.
J Pediatr Endocrinol Metab
November 2024
Department of Infectious Diseases, University of Health Sciences, Bursa Yuksek İhtisas Training and Research Hospital, Bursa, Türkiye.
Article Synopsis
Kidney involvement in Plasmodium falciparum infection in a pregnant patient.
Malar J
November 2024
Department of Nephrology, Hospital Juárez de México, Av Instituto Politécnico Nacional 5160, 07760, Mexico City, Mexico.
Article Synopsis
- A 29-year-old pregnant woman from Equatorial Guinea experienced severe malaria due to Plasmodium falciparum, leading to complications such as cerebral malaria and acute kidney injury (AKI), necessitating renal replacement therapy and a kidney biopsy.
- During her hospitalization, various tests confirmed her malaria diagnosis, and she was treated with antimalarial medications while experiencing significant symptoms including hypotension and haematological issues.
- The kidney biopsy revealed active tubulointerstitial nephritis, and after intensive dialysis, her kidney function improved, allowing for a successful cesarean delivery and subsequent recovery without deterioration in kidney health.*
Antepartum risk factors and outcomes of massive transfusion for elective cesarean section: a nationwide retrospective cohort study.
BMC Pregnancy Childbirth
October 2024
Department of Anesthesiology, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing, 100730, China.
Article Synopsis
- Postpartum hemorrhage is a major cause of maternal health issues, especially varying by the type of birth; this study focuses on antepartum risk factors specifically for elective cesarean sections.
- A retrospective analysis of over 294,000 women in China identified key risk factors for massive blood transfusion during elective cesarean deliveries, including maternal age, anemia, and various health conditions.
- Results indicated that certain factors, like coagulopathy and placenta previa, significantly increase the likelihood of needing massive transfusions, with a small percentage of women experiencing severe outcomes like death during hospitalization.
ANA-positive versus ANA-negative Antiphospholipid Antibody-positive Patients: Results from the APS ACTION Clinical Database and Repository.
Rheumatology (Oxford)
October 2024
University Center of Excellence on Nephrologic, Rheumatologic and Rare Diseases (ERK-Net, ERN-Reconnect and RITA-ERN Member) with Nephrology and Dialysis Unit and Center of Immuno-Rheumatology and Rare Diseases (CMID), Coordinating Center of the Interregional Network for Rare Diseases of Piedmont and Aosta Valley, San Giovanni Bosco Hub Hospital, Turin, Italy.
Article Synopsis
- - This study examined the occurrence and effects of antinuclear antibodies (ANA) in patients with antiphospholipid antibodies (aPL) but without other systemic autoimmune diseases, using data from the APS ACTION Registry.
- - Among the 430 analyzed patients, 56% tested positive for ANA, revealing significant links between ANA positivity and various autoimmune features like hematologic issues and joint involvement.
- - Despite the presence of these autoimmune characteristics in ANA-positive patients, the study found no connection between ANA status and complications related to thrombosis or pregnancy; interestingly, ANA-negative patients had more pregnancies and live births.
Associated Anomalies in Radial Ray Deficiency.
Am J Med Genet A
September 2024
Faculté de Médecine, Laboratoire de Génétique Médicale, Strasbourg, France.
Article Synopsis
- * In a study of 387,067 births in northeastern France from 1979 to 2007, 83 cases of RRD were found, resulting in a prevalence of 2.14 per 10,000 births, and 75.9% of these cases had additional congenital anomalies.
- * The co-occurring anomalies included chromosomal disorders, syndromic conditions like VACTERL association, and multiple congenital anomalies (MCA), affecting various systems such as musculoskeletal, cardiovascular, urinary, and orofacial; a multidisciplinary approach is advised for managing such cases.
Clinical Characteristics and Outcomes of Intrauterine Blood Transfusion (IUT) for Infectious Etiologies.
Prenat Diagn
December 2024
Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Fetal Center, Houston, Texas, USA.
Objective: Congenital viral infection may result in fetal anemia and thrombocytopenia. While intrauterine blood transfusions (IUTs) are more commonly performed for Rh alloimmunization, reports using IUT for infection have varying success. Our primary objective was to characterize the outcomes of patients undergoing IUT for infectious etiologies at our center compared with Rh disease.
View Article and Find Full Text PDFThrombotic microangiopathy (TMA) associated with pregnancy: role of the clinical laboratory in differential diagnosis.
Adv Lab Med
September 2024
Servicio de Medicina Intensiva, Hospital Universitario Río Hortega, Valladolid, Castilla y León, Spain.
Article Synopsis
- Thrombotic microangiopathy (TMA) is a dangerous condition that can happen during pregnancy, causing issues like low platelets and anemia.
- A woman in her 40s had to have an emergency C-section because she was very sick, and later developed a rare pregnancy-related type of TMA called atypical HUS (aHUS).
- Treatment with a special medicine called eculizumab helped her recover, showing that early diagnosis and help from medical labs is super important for this disease.
The Implications of a "Flat" Oral Glucose Tolerance Test Curve in Pregnancy.
Am J Perinatol
September 2024
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, David Geffen School of Medicine, UCLA, Los Angeles, California.
Article Synopsis
- This study investigated if pregnant women with "flat" oral glucose tolerance test (OGTT) curves are at higher risk for bad outcomes for themselves or their babies.
- It compared the outcomes of 1,060 women with flat OGTT curves to 10,591 with normal curves, focusing on issues like birth weight and delivery complications.
- Results showed women with flat curves were generally younger and had a lower risk of having larger babies and needing unplanned cesarean sections, but there was no significant difference in overall adverse outcomes for mothers or newborns.
The Phenomenon of Thrombotic Microangiopathy in Cancer Patients.
Int J Mol Sci
August 2024
Department of Obstetrics, Gynecology and Perinatal Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str. 8-2, 119991 Moscow, Russia.
Article Synopsis
- - Thrombotic microangiopathy (TMA) is a group of disorders where small blood vessel clotting causes organ damage, including conditions like thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS), each with unique causes and impacts on health.
- - In TMA, inflammation leads to endothelial damage and activates platelet and coagulation processes, often linked to low ADAMTS13 enzyme levels, particularly in cancer patients undergoing chemotherapy, which raises thrombotic risk by increasing the VWF/ADAMTS13 ratio.
- - Treatment focuses on diagnosing the specific cause and may include therapies to inhibit complement activation, supportive care, and plasmapheresis
Thrombotic Microangiopathy in Pregnancy: Current Understanding and Management Strategies.
Kidney Int Rep
August 2024
Division of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Article Synopsis
- Thrombotic microangiopathy (TMA) refers to a range of conditions marked by blood clots in tiny blood vessels, leading to damage in organs.
- Pregnancy-associated thrombotic microangiopathy (p-TMA) is a specific type of TMA that presents unique challenges in diagnosis and requires careful identification for proper treatment.
- The review discusses different types of p-TMA, focusing on their underlying causes and the latest advancements in how to diagnose and manage them.
Large placental chorioangioma with maternal and perinatal morbidity.
Eur J Obstet Gynecol Reprod Biol
September 2024
Department of Pathology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Article Synopsis
- Placental chorioangioma is a benign tumor typically without complications, but this case involves a large tumor leading to serious maternal and fetal issues during labor.
- A 38-year-old woman with a history of miscarriage experienced preterm labor at 33 weeks due to a 12x10 cm placental tumor and underwent an emergency caesarean delivery after signs of fetal distress.
- Following delivery, the mother and baby faced complications, including postpartum hemorrhage and neonatal anemia, highlighting the need for a multidisciplinary approach to manage such cases effectively.
Epidemiological, clinical, biochemical, and treatment characteristics of brucellosis cases in Turkey.
J Infect Dev Ctries
July 2024
Karadeniz Technical University Faculty of Medicine, Farabi Hospital, Infectious Diseases and Clinical Microbiology Department, Trabzon, Turkey.
Article Synopsis
- The study assessed the epidemiological characteristics and treatment effectiveness of brucellosis in patients with different organ issues over a decade, focused on data from two medical centers.
- The research included 297 patients, primarily farmers, highlighting that farming and raw dairy consumption were key transmission routes, with high positivity in diagnostic tests and various blood-related conditions reported.
- Findings indicated that treatments with doxycycline combined with either streptomycin or rifampicin were equally effective, with similar relapse rates, suggesting that careful monitoring and longer treatment durations could help reduce the risk of relapse.
Uterine sacrifice in obstetric emergencies case series: Complex cases of fetal distress, labor challenges, and life-saving interventions.
SAGE Open Med Case Rep
July 2024
Department Obstetrics and Gynecology at Lebanese University, Faculty of Medical Sciences, Beirut, Lebanon.
This study highlights the complexities and challenges in managing obstetric emergencies, detailing critical interventions and outcomes in various high-risk cases. A retrospective analysis was conducted on four high-risk obstetric cases, each characterized by distinct complications necessitating immediate medical interventions. The study specifically examined cases involving: Fetal Distress cases where fetal health was compromised, necessitating interventions such as emergency cesarean sections.
View Article and Find Full Text PDFRole of plasma exchange in a post-partum case of severe thrombotic thrombocytopenic purpura with acute kidney injury.
J Family Med Prim Care
June 2024
Department of Pathology, D.Y. Patil Medical College, Pune, Maharashtra, India.
Article Synopsis
- Thrombotic thrombocytopenic purpura (TTP) is a severe condition characterized by symptoms like anemia, fever, neurological issues, low platelet count, and kidney problems.
- A 27-year-old woman with TTP was admitted after experiencing unresponsiveness post-C-section, showing signs of acute kidney injury and severe complications.
- The patient underwent eight cycles of therapeutic plasma exchange (TPE), resulting in significant improvement in her blood and kidney function, highlighting TPE's potential as a life-saving treatment for TTP.
A Rare Case of Atypical Hemolytic Uremic Syndrome (HUS) in an Adult Male: A Catastrophic Presentation.
Cureus
June 2024
Internal Medicine, One Brooklyn Health-Interfaith Medical Center, Brooklyn, USA.
Article Synopsis
- * Atypical HUS is driven by uncontrolled activation of the complement system, which can be triggered by various factors such as infections, malignancies, and genetic mutations.
- * The case presented involves an adult with HUS leading to multiple organ failure and emphasizes the need to consider HUS in adult diagnoses of thrombotic microangiopathies.
Article Synopsis
- - Mirror syndrome is a rare condition featuring "triple edema," and Hemolytic Uremic Syndrome (PHUS) is a serious issue that can arise post-pregnancy, with both conditions being extremely rare to occur together.
- - A specific case is discussed where a patient was diagnosed with mirror syndrome, experienced severe complications post-cesarean section, and subsequently developed PHUS, leading to cardiac and renal issues.
- - The case highlights the importance of timely diagnosis and treatment for these rare diseases to improve maternal outcomes, stressing the need for increased awareness among healthcare professionals.
A healthy live birth after mosaic blastocyst transfer in preimplantation genetic testing for GATA1-related cytopenia combined with HLA matching.
BMC Med Genomics
July 2024
Department of Reproductive Medicine, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University (Shenzhen Maternity & Child Healthcare Hospital), Shenzhen, Guangdong, China.
Article Synopsis
- GATA1-related cytopenia (GRC) can result in low blood platelet counts and anemia; hematopoietic stem cell transplantation (HSCT) is a potential cure.
- A 6-year-old boy with severe anemia due to a novel GATA1 variant underwent preimplantation genetic testing (PGT) to ensure any future baby would be healthy and HLA-compatible.
- The successful transfer of a mosaic embryo resulted in the birth of a healthy baby, demonstrating that NGS-based PGT is an effective approach for managing GRC and related disorders.
Alloimmune Conditions in the Neonatal Foal.
Vet Clin North Am Equine Pract
August 2024
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California - Davis, 2108 Tupper Hall, 1 Garrod Drive, Davis, CA 95616, USA. Electronic address:
Alloimmune disorders occur in foals when pregnant mares produce antibodies against antigens on the foal's cells or tissues, and concentrate them within colostrum. Once foals nurse and absorb colostral antibodies, they can develop hematologic or cutaneous manifestations that can occur individually or in combination. These include neonatal isoerythrolysis, a hemolytic anemia directed against factors on the foal's erythrocytes, alloimmune thrombocytopenia when the antibodies are directed against platelet antigens, alloimmune neutropenia when they are directed against neutrophil antigens, and a combination of suspected alloimmune ulcerative dermatitis, neutropenia and thrombocytopenia.
View Article and Find Full Text PDFMagnitude and associated factors of thrombocytopenia, among pregnant women at Mizan Tepi university teaching hospital south west Ethiopia.
BMC Pregnancy Childbirth
June 2024
Department of Medical Laboratory sciences, College of Medicine and Health Sciences, Mizan Tepi University, Mizan, Ethiopia.
Article Synopsis
- * A study conducted at Mizan Tepi University Teaching Hospital from September to November 2023 with 230 pregnant women revealed a 24.35% prevalence of thrombocytopenia, categorized into mild, moderate, and severe cases.
- * Key factors linked to thrombocytopenia included malaria, short inter-birth intervals, history of abortion, hypertension, HIV, and HBV infection, highlighting the need for awareness and preventive measures.
The risk profiles of pregnancy-related cerebral venous thrombosis: a retrospective study in a comprehensive hospital.
BMC Neurol
May 2024
Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China.
Article Synopsis
- The study aimed to identify risk factors and causes of pregnancy-related cerebral venous thrombosis (PCVT) by analyzing a cohort of 16 women diagnosed during pregnancy and postpartum in China from 2009 to 2022.
- Results showed that PCVT was more frequent in the first trimester and postpartum, with patients exhibiting significantly higher rates of anemia and platelet disorders compared to those without PCVT.
- The research highlighted that autoimmune diseases and genetic factors were common causes for PCVT, suggesting that screening for these conditions is essential for effective treatment and management.
A retrospective review of antiphospholipid syndrome: a single tertiary centre experience.
Med J Malaysia
May 2024
Hospital Pulau Pinang, Medical Department, Rheumatology Unit, Penang, Malaysia.
Article Synopsis
- Antiphospholipid syndrome (APS) is an autoimmune disease causing thrombosis and pregnancy issues linked to antiphospholipid antibodies, and the study aimed to explore its clinical features, treatments, and outcomes in patients over a year-long period.
- The study analyzed 53 APS patients, revealing that thrombosis was the most common manifestation, with a significant proportion also experiencing pregnancy complications and various other related health issues.
- The majority of patients were treated with warfarin, and findings suggested high rates of pregnancy morbidity and similar thrombosis incidents compared to other global populations.