8,712 results match your criteria: "Anemia Megaloblastic"
Case Rep Hematol
December 2024
Department of Hematology-Oncology, Henry Ford Health System, Detroit, Michigan, USA.
Pancytopenia is characterized by a decrease in all three types of blood cells. Instead of being a standalone disease, it acts as a common outcome resulting from various factors, including infections, autoimmune disorders, genetic issues, nutritional deficiencies, and malignancies. Pinpointing the root cause of pancytopenia poses a challenge but is essential for devising an effective treatment plan and predicting the likely prognosis.
View Article and Find Full Text PDFCureus
November 2024
Medicine, Lady Reading Hospital Peshawar, Peshawar, PAK.
Background Pancytopenia is defined as a decrease in all three hematologic cell lines. The condition is not a disease in itself but a common pathway caused by various etiologies that can be infectious, autoimmune, genetic, nutritional, and/or malignant. Determining the cause of pancytopenia is a challenge and is key in determining the proper treatment regimen and estimating prognosis.
View Article and Find Full Text PDFJ Diet Suppl
December 2024
Department of Life and Consumer Sciences, University of South Africa, Johannesburg, South Africa.
Folic acid also known as folate and vitamin B9 is of the class of B complex vitamins. It is crucial for homeostatic function of the biological system and is not endogenously produced. It is medically approved for the treatment of megaloblastic anemia.
View Article and Find Full Text PDFBiosci Biotechnol Biochem
November 2024
Department of Agricultural, Life, and Environmental Sciences, Faculty of Agriculture, Tottori University, Tottori, Japan.
Vitamin B12 (B12) is a water-soluble substance that is a member of the B-vitamin family. Its recommended daily dose in adult men and women is 2.4 µg, which is the lowest among the 13 vitamins.
View Article and Find Full Text PDFFront Nutr
November 2024
Department of Oncology, University of Oxford, Oxford, United Kingdom.
Background: Vitamin B12 is essential for neurological function, red blood cell formation, and DNA synthesis. Deficiency can lead to diverse health conditions, including megaloblastic anemia and neurological issues. Oral supplementation is a standard treatment for B12 deficiency.
View Article and Find Full Text PDFCureus
November 2024
Ear, Nose, and Throat, Doncaster Royal Infirmary, Doncaster, GBR.
Background Pancytopenia, while a common manifestation of a multitude of diseases, remains a relatively lesser-researched topic, especially in developing countries. Its management depends largely on identifying the etiology, which can range from simple infections to more sinister causes like leukemia. This study aims to investigate the clinical presentations, hematological findings, and etiologies of pancytopenia in a developing country.
View Article and Find Full Text PDFActa Haematol
October 2024
University Leipzig Medical Center, Department of Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig, Germany.
Hematology
December 2024
Department of Hematology, Changzhou Hospital of Traditional Chinese Medicine, Changzhou, People's Republic of China.
Objectives: In this study, we aimed to explore the clinical characteristics of patients with megaloblastic anemia and pancytopenia.
Methods: Data on patient characteristics, laboratory examinations, clinical manifestations, and associated diseases were collected from Changzhou Hospital of Traditional Chinese Medicine. The participants were divided into two groups according to routine blood test results: megaloblastic anemia patients with pancytopenia (Group A) and megaloblastic anemia patients with simple anemia (Group B).
Expert Rev Hematol
November 2024
Department of Medicine, Karachi Medical and Dental College, Karachi, Pakistan.
The patient, a 30-year-old woman, presented with a sudden, painless, and severe decrease in vision in both eyes. The ophthalmological examination revealed a normal anterior segment and intraocular pressure, but a fundus examination showed bilateral macular hemorrhage. In the absence of a known history, a metabolic and hematological biological assessment was conducted.
View Article and Find Full Text PDFCureus
September 2024
Medical School, University of Tabuk, Tabuk, SAU.
BMJ Case Rep
October 2024
Internal Medicine, University of Kentucky, Lexington, Kentucky, USA.
Thiamine-responsive megaloblastic anaemia (TRMA) is a rare autosomal recessive disorder characterised by the clinical triad of megaloblastic anaemia, sensorineural hearing loss and diabetes mellitus (DM) in young patients. We present a case of a young man with type 1 DM who presented with pancytopenia of unclear aetiology, initially attributed to a COVID-19 infection. After obtaining a bone marrow biopsy and pursuing genetic testing, two pathogenic variants of the SLC19A2 gene consistent with TRMA were discovered in this patient.
View Article and Find Full Text PDFItal J Pediatr
September 2024
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Background: Imerslund-Gräsbeck syndrome (IGS) is an autosomal recessive disorder characterized by selective vitamin B12 malabsorption, resulting in vitamin B12 deficiency and impaired reabsorption of proximal tubular proteins.This case highlights a previously unidentified compound heterozygous variant in the Amnionless (AMN) gene that causes IGS syndrome and underscores the importance of long-term oral vitamin B12 replacement therapy in managing the condition.
Case Presentation: In this retrospective analysis, we present the clinical data of a 3-year and 6-month-old female child diagnosed with IGS at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China, in November 2018.
Cureus
August 2024
Internal Medicine, Mahatma Gandhi Institute of Medical Sciences, Wardha, IND.
Eur J Pediatr
December 2024
Leumit HMO, Tel-Aviv, Israel.
Ital J Pediatr
September 2024
Department of Pediatrics, Polytechnic University of Marche, via Corridoni, Ancona, 60123, Italy.
Food Chem
January 2025
Food Science and Technology Program, Department of Life Sciences, BNU-HKBU United International College, Zhuhai, Guangdong 519087, China.. Electronic address:
Hematology
December 2024
Department of Hematology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou, People's Republic of China.
Lab Med
September 2024
School of Medical Laboratory Sciences, Institute of Health, Jimma University, Jimma, Ethiopia.
Background: Pancytopenia is an important hematological problem encountered in routine clinical practice associated with a multitude of disease states. The possible causes of pancytopenia can be influenced by geography, socioeconomic conditions, and endemic illnesses. Information regarding the underlying clinical conditions and morphologic features of blood cells of pancytopenia is limited and varied across different regions.
View Article and Find Full Text PDFBMJ Case Rep
August 2024
Florida State University College of Medicine, Tallahassee, Florida, USA.
Cureus
July 2024
Hospital Medicine, Ochsner Clinic Foundation, New Orleans, USA.
Ann Hematol
October 2024
Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy.
Background: Megaloblastic anemia is a subtype of anemia with increased red blood cell volume. These megaloblastic cells can be easily destroyed in the bone marrow and spleen, leading to ineffective hematopoiesis. Insulin-degrading enzymes (IDE) in erythrocytes can break down the insulin into amino acid fragments; thus, when hemolysis occurs, IDE can be released into the blood, resulting in low insulin measurement values.
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