162 results match your criteria: "Andreas Syggros Hospital[Affiliation]"

Trichotillomania is a disorder of chronic hair pulling classified as an impulse control disorder that causes essential stress and leads to difficulties in functionality and severe alopecia. This is the case of a 43-year-old male without a serious medical history who was hospitalized with a large ulcerated plaque with smooth margins covering almost the entire occipital area. He received antibiotic and antidepressant treatment, after which he appeared to be improving.

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Introduction: Irritant contact dermatitis (ICD) is characterized by direct injury to the epidermal cells, activating the innate immune response. Allergic contact dermatitis (ACD), in contrast, is delineated by a delayed hypersensitivity reaction of type IV. Despite the distinct etiopathogenic mechanisms under-pinning each condition, the differentiation between them presents a significant diagnostic challenge.

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Number of melanoma deaths over time in relation to tumour thickness: Data from a Melanoma Unit Reference Center.

J Eur Acad Dermatol Venereol

November 2024

1st Department of Dermatology and Venereology, School of Medicine, National and Kapodistrian University of Athens, "Andreas Syggros" Hospital for Skin and Venereal Diseases, Athens, Greece.

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Background/aim: Melanoma, as a type of skin cancer, has undoubtedly gathered the interest of the global community in recent years, due to its rising incidence. Patients suffering from melanoma experience effects on their mental health, mainly depression and anxiety disorders. The present study aimed to examine the association of melanoma with the psychosomatic burden, personality traits, and demographic factors of the participants.

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Pathophysiology, diagnosis, and management of immune checkpoint inhibitor-induced diabetes mellitus.

Endocrine

September 2024

Endocrine Unit and Diabetes Center, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Immune Checkpoint Inhibitors (ICIs) have revolutionized cancer treatment, offering hope for patients with various malignancies. However, along with their remarkable anticancer effects, ICIs can also trigger immune-related adverse events (irAEs). One such noteworthy complication is the development of Diabetes Mellitus (DM), which particularly resembles Type 1 Diabetes Mellitus (T1DM).

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Effectiveness and safety of methotrexate in the treatment of mycosis fungoides: Real-world data from a multicentre study.

J Eur Acad Dermatol Venereol

September 2024

2nd Department of Dermatology, "Attikon" General Hospital, National & Kapodistrian University of Athens, Medical School, Athens, Greece.

Article Synopsis
  • - The study analyzed the effectiveness and safety of methotrexate (MTX) in treating mycosis fungoides (MF) across different stages, involving 211 patients from five Greek centers, with a median age of 68.3 years.
  • - Results showed an overall response rate of 55.5%, with better outcomes in patients receiving MTX as a first-line treatment and those with erythrodermic disease compared to tumor stage disease.
  • - The study concludes that MTX is a viable first-line treatment option for MF, demonstrating varying progression-free survival rates depending on the disease stage and acceptable safety profiles.
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Manifestations of Endocrine Disease in the Lower Extremities: Beyond the Diabetic Foot.

Int J Low Extrem Wounds

September 2024

Diabetes Centre, Second Department of Internal Medicine, University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.

Article Synopsis
  • The review discusses various endocrine diseases and their effects on the lower extremities, excluding diabetic foot.
  • Conditions such as acromegaly, Addison's disease, and thyroid disorders can manifest with distinct clinical signs in this area.
  • Early diagnosis through clinical suspicion and treating the endocrine issue typically leads to improvement in symptoms related to the lower extremities.
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Article Synopsis
  • * A thorough literature review identified 12 studies (10 on dupilumab, 2 on JAK inhibitors) and evaluated their effects on skin barrier metrics like transepidermal water loss and hydration, with a total of 416 participants across various study designs.
  • * Results showed that dupilumab significantly reduced transepidermal water loss and improved skin hydration, highlighting the effectiveness of IL-4/IL-13 inhibitors, while the data on JAK inhibitors is limited, suggesting further research is needed
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Beneath the surface: Novel insights into Amivantamab-induced acneiform rash.

Eur J Cancer

September 2024

1st Department of Dermatology, Cutaneous Toxicities Clinic, Onco-Dermaatology Department, "Andreas Syggros" Hospital for skin diseases, National & Kapodestrian University of Athens, Medical School, Greece.

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Preservative contact allergy in occupational dermatitis: a machine learning analysis.

Arch Dermatol Res

June 2024

Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis, Zografou, 15784, Athens, Greece.

Occupational dermatoses impose a significant socioeconomic burden. Allergic contact dermatitis related to occupation is prevalent among healthcare workers, cleaning service personnel, individuals in the beauty industry and industrial workers. Among risk factors, the exposure to preservatives is frequent, since they are extensively added in products for occupational use.

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Evaluation of Delayed Contact Hypersensitivity in Patients with Rosacea.

Skin Appendage Disord

June 2024

2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, Medical School, "Attikon" General University Hospital, Athens, Greece.

Introduction: Rosacea is a common chronic inflammatory dermatosis characterized by erythema, telangiectasia, papules, and pustules on the central face. The frequency of contact sensitization complicating rosacea and its therapy is unknown, with only few studies published in the literature. In the present study, we aimed to evaluate contact sensitivity in patients with rosacea.

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Diagnostics in suspected metal implant allergy; should cardiac implants be considered?

J Eur Acad Dermatol Venereol

November 2024

First Department of Dermatology-Venereology, Medical School, National and Kapodistrian University of Athens, Andreas Syggros Hospital, Athens, Greece.

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This study explores the previously uncharted territory of the effects of ultraviolet (UV) radiation on diabetic skin, compared to its well-documented impact on normal skin, particularly focusing on carcinogenesis and aging. Employing hairless SKH-hr2, Type 1 and 2 diabetic, and nondiabetic male mice, the research subjected these to UV radiation thrice weekly for eight months. The investigation included comprehensive assessments of photoaging and photocarcinogenesis in diabetic versus normal skin, measuring factors such as hydration, trans-epidermal water loss, elasticity, skin thickness, melanin, sebum content, stratum corneum exfoliation and body weight, alongside photo documentation.

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Five-Membered Nitrogen Heterocycles Angiotensin-Converting Enzyme (ACE) Inhibitors Induced Angioedema: An Underdiagnosed Condition.

Pharmaceuticals (Basel)

March 2024

Allergy Unit, 2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, University General Hospital 'Attikon', 12462 Athens, Greece.

Angiotensin-converting enzyme (ACE) inhibitors are used primarily in the treatment of hypertension, heart failure, and in the acute phase of myocardial infarction. Lisinopril [N-[(1S)-1-car-boxy-3-phenylpropyl]-L-lysyl-L-proline], enalapril [(S)-1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline] and ramipril [2-aza-bicyclo-[3.3.

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Article Synopsis
  • Dermatitis artefacta, also known as factitious dermatitis, manifests differently across the body and is often linked to psychological distress, such as borderline personality disorder and the risk of self-harm for attention.
  • A case study involves a 17-year-old girl with anxiety symptoms preparing for university who developed an ulcer on her ankle due to factitious disorder, revealing a need for emotional support rather than physical illness.
  • Treatment focuses on psychotherapy for the mental health aspect, while the ulcer necessitates dermatosurgical care to address the physical condition.
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Article Synopsis
  • - The BrIDGE study examined the real-world effectiveness of brodalumab in treating moderate-to-severe plaque psoriasis in Greece, focusing on the percentage of patients achieving complete clearance (PASI100) over 24 weeks and beyond.
  • - Results showed that 42% of patients reached PASI100 at Week 24, with this number increasing to 65% by Week 104, while significant improvements were noted in other assessment scores (PASI75, PASI90, and sPGA).
  • - Additionally, patients reported improved quality of life, with average scores on the Dermatology Life Quality Index (DLQI) decreasing significantly over the study period, indicating better overall well-being as a result of brodalumab treatment
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Article Synopsis
  • This systematic review examines how corticotropin-releasing hormone (CRH) family peptides and their receptors affect human health, focusing particularly on gynaecological cancers like breast and ovarian cancer.
  • The researchers analyzed data from three medical databases and discovered that CRH peptides and their receptors are present in various gynaecological tissues, revealing different expression patterns linked to cancer severity and patient outcomes.
  • The study found that CRH peptides significantly impact processes like cell growth, movement, and immune response in these cancers, suggesting that future research on CRH's role in tumour formation could lead to new treatment options.
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Simultaneous melanomas in the setting of multiple primary melanomas.

Melanoma Res

April 2024

First Department of Dermatology-Venereology, Medical School of Athens University, Andreas Syggros Hospital, Athens, Greece.

It is estimated that about 1-13% of melanoma patients will develop multiple primary melanomas. Although the occurrence of subsequent tumors has been described during the last few years, the development of simultaneous melanomas has not yet been extensively studied. We reviewed our registries to identify patients with multiple primary melanomas.

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Contact allergy caused by acrylates in nail cosmetics: A pilot study from Greece.

Contact Dermatitis

March 2024

First Department of Dermatology-Venereology, National and Kapodistrian University of Athens, Andreas Syggros Hospital, Athens, Greece.

Background: The growing popularity of nail techniques based on acrylates has led to a higher frequency of sensitization in both nail technicians and users.

Objectives: The study aimed to assess cases of allergic contact dermatitis (ACD) caused by acrylates in individuals with occupational or non-occupational exposure to nail techniques.

Methods: A preliminary study was conducted on 30 patients with ACD caused by acrylates in nail techniques, who were patch tested from September 2022 to March 2023 at the First Department of Dermatology and Venereology of Andreas Syggros Hospital, Athens, Greece.

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Background: The journey of patients with skin diseases through healthcare has been scarcely investigated.

Objective: To analyse the journey of people with skin diseases in the different healthcare environment in Europe.

Methods: This multinational, cross-sectional, European study was conducted on a representative sample of the adult general population of 27 European countries.

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Quality of life and stigmatization in people with skin diseases in Europe: A large survey from the 'burden of skin diseases' EADV project.

J Eur Acad Dermatol Venereol

October 2023

Department of Pediatric Dermatology, Carol Davila University of Medicine and Pharmacy, Colentina Clinical Hospital, Bucharest, Romania.

Background: Several large studies on the burden of skin diseases have been performed in patients recruited in hospitals or clinical centres, thus missing people with skin diseases who do not undergo a clinical consultation.

Objectives: To evaluate the burden of the most common dermatological diseases in adult patients across Europe, in terms of quality of life, work life, and stigmatization.

Methods: Population-based survey on a representative sample of the European general population aged 18 years or older.

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