Iron(III)-Catalyzed Regioselective Synthesis of Electron-Rich Benzothiazoles from Aryl Isothiocyanates via C-H Functionalization.

We report herein a direct synthetic route for the preparation of 2-arylbenzothiazoles using aryl isothiocyanates and electron-rich arenes. The synthetic route involves triflic acid promoted addition of the arenes to aryl isothiocyanates followed by FeCl-catalyzed C-S bond formation via C-H functionalization. The approach provides the advantage of synthesis of benzothiazoles without the conventional use of aryl aldehyde/carboxylic acid precursors employing the less expensive iron(III) catalyst.

Selective isolation and genomic characterization of biopolymer producer-a novel feature of halophile Brachybacterium paraconglomeratum MTCC 13074.

Background: Biopolymers like polyhydroxyalkanoates (PHA) are the best natural macromolecules to use as alternative to the synthetic polymers. Many prokaryotes accumulate PHA as cytoplasmic intracellular granules and their accumulation is triggered by starving conditions. The PHAs are ecofriendly and used to create biodegradable plastics.

Design, synthesis and evaluation of 1-(1,5-bis(4-substituted phenyl)-2-methyl-1-pyrrol-3-yl)--methylmethanamines as SERT inhibitors with potential antidepressant action.

BM212 is a potent anti-TB agent with pharmacophoric features similar to the antidepressant drug sertraline. The shape-based virtual screening of the DrugBank database on BM212 resulted in the identification of several CNS drugs with appreciable Tanimoto scores. The docking simulations also ascertained the selectivity of BM212 towards the serotonin reuptake transporter protein (SERT) with a docking score of -6.

Green Synthesis of Blue-Emitting Graphene Oxide Quantum Dots for In Vitro CT26 and In Vivo Zebrafish Nano-Imaging as Diagnostic Probes.

Graphene oxide quantum dots (GOQDs) are prepared using black carbon as a feedstock and HO as a green oxidizing agent in a straightforward and environmentally friendly manner. The process adopted microwave energy and only took two minutes. The GOQDs are 20 nm in size and have stable blue fluorescence at 440 nm.

A novel and efficient one-pot strategy for the synthesis of 1,2,4-triazoles: access to synthesis of penipanoid A and its analogues.

We developed a novel one-pot strategy for synthesizing biologically important 1,2,4-triazole motifs from easily accessible 4-hydroxy phenylacetic acid, formamidine hydrochloride and hydrazine derivatives under mild conditions. This strategy enabled us to synthesize the natural penipanoid A and its analogues in one step.

Improved Process for the Preparation of Naloxegol Oxalate, an Opiod Receptor Antagonist.

The present article discloses an improved and robust commercial process of the modern medicine naloxegol oxalate, which is used to treat opioid-induced constipation. The synthesis originates from the easily available key starting material, viz., naloxone, and ends with the oxalate salt of naloxegol (a pharmaceutically acceptable salt).

Herbs as a Source for the Treatment of Polycystic Ovarian Syndrome: A Systematic Review.

Background: Polycystic ovarian syndrome (PCOS) is a neuroendocrine metabolic disorder characterized by an irregular menstrual cycle. Treatment for PCOS using synthetic drugs is effective. However, PCOS patients are attracted towards natural remedies due to the effective therapeutic outcomes with natural drugs and the limitations of allopathic medicines.

Physiochemical characterization of sodium doped zinc oxide nano powder for antimicrobial applications.

Zinc oxide (ZnO) is one of the semiconductor materials with unique antimicrobial properties towards various microorganisms. In this article, pure and Na doped ZnO nanopowders were synthesized by easiest and cost-effective co-precipitation process. X-ray diffraction (XRD),Fourier transform infrared spectroscopy(FT-IR), ultraviolet - visible (UV - Vis) spectroscopy, scanning electron microscopy(SEM), and Energy dispersive X-ray analysis (EDAX) techniques were used to characterize the particle size, surface morphology and chemical composition of prepared materials.

QbD-based stability-indicating liquid chromatography (RP-HPLC) method for the determination of flurbiprofen in cataplasm.

A nonsteroidal drug called flurbiprofen (FBN) has analgesic, anti-inflammatory and antipyretic activity. Currently the determination of FBN in cataplasm does not have any pharmacopeial method. However, the drug substance, tablet and ophthalmic solution formulations do have pharmacopeial methods.

Generation of surrogate goldfish progeny from common carp parents.

Surrogate broodstock technology can increase the production efficiency of commercially important fishes that are difficult to breed in confinement and aid the propagation and recovery of endangered populations. In this study, we report the application of germ cell (GC) transplantation (GCT) for increasing the numbers of progeny produced by small-bodied ornamental fishes by using sexually mature adult fish as recipients. The GCs isolated from prepubertal male goldfish () donors ( = 5) were transplanted through the genital papilla into the gonads of adult common carp () recipients.

Self-regulated cobalt zinc ferrite system as a potential nanoplatform for the synergistic effect of hyperthermia-chemo agent for cancer therapy.

Magnetic hyperthermia (MH) has been studied for almost seventy-five years, but its efficacy in clinical applications is still fiercely contested. Despite this, few magnetic nanosystems are approved for clinical usage due to their strong affinity as drug carriers. The most important condition for hyperthermia applications for successful cancer therapy is magnetic nanoparticles with a controlled heating pattern (42-46 °C) for a prolonged timeframe.

Geospatial approaches of TGSI and morphometric analysis in the Mahi River basin using Landsat 8 OLI/TIRS and SRTM-DEM.

The research objective is to assess the Mahi River basin, morphometric parameters, and structurally controlled morphological terrains about the topsoil grain size index (TGSI), based on satellite data including Landsat 8 OLI/TIRS and SRTM-DEM data, using ArcGIS processing software. According to morphometric analysis, the Mahi River basin has an area of 28,844.2 km and is a drainage basin of the 8 order.

Experimentally induced animal models for cognitive dysfunction and Alzheimer's disease.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised pathologically by the presence of extracellular amyloid plaques and the intracellular neurofibrillary tangles, along with inflammation, and a compromised antioxidant system. Significant insights into the neurobiology to better understand the pathophysiology of AD and to evaluate the possibility of cutting-edge therapy strategies, can be obtained through the selection of a well-designed experimental animal model. From the transgenic to chemical/drug-induced models, none of them represents the complete picture of Alzheimer pathology and incidence of cognitive dysfunction.

Iron-Catalysed [3+3] Annulation of Oxime Acetates and Enaminones towards the Synthesis of Multi-Substituted Pyridines.

A direct access to unsymmetrical and symmetrical multi-substituted pyridines has been accomplished via iron-catalysed [3+3] annulation of oxime acetates with enaminones. This protocol is featured by easily available starting materials, no requirement of expensive additives and ligands, operational simplicity, and good tolerance with diverse functional groups.

Differential food utilization of benthic amphipods of a tropical estuary: a stable isotopic (δC and δN) investigation.

Globally, stable isotopic methods are rapidly being employed in food web studies to quantify the relative proportions of diverse primary carbon sources in an animal diet. Tropical estuarine ecosystems, one of the vital marine habitats, harbor complex food webs due to the multiplicity of habitats and resources. The complex system of inputs and exchanges of organic matter sometimes complicate identification of the carbon sources that support the higher trophic levels.

Isolation and structural characterization of two novel oxidative degradation products of losartan potassium active pharmaceutical ingredient using advanced analytical techniques.

Rationale: Losartan potassium (losartan) is the most frequently utilized antihypertensive medication in the world. However, partial oxidation of losartan produces toxic by-products that could be harmful to living organisms. Therefore, it is necessary to degrade the losartan and identify the potential toxic oxidative degradation products to minimize their formation during manufacturing, formulation, storage, and packing conditions.

The effect of torrefaction temperature and catalyst loading in Microwave-Assisted in-situ catalytic Co-Pyrolysis of torrefied biomass and plastic wastes.

In the current study, the effect of torrefaction temperatures (125-175 °C) and catalyst quantity (5-15 g) on co-pyrolysis of torrefied sawdust (TSD) and polystyrene (PS) are investigated to obtain value-added products. The role of torrefaction in co-pyrolysis of TSD: PS was analyzed to understand the product yields, synergy, and energy consumption . As the torrefaction temperature increases, oil yield (48.

Sustainable groundwater management through an optimal water supply system using a coupled simulation-optimization approach.

Meeting people's water supply needs in cities is an urgent challenge. Especially in coastal cities, surface water sources are usually inadequate and so groundwater is frequently over-exploited, resulting in its rapid decrease and intrusion of saltwater. Conjunctive use of surface water and groundwater is the best alternative approach to mitigate the overuse of groundwater through effective distribution of surface water sources.

Sickle cell disease-related knowledge and perceptions of traditional healers in tribal communities in India: implications on sickle cell disease programme.

Sickle cell disease (SCD) is a progressively debilitating genetic disease, and India is the second most affected nation in the prevalence of births with SCD. This SCD prevalence is high among Indian indigenous tribal communities, whose healthcare is pluralistic. Traditional healers are an essential part of tribal pluralistic care.

Abietic acid ameliorates nephropathy progression via mitigating renal oxidative stress, inflammation, fibrosis and apoptosis in high fat diet and low dose streptozotocin-induced diabetic rats.

Background: Abietic acid (AA) has been reported to exhibit anti-inflammatory activity, however its protective effect against inflammation and its trigger factor i.e., oxidative stress and the related sequelae i.

Covid-19 classification using sigmoid based hyper-parameter modified DNN for CT scans and chest X-rays.

Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Diagnosis of Computed Tomography (CT), and Chest X-rays (CXR) contains the problem of overfitting, earlier diagnosis, and mode collapse. In this work, we predict the classification of the Corona in CT and CXR images.

Development of a rapid and validated stability-indicating UPLC-PDA method for concurrent quantification of impurity profiling and an assay of ipratropium bromide and salbutamol sulfate in inhalation dosage form.

The objective of the proposed work was to develop a rapid and new reverse phase ultra-performance liquid chromatographic (RP-UPLC) method for the simultaneous quantification of related impurities of ipratropium bromide and salbutamol sulfate in the combined inhalation dosage form. Herein, the chromatographic separation was achieved on Acquity BEH C18 (100mm×2.1mm, 1.

Inclusive partnership and community mobilization approaches to improve maternal health care access among internal migrants in nine Indian cities.

Background: Disparities in healthcare access to internal migrants exist, and the gaps may widen further if appropriate steps are not taken. Innovative approaches are needed to better align the healthcare services with the migrants' needs.

Aim: The aim was to develop and test a supportive strategy of healthcare, which would achieve the desired level of access and delivery of maternal healthcare services to internal migrants living in nine Indian cities.

The role of solvent soaking and pretreatment temperature in microwave-assisted pyrolysis of waste tea powder: Analysis of products, synergy, pyrolysis index, and reaction mechanism.

This study focuses on microwave-assisted pyrolysis (MAP) of fresh waste tea powder and torrefied waste tea powder as feedstocks. Solvents including benzene, acetone, and ethanol were used for soaking feedstocks. The feedstock torrefaction temperature (at 150 °C) and solvents soaking enhanced the yields of char (44.