Assessment of Epidemiological Indicators for Evaluation of National Malaria Elimination Programme: A Retrospective Study.

Background: Malaria has been one of India's most considerable health problems since 1940. The objective of our study is to determine the status of the National Malaria Elimination Programme in India by using epidemiological indicators.

Methods And Materials: The annual reports of malaria for the years 2014-2021 and monthly reports for 2020 and 2021 were collected from the official web portal and were analysed for study specific assessments.

Identification of potential biomarkers for pancreatic ductal adenocarcinoma: a bioinformatics analysis.

PDA is an aggressive cancer with a 5-year survival rate, which is very low. There is no effective prognosis or therapy for PDA because of the lack of target biomarkers. The objective of this article is to identify the target biomarkers for PDA using a bioinformatics approach.

Efficiency and mechanistic insights of photocatalytic decomposition of tetracycline and rhodamine B utilizing Z-scheme g-CN/SnWO heterostructures under visible light irradiation.

The hydrothermal approach was used in the design and construction of the SnWO (SW) nanoplates anchored g-CN (gCN) nanosheet heterostructures. Morphology, optical characteristics, and phase identification were investigated. The heterostructure architect construction and successful interface interaction were validated by the physicochemical characteristics.

Synthesized pyrrole ester ameliorates adjuvant‑induced arthritis in Wistar rats by alleviating inflammation and downregulating the pro‑inflammatory cytokines.

Piperine is an amide alkaloid responsible for producing the pungent smell that comes from black pepper. Piperine has been explained to exhibit significant properties such as anti-rheumatic, anti-inflammatory, and antihypertensive effects. The aim of the study was to synthesize pyrrole ester from piperine and evaluate its anti-arthritis effects in adjuvant-induced arthritis female Wistar rats.

Design, synthesis and in silico molecular docking evaluation of novel 1,2,3-triazole derivatives as potent antimicrobial agents.

Chalcone and triazole scaffolds have demonstrated a crucial role in the advancement of science and technology. Due to their significance, research has proceeded on the design and development of novel benzooxepine connected to 1,2,3-triazolyl chalcone structures. The new chalcone derivatives produced by benzooxepine triazole methyl ketone and different aromatic carbonyl compounds are discussed in this paper.

Biosynthesis, characterization and study of the application of silver nanoparticle for 4-nitrophenol reduction, and antimicrobial activities.

Silver nanoparticles (AgNPs) were synthesized from (L) Walp extracted leaves, and characterized. The UV-Visible spectrum showed a peak between 411 and 415 nm at the Plasmon absorbance of the AgNPs. TEM showed that the size of AgNPs ranged from 5 to 13 nm.

Targeting triple negative breast cancer stem cells using nanocarriers.

Breast cancer is a complex and heterogeneous disease, encompassing various subtypes characterized by distinct molecular features, clinical behaviors, and treatment responses. Categorization of subtypes is based on the presence or absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), leading to subtypes such as luminal A, luminal B, HER2-positive, and triple-negative breast cancer (TNBC). TNBC, comprising around 20% of all breast cancers, lacks expression of ER, PR, and HER2 receptors, rendering it unresponsive to targeted therapies and presenting significant challenges in treatment.

Prevalence of gastrointestinal helminth parasite infections in country chicken from Visakhapatnam district Andhra Pradesh India.

Birds in a free environment carry huge risk of helminth parasite infections affecting the health of poultry and thereby indirectly leading to great economic loss. The present study aimed to evaluate the prevalence, intensity and species diversity of gastrointestinal helminth parasites (GIH) of country chicken () from local chicken markets of Visakhapatnam district, Andhra Pradesh. A total of 300 gastrointestinal tract (GIT) samples were examined from January to December 2021 and the collected parasites were separated, counted, identified and statistically analysed.

Performance, combustion and emission reduction characteristics of Metal-based silicon dioxide nanoparticle additives included in ternary fuel (diesel-SMME-iso butanol) on diesel engine.

Biodiesel has long been recognized as a viable alternative energy source. In order to enhance the quality, and performance of biodiesel-diesel fuel blends while reducing air pollution from combustion, additives must be employed. The present research aims to focus on the addition of SiO novel nanoparticles (at a concentration of 30, 60, and 90 mg/L) in the ternary fuel (TF) blend (75% of Diesel+ 15% of Sea Mango Methyl Ester (SMME15) + 10% of iso-Butanol on a volume basis) to determine engine performance, combustion, and emission characteristics of a 1-cylinder, direct injection, liquid-cooled, diesel engine.

Exposure and Health Risks Posed by Potentially Toxic Elements in Soils of Metal Fabrication Workshops in Mbarara City, Uganda.

Metal fabrication workshops (MFWs) are common businesses in Ugandan cities, and especially those producing metallic security gates, window and door frames (burglar-proof), and balcony and staircase rails. The objective of this study was to comparatively assess the pollution levels and potential health risks of manganese (Mn), chromium (Cr), cadmium (Cd), lead (Pd) and nickel (Ni) in pooled surface soil samples from four 5-, 7-, 8-, and 10-year-old MFWs ( = 28) and a control site ( = 8) in Mbarara City, Uganda. The concentration of the potentially toxic elements (PTEs) was determined using inductively coupled plasma-optical emission spectrometry.

Bioanalysis of bedaquiline in human plasma by liquid chromatography-tandem mass spectrometry: Application to pharmacokinetic study.

Introduction: A sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for estimation of bedaquiline (BDQ) in human plasma using the deuterated analogue of the analyte, bedaquiline-d6 (BDQ-d6) as the internal standard.

Methods: The plasma sample of 50 µL was extracted by liquid-liquid extraction using methyl tertiary butyl ether (MTBE). The separation was achieved on Zodiac C (50 x 4.

Ecosystem-scale insights into the dynamics of dissolved organic matter in an Asia's largest brackish water lagoon: Sources, fluxes, and biogeochemical significance.

A twenty-four month long observational study conducted in an Asia's largest brackish water ecosystem, Chilika Lagoon, India, aimed to unravel dissolved organic matter (DOM) dynamics in this tropical brackish water ecosystem. The study assessed the interplay between allochthonous and autochthonous DOM sources during lean and active flow periods based on regional rainfall. Dissolved organic carbon (DOC), nitrogen (DON), and phosphorus (DOP) fluxes were analyzed, considering catchment runoff, phytoplankton production, benthic-pelagic interactions, and sea-lagoon exchanges as contributors.

Improving lineament mapping using RISAT-1 SAR data, Nagpur and surrounding area in central India.

Lineaments are the linear geological features can extend from few meters to hundreds of kms. Geologically lineaments are either structural or stratigraphical, typically it will comprise fault, fold axis, bedding contacts, dyke intrusions, shear zone or a straight coast line. Mapping lineaments using remote sensing is economical, faster can act as a preliminary study for geophysical survey such as gravity, electrical, magnetic and seismic etc.

Strengthening Health System and Community Mobilization for Sickle Cell Disease Screening and Management among Tribal Populations in India: An Interventional Study.

Sickle cell disease (SCD) affects 5% of the global population, with over 300,000 infants born yearly. In India, 73% of those with the sickle hemoglobin gene belong to indigenous tribes in remote regions lacking proper healthcare. Despite the prevalence of SCD, India lacked state-led public health programs until recently, leaving a gap in screening and comprehensive care.

Stormwater reuse for water-sensitive city - Integrated analysis of urban hydrology for efficient alternatives of Amaravati city, India.

In the present study, Amaravati, a proposed city of Andhra Pradesh, India, is identified for stormwater reuse analysis and for various efficient options for reuse. Peak runoff from the entire catchment is determined for the management of stormwater using different models such as soil and water assessment tool (SWAT), stormwater management model, and intensity-duration-frequency curves by the log Pearson Type III method. Further, the bio-retention cell low-impact development option with 60% impervious area, 60% zero depression impervious area, bio-retention cell for 40% area for each sub-catchment, and the underground stormwater network system, for part of peak runoff reduction, remaining peak runoff is considered for reuse.

Six species of nonmazocraeid monogeneans including two new species from clupeiform fishes of Visakhapatnam coast, Bay of Bengal.

During a survey on monogenean parasites of clupeiform fishes of Visakhapatnam coast, Bay of Bengal, apart from typical mazocraeids, 6 species of nonmazocraeids, including two new species were encountered. These belonged to 5 genera distributed over 4 families: Family Gastrocotylidae: from ; n.sp.

Export of particulate organic carbon and nitrogen to the northern Indian Ocean by the monsoonal rivers of India.

This study analyses particulate organic carbon (POC) and particulate nitrogen (PN) export from Indian monsoonal rivers to the north Indian Ocean. Indian monsoonal rivers export approximately 1.2 Tg yr (1Tg = 10 g) of POC and 0.

Magnetic and Magnetostrictive Properties of Sol-Gel-Synthesized Chromium-Substituted Cobalt Ferrite.

Chromium (Cr)-doped cobalt ferrite nanoparticles were synthesized using a sol-gel autocombustion method, with the chemical formula CoCrFeO. The value of x ranged from 0.00 to 0.

Synthesis and screening of clerodane diterpene analogues from 16 hydroxycleroda 3,13(14)-Z-diene 15,16-olide for potential anti-mycobacterial activity.

In recent years, clerodane diterpenes, a class of bioactive compounds, have come into the spotlight due to their amazing bioactivities. Three novel clerodane diterpene analogues were obtained by synthesising 16-hydroxycleroda-3,13(14)-Z-diene-15,16-olide (Lactone) with primary amines. Anti-tubercular activity was determined using Microplate Alamar Blue Assay.

Methoxyhispolon Methyl Ether, a Hispolon Analog, Thwarts the SRC/STAT3/BCL-2 Axis to Provoke Human Triple-Negative Breast Cancer Cell Apoptosis In Vitro.

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with few treatment options. A promising TNBC treatment approach is targeting the oncogenic signaling pathways pivotal to TNBC initiation and progression. Deregulated activation of signal transducer and activator of transcription 3 (STAT3) is fundamental to driving TNBC malignant transformation, highlighting STAT3 as a promising TNBC therapeutic target.

AdaBoost based Random forest model for Emotion classification of Facial images.

Posting of visual data in the social network has now become a common trend. Mainly, users are posting selfies or facial images over the social media that depict various moods at different instances. This has attracted the attention of researchers to come up with facial expression mining from social media images.

Modelling biochemical oxygen demand in a large inland aquaculture zone of India: Implications and insights.

Water quality surveillance is tough, and a specific timely management is necessary for the inland aquaculture ponds and ecology as well. Real time quality monitoring involves the study of numerous parameters includes physical (turbidity, temperature, and specific conductivity), chemical (pH, calcium, manganese, chlorides, iron, biochemical oxygen demand), and biological (bacteria and algae). It is also crucial to recognize the inter-dependence among the parameters.