Antibiotic potentiation and anti-cancer competence through bio-mediated ZnO nanoparticles.

Zinc Oxide (ZnO) is currently used in nano-cosmeceuticals and nano-pharmaceuticals topically due to their multifunctional efficiency irrespective of the synthetic method. Bio-reducers are cosmopolitically famed to attain stable, reliable, and toxic free synthesis. Thus, the objective of the current study is to prepare ZnO NPs in a greener approach using Annona squamosa (AS) leaf extract and to evaluate their antibiotic potentiation capacity and anticancer activity.

Current Status in the Design and Development of Agonists and Antagonists of Adenosine A3 Receptor as Potential Therapeutic Agents.

Adenosine receptors (ARs) belongs to the family of G-protein coupled receptors (GPCR) that are responsible for the modulation of a wide variety of physiological functions. The ARs are also implicated in many diseases such as cancer, arthritis, cardiovascular and renal diseases. The adenosine A3 receptor (A3AR) has emerged as a potential drug target for the progress of new and effective therapeutic agents for the treatment of various pathological conditions.

P1 Receptor Agonists/Antagonists in Clinical Trials - Potential Drug Candidates of the Future.

Background: Adenosine mediates various physiological and pathological conditions by acting on its four P1 receptors (A1, A2A, A2B and A3 receptors). Omnipresence of P1 receptors and their activation, exert a wide range of biological activities. Thus, its modulation is implicated in various disorders like Parkinson's disease, asthma, cardiovascular disorders, cancer etc.

Two new species of Hermann (Monogenea: Mazocraeidae) from clupeoid fishes off Visakhapatnam, Bay of Bengal.

Two new species of Hermann (Monogenea: Mazocraeidae) are described infecting clupeoid fishes of Visakhapatnam coast, Bay of Bengal: n. sp. from Cuvier and n.

Toxicological Assessment of a Standardized Gum Resin Extract.

The acidic and non-acidic fractions of gum resin extracts were combined to prepare a unique product, LI13019F1 (Serratrin). The present series of studies evaluated LI13019F1 for acute and subchronic (28-day) toxicity in Wistar rats and acute dermal and eye irritation in New Zealand white rabbits. The mutagenicity and clastogenicity of LI13019F1 were evaluated in bacteria and mouse bone marrow erythrocytes, respectively.

Genome-wide codon usage bias analysis in Beauveria bassiana.

Codon usage bias analysis allows in identifying the factors that are influencing and contributing to shape the evolution of the organisms. Therefore, it is of interest to analyze 10363 gene sequences from . The GC content with 51.

Influence of wear parameters on friction performance of A356 aluminum - graphite/ granite particles reinforced metal matrix hybrid composites.

In this work aluminium-silicon alloy (A356) is strengthened with blends of granite and graphite particles using stir casting technique. Granite particulates, an industrial waste generated while cutting granite stones is used along with graphite particulates which has excellent lubricant properties. The reinforcements are mixed in different weight proportions, to base alloy at 2 and 4 weight percentages.

The structural, DC resistivity and magnetic properties of Zr and Co co-substituted NiZnFeO.

The Zr and Co co-substituted NiZnFeO have been synthesized by sol-gel auto combustion method. The XRD patterns provide single phase cubic spinel with ( ( )) space group and extra peaks found in XRD patterns from x = 0.24 to x = 0.

Bianchi type-V dark energy cosmological model in general relativity in the presence of massive scalar field.

In this paper, we discuss spatially homogeneous and anisotropic Bianchi type-V dark energy cosmological model in the presence of an attractive massive scalar field in general relativity. We have solved the field equations using (i) the shear scalar of the metric is proportional to the expansion scalar which results a relationship between metric potentials and (ii) a power law between the massive scalar field and the average scale factor. We have computed the cosmological parameters like dark energy density, equation of state parameter, skewness parameters, deceleration parameter and statefinder parameters of our dark energy model with massive strings and discussed their physical significance in the light of the recent scenario of accelerated expansion of the universe and cosmological observations.

Effects of microwave vacuum drying and conventional drying methods on the physicochemical and microstructural properties of squid shreds.

Background: Microwave vacuum drying is an innovative technology for drying fruits and vegetables. However, this technology has not been well explored for drying seafood. In the present study, the effects of microwave vacuum drying (MVD), hot air drying (HAD) and sun drying (SD) on the proximate composition, texture, rehydration, color and microstructure of squid shreds were investigated.

Quercetin reduced the formation of N-acetyl-p-benzoquinoneimine, a toxic metabolite of paracetamol in rats and isolated rat hepatocytes.

N-acetyl-p-benzoquinoneimine (NAPQI) is toxic metabolite of paracetamol formed primarily by cytochrome P4502E1 (CYP2E1) metabolic pathway when administered at therapeutic doses or overdose. The influence of quercetin (flavonoid) on the bioactivation of paracetamol to NAPQI was investigated using rat liver microsomes and rats in vivo. Paracetamol (80 mg/kg) was administered orally without or with silymarin (100 mg/kg), a known inhibitor of CYP2E1, CYP3A4 and quercetin (10 and 20 mg/kg) to rats for 15 consecutive days.

Protective effect of acetone extract against high-fat and high-sugar diet-induced obesity and memory impairment.

Roxb. (Mango ginger) was evaluated for anti-obesity, anti-amnesic and neuroprotection using high-fat and high-sugar diet (HFHS)-induced obesity and cognitive impairment in rats. Animals were exposed to HFHS diet to evaluate lipid parameters and subjected to Y maze test and Pole climbing test to evaluate the memory.

A comprehensive review on hepatoprotective and nephroprotective activities of chrysin against various drugs and toxic agents.

Chrysin belongs to the flavonoids and has been used as traditional medicine from ancient and has been reported to exhibit a wide range of pharmacological properties. The biochemical and molecular mechanisms involved in the hepato- and nephroprotective activities of chrysin were discussed in this review. Chrysin exhibited hepatoprotective activity against 2,3,7,8-tetrachlorodibenzo-p-dioxin, carbon tetrachloride, cisplatin, d-galactosamine, doxorubicin, ethanol, lipopolysaccharide/d-galactosamine, methotrexate, ammonium chloride, paracetamol, diethylnitrosamine, streptozotocin, tert-butyl hydroperoxide, thioacetamide, 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP), ischemia/reperfusion-induced hepatotoxicity and nephroprotective activity against cisplatin, doxorubicin, paracetamol, gentamicin, streptazotocin, N-nitrosodiethyl amine, 5-fluorouracil, adenine, carbon tetrachloride, copper, 2,3,7,8-tetrachlorodibenzo- p-dioxin, colistin, Nω-nitro-l-arginine-methylester and ethanol in various animal models due to its antioxidant, anti-apoptotic activities.

Stevioside, a diterpenoid glycoside, shows anti-inflammatory property against Dextran Sulphate Sodium-induced ulcerative colitis in mice.

Inflammatory bowel disease is an umbrella-term used to describe a set of chronic inflammatory conditions that affect the gastro-intestinal tract. Since most of the inflammatory medications in current use have several undesirable side-effects, stevioside, a naturally occurring, high-intensity sweetener was assessed in our study for its anti-inflammatory properties by in-vitro and in-vivo experiments. Stevioside was observed to significantly inhibit the levels of LPS induced elevation of cytokines, TNF-α (P < 0.

Impact assessment of India's Swachh Bharat Mission - Clean India Campaign on acute diarrheal disease outbreaks: Yes, there is a positive change.

Background: Enough evidence exists to attribute the occurrence of diarrheal disease outbreaks due to open defecation practice and unsafe sanitation methods. Open defecation enables pathogens such as virus, bacteria, and protozoa to infect humans by means of fecal-oral transmission methods through contaminated fluids, water, and fomites. To curb the malefic effects of open defecation, the Indian government had initiated pro sanitation program namely Swachh Bharat Mission (SBM) in 2014.

Quantification and In Silico Toxicity Assessment of Tazarotene and its Impurities for a Quality and Safe Drug Product Development.

Tazarotene is internationally accepted common name for ethyl 6-[(4,4-dimethylthiochroman-6-yl)ethynyl]nicotinate. It is a synthetic retinoid used for the topical treatment of mild to moderate plaque psoriasis, acne vulgaris and photo aging. To ensure the quality of drug product and drug substance, a LC-MS compatible UHPLC method was developed for quantification of drug and its related substances.

Does microhabitat influence the testate amoebae communities in the Nameri National Park, northeastern India? A tropical forest perspective.

The community structure of testate amoebae inhabiting different microhabitats (soil and tree-moss) within a tropical forest biome in Nameri National Park, northeastern India, was investigated. A total of 33 testate amoebae species belonging to 13 genera were identified. Species belonging to the class Lobosea constituted 73% of total testate amoebae density in the soil habitat, whereas the class Filosea constituted the most dominant forms (58%) in the moist tree-moss habitat.

Degradation studies of Ibrutinib under stress conditions: Characterisation and structural elucidation of novel degradants.

The aim of the research work is to study the degradation behaviour of Ibrutinib (IBN) which is performed under different stress conditions according to International Conference on Harmonization guidelines (ICH). The study included monitoring degradation of the Ibrutinib drug under acidic, base, oxidation, thermal and photolytic conditions followed by isolation and characterisation of degradation products (DP) by Liquid Chromatography Mass Spectrometry (LCMS), High resolution Mass Spectrometry (HR-MS/MS) and Nuclear Magnetic Resonance (NMR) studies. The IBN drug is stable under oxidation, thermal and photolytic conditions.

Multiple logistic regression analysis predicts cancer risk among tobacco usage with glutathione -transferase p1 genotyping in patients with head and neck cancer.

Introduction: Numerous studies have been investigated to understand the association between glutathione S-transferase P1 (GSTP1) polymorphism and risk of head and neck cancer (HNC) but yielded contradictory results, and no studies could confirm polymorphism in GSTP1 and that tobacco usage increases the risk of HNCs. Therefore, this study aimed to understand the association of GSTP1 Ile105Val polymorphism with or without tobacco usage in carcinogenesis and clinicopathological characteristics of patients with HNC.

Materials And Methods: Binary logistic regression analysis was performed to predict HNC risk with tobacco use and GSTP1 genotyping.

Biogenic synthesis and characterization of silver nanoparticles using aqueous leaf extract of L. and assessment of their antimicrobial property.

Naturally occurring phytochemicals serve as an excellent substitute in synthesizing nanomaterials. A process for the synthesis of silver nanoparticles (AgNPs) from the aqueous leaf extract of naturally occurring is described here. The extracellular formation of AgNPs occurred within few minutes upon incubation of aqueous leaf extract (0.

Basin-wide sea level coherency in the tropical Indian Ocean driven by Madden-Julian Oscillation.

Changes in sea level may be attributed either to barotropic (involving the entire water column) or baroclinic processes (governed by stratification). It has been widely accepted that barotropic sea level changes in the tropics are insignificant at intraseasonal time scales (periods of 30-80 days). Based on bottom pressure records, we present evidence for significant basin-wide barotropic sea level variability in the tropical Indian Ocean during December-April with standard deviations amounting to ∼30-60% of the standard deviation in total intraseasonal sea level variability.

Synthesis, Screening and Docking Analysis of Hispolon Pyrazoles and Isoxazoles as Potential Antitubercular Agents.

Background: Hispolons are natural products known to possess cytoprotective, antioxidant and anti-cancer activities. We have found recently anti TB activity in these compounds. Efforts were made to optimize the structure with bioisosteric replacement of 1,3-diketo functional group with the corresponding pyrazole and isoxazole moieties.

Novel indolizine derivatives lowers blood glucose levels in streptozotocin-induced diabetic rats: A histopathological approach.

Background: Diabetes mellitus is a deadly disorder in human which induce chronic complications. The streptozotocin (STZ)-induced diabetes in rat is the most common animal model of human diabetes. The present study investigated the effects of novel indolizine derivatives (1-16) on plasma blood glucose concentrations in STZ-diabetic rats.

Effect of chrysin on the formation of N-acetyl-p-benzoquinoneimine, a toxic metabolite of paracetamol in rats and isolated rat hepatocytes.

Paracetamol (N-acetyl-para amino phenol) is the most commonly used analgesic and antipyretic around the world. Its causes hepatotoxicity and nephrotoxicity at overdose or even at therapeutic doses. It is primarily metabolized by glucuronidation and sulfate conjugation.