Characterization of Five Oxidative Degradation Impurities and One Process Impurity of Suvorexant Drug Substance by LC-MS/MS, HR-MS and 1D, 2D NMR: Validation of Suvorexant Drug Substance and Process Impurities by HPLC and UPLC.

During the oxidative (10% H2O2) degradation of suvorexant drug substance, around 1.0% of one impurity and less than 1.0% four impurities were found by a new high-performance liquid chromatography (HPLC) assay and related substance method.

Base mediated spirocyclization of quinazoline: one-step synthesis of spiro-isoindolinone dihydroquinazolinones.

A novel approach for the spiro-isoindolinone dihydroquinazolinones has been demonstrated from 2-aminobenzamide and 2-cyanomethyl benzoate in the presence of KHMDS as a base to get moderate yields. The reaction has been screened in various bases followed by solvents and a gram scale reaction has also been executed under the given conditions. Based on the controlled experiments a plausible reaction mechanism has been proposed.

Topical administration of mangiferin promotes healing of the wound of streptozotocin-nicotinamide-induced type-2 diabetic male rats.

Purpose: This study identifies the potential use of mangiferin gel to promote wound healing in diabetes mellitus (DM).

Materials And Methods: Male rats were rendered diabetes mellitus intraperitoneal injection of streptozotocin and nicotinamide. Following diabetes development, wound was created at the back of the neck.

Synthesis, Biological and Computational Evaluation of Novel 2,3-dihydro-2-aryl-4-(4- isobutylphenyl)-1,5-benzothiazepine Derivatives as Anticancer and Anti-EGFR Tyrosine Kinase Agents.

Background: Despite the availability of a variety of chemotherapeutic agents, cancer is still one of the leading causes of death worldwide because of the problems with existing chemotherapeutic agents like objectionable side effects, lack of selectivity, and resistance. Hence, there is an urgent need for the development of novel anticancer agents with high usefulness, fewer side effects, devoid of resistance and superior selectivity.

Objective: The objective of this study is to synthesize a series of novel 1,5-benzothiazepine derivatives and evaluate their anticancer activity employing biological and computational methods.

Publisher Correction: Synthesis of Saccharumoside-B analogue with potential of antiproliferative and pro-apoptotic activities.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Carbamazepine-induced hyperglycemia: A rare case report.

Carbamazepine is a commonly used iminostilbene antiepileptic medication and it is estimated that 46.9% of the total antiepileptic drug overdose in the United Kingdom is because of this drug. The overdose of Carbamazepine can show negative effects on multiple systems, these include neurologic (ataxia, seizures, and altered sensorium), cardiac (tachycardia, hypotension) and metabolic manifestations.

Antibacterial efficacy of green synthesized α-FeO nanoparticles using plant extract.

The aim of the work is to synthesize iron oxide (α-FeO) nanoparticles using plant extract along with evaluation of its antibacterial activity. The presence of phytochemicals in methanolic plant extract was investigated by HPTLC and LC-MS/TOF. The probable mechanism for formation of α-FeO nanoparticles in mediation with plant extract was demonstrated.

Twofold expansion of the Indo-Pacific warm pool warps the MJO life cycle.

The Madden-Julian Oscillation (MJO) is the most dominant mode of subseasonal variability in the tropics, characterized by an eastward-moving band of rain clouds. The MJO modulates the El Niño Southern Oscillation, tropical cyclones and the monsoons, and contributes to severe weather events over Asia, Australia, Africa, Europe and the Americas. MJO events travel a distance of 12,000-20,000 km across the tropical oceans, covering a region that has been warming during the twentieth and early twenty-first centuries in response to increased anthropogenic emissions of greenhouse gases, and is projected to warm further.

Green syntheses of silver nanoparticle decorated reduced graphene oxide using l-methionine as a reducing and stabilizing agent for enhanced catalytic hydrogenation of 4-nitrophenol and antibacterial activity.

Herein, we have reported a facile and green synthesis approach of Ag NP decorated reduced graphene oxide (RGO) through an self-assembly method in the presence of l-methionine (l-Met) as reducing and stabilizing agent. The electronic properties, crystal structure, and morphology of the as-synthesized RGO-Ag nanocomposite were investigated by UV-Visible (UV-Vis) spectroscopy, Fourier transform-infrared (FTIR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM) techniques. UV-Vis and FTIR show the effective reduction of GO and the formation of Ag NPs using l-Met.

Development of response surface methodology for optimization of parameters and quantitative analysis of chebulinic acid from composition of medicinal herbs by HPLC.

The purpose of the research is to study the development of response surface methodology for optimization of chebulinic acid extraction from composition of medicinal herbs such as , and seeds of . Optimization of extraction parameters such as weight dosages, pH and time were carried out by response surface methodology (RSM). The optimal conditions determined for extraction of chebulinic acid through response surface methodology were dosage (6.

Applications of geochemical and multivariate statistical approaches for the evaluation of groundwater quality and human health risks in a semi-arid region of eastern Maharashtra, India.

A qualitative approach, including geochemical and multivariate statistical approaches, is applied to evaluate the groundwater quality and human health risk, based on analytical data of 72 samples collected from a semi-arid region of eastern Maharashtra, India. The shifting of hydrochemical type from Ca-Na-[Formula: see text] to Na-Ca-Cl type was observed along different flow paths. The main controlling processes observed from the chemical characterisation of the groundwater are water-rock interactions, dedolomitisation and reverse ion exchange.

Green synthesis of zinc oxide nanostructures and investigation of their photocatalytic and bactericidal applications.

We report a facile one-pot green synthesis of zinc oxide (ZnO) nanostructures using aqueous leaf extract of L. as the reducing and capping agent. The optical properties, structure and morphology of the as-synthesized ZnO nanostructures have been characterized by UV-Visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM) supported with energy dispersive X-ray spectroscopy (EDX), and transmission electron microscopy (TEM).

Operationally defined mercury (Hg) species can delineate Hg bioaccumulation in mangrove sediment systems: A case study.

This study investigated the linkage between mercury (Hg) speciation in the surficial sediments from a mangrove ecosystem of the Zuari Estuary, west coast of India, with Hg bioaccumulation in gastropods collected from the same area. Multiple operationally defined protocols and methods were used for determination of Hg speciation study in the mangrove sediments. Moderately low concentrations of Hg were observed in the sediments, ranging from 37.

Four species of Mazocraeoides Price, 1936 (Monogenea: Mazocraeidae), including two new species from clupeiform fishes off Visakhapatnam coast, Bay of Bengal.

Four species of Mazocraeoides Price, 1936 including two new species are recorded from clupeiform fishes collected from Visakhapatnam Coast, Bay of Bengal: M. rotundus n. sp.

Patient experiences and health system responsiveness among internal migrants: A nationwide study in 13 Indian cities.

Objective: To report various components of health system responsiveness among poor internal migrants who availed the government health facilities in 13 Indian cities.

Materials And Methods: Cluster random sampling was used to select 50,806 migrant households, of which 14,263 households avail the government health facility in last six months. In addition, 5072 women, who sought antenatal care and 3946 women who had delivery in government health facility during last six months were also included.

Purification, characterization, and structural elucidation of serralysin-like alkaline metalloprotease from a novel source.

Background: Serratiopeptidase is an alkaline metalloendopeptidase, which acquired wide significance because of its therapeutic applications. The present study was undertaken for purification, characterization, and structural elucidation of serratiopeptidase produced from Streptomyces hydrogenans var. MGS13.

A systematic review on hepatoprotective activity of quercetin against various drugs and toxic agents: Evidence from preclinical studies.

Quercetin is one of the most abundant flavonoids in human diet that has been reported to exhibit a wide range of pharmacological properties. The biochemical and molecular mechanisms involved in the hepatoprotective activity of quercetin were discussed in this review. Quercetin exhibited hepatoprotective activity against 2-butoxyethanol, acrylamide, acrylonitrile, aflatoxin B1, aroclor-1254, arsenic, sodium arsenite, azathioprine, cadmium chloride, carbon tetrachloride, chlorpyrifos, cyclosporine A, diazinon, dimethylnitrosamine, doxorubicin, epirubicin, ethanol, fenvalerate, isoniazide, rifampicin, lead acetate, lindane, D-galactosamine, methotrexate, methylmercury, nickel sulfate, paracetamol, perfluorooctanoic acid, polychlorinated biphenyls, pyrrolizidine alkaloid clivorine, rotenone, sodium fluoride, streptazotocin, tert-butyl hydroperoxide, thioacetamide, titanium dioxide, tumor necrosis factor-α, tripterygium glycoside, triptolide, ultraviolet A light, concavalin A, bisphenol, and ischemia-induced hepatotoxicity in various animal models due to its antioxidant, free radical-scavenging,anti-inflammatory, antiapoptotic, and cytochrome P450 2E1 (CYP2E1) inhibitory activities.

Structural variation of coloured dissolved organic matter during summer and winter seasons in a tropical estuary: A case study.

The diurnal variations in water quality and optical properties of organic matter were studied in the Gautami-Godavari estuary during two contrasting seasons. Dissolved inorganic nitrogen (DIN) and silicate showed similar patterns with the tide during summer, whereas in winter contrasting trends were noticed. Three-folds higher N to P ratio was recorded in winter than in summer.

An Orthogonal Approach for Determination of Acetamide Content in Pharmaceutical Drug Substance and Base-Contaminated Acetonitrile by GC and GC-MS External Method.

Acetamide is a potential genotoxic impurity; it should control in drug substance based on daily dosage level. It forms from base-contaminated acetonitrile and by-product of some drug substances. The available methods for acetamide in drug substance and water samples were determined by GC-MS using internal standard with critical procedures.

Separation of Unprecedented Degradants of Domperidone by Ultra-Performance Convergence Chromatography and Their Structure Elucidation.

Domperidone, a gastroprokinetic agent, is a common drug to treat emesis. It was subjected to acid, base-mediated hydrolysis, peroxide-mediated oxidation, photolysis and thermal degradation according to ICH guidelines to observe stability of the selected drug under the stress conditions. Although the drug is resistant to base hydrolysis, photolysis and thermal stressors, two degradants (DP-ISO1 and DP-ISO2) were formed in acid mediated hydrolysis.

Nannochloropsis Extract-Mediated Synthesis of Biogenic Silver Nanoparticles, Characterization and In Vitro Assessment of Antimicrobial, Antioxidant and Cytotoxic Activities.

Objective: To investigate the biogenic synthesis of silver nanoparticles (AgNPs) using partially purified ethyl acetate extract of Nannochloropsis sp. hexane (EAENH) fraction of microalga. Methods: The green synthesis of AgNPs was confirmed with UV-Vis spectrum which shows the surface plasmon resonance (SPR) at 421 nm.

Quality criteria for groundwater use from a rural part of Wanaparthy District, Telangana State, India, through ionic spatial distribution (ISD), entropy water quality index (EWQI) and principal component analysis (PCA).

The present study region comprises granite and granite gneisses aquifer system constituted by Precambrian rocks. Groundwater is the primary source for drinking and other domestic purposes. Many developing regions in the world suffer from lack of safe drinking water.

Assessment of Circulating Biomarkers in Relation to Various Stages of Diabetic Retinopathy in Type 2 Diabetic Patients-A Cross Sectional Study.

Aim: The aim of this study is to examine the relationship between inflammatory markers, and diabetic retinopathy in type II diabetic patients.

Methods: The study was a cross-sectional study included 150 type 2 diabetic patients who were divided into 3 groups. 50 in each group are divided as Diabetic patients without retinopathy (DM, n=50), nonproliferative diabetic retinopathy patients (NPDR, n=50), proliferative diabetic retinopathy patients (PDR, n=50).