Design and Evaluation of 5-Oxo-1,2,4-triazole-3-carboxamide Compounds as Promising Anticancer Agents: Synthesis, Characterization, In vitro Cytotoxicity and Molecular Docking Studies.

Background: Cancer presents a significant global health challenge, necessitating effective treatment strategies. While chemotherapy is widely employed, its non-specific nature can induce adverse effects on normal cells, prompting the exploration of targeted therapies. The 1,2,4-triazole scaffold has emerged as a promising element in anticancer drug development due to its structural diversity and potential to target cancer cells.

Influence of Nd ion on piezoelectric studies in lead barium niobate ferroelectric ceramics for device applications.

Pb₁₋ₓ₋₃BaₓReᵧ³⁺Nb₂O₆ (PBN) ceramics, where x = 0.35 and y = 0.00, 0.

Optimization of Bromelain extraction from green papaya (Carica papaya) peel waste and its application in the recovery of silver from waste of X-ray photographic films.

As bromelain is a proteolytic enzyme present in many fruits, this study utilises the bromelain content present in unripe papaya (Carica papaya L.) by extraction and characterisation of bromelain extract from the unripe papaya peel waste. The extracted bromelain was utilised in the recovery of silver from waste of X-ray films, since the toxicity of silver directly impacts on the environment to treat and recover silver bromelain enzyme was used as a biocatalyst in this study.

Amide Functionalized Novel Pyrrolo-pyrimidine Derivative as Anticancer Agents: Synthesis, Characterization and Molecular Docking Studies.

Background: The development of new therapies targeting crucial kinases involved in cancer progression is a promising area of research. Pyrazolo pyrimidine derivatives have emerged as potential candidates for this purpose.

Objective: This study aims to synthesize pyrazolo pyrimidine derivatives (5a-5r), evaluate their molecular docking against key kinases, and assess their anticancer activity.

Isolation, Screening and Identification of Biosurfactant Producing Strain Nocardiopsis dassonvillei var B2 From Oil Contaminated Soil.

Petroleum and other oil manufacturing industries contribute to environmental pollution by releasing hazardous hydrocarbons. Biosurfactants offer a sustainable solution for mitigating oil pollution through emulsification processes, safeguarding agricultural soils, aquatic ecosystems, and human health. This study focuses on isolating, screening, and identifying actinomycetes producing biosurfactant from oil-polluted soil in the naval dockyard of Visakhapatnam.

Minimum dietary diversity is associated with lower risk of childhood underweight: Evidence from the 2019/2021 National Family Health Survey of India.

A lack of consumption of a diversified diet is associated with poor physical and cognitive development in children. Evidence on the relationship between minimum dietary diversity (MDD) and childhood malnutrition remains inconclusive in India. We hypothesized that children aged 6 to 23 months on a diversified diet (five out of eight defined foods and beverages) are less likely to be malnourished (stunting, wasting, and underweight) compared to their counterparts who are not on a diversified diet.

Genomic portraits of methicillin-resistant staphylococci (MRS) from food fish unveiled the genes associated with staphylococcal food poisoning (SFP), virulence and antimicrobial resistance.

Background: Characteristics of non-clinical strains of methicillin-resistant Staphylococcus aureus (MRSA) especially from fishery environment are poorly understood. This research, in addition to comprehensive characterisation, sought to delineate the genetic relatedness between the MRSA strains originating from clinical as well as non-clinical settings. Out of 39 methicillin-resistant staphylococcal isolates from 197 fish samples, 6 (Three each of methicillin-resistant S.

Improved, Efficient, and Simple Methodology for the Resolution of Racemic Benoxaprofen: A Nonsteroidal Anti-Inflammatory Drug (NSAID).

The present article discloses an improved, efficient, and simple resolution methodology for the preparation of (S)-benoxaprofen which is a nonsteroidal anti-inflammatory drug (NSAID). The resolution of racemic benoxaprofen uses an easily available, efficient, recoverable, and cost-effective chiral reagent, namely, (1R,2S)-(+)-cis-1-amino-2-indanol. This novel resolution process is having a very high purity of (S)-benoxaprofen, greater than 99%, substantially free from (R)-benoxaprofen (less than 1%).

Substituent-Oriented Synthesis of Substituted Pyridines/Pyrido[3,2-C]coumarins Sequential Reactions of α-H and Me/Aryl Substituted Oxime Acetates and 3-Formylchromones.

A facile one pot sequential and highly chemoselective synthesis of substituted pyridines/pyrido[3,2-]coumarins has been developed from oxime acetates and 3-formylchromones in the presence of FeCl. This reaction was oriented by different substituents on the α-position (H, methyl/aryl) of oxime acetates. Mechanistic investigations suggested that substituted pyridines were formed via intramolecular aza-Michael addition followed by ring opening, while pyrido[3,2-]coumarins were formed via intermolecular Michael addition.

A case report of tuberculous meningitis resulting in irreversible visual impairment due to delayed diagnosis.

Key Clinical Message: Prompt diagnosis of tuberculous meningitis (TBM) is crucial to prevent severe complications like cranial nerve involvement and irreversible visual impairment. Early suspicion and intervention are essential, especially in tuberculosis-endemic regions. Rapid initiation of anti-tuberculosis therapy and vigilant monitoring for complications, such as hydrocephalus, improve patient outcomes and prevent long-term disabilities.

New stability indicating RP-HPLC methods for the determination of related substances and assay of trametinib acetic acid: a mass balance approach.

New stability indicating related substances and assay methods for trametinib acetic acid by RP-HPLC have been developed and validated through forced degradation and mass balance studies for the first time. In related substances (RS) method, trametinib acetic acid was successfully separated from its six related substances namely, cyclopropanamide impurity, desiodo trametinib, desacetyl trametinib, trione acetamide intermediate, trione intermediate, and trione PTSA intermediate using YMC-Triart C18 (150 × 4.6 mm, 3 µm) column.

Chromophoric dissolved organic matter traces seasonally changing coastal processes in a river-influenced region of the western Bay of Bengal.

The optical characteristics of colored dissolved organic matter (CDOM) serve as a convenient tool for evaluating coastal processes, e.g., river runoff, anthropogenic inputs, primary production, and bacterial/photochemical processes.

Synthesized diterpene lactone derivative attenuated Freund's complete adjuvant-induced arthritis in Wistar rats.

Objectives: In this study, the SP-38 (Diterpene Lactone derivative) was designed, synthesized from clerodane diterpene (lactone) isolated from var. pendula, and tested for anti-arthritic activity using the FCA-induced arthritic rat model.

Materials And Methods: This study examined the effects of SP-38 using three different doses (20, 10, and 5 mg/kg) by oral administration for 21 days from day 8 after 0.

Advancements in nanobody generation: Integrating conventional, in silico, and machine learning approaches.

Nanobodies, derived from camelids and sharks, offer compact, single-variable heavy-chain antibodies with diverse biomedical potential. This review explores their generation methods, including display techniques on phages, yeast, or bacteria, and computational methodologies. Integrating experimental and computational approaches enhances understanding of nanobody structure and function.

Cisplatin Encapsulated Plasmonic Blackbodies for NIR Light Activatable Chemo-Phototherapy and Reduction of 4-Nitrophenol.

Cisplatin (CDDP) is an FDA-approved chemotherapeutic drug used for treating various solid tumors. Despite of its effectiveness towards chemotherapy, it faces several challenges, such as multi-drug resistance (MDR) and significant damage to the normal tissues. To address these challenges, various nanoformulations were developed to improve the delivery and safety of CDDP.

Design, synthesis, and anti-mycobacterial evaluation of 1,8-naphthyridine-3-carbonitrile analogues.

Twenty-eight compounds, , 1,8-naphthyridine-3-carbonitrile (ANC and ANA) derivatives, were designed and synthesized through a molecular hybridization approach. The structures of these compounds were analyzed and confirmed using H NMR, C NMR, LCMS, and elemental analyses. The synthesized compounds were evaluated by testing for their effectiveness against tuberculosis using the MABA assay, targeting the H37Rv strain.

Sickle cell disease in Indian tribal population: Findings of a multi-centre Indian SCD registry.

Background: Sickle cell disease (SCD) registries provide crucial real-world data on demographics, epidemiology, healthcare, patient outcomes, and treatment efficacy. This paper presents findings from the Indian SCD Registry (ISCDR) on clinical manifestations, crisis episodes, disease management, and healthcare utilization in patients with SCD from 12 primary health centres (PHCs) in six tribal districts of India.

Methods: The ISCDR was introduced along with a three-tier screening process.

Resource utilisation and trophic niche overlap of coralline intertidal benthic amphipods: an isotopic perspective.

Benthic amphipod feeding groups are a well-established trophic classification that is mostly based on field observations and laboratory tests and are used in ecological studies to monitor the ecological state of benthic ecosystems. Globally, carbon and nitrogen stable isotope ratio investigations have provided confirmation of, and novel insights into, the trophic ecology of benthic animals, such as polychaetes. However, stable isotopic examinations of benthic amphipods have been limited.

Balancing aquaculture and estuarine ecosystems: machine learning-based water quality indices for effective management.

This study delves into the environmental impact of inland aquaculture on estuarine ecosystems by examining the water quality of four estuarine streams within the key inland aquaculture zone of South India. In this region, extensive and intensive aquaculture practices are common, posing potential challenges to estuarine health. The research explores the predictive capabilities of the Gaussian elimination method (GEM) and machine learning techniques, specifically multi-linear regression (MLR) and support vector regressor (SVR), in forecasting the water quality index of these streams.

Analyzing Children's Weight Growth Variations and Associated Factors in Ethiopia, India, Peru, and Vietnam: Using Fractional Polynomial Mixed-Effects Model.

Background: Children's growth is increasingly considered a key mediator of later life outcomes. When examining weight growth, the correlation between repeated observations on the same subject must be regarded as well-modelled. This study aimed to analyze children's weight growth variations and associated factors in Ethiopia, India, Peru, and Vietnam using a fractional polynomial mixed-effects model.

Selection of an alternate cementitious mortar using ceramic tile dust waste: a hybrid MCDM approach.

Selection of a suitable alternative material from a pool of alternatives with many conflicting criteria becomes a Multi-Criteria Decision Making (MCDM) problem. In the present study, ternary blended mortars were prepared using ceramic tile dust waste (CTD), fly ash (FA), and ground granulated blast furnace slag (GGBFS) as binder components. Crusher dust (CD) was used as a fine aggregate component.

New cytotoxic spatane diterpenoids from marine alga Stoechospermum marginatum.

Three new spatane diterpenoids (1-3) were isolated from the brown alga Stoechospermum marginatum together with three known compounds (4-6). The structures of these compounds were determined by the detailed NMR spectroscopic and Mass spectrometric analyses. All the isolated compounds were screened for their cytotoxic potentials against a panel of four human cancer cell lines, which include DU145 (Prostate), B16F10 (Melanoma), MDA MB-231 (Breast), and HeLa (Cervical) along with a normal cell line (HEK).

Gd substitution induced incommensurate antiferromagnetism in B20 noncentrosymmetric CoSi.

Rare-earth element Gd doped CoSi, Co1-xGdSi (= 0.01), is investigated using x-ray diffraction and magnetization. It crystallizes in B20 cubic structure with lattice parameter of= 4.