10,350 results match your criteria: "Anderson's College Medical School; late President[Affiliation]"
Application of Artificial Intelligence in Symptom Monitoring in Adult Cancer Survivorship: A Systematic Review.
JCO Clin Cancer Inform
December 2024
Department of Medical Oncology & Hematology, Odette Cancer Centre, Sunnybrook Health Science Centre, Toronto, ON, Canada.
Purpose: The adoption of artificial intelligence (AI) in health care may afford new avenues for personalized and patient-centered care. This systematic review explored the role of AI in symptom monitoring for adult cancer survivors.
Methods: A comprehensive search was performed from inception to November 2023 in seven bibliographic databases and three clinical trial registries.
Racial and Ethnic Disparities in Failure-to-Rescue After Postoperative Sepsis After Noncardiac Surgery.
Anesth Analg
December 2024
Department of Public Health Sciences, University of Rochester School of Medicine, Rochester, New York.
Background: Sepsis disproportionately affects marginalized communities. This study aims to evaluate racial and ethnic disparities in failure-to-rescue (FTR) after postoperative sepsis.
Methods: This cross-sectional study used data from the American College of Surgeons National Surgical Quality Improvement Program for patients who underwent inpatient noncardiac surgery between 2018 and 2021.
Long-term functional recovery after rib fractures: The impact of frailty.
J Trauma Acute Care Surg
November 2024
From the Division of Trauma, Emergency General Surgery and Surgical Critical Care (W.R., V.S.P., M.A., J.O.H.), Massachusetts General Hospital; Medical College, Harvard Medical School (A.Y.); Center for Surgery and Public Health, Brigham and Women's Hospital (P.H., S.I., G.A.A., J.P.H.-E.); Chobanian and Avedesian School of Medicine (A.H.), Boston University; Medical Center, Beth Israel Deaconess Medical Center (S.G.); Department of Surgery, Boston Medical Center (S.E.S.), Boston, Massachusetts.
Background: Previous studies have shown that patients with rib fractures experience long-term functional limitations. However, the specific predictors of these worse long-term functional limitations remain under-characterized.
Methods: We conducted a prospective cohort study including patients ≥18 years with an injury severity score ≥9 and isolated chest injury.
STIM1 and lipid interactions at ER-PM contact sites.
Am J Physiol Cell Physiol
January 2025
Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, Texas, United States.
Store-operated calcium (Ca) entry (SOCE) represents a major route of Ca permeation across the plasma membrane (PM) in nonexcitable cells, which plays an indispensable role in maintaining intracellular Ca homeostasis. This process is orchestrated through the dynamic coupling between the endoplasmic reticulum (ER)-localized Ca sensor stromal interaction molecule 1 (STIM1) and the PM-resident ORAI1 channel. Upon depletion of ER Ca stores, STIM1 undergoes conformational rearrangements and oligomerization, leading to the translocation of activated STIM1 toward the PM.
View Article and Find Full Text PDFBalancing High Clinical Volumes and Non-RVU-generating Activities in Radiology, Part I: The Current Landscape.
Acad Radiol
November 2024
Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (G.J.W.).
Article Synopsis
- * AAR-RRA's task force studied how academic radiologists contribute beyond just high clinical volumes and RVU-generating work, highlighting the importance of these additional roles.
- * Their findings are shared in a two-part report, with the first part addressing the current situation in radiology and the second part outlining future strategies for striking a better balance between clinical work and non-RVU activities.
Endovascular therapy versus medical management in isolated anterior cerebral artery acute ischemic stroke: a multinational multicenter propensity score-weighted study.
J Neurointerv Surg
November 2024
Neuroendovascular Program, Massachusetts General Hospital, Harvard University, Boston, Massachusetts, USA
Article Synopsis
- The study examined the effectiveness of endovascular therapy (EVT) versus best medical therapy (BMT) for isolated anterior cerebral artery occlusions (ACAo) in acute stroke patients.
- The analysis involved 108 patients from various countries, comparing outcomes like functional independence at 90 days, with results showing no significant difference in success rates between EVT and BMT.
- Conclusions indicate that while EVT had a high success rate in procedures, it did not lead to better functional outcomes or lower mortality compared to BMT, suggesting a need for more randomized trials.
Disruption of distal appendage protein CEP164 causes skeletal malformation in mice.
Biochem Biophys Res Commun
December 2024
Department of Pediatrics, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA; Graduate Program in Genetics and Epigenetics, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. Electronic address:
The primary cilium is a cellular antenna to orchestrate cell growth and differentiation. Deficient or dysfunctional cilia are frequently linked to skeletal abnormalities. Previous research demonstrated that ciliary proteins regulating axoneme elongation are essential for skeletogenesis.
View Article and Find Full Text PDFState-of-the-Art Deep Learning CT Reconstruction Algorithms in Abdominal Imaging.
Radiographics
December 2024
From the Department of Radiology, University of Washington School of Medicine, Seattle, Wash (A.M.); Department of Radiology, Mayo Clinic, Rochester, Minn (L.Y.); Department of Radiology, New York University Grossman School of Medicine, NYU Langone Health, New York, NY (J.W.R.); Departments of Radiation Oncology (S.K.) and Abdominal Imaging (M.A.S., J.J.I.R., V.K.W., K.M.E., C.T.J.), The University of Texas MD Anderson Cancer Center, 1400 Pressler St, Unit 1473, Houston, TX 77030-4009; Department of Radiology, Texas Children's Hospital, Houston, Tex (A.M.R.C.); and Department of Radiology, Seoul National University College of Medicine, Seoul, South Korea (J.M.L.).
Article Synopsis
- The development of deep neural networks has led to deep learning reconstruction (DLR) CT algorithms, enhancing image creation processes by integrating deep learning at various stages of imaging.
- DLR techniques effectively reduce image noise from lower radiation doses while maintaining image quality and diagnostic performance compared to traditional methods like filtered backprojection (FBP) and iterative reconstruction (IR).
- Clinical evidence supports the use of DLR algorithms for abdominal imaging across multiple tasks, showcasing their benefits, current limitations, and future prospects in CT imaging.
Which is the better polyp detection metric: adenomas per colonoscopy or adenoma detection rate? A simulation modeling study.
Endosc Int Open
November 2024
Dartmouth College Geisel School of Medicine, Hanover, United States.
We compared the ability of adenoma detection rate (ADR) and adenoma per colonoscopy (APC) to assess endoscopist detection, using statistical principles and simulations. We simulated a population of endoscopists and patients to compare the ability of ADR versus APC for capturing true endoscopist ability (TEA). We compared these rates with and without adjustment for patient and exam factors using multivariable models, and adjustment for imprecision due to low volume using empirical Bayes (shrinkage).
View Article and Find Full Text PDF2024 Canadian Surgery Forum: Sept. 25-28, 2024.
Can J Surg
November 2024
From St. Michael's Hospital (Naveed, Deshpande, Gomez, Rezende-Neto, Ahmed, Beckett), and the University of Toronto (Naveed).
Chemoresistance-motility signature of molecular evolution to chemotherapy in non-muscle-invasive bladder cancer and its clinical implications.
Cancer Lett
February 2025
Department of Biomedical Sciences, Dong-A University, Busan, 49315, South Korea; Department of Health Sciences, The Graduated of Dong-A University, Busan, 49315, South Korea. Electronic address:
Article Synopsis
- * The researchers created a 63-gene signature called Chemoresistance-Motility (CrM) to study how NMIBC evolves over time and used it to analyze 1,846 samples, revealing that early resistance stages are linked to increased cell movement and metastasis.
- * The study suggests that patients with high CrM scores have worse outcomes, ineffective responses to BCG and immune therapies, and identifies five alternative drugs to gemcitabine that may be effective, proposing a need for further validation of these findings.
Corrigendum to 'Real-World Multicenter Study of PD-1 Blockade in HIV-Associated Classical Hodgkin Lymphoma Across the United States' [Clinical Lymphoma, Myeloma, and Leukemia Volume 24, Issue 8, August 2024, Pages 523-530].
Clin Lymphoma Myeloma Leuk
December 2024
City of Hope Medical Center, Duarte, CA.
Intake and Nutritional Adequacy in Patients With Cancer Diagnosed With Malignant Bowel Obstruction: A Secondary Analysis of a Randomized Trial.
J Acad Nutr Diet
November 2024
Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania; Wilmington Veterans Affairs Medical Center, Wilmington, Delaware; Department of Surgery, Penn Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Background: Malignant bowel obstruction (MBO) is experienced by many with advanced cancer. Patients with MBO cannot eat and may have reduced ability to eat once the acute process has resolved. Sparse data exist to describe oral intake capacity and adequacy of nutrition in patients with MBO.
View Article and Find Full Text PDFObecabtagene Autoleucel in Adults with B-Cell Acute Lymphoblastic Leukemia.
N Engl J Med
December 2024
From the Cancer Institute, University College London (C.R., K.S.P., M.P.), University College London Hospitals NHS Foundation Trust (C.R.), King's College Hospital NHS Foundation Trust (D.Y.), and Autolus Therapeutics (P.L.-S., Y.Z., W.B., E.B., M.P.), London, Manchester Royal Infirmary, Manchester (E.T.), University Hospitals Birmingham NHS Foundation Trust, Birmingham (S.C.), University Hospitals Bristol NHS Foundation Trust, Bristol (K.H.), Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle (T.M.), and Cambridge University Hospitals NHS Foundation Trust, Cambridge (R.M.) - all in the United Kingdom; City of Hope National Medical Center, Duarte (K.S.S.), the Hematology, Blood and Marrow Transplant, and Cellular Therapy Program, University of California, San Francisco, San Francisco (A.C.L.), and UC Davis Medical Center, Sacramento (M.A.) - all in California; the Sarah Cannon Transplant and Cellular Therapy Program, Methodist Hospital, San Antonio (P.S.), and the University of Texas M.D. Anderson Cancer Center, Houston (E.J.) - both in Texas; Hospital Universitari Vall d'Hebron-Universitat Autónoma de Barcelona, Barcelona (P.B.), and Hospital Universitari i Politècnic La Fe, Valencia (M.G.) - both in Spain; Washington University School of Medicine, St. Louis (A.G.); the Sarah Cannon Transplant and Cellular Therapy Program, TriStar Centennial Medical Center, Nashville (J.M.P.); the University of Maryland Medical Center, Baltimore (J.A.Y.); Miller School of Medicine, University of Miami, Miami (A.M.B.), and Moffitt Cancer Center, Tampa (B.D.S.) - both in Florida; Winship Cancer Institute of Emory University, Atlanta (M.L.A.); Colorado Blood Cancer Institute, Denver (L.M.); the University of Rochester Medical Center, Rochester (K.M.O.), and Memorial Sloan Kettering Cancer Center, New York (J.H.P.) - both in New York; the David and Etta Jonas Center for Cellular Therapy, University of Chicago, Chicago (M.R.B.); and Dana-Farber Cancer Institute, Boston (D.J.D.).
Article Synopsis
Comprehensive Assessment of Initial Adaptation of ESBL Positive ST131 Escherichia coli to Carbapenem Exposure.
J Infect Dis
November 2024
Department of Infectious Diseases and Infection Control, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Background: It remains unclear how high-risk Escherichia coli lineages, like sequence type (ST) 131, initially adapt to carbapenem exposure in their progression to carbapenem resistance.
Methods: Carbapenem mutation frequency was measured in multiple subclades of extended-spectrum β-lactamase (ESBL) positive ST131 clinical isolates using a fluctuation assay followed by whole genome sequencing (WGS) characterization. Genomic, transcriptomic, and porin analyses of ST131 C2/H30Rx isolate, MB1860, under prolonged, increasing carbapenem exposure was performed using two experimental evolutionary platforms to measure fast vs.
Lethal COVID-19 associates with RAAS-induced inflammation for multiple organ damage including mediastinal lymph nodes.
Proc Natl Acad Sci U S A
December 2024
COVID-19 International Research Team, Medford, MA 02155.
Lethal COVID-19 outcomes are attributed to classic cytokine storm. We revisit this using RNA sequencing of nasopharyngeal and 40 autopsy samples from patients dying of SARS-CoV-2. Subsets of the 100 top-upregulated genes in nasal swabs are upregulated in the heart, lung, kidney, and liver, but not mediastinal lymph nodes.
View Article and Find Full Text PDFAssociations between multimorbidity burden and objective and patient-reported sleep outcomes among people living with HIV.
AIDS
November 2024
Department of Infectious Disease, Imperial College London, London, UK.
Background: We aimed to provide insights into the effects of comorbidities on sleep health in people with HIV by assessing associations between multimorbidity patterns and sleep outcomes in the Pharmacokinetic and clinical Observations in PeoPle over fiftY (POPPY) sub-study.
Methods: Principal component analysis identified six multimorbidity patterns among participants with HIV (n = 1073) at baseline: Cardiovascular diseases (CVDs), Sexually transmitted diseases, Metabolic, Mental/Joint, Neurological and Cancer/Other. Burden z-scores were calculated for each individual/pattern.
Direct and Gradual Electrical Testicular Shocks Stimulate Spermatogenesis and Activate Sperms in Infertile Men: A Randomized Controlled Trial.
Am J Mens Health
November 2024
Urology Department, McGovern Medical School, University of Texas, Houston, TX, USA.
Infertility was reported in approximately 15% of all heterozygous couples, with the male factor accounting for nearly half of the cases. This typically occurs due to low sperm production, sperm dysfunction, and sperm delivery obstruction. In this randomized controlled single-blind clinical trial, 90 infertile male subjects diagnosed with oligospermia, hypospermia, asthenozoospermia, or necrozoospermia were recruited.
View Article and Find Full Text PDFChildren and youth with special health care needs (CYSHCN) are living longer than ever. These advances come with a price: Patients, families, communities, and systems must absorb the challenges of chronic caregiving, including protracted stress and poor mental health. In 2023, the National Academies of Science, Engineering, and Medicine convened thought-leaders for conversations about supporting the emotional well-being of CYSHCN and their families.
View Article and Find Full Text PDFEffects of Supervised Exercise Therapy on Muscle Function During Walking in Patients with Peripheral Artery Disease.
Bioengineering (Basel)
October 2024
Department of Surgery and Research Service, Nebraska-Western Iowa Veterans Affairs Medical Center, Omaha, NE 68105, USA.
Background: Although supervised exercise therapy (SET) is a primary treatment for peripheral artery disease (PAD), the current literature is limited regarding the mechanisms contributing to increased walking distances, including how lower extremity muscle function is altered after SET. This study aimed to investigate the effects of SET on lower extremity muscle function during walking in patients with PAD.
Methods: Twelve patients with PAD participated in a 6-month SET program consisting of three weekly exercise sessions (a total of 72 sessions) and adhered to the American College of Sports Medicine's (ACSM) recommendations.
Vaccine value profile for schistosomiasis.
Vaccine
July 2024
World Health Organization, Geneva, Switzerland.
Article Synopsis
- * In 2019, approximately 236.6 million people required treatment for schistosomiasis, highlighting its significant impact on fishing and agricultural communities.
- * The Vaccine Value Profile (VVP) is a comprehensive assessment created by a group of experts to evaluate the public health and economic potential of new vaccines targeting schistosomiasis, emphasizing the need to address existing research gaps.
MuscleMap: An Open-Source, Community-Supported Consortium for Whole-Body Quantitative MRI of Muscle.
J Imaging
October 2024
Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.
Disorders affecting the neurological and musculoskeletal systems represent international health priorities. A significant impediment to progress in trials of new therapies is the absence of responsive, objective, and valid outcome measures sensitive to early disease changes. A key finding in individuals with neuromuscular and musculoskeletal disorders is the compositional changes to muscles, evinced by the expression of fatty infiltrates.
View Article and Find Full Text PDFParkinson's Disease: A Narrative of the Evolving Understanding of the Role of α-Synuclein in Screening.
Curr Issues Mol Biol
November 2024
Department of Anesthesiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71103, USA.
The present investigation aims to examine the role of α-synuclein seed amplification assays for screening Parkinson's disease. Parkinson's disease (PD) is a debilitating neurodegenerative disorder caused by the loss of dopaminergic neurons in the midbrain, leading to symptoms such as tremors, bradykinesia, postural instability, dementia, and depression. It is classified as an α-synucleinopathy related to the role of α-synuclein aggregates in neuron degeneration.
View Article and Find Full Text PDFInsights from a multiscale framework on metabolic rate variation driving glioblastoma multiforme growth and invasion.
Commun Eng
November 2024
Department of Mechanical Engineering, University of Victoria, 3800 Finnerty Road, Victoria, V8P 5C2, BC, Canada.
Non-physiological levels of oxygen and nutrients within the tumors result in heterogeneous cell populations that exhibit distinct necrotic, hypoxic, and proliferative zones. Among these zonal cellular properties, metabolic rates strongly affect the overall growth and invasion of tumors. Here, we report on a hybrid discrete-continuum (HDC) mathematical framework that uses metabolic data from a biomimetic two-dimensional (2D) in-vitro cancer model to predict three-dimensional (3D) behaviour of in-vitro human glioblastoma (hGB).
View Article and Find Full Text PDFA deconvolution framework that uses single-cell sequencing plus a small benchmark data set for accurate analysis of cell type ratios in complex tissue samples.
Genome Res
January 2025
Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA;
Article Synopsis
- Bulk deconvolution using single-cell RNA-seq is important for analyzing complex biological samples, but differences in sequencing technology can lead to inaccuracies.
- The researchers created a new framework called DeMixSC that improves deconvolution by utilizing well-matched benchmark datasets to account for these technological discrepancies.
- DeMixSC was tested on datasets from healthy retinas and ovarian cancer tissues, showing improved accuracy and the ability to reveal significant biological differences in patient groups, highlighting its usefulness in clinical applications.