Novel Schiff Base Sulfonate Derivatives as Carbonic Anhydrase and Acetylcholinesterase Inhibitors: Synthesis, Biological Activity, and Molecular Docking Insights.

Sulfonate derivatives are an essential class of compounds with diverse pharmacological applications. This study presents the synthesis and detailed characterization of six novel Schiff base sulfonate derivatives (L1-L6) through spectroscopic techniques (FTIR and NMR). Their inhibitory potential was evaluated against human carbonic anhydrase isoenzymes (hCA I and hCA II) and acetylcholinesterase (AChE), which are crucial therapeutic targets for diseases such as glaucoma, epilepsy, and Alzheimer's disease.

Evaluation of Ayres Sensory Integration Intervention on Sensory Processing and Motor Function in a Child with Rubinstein-Taybi Syndrome: A Case Report.

The Rubinstein-Taybi Syndrome (RSTS) literature is limited about sensory integration, which is a foundational neurological function of the central nervous system that may affect the development of cognitive, social, and motor skills. The aim of this case report was to investigate the effects of Ayres Sensory Integration (ASI) intervention on processing and integrating sensations, motor functions and parental goals of 3-year-old child with RSTS. Analysis of assessment data reviewed before and after treatment.

The Impact of COVID-19 on Education: A Meta-Narrative Review.

The rapid and unexpected onset of the COVID-19 global pandemic has generated a great degree of uncertainty about the future of education and has required teachers and students alike to adapt to a new normal to survive in the new educational ecology. Through this experience of the new educational ecology, educators have learned many lessons, including how to navigate through uncertainty by recognizing their strengths and vulnerabilities. In this context, the aim of this study is to conduct a bibliometric analysis of the publications covering COVID-19 and education to analyze the impact of the pandemic by applying the data mining and analytics techniques of social network analysis and text-mining.

Role of positive mental health in reducing fears related to COVID-19 and general anxiety disorder in Khyber Pakhtunkhwa, Pakistan.

Background: The outbreak of the novel coronavirus disease (COVID-19) has posed multiple challenges to healthcare systems. Evidence suggests that mental well-being is badly affected due to compliance with preventative measures in containing the COVID-19 pandemic. This study aims to explore the role of positive mental health (subjective sense of wellbeing) to cope with fears related to COVID-19 and general anxiety disorder in the Pashtun community in Pakistan.

Effectiveness of pre-employment independent life education program designed for young adults with intellectual disability.

It is important to provide the independent life support individuals with intellectual disabilities need in preparing for employment. The primary purpose of this study was to investigate the effectiveness of the Pre-Employment Independent Life Education Program (PILEP) design based on the needs to inform and support young adults. The research model is a pre-test post-test control group design.

Evidence-Based Practices for Children, Youth, and Young Adults with Autism: Third Generation Review.

This systematic review describes a set of practices that have evidence of positive effects with autistic children and youth. This is the third iteration of a review of the intervention literature (Odom et al. in J Autism Dev Disorders 40(4):425-436, 2010a; Prevent School Fail 54(4):275-282, 2010b; Wong et al.

Dataset on the fear, preventive behaviour and anxiety disorder during the COVID-19 pandemic in Khyber Pakhtunkhwa, Pakistan.

The outbreak of COVID-19 has raised numerous challenges to the present world. Due to the rapid spread of coronavirus, the high death toll, and enforcement of lock-down, people around the globe have faced fearful situations. Researches have also shown that a massive increase in psychological and mental health disorders is reported during the ongoing pandemic.

The Psychometric Validation of FCV19S in Urdu and Socio-Demographic Association with Fear in the People of the Khyber Pakhtunkhwa (KPK) Province in Pakistan.

This study rests on two important considerations: the rapid increase of COVID-19 cases in Pakistan and also the marginalization of the people of the KPK province, which would make them more vulnerable in fearing COVID-19. We aim to translate and validate FCV-19S into the Urdu language and to identify the socio-demographic associations with fear in the people of the KPK. Using an online Google survey, we were able to sample 501 respondents from the KPK.

Application of LC-ESI-MS/MS Method for Analysis of Escitalopram Oxalate in Human Urine and Pharmaceutical Dosage Forms.

An effective and sensitive liquid chromatographic-electrospray ionization tandem mass-spectrometric (LC-ESI-MS/MS) method was developed and validated for quantification of escitalopram oxalate (ESC-OX), antidepressant drug in spiked human urine and pharmaceutical formulations. In this work, simple liquid-liquid extraction was optimized and used for extraction of cited drug from urine samples. The chromatographic separation was attained within 6 min including re-equilibration time by using gradient elution with 0.

High-technology augmentative and alternative communication for individuals with intellectual and developmental disabilities and complex communication needs: a meta-analysis.

The use of mobile technology is ubiquitous in modern society and is rapidly increasing in novel use. The use of mobile devices and software applications ("apps") as augmentative and alternative communication (AAC) is rapidly expanding in the community, and this is also reflected in the research literature. This article reports the social-communication outcome results of a meta-analysis of single-case experimental research on the use of high-tech AAC, including mobile devices, by individuals with intellectual and developmental disabilities, including autism spectrum disorder.

In vitro evaluation of combination of EGCG and Erlotinib with classical chemotherapeutics on JAR cells.

Gestational Trophoblastic Neoplasia (GTN) is a term used for a group of malignant gynecological tumors including choriocarcinoma. Low-risk neoplasias can be cured using single agents Methotrexate (MTX) and actinomycin-D (ACD), but in certain cases, decreased responsiveness and serious side effects occur. Therefore, researchers have been attempting to find new treatment modalities.

Stroke and aphasia quality-of-life scale-39: Reliability and validity of the Turkish version.

Purpose: The aim of this study was to adapt the stroke and aphasia quality-of-life scale-39 (SAQoL-39) to the Turkish language and carry out a reliability and validity study of the instrument in a group of patients with aphasia.

Method: The study was a descriptive study and contained three phases: adaptation of the SAQoL-39 to the Turkish language, administration of the scale to 30 aphasia patients and reliability and validity studies of the scale. Internal consistency was assessed with Cronbach's alpha and test-re-test reliability was explored (n = 14).

Electrochemical degradation and toxicity reduction of C.I. Basic Red 29 solution and textile wastewater by using diamond anode.

Electrochemical oxidation of Basic Red 29 (BR29) was studied in a bipolar trickle tower (BTT) reactor by using Raschig ring shaped boron-doped diamond (BDD) electrodes, which were originally employed by the present researchers, in a recirculated batch mode. The model solution was prepared with BR29 using distilled water. The effects of initial dye concentration, Na(2)SO(4) concentration as supporting electrolyte, current density, flow rate and initial pH on the removal efficiency were investigated, and practically, complete BR29 removal (over 99%) was obtained in all the studies.

Electrochemical oxidation of phenol in a parallel plate reactor using ruthenium mixed metal oxide electrode.

In this study, electrochemical oxidation of phenol was carried out in a parallel plate reactor using ruthenium mixed metal oxide electrode. The effects of initial pH, temperature, supporting electrolyte concentration, current density, flow rate and initial phenol concentration on the removal efficiency were investigated. Model wastewater prepared with distilled water and phenol, was recirculated to the electrochemical reactor by a peristaltic pump.

Removal of nitrate from water by electroreduction and electrocoagulation.

The aim of this work was to investigate the feasibility of the removal of nitrate from water by applying electrochemical methods such as electroreduction and electrocoagulation. In electroreduction, removal of nitrate to an allowable concentration has been accomplished at the pH range of 5-7 with energy consumption value of 1 x 10(-3) kWh g(-1). In electrocoagulation, an allowable concentration of nitrate has been achieved at the pH range of 9-11 with energy consumption value of 0.

[Actinomycosis abscess developing in the rectus muscle. (One case history)].

A 36 year old male patient having an abscess in right rectus muscle's cover 2 years after stomach operation; attended to our hospital. The abscess was discharged. Following this, at 6 months intervals new abscess were formed in left lower and right upper rectus cover and discharged.

[Antimicrobial sensitivity of some gram-negative bacterial strains causing hospital or community-acquired infections].

The susceptibility to various antimicrobics of E. coli, Klebsiella, S. typhimurium, Pseudomonas, Proteus and Edwardsiella strains causing hospital or community acquired infections were investigated by Kirby-Bauer's disk diffusion method.

[Histopathological examinations of skin biopsy specimens from patients with acute HAV and HBV infections].

Punch skin biopsy is performed from 35 patients who are hospitalized with the diagnosis of acute viral hepatitis (AVH) at clinical examination and to 13 control groups. Thirteen of the 35 patients (37.4%) are diagnosed as Hepatitis A (HAV) infection, and 22 (62.

[The antibacterial activity of the amniotic fluid during the last week of pregnancy].

Amnion fluid samples were obtained from 100 pregnant women in the last week of pregnancy just before in labor. In detecting of antibacterial effectiveness, S. aureus ATCC 29213, E.

[Polymerase chain reaction].

The PCR is a method for obtaining millions of copies of a specific DNA sequence in vitro. It appears that this method will lead to several developments in the diagnosis and treatment of many disorders. Especially in genetics and infectious diseases successful results have been achieved.

[Recombinant DNA technology].

Recombinant DNA technology is a method depending on realization of genetic recombination events artificially. It became possible to obtain any ordered gene or its product with this method. Before production step, ordered gene is derived from original chromosome by endonuclease enzyme and integrated to a vector as a plasmid or a phage.

[The effects of ciprofloxacin and ofloxacin on the cellular and humoral immune response in mice].

The effects of a 7 days chemotherapy with ciprofloxacin or ofloxacin on the cellular and humoral immune responses in albino mice were studied. The non-toxic doses of the drugs (10 or 30 mg/kg/day) were used. The delayed-type hypersensitivity reaction to sheep blood cells and skin biopsy were evaluated for cellular immune response.

[Comparison of latex agglutination and bacitracin-SXT methods used for the identification of 142 beta-hemolytic streptococci].

We compared the latex agglutination and bacitracin-SXT methods to identify Group A Streptococci (GAS) from throat cultures. In our study all 118 GAS strains identified by latex agglutination method were found susceptible to bacitracin, 115 were found resistant and 3 were susceptible to SXT. All beta hemolytic streptococci rather than GAS were found resistant to bacitracin.

[Haemophilus influenzae strains isolated from various clinical specimens and their antibiotic susceptibilities].

In this study, a bacteriological examination was performed in the specimens of nose, ear and conjunctiva taken from 135 patients aged between 0-6 years old and 335 patients aged more than six years old for the isolation of H. influenzae. Ten H.