The role of neutrophil extracellular traps in Crohn's disease.

Crohn's disease (CD) is an idiopathic and chronic inflammation of the gastrointestinal (GI) tract. The underlying pathogenesis of CD is multifaceted, with complex interactions between genetic predisposition, environmental triggers, and abnormalities within the immune system. Neutrophil extracellular traps (NETs) have gained significant attention as a novel component in the pathogenesis of CD.

PKR downregulation prevents copper-induced synaptic dysfunction and cognitive impairment in a murine model of Wilson's disease.

Synaptic efficacy is critical for memory formation and consolidation. Accumulating evidence suggest that synapses are impaired during Wilson's disease (WD), contributing to neuronal dysfunction and cognitive decline. WD is a prototypical condition among the copper metabolism disorders.

A bibliometric analysis of hepatolenticular degeneration research in traditional Chinese medicine using CiteSpace and VOSviewer: A study protocol for systematic review.

Background: The purpose of this review was to analyze treatments for hepatolenticular degeneration (HLD) in traditional Chinese medicine (TCM), exploring the potential mechanisms and latest advances, as well as potential future directions.

Methods: We searched articles from the China National Knowledge Infrastructure, the Wanfang database, the Chinese Medical Journal Database, PubMed, the Cochrane Library, and Embase. We used CiteSpace (version 5.

Study on the influencing factors of primary dysmenorrhea in female college students: Systematic review and meta-analysis.

Background: The influencing factors of primary dysmenorrhea in female college students were analyzed through meta-analysis to provide the corresponding basis for its prevention and treatment.

Methods: The databases, including China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, VIP database, China Biology Medicine Disc, Pubmed, Embase, Cochrane library, and Web of science were searched for the literature on the influencing factors of primary dysmenorrhea in female college students was retrieved from the science database from the establishment of the database to July 17, 2023. The Newcastle-Ottawa Quality Scale was used to score the quality of cohort and case-control studies included in the study.

Electroacupuncture alleviates cerebral ischemia injury by regulating PI3K/AKT/NF-κB signaling in microglia of ischemic stroke rats.

This study aimed to investigate the potential of electroacupuncture as an intervention for inducing 'Awakening and Opening of the Brain' in rats with stroke models induced by middle cerebral artery occlusion/reperfusion (MCAO/R). The efficacy of electroacupuncture in alleviating cerebral ischemic injury was evaluated using Longa scores, triphenyl tetrazolium chloride staining, and hematoxylin and eosin staining. Non-targeted metabolomics analysis was conducted to identify differential metabolite changes before and after electroacupuncture treatment in MCAO/R rats.

Advances of M1 macrophages-derived extracellular vesicles in tumor therapy.

Extracellular vesicles derived from classically activated M1 macrophages (M1 EVs) have shown great potential in both tumor treatment and drug delivery. M1 EVs inherit specific biological messengers from their parent cells and possess the capability to activate immune cells residing in close or distant tumor tissues for antitumor therapy. Moreover, M1 EVs are commonly used as an attractive drug delivery system due to their tumor-targeting ability, biocompatibility, and non-toxic.

Synergistic inhibitory effect of atmospheric pressure plasma and berberine on non‑small cell lung cancer cells via inducing apoptosis.

Background: Non-small cell lung cancer (NSCLC) is a type of lung cancer, the incidence and mortality rate have been high, and the use of monotherapy is easy to make patients develop tolerance. Atmospheric pressure plasma (APP) is an emerging technology for killing cancer cells in recent years, and combination of berberine (BBR) mechanism has not been fully elucidated for NSCLC. The article's primary goal is to investigate the effect of combination on NSCLC and its associated characterization.

Corrigendum to 'Mechanism of action of huxiang powder in diabetic gastroparesis: Gut microbiota and cAMP/PKA pathway' [Heliyon Volume , Issue 16, 30 August 2024, Article e35558].

[This corrects the article DOI: 10.1016/j.heliyon.

Protective effect of Shenqi Wenfei Formula against lipopolysaccharide/cigarette smoke-induced COPD in Rat based on gut microbiota and network pharmacology analysis.

Introduction: The incidence of chronic obstructive pulmonary disease (COPD) appears to be increasing and evidence suggests that the intestinal flora may play a causative role in its development. Previous studies found that the Shenqi Wenfei Formula (SQWF) can regulate pyroptosis via the NLRP3/GSDMD pathway, thereby reducing the inflammatory response in the lungs of COPD model rats. However, there is no information on whether the drug's effects are associated with intestinal flora.

Exploring the mechanism of Taohong Siwu Decoction in treating ischemic stroke injury via the circDnajc1/miR-27a-5p/C1qc signaling axis.

Background: Ischemic stroke (IS) is the most prevalent type of cerebrovascular disease. Taohong Siwu Decoction (THSWD) has been demonstrated to have neuroprotective benefits during Cerebral Ischemia-Reperfusion Injury (CIRI). Whether THSWD mitigates CIRI by modulating the circDnajc1/miR-27a-5p/C1qc signaling axis is not known.

Ganoderic acid a alleviates Aβ-induced HT22 cell apoptosis through the ERK/MAPK pathway: a system pharmacology and in vitro experimental validation.

Alzheimer's disease (AD) is a neurodegenerative disorder that occurs with aging. Ganoderma lucidum (Curtis.) P.

Research trends and hotspots on global influenza and inflammatory response based on bibliometrics.

The influenza virus is considered as a kind of significant zoonotic infectious disease identified to date, with severe infections in humans characterized by excessive inflammation and tissue damage, usually resulting in serious complications. Although the molecular mechanisms underlying inflammation after influenza infection have been extensively studied, bibliometric analysis on the research hotspots and developing trends in this field has not been published heretofore. Articles related to influenza and inflammatory response were retrieved from the Web of Science Core Collection (WoSCC) database (1992-2024) and analyzed using various visualization tools.

Association between obesity measurement indexes and symptomatic knee osteoarthritis among the Chinese population: analysis from a nationwide longitudinal study.

Background: The current literature lacks robust clinical data and evidence delineating the relationship between obesity measurement indexes and knee osteoarthritis (KOA). Consequently, this investigation seeks to elucidate the potential link between obesity measurement indexes and KOA among Chinese adults in a nationally representative study.

Methods: Firstly, this research performed an observational study in the China Health and Retirement Longitudinal Study (CHARLS).

Electroacupuncture Protects Against Cerebral Ischemia-Reperfusion Injury: Reducing Inflammatory Response and Cell Pyroptosis by Inhibiting P2X7/NLRP3/GSDMD Pathway.

Purpose: To investigate the mechanism underlying the effects of Tongdu Tiaoshen electroacupuncture in the treatment of cerebral ischemia-reperfusion (I/R) injury.

Methods: Sixty adult male Sprague-Dawley (SD) rats were randomly allocated to five groups (n=12): Sham, I/R, electroacupuncture (EA), BBG (P2X7R inhibitor), and MCC950 (NLRP3 inhibitor). The EA group received acupuncture at Shenting (GV24), Baihui (GV20), and Dazhui (GV14) points with a stimulation frequency of 2/5 Hz, intensity of 2 mA, and a duration of 40 min.

Atractylenolide III ameliorates DSS-induced colitis by improving intestinal epithelial barrier via suppressing the NF-κB-Mediated MLCK-pMLC signaling pathway.

This study is to demonstrate the protection of atractylenolide III (AT III) on intestinal barrier dysfunction in ulcerative colitis (UC). UC model was established by 3% dextran sulfate sodium (DSS), and TNF-α was used to induce dysfunction in the intestinal epithelial barrier. TEER, FD-4 transmembrane flux and DAI were measured.

Post-translational modifications in drug resistance.

Resistance to antitumor drugs, antimicrobial drugs, and antiviral drugs severely limits treatment effectiveness and cure rate of diseases. Protein post-translational modifications (PTMs) represented by glycosylation, ubiquitination, SUMOylation, acetylation, phosphorylation, palmitoylation, and lactylation are closely related to drug resistance. PTMs are typically achieved by adding sugar chains (glycosylation), small proteins (ubiquitination), lipids (palmitoylation), or functional groups (lactylation) to amino acid residues.

MYB transcription factors in Peucedanum Praeruptorum Dunn: the diverse roles of the R2R3-MYB subfamily in mediating coumarin biosynthesis.

Background: The MYB superfamily (v-myb avian myeloblastosis viral oncogene homolog) plays a role in plant growth and development, environmental stress defense, and synthesis of secondary metabolites. Little is known about the regulatory function of MYB genes in Peucedanum praeruptorum Dunn, although many MYB family members, especially R2R3-MYB genes, have been extensively studied in model plants.

Results: A total of 157 R2R3-MYB transcription factors from P.

Global research trends of MicroRNAs in rheumatoid arthritis: bibliometrics and visualization analysis.

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder, and a growing body of research has demonstrated the involvement and regulatory roles of microRNAs (miRNAs) in the pathogenesis of RA. Consequently, this study aims to evaluate the current status and emerging trends in miRNA research related to RA by employing bibliometric analyses from a comprehensive perspective.

Methods: Relevant literature pertaining to miRNA-related RA was systematically searched and screened from the Web of Science Core Collection (WOSCC) database, covering the period from January 1, 2010 to June 30, 2024.

Shugan Jianpi Formula attenuate liver fibrosis via regulation of miR-193a-3p/TGF-β2 in hepatic stellate cells: An in vivo and in vitro study.

Ethnopharmacological Relevance: The Chinese herbal medicine Shugan Jianpi Formula (SGJPF) has traditionally been used to treat various chronic liver disorders. Previous studies have indicated that SGJPF inhibits hepatic stellate cells (HSCs) activation in rats with liver fibrosis (LF) and that miR-193a-3p may be a crucial molecule in LF. However, the mechanisms by which SGJPF regulates HSCs activation through miR-193a-3p remain unclear.

Comparative Analysis of the Morphological Traits of Cucumis melo Seed Remains Discovered in the Graveyard of the Haihun Marquis in Nanchang and Modern C. melo Seeds Using Scanning Electron Microscopy.

The graveyard of the Haihun Marquis in Nanchang is the largest and best-preserved Han Dynasty mausoleum discovered in China. Within the tomb's beam bank (M1), archaeologists have uncovered a variety of plant remains, such as melon seeds, the traits and origins of which warrant timely investigation. Cucumis melo L.

Nine New Glycosylated Compounds from the Leaves of the Medicinal Plant .

Nine new compounds (-), including four dihydrochalcone glycosides, two dibenzofuran glycosides, and two biphenyl glycosides, were isolated from the leaves of the medicinal plant collected in Shennongjia Forestry District (Hubei, China). Their structures were elucidated by comprehensive spectroscopic techniques, including HRESIMS and NMR spectra. All compounds were tested by preliminary biological evaluation for their α-glucosidase inhibitory and NO production activities.

Iron-catalyzed ligand-free diazidation of alkenes controlled by the ratio of TBHP to TMSN.

The diazidation of alkenes through an iron-catalyzed, ligand-free system has been established, providing straightforward access to structurally vicinal diazides in good yields at room temperature with TMSN as the azido source. The ratio of BuOOH to TMSN was essential for the reaction: one equivalent TMSN was needed to react with BuOOH to form HN as a nucleophile in the reaction ultimately achieving the diazidation of alkenes.