80 results match your criteria: "An Institute of the Royal Netherlands Academy of Arts and Sciences KNAW[Affiliation]"
Perceptual learning rules based on reinforcers and attention.
Trends Cogn Sci
February 2010
Department of Vision & Cognition, Netherlands Institute for Neurosciences, an institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands.
How does the brain learn those visual features that are relevant for behavior? In this article, we focus on two factors that guide plasticity of visual representations. First, reinforcers cause the global release of diffusive neuromodulatory signals that gate plasticity. Second, attentional feedback signals highlight the chain of neurons between sensory and motor cortex responsible for the selected action.
View Article and Find Full Text PDFThe complement component 5 gene and age-related macular degeneration.
Ophthalmology
March 2010
Department of Clinical and Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, The Netherlands.
Objective: To investigate the association between variants in the complement component 5 (C5) gene and age-related macular degeneration (AMD).
Design: Separate and combined data from 3 large AMD case-control studies and a prospective population-based study (The Rotterdam Study).
Participants: A total of 2599 AMD cases and 3458 ethnically matched controls.
The dynamic nature of Bruch's membrane.
Prog Retin Eye Res
January 2010
Department of Clinical and Molecular Ophthalmogenetics, Netherlands Institute of Neurosciences (NIN), An Institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.
Bruch's membrane (BM) is a unique pentalaminar structure, which is strategically located between the retinal pigment epithelium (RPE) and the fenestrated choroidal capillaries of the eye. BM is an elastin- and collagen-rich extracellular matrix that acts as a molecular sieve. BM partly regulates the reciprocal exchange of biomolecules, nutrients, oxygen, fluids and metabolic waste products between the retina and the general circulation.
View Article and Find Full Text PDFMatching of visual input to only one item at any one time.
Psychol Res
May 2009
Department of Vision and Cognition, Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands.
When we perform a visual search we know what we are looking for and determine where it is. A representation of the object in our working memory, the 'search-template', is compared to the items in the scene until a match is found. So far it is unknown whether observers can search for multiple items at the same time.
View Article and Find Full Text PDFComparison of human retinal pigment epithelium gene expression in macula and periphery highlights potential topographic differences in Bruch's membrane.
Mol Vis
September 2007
Department of Clinical and Molecular Ophthalmogenetics, The Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), Meibergdreef, Amsterdam, The Netherlands.
Purpose: To describe gene expression differences between healthy, young human retinal pigment epithelium (RPE) cells from the macular area and RPE cells from two locations in the retinal periphery.
Methods: RPE cells from six human donor eyes, ages 17-36, without histopathological abnormalities, were dissected by laser and isolated from cryosections. Total RNA was isolated, amplified, and hybridized to a custom made oligonucleotide array containing 22,000 genes.