275 results match your criteria: "Amyloidosis Macular"
A case presentation of widespread macular amyloidosis associated with dual hepatitis B and hepatitis C infection.
Dermatol Online J
August 2024
Department of Dermatology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Macular amyloidosis is a variant of primary localized cutaneous amyloidosis in which amyloid protein is believed to be derived from keratinocytes. The care of this variant generally focuses on addressing the associated symptoms without the need to assess for underlying disease. However, an increasing number of cases of primary localized cutaneous amyloidosis have been reported in association with systemic diseases, particularly autoimmune diseases.
View Article and Find Full Text PDFCombined fractional CO laser with dimethyl sulfoxide (DMSO) 50% versus fractional CO Laser alone in the treatment of macular amyloidosis: clinical and histopathological assessment.
Arch Dermatol Res
October 2024
Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt.
Background: Macular amyloidosis (MA) could be of cosmetic concern with a significant psychological impact for patients, and its treatment is challenging.
Aim Of The Work: To compare the efficacy and safety of combined fractional CO laser with dimethyl sulfoxide (DMSO) 50% versus fractional CO laser alone in the treatment of macular amyloidosis.
Patients And Methods: Twenty patients with macular amyloidosis were treated with monthly session of fractional CO laser only in one side of the lesion (area A), and fractional laser followed by application of DMSO 50% solution in the other side of the lesion (area B).
[Endogenous skin overloads].
Ann Pathol
November 2024
Département de Pathologie, université Paris Est Créteil (UPEC), hôpital Henri-Mondor, AP-HP, 1, rue Gustave Eiffel, 94000 Créteil, France. Electronic address:
Article Synopsis
- * Some skin lesions can be subtle, often categorized as "invisible" dermatoses, like primary macular cutaneous amyloidosis and calciphylaxis, necessitating detailed examination.
- * Certain conditions have significant prognostic implications, indicating potential underlying diseases like monoclonal gammopathies or association with visceral damage, underscoring the importance of clinical-pathological comparison to differentiate between serious conditions.
The effect of topical tranexamic acid with micro-needling and micro-needling alone in treatment of macular amyloidosis.
J Cosmet Dermatol
December 2024
Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Article Synopsis
- - The study focused on comparing the effectiveness of combining topical tranexamic acid with micro-needling versus micro-needling alone in treating macular amyloidosis, a skin condition characterized by itchy, pigmented macules.
- - A total of 20 female patients participated, with their skin being treated in two groups over four sessions; results showed improvements in both groups regarding pigmentation and itchiness, but no significant difference was found between the two treatment methods.
- - Ultimately, micro-needling alone was effective in reducing pruritus and pigmentation, while the addition of tranexamic acid did not provide any extra benefits.
A clinico-epidemiological study of different dermoscopic patterns in hyperpigmented facial lesions in a tertiary care centre.
J Cutan Aesthet Surg
January 2024
Department of Dermatology, B. Y. L. Nair Charitable Hospital & Topiwala National Medical College, Mumbai, Maharashtra, India.
Article Synopsis
- Facial pigmentation is a significant issue for many patients in dermatology, often linked to psychological distress and a decreased quality of life.
- The study focused on analyzing different dermoscopic patterns of facial melanosis and determining their frequency among patients with facial hyperpigmentation.
- Results showed that 100 patients were affected, predominantly females aged 21-40, with melasma being the most common type of facial pigmentation, accounting for nearly half of the cases.
A prospective comparative study of efficacy and safety of 15% trichloroacetic acid peel, 35% glycolic acid peel and Q-switched Nd-YAG laser in patients of macular amyloidosis.
J Cutan Aesthet Surg
January 2024
Department of Skin & V. D., Civil Hospital, B. J. Medical College, Ahmedabad, Gujarat, India.
Article Synopsis
- The study aimed to evaluate the effectiveness and safety of three different treatments for macular amyloidosis: 15% trichloroacetic acid (TCA) peel, 35% glycolic acid (GA) peel, and Q-switched Nd-YAG Laser over a course of 6 sessions.
- A total of 75 patients participated, with TCA peels showing the greatest improvement in skin color, subjective ratings, and global assessments compared to the other two methods.
- Although TCA peels had more adverse effects, they were still deemed the most effective and cost-efficient treatment option without any lasting side effects for patients.
An Interesting Case of Macular Amyloidosis With No Significant Etiology.
Cureus
March 2024
Preventive Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Article Synopsis
- Macular amyloidosis is a localized skin condition characterized by the buildup of amyloid proteins, leading to dark patches on the skin without affecting the overall immune system.
- It commonly affects young women, particularly in India, often linked to skin friction from scrubbing tools.
- The case discussed involves a 23-year-old female with hyperpigmented patches who lacked typical friction history, prompting further investigation into potential other causes like genetics, infections, and UV exposure; treatment focuses on symptom management rather than a complete cure.
Macular amyloidosis diagnostic outcomes of skin biopsy: A systematic review.
J Cutan Pathol
May 2024
Dermatology Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Article Synopsis
- Macular amyloidosis (MA) is a skin condition marked by amyloid deposits in the skin, leading to itchy, dark patches with a unique pattern.
- It commonly appears on the upper back and arms.
- The diagnosis of MA typically requires a biopsy, which is the main focus of this systematic review examining biopsy results in affected patients.
Dermatoscopy of primary localised cutaneous amyloidosis - A cross-sectional study in a setting of South Asian public dermatology department.
Skin Health Dis
February 2024
Dermatology Private Practice Poznań Poland.
Article Synopsis
- Amyloidosis is a condition where misfolded proteins deposit in the body, notably affecting the skin of individuals from the Asian subcontinent, leading to a subtype known as Primary Cutaneous Amyloidosis (PCA).
- This study focuses on identifying and confirming the dermoscopic features of two types of PCA—Macular Amyloidosis (MA) and Papular Amyloidosis (PA)—in 42 patients, primarily of skin color from a government hospital in Southeast Asia.
- Using a specialized dermoscope, researchers documented the typical characteristics of PCA to aid in accurate diagnosis without resorting to invasive biopsies, which is especially important in settings with limited healthcare resources.
Efficacy of topical gabapentin in women with primary macular amyloidosis: A side-by-side triple-blinded randomized clinical trial.
J Cosmet Dermatol
May 2024
Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Article Synopsis
- Primary cutaneous macular amyloidosis (PCMA) is a skin condition that causes chronic itching due to amyloid protein buildup in the skin.
- This study tested a 6% gabapentin cream on 34 PCMA patients, comparing its effects against a control cream in a triple-blind trial.
- Results showed significant itching and pigmentation improvements in the gabapentin group after one month, though changes in pigmentation were not sustained over time; further research is suggested for better efficacy verification.
Evaluation and comparison of Q-switched Nd: YAG laser 1064 nm and Er: YAG laser 2940 nm in the treatment of macular amyloidosis.
Lasers Med Sci
January 2024
Department of Community Medicine, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Article Synopsis
- - Macular amyloidosis (MA) is a common skin condition primarily affecting the trunk and extremities, and this study compares the effectiveness of two types of lasers—Q-switched Nd: YAG and Er: YAG—in treating it.
- - Conducted between 2020-2021 with 33 female participants, the study involved randomly dividing treatment areas to evaluate changes in pigmentation, pruritus intensity, and overall satisfaction among patients and physicians after the treatments.
- - Results showed significant improvement in pruritus for all patients, but no notable differences in effectiveness or satisfaction levels between the two laser treatment groups, indicating that both lasers are beneficial for managing MA.
Primary Localized Cutaneous Amyloidosis in Central Europe: A Retrospective Monocentric Study on Epidemiology and Therapy.
J Clin Med
December 2023
Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, Hungary.
Article Synopsis
- Amyloid deposits are linked to various chronic diseases, with Primary Localized Cutaneous Amyloidosis (PLCA) being a dermatological condition characterized by amyloid buildup in the skin.
- The study analyzed 41 PLCA patients in Central Europe, revealing a higher prevalence in females and specific age and location patterns of the disease.
- Most patients responded best to topical corticosteroids, but the study highlights the need for more research and standardized treatment guidelines due to the condition's rarity.
Characterization of Epidermal Function in Individuals with Primary Cutaneous Amyloidosis.
Clin Cosmet Investig Dermatol
November 2023
Department of Dermatology, Dermatology Hospital of Southern Medical University, Guangzhou, People's Republic of China.
Article Synopsis
- - The study aimed to compare the skin properties of individuals with primary cutaneous amyloidosis (PCA) against healthy individuals, using different measurement tools to assess parameters like water loss, hydration, and skin pH.
- - Results showed that PCA patients had higher skin surface pH and transepidermal water loss (TEWL), along with lower hydration and sebum levels compared to the control group; these changes correlated with the severity of itching.
- - In conclusion, the epidermal function is impaired in PCA patients, but the reasons behind these alterations still need more research to fully understand.
Insulin-Derived Cutaneous Amyloidosis: A Possible Complication of Repeated Insulin Injections.
Ann Dermatol
May 2023
Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Article Synopsis
- Primary localized cutaneous amyloidosis (PLCA) involves the buildup of abnormal protein structures in the skin, presenting in forms like macular, papular, and nodular amyloidosis, without affecting the rest of the body.
- The exact causes of PLCA are not well understood, but it is thought to be triggered by recurring skin injuries, such as repeated insulin injections.
- A case study highlights a 54-year-old Korean male who developed cutaneous localized amyloidosis after frequent local insulin injections, suggesting a link between insulin therapy in diabetes patients and the development of amyloid deposits in the skin.
Ophthalmological involvement in wild-type transthyretin amyloidosis: A multimodal imaging study.
J Peripher Nerv Syst
December 2023
Department of Neuroscience-Neurology Unit, University of Padova, Padova, Italy.
Article Synopsis
- The study investigates ophthalmological abnormalities in patients with wild-type transthyretin-related amyloidosis (ATTRwt) compared to variant transthyretin-related amyloidosis (ATTRv) and light chain amyloidosis (AL).
- Patients with ATTRwt showed worse visual acuity, higher rates of glaucoma, cataracts, and significant changes in corneal and retinal structures using advanced imaging techniques.
- Findings suggest that ATTRwt leads to notable eye problems that could serve as early indicators for diagnosis, emphasizing the need for regular eye examinations in affected populations.
Evaluation of Psychopathologies and Health-Related Quality of Life in Patients With Macular Amyloidosis.
Actas Dermosifiliogr
October 2023
Centro de Investigación de Leishmaniasis Cutánea, Universidad de Ciencias Médicas de Mashhad, Mashhad, Irán. Electronic address:
Article Synopsis
- Macular amyloidosis (MA) is a skin disorder mainly affecting younger women, prompting a study on its impact on their quality of life (QoL) and mental health.
- A cross-sectional study involving 40 women with MA revealed significantly lower QoL scores on the SF-36 and higher levels of psychological distress on the SCL-90-R compared to matched controls.
- The study found that factors like the severity of itching and the location of skin lesions were correlated with lower QoL, indicating that psychiatric support may help improve the well-being of these patients.
Age-related macular degeneration is associated with probable cerebral amyloid angiopathy: A case-control study.
J Stroke Cerebrovasc Dis
August 2023
Department of Neurology, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL 32224, United States. Electronic address:
Article Synopsis
- * Researchers analyzed data from 256 matched pairs of patients (with and without AMD) over 40 years old who underwent retinal and brain imaging, finding that patients with AMD had a higher prevalence of CAA and superficial siderosis.
- * The results suggest that late AMD is significantly linked to increased odds of CAA and superficial siderosis, indicating a potential role of amyloid deposits in AMD's development, but further research is needed to explore this connection.
Evaluation of Psychopathologies and Health-Related Quality of Life in Patients With Macular Amyloidosis.
Actas Dermosifiliogr
October 2023
Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
Article Synopsis
- Macular amyloidosis (MA) primarily affects young women and impacts their quality of life (QoL) and mental health.
- A study involving 40 women showed that those with MA had significantly lower QoL scores (SF-36) and higher psychopathology scores (SCL-90-R) compared to matched controls.
- Factors such as age and severity of itching (pruritus) were associated with lower QoL, especially in cases with visible skin lesions, suggesting that these patients may benefit from psychiatric treatment.
Localized Cutaneous Nodular Amyloidosis in a Patient with Sjögren's Syndrome.
Int J Mol Sci
May 2023
Department of Dermatology, Hospital Universitario San Cecilio, Avda Conocimiento 33, 18016 Granada, Spain.
Article Synopsis
- Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare skin condition linked to the buildup of immunoglobulin light chains due to plasma cell proliferation.
- A case study involved a 75-year-old woman with Sjogren's syndrome presenting with painless yellowish nodules on her leg, which were diagnosed as nodular amyloidosis after dermoscopy and histopathological examination.
- Given that 25% of PLCNA cases are seen in patients with Sjogren's syndrome, it's important to screen for this autoimmune condition alongside confirming the diagnosis of PLCNA.
Elevated number and density of macrophage-like cell as a novel inflammation biomarker in diabetic macular edema.
Sci Rep
March 2023
Department of Ophthalmology, Eye Diseases and Optometry Institute, Peking University People's Hospital, Beijing, 100044, China.
To quantitatively analyze the number and density of macrophage-like cells (MLCs) at the vitreoretinal interface at macular region in diabetic retinopathy (DR) with and without diabetic macular edema (DME). This cross-sectional study involved 240 eyes of 146 treatment-naïve DR patients, including 151 eyes with DME. The number and density of MLCs were analyzed quantitatively using optical coherence tomography angiography (OCTA) and were compared between DME and non-DME eyes as well as proliferative DR (PDR) and non-PDR (NPDR) eyes.
View Article and Find Full Text PDFPrimary cutaneous amyloidosis: A review of the available studies and gaps in data.
Australas J Dermatol
May 2023
Department of Dermatology, Cheikh Khalifa International University Hospital, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.
Multiple skin neoplasms at one site (MUSK IN A NEST): collision tumor consisting of epidermal (macular seborrheic keratosis) and dermal (lichen amyloidosis) components.
Dermatol Online J
October 2022
Department of Dermatology, University of California Davis Medical Center, Sacramento, CA; Touro University California College of Osteopathic Medicine, Vallejo, CA.
Article Synopsis
- A collision tumor is a lesion made up of two or more distinct tumors located in the same area, which can also be referred to as a "MUSK IN A NEST" when it involves multiple skin tumors.
- A case study of a 42-year-old woman with a long-term itchy skin condition revealed a combination of macular seborrheic keratosis and lichen amyloidosis, showcasing a clear example of a MUSK IN A NEST.
- The findings suggest that occurrences of this combined tumor phenomenon could be more common than previously documented in medical literature.
Ocular Morpho-Functional Evaluation in ATTRv Pre-Symptomatic Carriers: A Case Series.
Diagnostics (Basel)
January 2023
Institute of Ophthalmology, Università Cattolica del Sacro Cuore, 00135 Rome, Italy.
Article Synopsis
- * Results showed that these carriers had reduced central macular thickness and outer nuclear layer thickness compared to healthy individuals, along with altered retinal vascular patterns and specific retinal responses.
- * The findings suggest the need for thorough eye examinations for these pre-symptomatic carriers, as they may have early structural and functional eye changes, highlighting the potential for discovering new disease biomarkers given advancements in treatment options.
Common features of neurodegenerative disease: exploring the brain-eye connection and beyond (part 2): the 2021 pre-symposium of the 15th international conference on Alzheimer's and Parkinson's diseases.
Mol Neurodegener
November 2022
BrightFocus Foundation, 22512 Gateway Center Dr, Clarksburg, 20871, MD, USA.