26 results match your criteria: "Amsterdam University Medical Centers location Academic Medical Center[Affiliation]"

Since the early 2000s, malaria cases in Cambodia have declined steadily. Village malaria workers (VMWs) have played a critical role in reducing malaria transmission and progress towards malaria elimination. To prevent malaria re-establishment, however, implementation strategies need to consider carefully the changing healthcare needs in the communities as well as challenges to, and opportunities for, programme adaptation.

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  • - The Intensive Care Medicine Rapid Practice Guideline (ICM-RPG) provides evidence-based recommendations for using small-volume versus conventional blood collection tubes in adult ICU patients.
  • - A systematic review of 23 panelists across 8 countries revealed high certainty that small-volume tubes minimize blood sampling volume and show moderate certainty in reducing transfusion risks, despite some imprecision in the data.
  • - The panel strongly recommends small-volume tubes due to their benefits, including reduced waste and successful implementation in various countries, although there are initial costs related to validating these tubes for laboratory use.
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While several effective therapies for critically ill patients with COVID-19 have been identified in large, well-conducted trials, the mechanisms underlying these therapies have not been investigated in depth. Our aim is to investigate the association between various immunosuppressive therapies (corticosteroids, tocilizumab and anakinra) and the change in endothelial host response over time in critically ill COVID-19 patients. We conducted a pre-specified multicenter post-hoc analysis in a Dutch cohort of COVID-19 patients admitted to the ICU between March 2020 and September 2021 due to hypoxemic respiratory failure.

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The plasma lipidome has the potential to reflect many facets of the host status during severe infection. Previous work is limited to specific lipid groups or was focused on lipids as prognosticators. To map the plasma lipidome during sepsis due to community-acquired pneumonia (CAP) and determine the disease specificity and associations with clinical features.

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Neurofilament light protein as a biomarker for spinal muscular atrophy: a review and reference ranges.

Clin Chem Lab Med

June 2024

Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

Spinal muscular atrophy (SMA) is the leading genetic cause of infant mortality, characterized by progressive neuromuscular degeneration resulting from mutations in the survival motor neuron () gene. The availability of disease-modifying therapies for SMA therapies highlights the pressing need for easily accessible and cost-effective blood biomarkers to monitor treatment response and for better disease management. Additionally, the wide implementation of newborn genetic screening programs in Western countries enables presymptomatic diagnosis of SMA and immediate treatment administration.

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Background: Clinical and laboratory diagnosis of cutaneous leishmaniasis (CL) is hampered by under-ascertainment of direct microscopy.

Methods: This study compared the diagnostic accuracy of qPCR on DNA extracted from filter paper to the accuracy of direct smear slide microscopy in participants presenting with a cutaneous lesion suspected of leishmaniasis to 16 rural healthcare centers in the Ecuadorian Amazon and Pacific regions, from January 2019 to June 2021. We used Bayesian latent class analysis to estimate test sensitivity, specificity, likelihood ratios (LR), and predictive values (PV) with their 95% credible intervals (95%CrI).

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  • Inherited forms of arrhythmogenic and dilated cardiomyopathy (ACM and DCM) exhibit varying symptoms and risk levels depending on age, with calcium regulation being a key factor in these heart conditions.
  • A specific genetic change, c.286T>G p.(Ser96Ala), linked to serious arrhythmias in DCM patients, was examined for its impact on different cardiomyopathy groups, including those with a known pathogenic variant.
  • The study found no significant differences in allele frequency between the general population and those with cardiomyopathy, indicating the p.(Ser96Ala) polymorphism does not modify disease severity or risk, suggesting the need for further research into reliable genetic markers for these heart conditions
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Remote monitoring technologies (RMTs) allow continuous, unobtrusive, and real-time monitoring of the cardiovascular system. An overview of existing RMTs measuring cardiovascular physiological variables is lacking. This systematic review aimed to describe RMTs measuring cardiovascular functions in community-dwelling adults.

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The influence of impact velocity on bullet trajectory deflection through ballistic gelatine.

Forensic Sci Int

May 2023

Ecole des Sciences Criminelles (ESC), Université de Lausanne, Batochime, 1015 Lausanne, Switzerland; Centre romand de médecine légale (CURML), Chemin de la Vulliette 4, 1000 Lausanne, Switzerland.

This paper presents the results of a study on bullet trajectory deflection, for 9 mm Luger Full Metal Jacket Round Nose (FMJ-RN) bullets fired through 23-24 cm of ballistic gelatine. The bullets were fired at different velocities. Impact velocity, energy transfer and bullet trajectory deflection after gelatine perforation were measured and calculated.

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Editorial: Human organoid technology for virus research.

Front Cell Infect Microbiol

March 2023

Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute, Katholic University Leuven, Leuven, Belgium.

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Comorbidities, clinical characteristics and outcomes of COVID-19 in pediatric patients in a tertiary medical center in the Netherlands.

World J Pediatr

August 2022

Department of Pediatric Infectious Diseases, Rheumatology and Immunology, Amsterdam University Medical Centers Location Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands.

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Article Synopsis
  • * Twelve recent studies have created machine learning models for various tasks like frame selection and lesion assessment, demonstrating moderate to good performance, but only three have been independently validated.
  • * Future advancements in AI could lead to less-invasive and more objective diagnoses of coronary artery disease (CAD) and enhance treatment decisions and efficiency in catheterization labs through improved analysis integration.
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Background: In the Greater Mekong Subregion, adults are at highest risk for malaria, particularly those who visit forests. The absence of effective vector control strategies and limited periods of exposure during forest visits suggest that chemoprophylaxis could be an appropriate strategy to protect forest goers against malaria.

Methods: Alongside a clinical trial of anti-malarial chemoprophylaxis in northern Cambodia, qualitative research was conducted, including in-depth interviews and observation, to explore the acceptability of malaria prophylaxis for forest goers, the implementation opportunities, and challenges of this strategy.

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AI-Based Quantification of Planned Radiation Therapy Dose to Cardiac Structures and Coronary Arteries in Patients With Breast Cancer.

Int J Radiat Oncol Biol Phys

March 2022

Image Sciences Institute, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers - Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers - Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers - location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

Purpose: The purpose of this work is to develop and evaluate an automatic deep learning method for segmentation of cardiac chambers and large arteries, and localization of the 3 main coronary arteries in radiation therapy planning on computed tomography (CT). In addition, a second purpose is to determine the planned radiation therapy dose to cardiac structures for breast cancer therapy.

Methods And Materials: Eighteen contrast-enhanced cardiac scans acquired with a dual-layer-detector CT scanner were included for method development.

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Antithrombotic therapy influences clinical outcome after spontaneous intracerebral hemorrhage (ICH). However, evidence on the effect of different antithrombotic therapies on outcome and a comparison between different therapies is scarce, while this is important for medical decision making. Therefore, we investigated clinical outcome after ICH stratified by type of antithrombotic therapy.

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Routine Echocardiography and Artificial Intelligence Solutions.

Front Cardiovasc Med

February 2021

Amsterdam University Medical Centers -Location Academic Medical Center, Department of Cardiology, University of Amsterdam, Amsterdam, Netherlands.

Echocardiography is widely used because of its portability, high temporal resolution, absence of radiation, and due to the low-costs. Over the past years, echocardiography has been recommended by the European Society of Cardiology in most cardiac diseases for both diagnostic and prognostic purposes. These recommendations have led to an increase in number of performed studies each requiring diligent processing and reviewing.

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Purpose: To describe experience with partial nephrectomy combined with brachytherapy as part of the local management of bilateral Wilms tumor (WT) including a review of the available literature.

Results (methods And Case Description): Between 2011 and 2014, three highly selected patients (age nine months, 16 months, and 4 years) with bilateral WT (two synchronous and one metachronous) underwent enucleation and perioperative brachytherapy to the tumor bed. With a minimum follow-up of 5 years, all three patients are in continuous complete remission with preserved kidney function.

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Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID): a national, multicentre, observational cohort study.

Lancet Respir Med

February 2021

Department of Intensive Care, Amsterdam University Medical Centers location Academic Medical Center, Amsterdam, Netherlands; ACHIEVE, Centre of Applied Research, Amsterdam University of Applied Sciences, Faculty of Health, Amsterdam, Netherlands.

Background: Little is known about the practice of ventilation management in patients with COVID-19. We aimed to describe the practice of ventilation management and to establish outcomes in invasively ventilated patients with COVID-19 in a single country during the first month of the outbreak.

Methods: PRoVENT-COVID is a national, multicentre, retrospective observational study done at 18 intensive care units (ICUs) in the Netherlands.

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Amsterdam Research Initiative for Sub-surface Taphonomy and Anthropology (ARISTA) - A taphonomic research facility in the Netherlands for the study of human remains.

Forensic Sci Int

December 2020

Dept. of Biomedical Engineering and Physics, Amsterdam University Medical Centers - location Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, P.O.Box 22660, 1100 DD, Amsterdam, the Netherlands; CLHC-Amsterdam Center for Forensic Science and Medicine, Science Park - Building 904 (Room C2.243), 1098 XH, Amsterdam, the Netherlands. Electronic address:

A taphonomic research facility for the study of human remains was recently realized in Amsterdam, the Netherlands, to systematically investigate the decomposition of the human body under known conditions. Governmental authorization was obtained to make use of the body donation program of the Amsterdam University Medical Centers, location Academic Medical Center, for this specific purpose. In contrast to the small number of comparable initiatives elsewhere, this facility specifically allows for the study of buried bodies e.

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In Europe, ticks transmit pathogens such as sensu lato and tick-borne encephalitis virus (TBEV). In addition, there is evidence for transmission to humans from of , , , , and . However, whether infection with these potential tick-borne pathogens results in human disease has not been fully demonstrated for all of these tick-borne microorganisms.

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Cognitive deficits in childhood, adolescence and adulthood in 22q11.2 deletion syndrome and association with psychopathology.

Transl Psychiatry

February 2020

Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, Wales, UK.

22q11.2 Deletion Syndrome (22q11.2DS) is associated with high risk of psychiatric disorders and cognitive impairment.

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Background: It is unknown if the implementation of an advance care planning (ACP) program is feasible in daily clinical practice for glioblastoma patients. We aimed to develop an ACP program and assess the preferred content, the best time to introduce such a program in the disease trajectory, and possible barriers and facilitators for participation and implementation.

Methods: A focus group with health care professionals (HCPs) and individual semi-structured interviews with patients and proxies (of both living and deceased patients) were conducted.

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Electrocardiograms (ECGs) are frequently recorded in primary care for screening purposes. An ECG is essential in diagnosing atrial fibrillation, and ECG abnormalities are associated with cardiovascular events. While recent studies show that ECGs adequately reclassify a proportion of patients based on the clinical risk score calculations, there are no data to support that this also results in improved health outcomes.

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