Impact of COVID-19 pandemic on mortality rate in memory clinic patients.

Introduction: We investigated whether mortality in memory clinic patients changed due to coronavirus disease 2019 (COVID-19) pandemic.

Methods: We included patients from the Amsterdam Dementia Cohort: (1)  = 923 pandemic patients (baseline visit: 2017-2018, follow-up: until 2021), and (2)  = 830 historical control patients (baseline visit: 2015-2016, follow-up: until 2019). Groups were well-balanced.

Causal Association of Cardiovascular Risk Factors and Lifestyle Behaviors With Peripheral Artery Disease: A Mendelian Randomization Approach.

Background We investigated the causal associations between the genetic liability to cardiovascular and lifestyle risk factors and peripheral artery disease (PAD), using a Mendelian randomization approach. Methods and Results We performed a 2-sample inverse-variance weighted Mendelian randomization analysis, multiple sensitivity analyses to assess pleiotropy and multivariate Mendelian randomization analyses to assess mediating/confounding factors. European-ancestry genomic summary data (<5×10) for type 2 diabetes, lipid-fractions, smoking, alcohol and coffee consumption, physical activity, sleep, and education level were selected.