3,059 results match your criteria: "Amsterdam Smit; El Palo Health Centre[Affiliation]"

Article Synopsis
  • The study investigates the challenges of diagnosing and treating leptomeningeal metastases (LM) in patients with EGFR mutation positive non-small cell lung cancer (NSCLC) who are being treated with osimertinib, focusing on identifying resistance mechanisms in cerebrospinal fluid (CSF) and plasma.
  • A group of 28 patients was analyzed, with a high detection rate of the driver mutation in CSF, but resistance mechanisms were found in 27%, indicating limitations in treatment options available at this time.
  • After four weeks on an escalated osimertinib dosage, many patients showed stabilization or worsening of symptoms, suggesting that while some had radiological improvement, overall clinical efficacy remains
View Article and Find Full Text PDF

Introduction: We investigated how cerebrospinal fluid levels of synaptic proteins associate with memory function in normal cognition (CN) and mild cognitive impairment (MCI), and investigated the effect of amyloid positivity on these associations.

Methods: We included 242 CN (105(43%) abnormal amyloid), and 278 MCI individuals (183(66%) abnormal amyloid) from EMIF-AD MBD and ADNI. For 181 (EMIF-AD MBD) and 36 (ADNI) proteins with a synaptic annotation in SynGO, associations with word learning recall were analysed with linear models.

View Article and Find Full Text PDF

The aim of this study was to investigate the associations among sex hormone-binding globulin (SHBG), visceral adipose tissue (VAT), liver fat content, and risk of type 2 diabetes (T2D). In the Netherlands Epidemiology of Obesity study, 5,690 women (53%) and men (47%) without preexisting diabetes were included and followed for incident T2D. SHBG concentrations were measured in all participants, VAT was measured using MRI, and liver fat content was measured using proton magnetic resonance spectroscopy in a random subset of 1,822 participants.

View Article and Find Full Text PDF

Background: Evidence shows that online interventions could prevent depression. However, to improve the effectiveness of preventive online interventions in individuals with subthreshold depression, it is worthwhile to study factors influencing intervention outcomes. Outcome expectancy has been shown to predict treatment outcomes in psychotherapy for depression.

View Article and Find Full Text PDF

Multivalent CXCR4-targeting nanobody formats differently affect affinity, receptor clustering, and antagonism.

Biochem Pharmacol

September 2024

QVQ Holding BV, 3584 CL Utrecht, The Netherlands; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, 1081 HV, The Netherlands; Amsterdam Institute of Molecular and Life Sciences (AIMMS), 1081 HV, Amsterdam, The Netherlands. Electronic address:

The chemokine receptor CXCR4 is involved in the development and migration of stem and immune cells but is also implicated in tumor progression and metastasis for a variety of cancers. Antagonizing ligand (CXCL12)-induced CXCR4 signaling is, therefore, of therapeutic interest. Currently, there are two small-molecule CXCR4 antagonists on the market for the mobilization of hematopoietic stem cells.

View Article and Find Full Text PDF

Background: Patients with EGFR-mutated non-small-cell lung cancer (NSCLC) and MET amplification as a mechanism of resistance to first-line osimertinib have few treatment options. Here, we report the primary analysis of the phase 2 INSIGHT 2 study evaluating tepotinib, a highly selective MET inhibitor, combined with osimertinib in this population.

Methods: This open-label, phase 2 study was conducted at 179 academic centres and community clinics in 17 countries.

View Article and Find Full Text PDF

Background: The efficacy of PD-1 blocking agents in advanced NSCLC has shown prolonged effectiveness, but only in a minority of patients. Multiple biomarkers have been explored to predict treatment benefit, yet their combined performance remains inadequately examined. In this study, we assessed the combined predictive performance of multiple biomarkers in NSCLC patients treated with nivolumab.

View Article and Find Full Text PDF

Introduction: Molecular profiling of NSCLC is essential for optimising treatment decisions, but often incomplete. We assessed the efficacy of protocolised molecular profiling in the current standard-of-care (SoC) in a prospective observational study in the Netherlands and measured the effect of providing standardised diagnostic procedures. We also explored the potential of plasma-based molecular profiling in the primary diagnostic setting.

View Article and Find Full Text PDF

The effect of an integrated workplace health promotion program on health behaviors targeted after 12 months: Results of a cluster randomized controlled trial.

Appl Ergon

November 2024

Centre for Prevention, Lifestyle and Health, Department Behavior & Health, National Institute for Public Health and the Environment, Bilthoven, the Netherlands; Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Introduction: An integrated workplace health promotion program (WHPP) targeting multiple health behaviors by implementing activities at the individual and organizational level is potentially effective. The aim of this study was to evaluate the effect of implemented activities on targeted health behaviors.

Methods: Data from four organizations in a cluster randomized controlled trial, including 173 employees, were used.

View Article and Find Full Text PDF

Purpose: Human herpesviruses, particularly cytomegalovirus (CMV) and herpes simplex virus (HSV), frequently reactivate in critically ill patients, including those with acute respiratory distress syndrome (ARDS) related to coronavirus disease 2019 (COVID-19). The clinical interpretation of pulmonary herpesvirus reactivation is challenging and there is ongoing debate about its association with mortality and benefit of antiviral medication. We aimed to quantify the incidence and pathogenicity of pulmonary CMV and HSV reactivations in critically ill COVID-19 patients.

View Article and Find Full Text PDF

What Is This Summary About?: This is a summary of the publication about the DESTINY-Lung01 study, which was published in the in September 2021. The DESTINY-Lung01 study includes 181 adults with non-small-cell lung cancer (NSCLC) that could not be treated with surgery and who have had previous standard anticancer treatment. The publication includes information and results about 91 of the 181 study participants.

View Article and Find Full Text PDF

High PEEP/low FiO ventilation is associated with lower mortality in COVID-19.

J Crit Care

October 2024

Department of Intensive Care, Amsterdam University Medical Centers, Location AMC, Amsterdam, the Netherlands; Mahidol Oxford Tropical Medicine Research Unit (MORU), Mahidol University, Bangkok, Thailand; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Department of Anesthesia, General Intensive Care and Pain Management, Division of Cardiothoracic and Vascular Anesthesia & Critical Care Medicine, Medical University of Vienna, Vienna, Austria.

Article Synopsis
  • The study looks at the effects of high PEEP (positive end-expiratory pressure) versus low PEEP ventilation strategies on COVID-19 patients with acute respiratory distress syndrome during the second wave in the Netherlands.
  • A total of 790 patients were analyzed, showing that 22.5% of those on high PEEP died compared to 39.2% on low PEEP, indicating higher survival rates with high PEEP (HR 0.66).
  • The results suggest that using high PEEP ventilation could improve survival rates in ICU for patients suffering from COVID-ARDS.
View Article and Find Full Text PDF

Background: Visualizing (micro)vascular structures remains challenging for researchers and clinicians due to limitations in traditional radiological imaging methods. Exploring the role of vascular development in craniofacial malformations in experimental settings can enhance understanding of these processes, with the effectiveness of high-resolution imaging techniques being crucial for successful research in this field. Micro-CT imaging offers 3D microstructural insights, but requires contrast-enhancing staining agents (CESAs) for visualizing (micro)-vascular tissues, known as contrast-enhanced micro-CT (CECT).

View Article and Find Full Text PDF

Background: The process of tailored implementation is ill-defined and under-explored. The ItFits-toolkit was developed and subsequently tested as a self-guided online platform to facilitate implementation of tailored strategies for internet-based cognitive behavioural therapy (iCBT) services. In ImpleMentAll, ItFits-toolkit had a small but positive effect on the primary outcome of iCBT normalisation.

View Article and Find Full Text PDF

Background: Lung ultrasound (LUS) in an emerging technique used in the intensive care unit (ICU). The derivative LUS aeration score has been shown to have associations with mortality in invasively ventilated patients. This study assessed the predictive value of baseline and early changes in LUS aeration scores in critically ill invasively ventilated patients with and without ARDS (Acute Respiratory Distress Syndrome) on 30- and 90-day mortality.

View Article and Find Full Text PDF

Background: Acute respiratory distress syndrome (ARDS) is a life-threatening respiratory condition with high mortality rates, accounting for 10% of all intensive care unit admissions. Lung ultrasound (LUS) as diagnostic tool for acute respiratory failure has garnered widespread recognition and was recently incorporated into the updated definitions of ARDS. This raised the hypothesis that LUS is a reliable method for diagnosing ARDS.

View Article and Find Full Text PDF

Incidence of catheter-related thrombosis and its association with outcome in critically ill patients: A prospective observational study.

Thromb Res

September 2024

Department of Intensive Care Medicine, Amsterdam Institute for Infection and Immunity (AII), and Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands; Amsterdam Leiden Intensive care Focused Echography (ALIFE), the Netherlands.

Background: Incidence of central venous catheter (CVC)-related thrombosis in critically ill patients remains ambiguous and its association with potential hazardous sequelae unknown. The primary aim of the study was to evaluate the epidemiology of CVC-related thrombosis; secondary aims were to assess the association of catheter-related thrombosis with catheter-related infection, pulmonary embolism and mortality.

Methods: This was a single-center, prospective observational study conducted at a tertiary intensive care unit (ICU) in the Netherlands.

View Article and Find Full Text PDF
Article Synopsis
  • A study was conducted to evaluate clinical outcomes and patient-reported experiences following thumb ulnar collateral ligament (UCL) reconstruction using a tendon autograft from December 2011 to February 2021.
  • Results showed that patients' Michigan Hand Outcomes Questionnaire (MHQ) scores significantly improved over 12 months, indicating better pain management and hand function post-surgery.
  • Although most patients experienced stability restoration, those with ongoing instability or diagnosed metacarpophalangeal arthritis had limited improvement in their outcomes, emphasizing the complexity of healing in such cases.
View Article and Find Full Text PDF

Purpose: In this study, we aimed to evaluate the potential of routine blood markers, serum tumour markers and their combination in predicting RECIST-defined progression in patients with stage IV non-small cell lung cancer (NSCLC) undergoing treatment with immune checkpoint inhibitors.

Methods: We employed time-varying statistical models and machine learning classifiers in a Monte Carlo cross-validation approach to investigate the association between RECIST-defined progression and blood markers, serum tumour markers and their combination, in a retrospective cohort of 164 patients with NSCLC.

Results: The performance of the routine blood markers in the prediction of progression free survival was moderate.

View Article and Find Full Text PDF

Activation of G Signaling in Cortical Astrocytes Does Not Influence Formation of a Persistent Contextual Memory Engram.

eNeuro

June 2024

Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands

Formation and retrieval of remote contextual memory depends on cortical engram neurons that are defined during learning. Manipulation of astrocytic G and G associated G-protein coupled receptor (GPCR) signaling has been shown to affect memory processing, but little is known about the role of cortical astrocytic G-GPCR signaling in remote memory acquisition and the functioning of cortical engram neurons. We assessed this by chemogenetic manipulation of astrocytes in the medial prefrontal cortex (mPFC) of male mice, during either encoding or consolidation of a contextual fear memory, while simultaneously labeling cortical engram neurons.

View Article and Find Full Text PDF
Article Synopsis
  • Major depressive disorder (MDD) and cardiovascular disease (CVD) often occur together, leading to increased health issues and mortality rates.
  • A study discovered that many genetic risk factors for CVD overlap with those for MDD, indicating a shared biological basis, particularly involving specific brain regions and cell types.
  • The findings suggest that genetic predisposition to MDD can increase the risk of developing CVD, while lifestyle and metabolic factors also play significant roles, potentially creating an immunometabolic subtype of MDD more closely linked with CVD.
View Article and Find Full Text PDF

Background: The antibody-drug conjugate sacituzumab govitecan is approved for metastatic triple-negative breast cancer and has shown promising results in various other types of cancer. Its costs may limit patient access to this novel effective treatment modality.

Objective: The purpose of this study was to develop an evidence-based rational dosing regimen that results in targeted drug exposure within the therapeutic range while minimizing financial toxicity, to improve treatment access.

View Article and Find Full Text PDF

Clinical Management of Patients With Relapsed/Refractory Multiple Myeloma Treated With Talquetamab.

Clin Lymphoma Myeloma Leuk

October 2024

Department of Hematology, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Article Synopsis
  • Talquetamab is a bispecific antibody that targets the GPRC5D antigen in patients with relapsed/refractory multiple myeloma, showing over 71% overall response rates in clinical trials.
  • Adverse events (AEs) associated with talquetamab mainly included dermatologic and oral issues, although the majority were low grade and manageable through various treatment strategies.
  • Effective management of more serious AEs, like cytokine release syndrome and neurotoxicity, along with proper education for healthcare providers, can help maintain the quality of life for patients undergoing treatment.
View Article and Find Full Text PDF

Background: Insomnia is a highly prevalent disorder associated with numerous adverse health outcomes. Cognitive behavioural therapy for insomnia (CBT-I) is recommended as first-line treatment by clinical guidelines but is accessible to only a minority of patients suffering from insomnia. Internet-delivered CBT-I (iCBT-I) could contribute to the widespread dissemination of this first-line treatment.

View Article and Find Full Text PDF