Biofunctionalized polymeric nanoparticles for the enhanced delivery of erlotinib in cancer therapy.

Erlotinib, a potent epidermal growth factor receptor (EGFR) inhibitor, faces bioavailability challenges due to poor water solubility and stability. This study aims to optimize erlotinib-loaded PLGA nanoparticles using a 3 factorial design to enhance drug delivery and therapeutic efficacy. The effects of PLGA concentration (R1) and NaTPP concentration (R2) on nanoparticle characteristics, including particle size, zeta potential, and polydispersity index (PDI), were investigated.

Immunoproteomics: Approach to Diagnostic and Vaccine Development.

The study of large protein sets (proteomics) involved in the immunological reaction is known as immunoproteomics. The methodology of immunoproteomics plays a major role in identifying possible vaccine candidates that could protect against pathogenic infection. The study of immunogenic proteins that are expressed during the outset of infection is the focus of the crosstalk between proteomics and immune protection antigens utilizing serum.

Next-Generation BiOCl/MXene Nanocomposites: Optimized for Dye Removal and Supercapacitor Applications.

The study focuses on the development of an efficient and sustainable solution for synthetic dye degradation through the hydrothermal synthesis of BiOCl and BiOCl/MXene heterostructures. Structural and compositional properties were analyzed by using X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM), field emission scanning electron microscopy (FESEM), and X-ray photoelectron spectroscopy (XPS) techniques. A significant reduction in the band gap of BiOCl/MXene to 2.

Early prediction of grape disease attack using a hybrid classifier in association with IoT sensors.

Machine learning with IoT practices in the agriculture sector has the potential to address numerous challenges encountered by farmers, including disease prediction and estimation of soil profile. This paper extensively explores the classification of diseases in grape plants and provides detailed information about the conducted experiments. It is important to keep track of each crop's current environmental conditions because different environmental conditions, such as humidity, temperature, moisture, leaf wetness, light intensity, wind speed, and wind direction, can affect or sustain the quality of a crop.

Assessing the efficacy of carbon nanodots derived from curcumin on infectious diseases.

Introduction: The threat of new, emerging, and multidrug-resistant microbes is increasing which has created the necessity for new antimicrobials. In this regard, nanotechnology can be an alternative for the treatment of infectious microbes. Curcumin has been used since ancient times as antimicrobials; however, it has limitations due to its less aqueous solubility, bioavailability, and biocompatibility.

Carbon Nanodot-Microbe-Plant Nexus in Agroecosystem and Antimicrobial Applications.

The intensive applications of nanomaterials in the agroecosystem led to the creation of several environmental problems. More efforts are needed to discover new insights in the nanomaterial-microbe-plant nexus. This relationship has several dimensions, which may include the transport of nanomaterials to different plant organs, the nanotoxicity to soil microbes and plants, and different possible regulations.

Analysis of Fluorescent Carbon Nanodot Formation during Pretzel Production.

Baked pretzels are a popular choice for a quick snack, easily identifiable by their classic twisted shape, glossy exterior, and small salt crystals sprinkled on top, making them a standout snack. However, it is not commonly known that compounds with fluorescent properties can be formed during their production. Carbon nanodots (CNDs) with an average size of 3.

Fabrication, Characterization, and Biological Evaluation of Incorporated Titanium-Doped ZnO/Cellulose Nanocomposite Films as a Therapeutic Hemostatic Scaffolds for Diabetic Wound Healing.

The advent of biobased materials exhibiting remarkable effectiveness and performance has ushered in a paradigm shift in the field of biomedical science. Polymers are often used in the medical sector, particularly in the regeneration of bones, tissues, and wounds. Fast wound healing and self-healing polymers created from sustainable surroundings are attractive alternatives to create demand for new pathways in polymer research.

Exploring sustainable management by using green nano-silver to combat three post-harvest pathogenic fungi in crops.

Global crop protection and food security have become critical issues to achieve the 'Zero Hunger' goal in recent years, as significant crop damage is primarily caused by biotic factors. Applying nanoparticles in agriculture could enhance crop yield. Nano-silver, or AgNPs, have colossal importance in many fields like biomedical, agriculture, and the environment due to their antimicrobial potential.

Analysis of SIKVAV's receptor affinity, pharmacokinetics, and pharmacological characteristics: a matrikine with potent biological function.

Matrikines are biologically active peptides generated from fragments fragmentation of extracellular matrix components (ECM) that are functionally distinct from the original full-length molecule. The active matricryptic sites can be unmasked by ECM components enzymatic degradation or multimerization, heterotypic binding, adsorption to other molecules, cell-mediated mechanical forces, exposure to reactive oxygen species, ECM denaturation, and others. Laminin α1-derived peptide (SIKVAV) is a bioactive peptide derived from laminin-111 that participates in tumor development, cell proliferation, angiogenesis in various cell types.

Enhanced supercapacitor performance of a Cu-FeO/g-CN composite material: synthesis, characterization, and electrochemical analysis.

A Cu-doped FeO/g-CN composite, synthesized a straightforward hydrothermal process with controlled morphologies, represents a significant advancement in supercapacitor electrode materials. This study systematically analyzes the impact of Cu doping in FeO and its synergistic combination with g-CN to understand their influence on the electrochemical performance of the resulting composite, focusing on Cu doping in FeO rather than varying FeO/g-CN content. The comprehensive characterization of these composites involved a suite of physicochemical techniques.

Role of diosgenin extracted from L in suppression of HIV-1 replication: An preclinical study.

Background: Diosgenin, an essential sapogenin steroid with significant biological implications, is composed of a hydrophilic sugar moiety intricately linked to a hydrophobic steroid aglycone. While the antiviral properties of diosgenin against numerous RNA viruses have been extensively documented, its potential in combating Human Immunodeficiency Virus infections remains unexplored.

Experimental Procedure: This current investigation presents a comprehensive and systematic analysis of extracts derived from the leaves of , which are notably enriched with diosgenin.

Unlocking the enigma of phenotypic drug tolerance: Mechanisms and emerging therapeutic strategies.

In the ongoing battle against antimicrobial resistance, phenotypic drug tolerance poses a formidable challenge. This adaptive ability of microorganisms to withstand drug pressure without genetic alterations further complicating global healthcare challenges. Microbial populations employ an array of persistence mechanisms, including dormancy, biofilm formation, adaptation to intracellular environments, and the adoption of L-forms, to develop drug tolerance.

Sustainable Applications of Nanopropolis to Combat Foodborne Illnesses.

Propolis has numerous biological properties and technological potential, but its low solubility in water makes its use quite difficult. With the advent of nanotechnology, better formulations with propolis, such as nanopropolis, can be achieved to improve its properties. Nanopropolis is a natural nanomaterial with several applications, including in the maintenance of food quality.

Cell free extract-mediated biogenic synthesis of ZnONPs and their application with kanamycin as a bactericidal combination.

Antimicrobial resistance (AMR) is a main public health issue and a challenge for the scientific community all over the globe. Hence, there is a burning need to build new bactericides that resist the AMR. The ZnONPs were produced by cell free extract of mint (Mentha piperita L.

Experimental investigation of HPO activated papaya peels for methylene blue dye removal from aqueous solution: Evaluation on optimization, kinetics, isotherm, thermodynamics, and reusability studies.

This investigation is centered on the effectiveness of methylene blue (MB), a cationic dye, adsorbed from an aqueous media by HPO activated papaya skin/peels (PS), with initial pH (2-10), contact time (30-180 min), MB dye concentration (varying from 10 to 50 mg/L), and MB dose (0.1-0.5 gm).

Pullulan-based films impregnated with silver nanoparticles from the strain JTW1 for potential applications in the food industry and medicine.

Biopolymers, such as pullulan, a natural exopolysaccharide from , and their nanocomposites are commonly used in the food, pharmaceutical, and medical industries due to their unique physical and chemical properties. Pullulan was synthesized by the ATCC 201253 strain. Nanocomposite films based on biosynthesized pullulan were prepared and loaded with different concentrations of silver nanoparticles (AgNPs) synthesized by the strain JTW1.

Biofabrication of novel silver and zinc oxide nanoparticles from IOR 825 and their potential application in agriculture as biocontrol agents of phytopathogens, and seed germination and seedling growth promoters.

Plant pathogenic microorganisms adversely affect the growth and yield of crops, which consequently leads to losses in food production. Metal-based nanoparticles (MNPs) can be a remedy to solve this problem. Novel silver nanoparticles (AgNPs) and zinc oxide nanoparticles (ZnONPs) were biosynthesized from IOR 825 and characterized using Dynamic Light Scattering (DLS), Fourier Transform Infrared (FTIR) spectroscopy, Transmission Electron Microscopy (TEM), X-ray diffraction (XRD) and measurement of Zeta potential.

First case report of isolation of Micrococcus lylae from urinary catheter of a 50-year-old woman suffering from malignancy.

Introduction: Catheter-associated urinary tract infection (CAUTI) is the most common healthcare-associated infection which tends to cause increased length of morbidity, and mortality of patients, in addition to increased bacterial resistance to antibiotics.

Methodology: In the present study, urinary catheters were collected from a 50-year-old woman suffering from malignancy, bedridden, and having urinary incontinence. These catheters were processed in laboratory for isolation of bacteria using standard procedures.

Phoma spp. an untapped treasure of cytotoxic compounds: current status and perspectives.

The genus Phoma has been explored for a wide range of secondary metabolites signifying a huge range of bioactivities. Phoma sensu lato is a major group that secretes several secondary metabolites. The genus Phoma mainly includes Phoma macrostoma, P.

Novel nanotechnological approaches for managing Phytophthora diseases of plants.

Members of the Phytophthora genus are soil-dwelling pathogens responsible for diseases of several important plants. Among these, Phytophthora infestans causes late blight of potatoes, which was responsible for the Irish potato famine during the mid-19th century. Various strategies have been applied to control Phytophthora, including integrated management programs (IMPs) and quarantine, but without successful full management of the disease.

Michael Adduct of Sulfonamide Chalcone Targets Folate Metabolism in Brugia Malayi Parasite.

A series of Michael adducts of malononitrile and sulfonamide chalcones were synthesized, characterized, and evaluated for their antifilarial activity. Out of 14 compounds, N-(4-(4,4-dicyano-3-p-tolylbutanoyl)phenyl)benzenesulfonamide showed favorable drug-likeness properties with marked antifilarial effects at micro-molar dosages. Apoptosis in microfilariae was confirmed by EB/AO staining, MTT assay, and cytoplasmic cytochrome c ELISA.