1,819 results match your criteria: "Ampullary Carcinoma"
Establishment and characterization of a new intestinal-type ampullary carcinoma cell line, DPC-X3.
BMC Cancer
December 2024
The Fourth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, 730000, China.
Ampullary carcinoma (AC) of the intestinal type represents a distinct variant within the broader category of ampullary neoplasms. The scarcity of pertinent cellular models has constrained investigations centered on this particular malignancy. This research effectively generated a cell line (CL) of intestinal-type AC (DPC-X3).
View Article and Find Full Text PDFCollision of a Pancreatic Neuroendocrine Tumor and Intra-ampullary Carcinoma: A Case Report and Review of the Literature.
Cureus
November 2024
Department of Pathology, Universidad Nacional de Colombia, Bogota, COL.
This manuscript reports the case of a 75-year-old patient presenting with a collision tumor consisting of a pancreatic neuroendocrine tumor and intra-ampullary adenocarcinoma, which manifested with obstructive jaundice and was treated with primary surgical cytoreduction. Additionally, a bibliographic search of original articles was performed in the Medical Literature Analysis and Retrieval System Online (MEDLINE; via PubMed) and the Latin American and Caribbean Literature on Health Sciences (LILACS) databases to review the literature on pancreaticobiliary collision tumors. Currently, information regarding pancreatic and bile duct collision tumors is limited due to their very low incidence.
View Article and Find Full Text PDFLaparoscopic-assisted pancreaticoduodenectomy for periampullary carcinoma: An experience of 50 cases from a single tertiary care center.
Turk J Surg
June 2024
Department of Surgical Gastroenterology, All India Institute of Medical Sciences, Patna, India.
Objectives: Laparoscopic-assisted pancreaticoduodenectomy (LAPD) is being performed in several centers worldwide. The proportion of minimally invasive pancreaticoduodenectomy for periampullary carcinoma (PAC) has recently increased, owing to its potential benefits. However, the safety and feasibility of LAPD have not yet been standardized.
View Article and Find Full Text PDFPrognostic impact of osteosarcopenia on postoperative outcomes in patients with biliary tract cancer.
Surg Today
December 2024
Department of Gastroenterological Surgery, NHO Kyushu Cancer Center, Fukuoka, Japan.
Article Synopsis
- Osteosarcopenia, a condition combining sarcopenia and osteopenia, is linked to poor survival rates in patients who have undergone biliary tract cancer (BTC) resection.
- A study of 109 patients revealed that 28% had osteosarcopenia, which was associated with higher rates of lymph node metastasis and worse disease-free and overall survival outcomes.
- The findings indicate that osteosarcopenia is an important prognostic factor for predicting adverse outcomes following BTC surgery.
Unusual Metastasis of Pancreatic Adenocarcinoma Into the Bladder: Two Case Reports and Literature Review.
Case Rep Urol
November 2024
Desai Sethi Urology Institute, Miller School of Medicine, University of Miami, Coral Gables, Florida, USA.
We described two patients diagnosed with rare bladder metastasis (BM) from pancreatic adenocarcinoma, a prevalent neoplastic disease primarily associated with ductal adenocarcinoma. The overall prognosis for those patients with metastasis is very poor, with a 5-year survival rate of < 3%. The scarcity of cases in the literature makes this series a significant contribution as it presents the first documented instance of BM originating from pancreatobiliary ampullary cancer and a rare case associated with the Krukenberg tumor.
View Article and Find Full Text PDFPrognostic efficacy of lymph node parameters in resected ampullary adenocarcinoma based on long-term follow-up data after adjuvant treatment.
World J Surg Oncol
November 2024
Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-Ro, Jongno-Gu, Seoul, 03080, Republic of Korea.
Article Synopsis
- * Analyzed data from 86 patients showed that multiple LN metrics were linked to overall survival (OS), disease-free survival (DFS), and distant metastasis-free survival (DMFS), particularly highlighting the number of metastatic LNs (LNN) as a strong predictor in multivariable analysis.
- * Key findings included LNN ≥ 2 as a significant factor for OS, DFS, and DMFS, while lymph node ratio (LNR) was notable for DFS and DMFS; however, certain parameters like log odds of positive
Four cases of early stage poorly differentiated non-ampullary duodenal adenocarcinoma: a case report.
Clin J Gastroenterol
November 2024
Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto-Ward, Tokyo, 135-8550, Japan.
Article Synopsis
A simple prognostic score to predict recurrence after pancreaticoduodenectomy for ampullary carcinoma: results from the French prospective FFCD-AC cohort.
ESMO Open
November 2024
Institut du Cancer Paris CARPEM, APHP, Hepatogastroenterology and GI Oncology Department, APHP Centre-Université Paris Cité, Hôpital Européen G. Pompidou, Paris, France. Electronic address:
Article Synopsis
Accurate prediction of the lymph node status in ampullary duodenal carcinoma: potential guidance for clinical management.
BMC Cancer
November 2024
Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou, Zhejiang, 310004, China.
Article Synopsis
- - The study focused on identifying risk factors for lymph node metastasis (LNM) in ampullary duodenal carcinoma (a-DC) patients and creating a nomogram to predict these risks based on data from over 4,000 patients.
- - Four key independent risk factors for LNM were found: sex, tumor size, tumor grade, and tumor extension, with the nomogram showing a prediction accuracy of 74.8% for the training group and 88.9% for an external validation group.
- - The results indicated that the nomogram is a reliable clinical tool for predicting LNM in a-DC patients, as it closely matched actual outcomes and demonstrated practical usefulness in clinical settings.
Thioredoxin System Protein Expression in Carcinomas of the Pancreas, Distal Bile Duct, and Ampulla in the United Kingdom.
Diseases
September 2024
Nottingham Breast Cancer Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Poor survival outcomes in periampullary cancer highlight the need for improvement in biomarkers and the development of novel therapies. Redox proteins, including the thioredoxin system, play vital roles in cellular antioxidant systems. In this retrospective study, thioredoxin (Trx), thioredoxin-interacting protein (TxNIP), and thioredoxin reductase (TrxR) protein expression was assessed in 85 patients with pancreatic ductal adenocarcinoma (PDAC) and 145 patients with distal bile duct or ampullary carcinoma using conventional immunohistochemistry.
View Article and Find Full Text PDFComparison of Ampullary and Pancreatic Adenocarcinomas: Smaller Invasion, Common Adenomatous Components, Resectability, and Histology are Factors for Improved Survival for Patients with Ampullary Adenocarcinoma.
Ann Surg Oncol
October 2024
Department of Pathology, School of Medicine, Koc University, Istanbul, Turkey.
Article Synopsis
Genetic characteristics and extracolonic phenotypic manifestations in patients with familiar adenomatous polyposis.
Gastroenterol Hepatol
October 2024
Unidad de Endoscopia, Hospital Universitari i Politècnic La Fe/IIS La Fe, Valencia, España.
Article Synopsis
- Familial adenomatous polyposis (FAP) is a genetic disorder linked to APC gene mutations, leading to both intestinal and extraintestinal health issues.
- A study of 45 FAP patients revealed that 80% experienced upper digestive tract issues, with common findings such as duodenal adenomas and desmoid tumors.
- Despite identifying various genetic mutations, no significant link was found between the type of mutation and the severity of symptoms in patients, with a notable one-third exhibiting an aggressive disease phenotype.
Different Etiologies of Dilated Pancreatic Duct Based on Endoscopic Ultrasonography Findings.
Middle East J Dig Dis
July 2024
Commission for Academic Accreditation, Ministry of Education, Khalifa City, Abu Dhabi, UAE.
Article Synopsis
- The study investigates pancreatic duct (PD) dilation identified through endoscopic ultrasonography (EUS) and its potential links to various pancreatic and biliary diseases.
- Among 3,109 subjects, 599 had PD dilation; the most common diagnosis was pancreatic adenocarcinoma, found in 39.4% of cases, followed by sphincter of Oddi dysfunction.
- The findings suggest that PD dilation is a significant indicator of pancreatic neoplasms and other related conditions, highlighting its importance in clinical assessments even when the cause is not clear.
Dunking Pancreaticojejunostomy With Braun's Jejunojejunostomy: Perioperative Outcomes of a Hundred Pancreaticoduodenectomies.
Cureus
September 2024
Department of Surgical Gastroenterology, Tribhuvan University Teaching Hospital, Maharajgunj Medical Campus, Institute of Medicine, Kathmandu, NPL.
Article Synopsis
- The study examines the effectiveness of the dunking technique for pancreaticojejunostomy (PJ) combined with Braun's jejunojejunostomy (JJ) in 100 pancreaticoduodenectomy patients, focusing on surgical outcomes and complications.
- Conducted at Tribhuvan University Hospital, patient data from 2012 to 2023 revealed that the most common reason for surgery was ampullary carcinoma, with various complication rates such as postoperative pancreatic fistulas and delayed gastric emptying (DGE).
- Results indicate that the dunking technique is adaptable and less time-consuming, while incorporating Braun's JJ may help reduce DGE and improve postoperative recovery despite a higher risk of hemorrhage.
Usefulness of multigene liquid biopsy of bile for identifying driver genes of biliary duct cancers.
Cancer Sci
December 2024
Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Article Synopsis
- Liquid biopsy (LB) is a minimally invasive method for analyzing tumor-derived materials, and this study explores the potential of bile as a superior source of cell-free DNA (cfDNA) compared to plasma for detecting mutations in biliary tract cancers.
- The research involved collecting cfDNA from the bile of 24 cancer cases, including various types of biliary tract cancers, and applying a multigene panel to identify cancer driver mutations.
- Results indicated that bile yielded a higher detection rate of cancer driver mutations, with 54% of bile samples testing positive compared to just 17% of plasma samples, highlighting bile's effectiveness for liquid biopsy analysis.
Periampullary duodenal neuroendocrine tumor in a patient with neurofibromatosis-1: A case report.
World J Clin Oncol
September 2024
Clinical School of the Second People's Hospital, Tianjin Medical University, Tianjin 300192, China.
Article Synopsis
- - Patients with neurofibromatosis type 1 (NF1) are at increased risk for developing neuroendocrine tumors, particularly in the duodenum and periampullary regions.
- - A 50-year-old male with NF1 presented with jaundice, leading to the discovery of a 1.2 cm × 1.4 cm ampullary tumor, which was confirmed as a duodenal G1 neuroendocrine tumor after surgical intervention.
- - The study also included a bibliometric analysis showing a growing trend in research publications related to periampullary neuroendocrine neoplasms, mainly focusing on treatment and diagnosis.
The added value of MRI in distinguishing malignant and benign ampullary strictures: a multicenter retrospective study.
Jpn J Radiol
September 2024
Department of Biostatistics, Clinical Trial Center, Soonchunhyang University College of Medicine, Bucheon Hospital, 170 Jomaru-Ro, Bucheon-Si, Gyeonggi-do, 14584, Republic of Korea.
Article Synopsis
Article Synopsis
- The ampulla of Vater is a critical site in the duodenal wall where pancreatic and biliary ducts meet, often linked to tumors known as ampullary adenocarcinomas.
- A study analyzed 188 cases to compare intra-ampullary and periampullary carcinomas in terms of pathology and survival, revealing that most tumors were found in males around 55 years old, with a predilection for the pancreatobiliary subtype.
- Results indicated that intra-ampullary carcinomas had worse outcomes, showing more extensive invasion and lower median survival rates (46 months) compared to periampullary carcinomas (53.5 months).
Clinicopathologic features and surgery-related outcomes of duodenal adenocarcinoma: A multicenter retrospective study.
Surgery
December 2024
Pancreatic and Gastric Surgery Department, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:
Article Synopsis
Genome-Derived Ampullary Adenocarcinoma Classifier and Postresection Prognostication.
JAMA Surg
December 2024
Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Article Synopsis
- Ampullary adenocarcinoma (AA) shows clinical and genetic diversity, and a new genomic classifier may improve patient classification beyond traditional methods, but it needs validation before being widely used.
- A study involving 192 patients with AA assessed the accuracy of this genomic classifier against standard histology to see if it could predict survival outcomes.
- Results indicated a 55% agreement between genomic and histological classifications; however, while histological subtypes did not predict survival, the genomic scores did correlate with survival probabilities, suggesting the genomic approach might be more effective.
Endoscopic Resection for Superficial Non-Ampullary Duodenal Epithelial Tumors.
Gut Liver
September 2024
Department of Internal Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Article Synopsis
- - The rise in superficial non-ampullary duodenal epithelial tumors (SNADETs) is linked to advancements in endoscopic imaging techniques and greater awareness of the condition.
- - Endoscopic resection is the primary treatment for SNADETs, utilizing various methods like cold snare polypectomy and underwater EMR, but poses more risks due to unique anatomical challenges in the duodenum.
- - Treatment strategies depend on the tumor size: smaller lesions may be treated with less invasive techniques, while larger or suspected cancerous tumors necessitate more aggressive approaches like endoscopic submucosal dissection or surgical resection.
Long-term outcomes after resection of extra-ampullary duodenal adenocarcinomas: single-center experience.
J Gastrointest Surg
November 2024
Division of Hepatopancreatobiliary Surgical Oncology, Department of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Parel, Mumbai, India. Electronic address:
Article Synopsis
- Extra-ampullary duodenal adenocarcinoma is a rare cancer, and this study examined the long-term outcomes and survival factors in patients who underwent surgery for it.
- The analysis included 59 patients, primarily males aged around 60, with most tumors located in the second part of the duodenum, and followed them for a median of 32 months post-surgery.
- Key findings revealed that factors like having clear surgical margins, the type of adenocarcinoma, and the lymph node ratio significantly impacted overall survival rates, while the effectiveness of adjuvant chemotherapy is still uncertain.
A Complex Case of Obstructive Jaundice in a Septuagenarian: Diagnostic Challenges and Therapeutic Strategies.
Cureus
July 2024
Medicine and Surgery, Jinnah Hospital Lahore, Lahore, PAK.
Obstructive jaundice occurs when an obstruction in the bile duct system prevents bile from flowing from the liver into the intestine, accumulating bilirubin in the blood. This condition can result from various causes, including gallstones, tumors, or inflammation of the bile ducts. The management of obstructive jaundice depends on the underlying cause (malignant obstructions such as cholangiocarcinoma or pancreatic cancer), indicating the need for surgical intervention.
View Article and Find Full Text PDFInitial Tumor Size and Narrow-Band Image Findings Estimate Growth Speed in Duodenal Tumors.
Dig Dis
December 2024
Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Introduction: Recently, the detection of superficial non-ampullary duodenal epithelial tumors (SNADETs) including adenomas and superficial duodenal carcinomas has increased. Various endoscopic treatment methods have also been reported for SNADETs, but there are few reports on the natural history. The aim of this study was to analyze factors related to tumor growth and determine the characteristics of SNADETs which need early therapeutic intervention.
View Article and Find Full Text PDFLaparoscopic versus open pancreaticoduodenectomy: Long-term outcome from a tertiary care centre.
J Minim Access Surg
July 2024
Department of Surgical Gastroenterology, Father Muller Medical College, Mangalore, Karnataka, India.