1,621 results match your criteria: "Amniotic Fluid Embolism"
Effectiveness and acceptability of a 24-h interval versus a 48-h interval between mifepristone intake and misoprostol administration for in-hospital abortion at 9-20 gestational weeks: an international, open-label, randomised, controlled, non-inferiority trial.
Lancet Glob Health
January 2025
Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; WHO Collaborating Centre, Karolinska University Hospital, Stockholm, Sweden.
Background: Optimising management of second-trimester medical abortion is important, as complications increase with gestational age. We aimed to compare a 24-h interval with a 48-h interval between mifepristone intake and misoprostol administration in in-hospital, second-trimester medical abortion for effectiveness and acceptability.
Methods: This open-label, randomised, controlled, non-inferiority trial was conducted at nine hospitals in India, Sweden, Thailand, and Viet Nam among adults undergoing medical abortion for a singleton viable pregnancy at a gestation of between 9 weeks and 20 weeks.
Cell salvage for the management of postpartum haemorrhage.
Cochrane Database Syst Rev
December 2024
Liverpool Reviews and Implementation Group, Department of Health Data Science, University of Liverpool, Liverpool, UK.
Rationale: Postpartum haemorrhage (PPH), defined as a blood loss of 500 mL or more within 24 hours of birth, is the leading global cause of maternal morbidity and mortality. Allogenic blood transfusions are a critical component of PPH management, yet are often unfeasible, particularly in resource-poor settings where maternal morbidity is highest. Autologous cell salvage in the management of PPH has been proposed to combat limitations in access to allogenic blood and potential transfusion-related risks.
View Article and Find Full Text PDFAnalysis of Risk Factors and Establishment of a Risk Prediction Model for Severe Postpartum Haemorrhage.
Br J Hosp Med (Lond)
November 2024
Maternity Ward, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Severe postpartum haemorrhage (PPH) is a dangerous condition, characterized by rapid progression and poor prognosis. It remains the leading preventable cause of maternal death worldwide. This study aimed to investigate the risk factors for severe PPH and establish a prediction model to identify severe PPH early, allowing for early intervention reduce maternal death.
View Article and Find Full Text PDFProbable acute fatty liver of pregnancy presenting with dyspnoea and ground-glass opacities.
Obstet Med
June 2024
QLD Diabetes and Endocrine Centre, Mater Health, Australia.
Article Synopsis
- A postpartum woman experienced sudden difficulty breathing and low oxygen levels, prompting medical evaluation.
- Tests revealed liver enzyme issues and a possible imbalance in liver function.
- Imaging of her chest showed unusual lung patterns, leading to a discussion on possible causes, including amniotic fluid embolism and acute fatty liver, as well as pulmonary fat embolism.
Heterotopic pregnancy and amniotic embolism: a case report.
BMC Pregnancy Childbirth
November 2024
Department of Tocogynecology, Federal University of Paraná, Curitiba, Paraná, Brazil.
Background: Heterotopic pregnancy and amniotic embolism are rare conditions that can be challenging to diagnose. To date, there are no cases of heterotopic pregnancy associated with amniotic embolism described in the literature. Therefore, we report the case of a pancreatic heterotopic pregnancy, which led to amniotic embolism and an unfavorable maternal outcome.
View Article and Find Full Text PDF[Cell salvage in obstetrics-Background and practical implementation].
Anaesthesiologie
December 2024
Klinik und Poliklinik für Anästhesiologie, Intensivmedizin, Notfallmedizin und Schmerztherapie, Universitätsklinikum Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Deutschland.
Article Synopsis
An Unusual Presentation of an Amniotic Fluid Embolism: Fetal Bradycardia As the First Sign.
Cureus
August 2024
Anesthesiology and Perioperative Care, UCI Health, Orange, USA.
Article Synopsis
- * In a case study, fetal distress—specifically bradycardia—was observed before any maternal symptoms, indicating that fetal complications can occur independently of the mother's health.
- * The patient, a 34-year-old woman at full term, experienced seizures and cardiac arrest during an emergency cesarean delivery for fetal distress, leading to immediate interventions, stabilization, and recovery in the surgical intensive care unit.
Amniotic Fluid Embolism in a Patient Presenting for Induction of Labor for Cholestasis of Pregnancy.
Cureus
August 2024
Anesthesiology, Mountain West Anesthesia, Lehi, USA.
Article Synopsis
- * A 28-year-old woman with multiple health issues was induced for labor but suffered a sudden cardiac arrest, necessitating an emergency cesarean section.
- * Following the event, the patient faced complications such as coagulopathy and uterine atony, leading to a hysterectomy and supportive treatment before being stabilized for transport to a specialized care facility.
Insights from preventability assessments across 42 state and city maternal mortality reviews in the United States.
Am J Obstet Gynecol
August 2024
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD. Electronic address:
Article Synopsis
- The United States has seen a troubling increase in maternal mortality rates over the past 30 years, setting it apart from other wealthy countries.
- A study was conducted analyzing data from 42 states and cities to determine how many of these maternal deaths were preventable and to identify contributing factors.
- Results showed that a significant majority, up to 93.8%, of pregnancy-associated deaths and up to 100% of pregnancy-related deaths were deemed preventable, with key contributing factors linked to community, patient-family, provider, facility, and health system issues.
Breaking Barriers in the Management of Amniotic Fluid Embolism With Interventional Radiology: A Case Report.
Cureus
August 2024
Department of Interventional Radiology, University Health Truman Medical Center, Kansas City, USA.
Article Synopsis
- - Amniotic fluid embolism (AFE) is a rare but serious condition during pregnancy that can lead to high mortality rates, often caused by an inflammatory reaction to amniotic fluid entering the bloodstream, leading to multi-organ failure.
- - A case study is presented about a 27-year-old woman who experienced AFE and severe bleeding after a cesarean delivery due to placental complications, showcasing the urgency of recognizing the condition.
- - The patient was successfully treated through interventional radiology techniques, specifically coil embolization of bleeding arteries, which stabilized her condition and saved her life, emphasizing the importance of prompt and multidisciplinary care in AFE cases.
Early recognition and mobilization of resources in managing amniotic fluid embolism for a high-risk obstetric patient: A case report.
Case Rep Womens Health
October 2024
University of Miami Miller School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, United States of America.
Article Synopsis
- - A 33-year-old pregnant woman at 39 weeks had a seizure while being induced for labor and required an emergency cesarean delivery due to the baby's concerns.
- - After the delivery, she showed signs of amniotic fluid embolism (AFE), leading to serious complications like cardiovascular collapse and heart failure.
- - The hospital quickly mobilized multiple resources to address the situation and discussed creating a specific treatment order set for handling AFE cases.
Sudden Deterioration of a Young Patient During Elective Cesarean Section. Amniotic Fluid Embolism… or Else? - A Case Report.
J Crit Care Med (Targu Mures)
January 2024
Faculty of Medicine, Lucian Blaga University of Sibiu, Romania.
Article Synopsis
- * A case is presented of a patient with no prior health issues who experienced severe complications after a C-section, leading to a diagnosis consideration of either amniotic fluid embolism or anaphylaxis immediately following delivery.
- * Timely recognition and differentiation between these two conditions are crucial for effective treatment, and the patient ultimately recovered and was discharged after three days in the hospital.
Amniotic Fluid Embolism: An Illustrated Report and Review of Literature.
Am J Forensic Med Pathol
December 2024
From the Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL.
Postpartum acute myometritis suppresses expression of contraction-associated proteins in the gravid uterus.
J Reprod Immunol
September 2024
Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Article Synopsis
- This study examined the expression of proteins crucial for uterine contractions, comparing tissue samples from 38 PAM patients and 10 controls during cesarean sections.
- Results showed reduced expression of several contraction-associated proteins in PAM tissues, suggesting that inflammation could hinder uterine contractions and contribute to uterine atony, prompting the need for further research on the underlying mechanisms.
Extracorporeal Membrane Oxygenation in Amniotic Fluid Embolism: A Systematic Review of Case Reports.
ASAIO J
July 2024
Department of Internal Medicine, Wayne State University, Michigan, USA.
Article Synopsis
- * A systematic review of 141 studies identified 33 relevant studies that included 79 AFE patients, mostly occurring during cesarean sections, with a median maternal age of 34 years and a gestational age of 37.5 weeks.
- * The review found a maternal survival rate of 72% with ECMO treatment, noting that while most patients fared well, there were some neurological issues; early initiation of ECMO is recommended,
[Fulminant amniotic fluid embolism with subsequent cesarean section under prolonged resuscitation-A case report].
Anaesthesiologie
July 2024
Klinik für operative Intensivmedizin, Kantonsspital St. Gallen, St. Gallen, Schweiz.
Resuscitative endovascular balloon occlusion of the aorta: A novel approach for treating amniotic fluid embolism with disseminated intravascular coagulopathy-A report of two cases.
J Obstet Gynaecol Res
September 2024
Department of Obstetrics and Gynecology, Kurume University School of Medicine, Kurume, Japan.
Article Synopsis
- * The cases are significant as they demonstrate the successful use of resuscitative endovascular balloon occlusion of the aorta (REBOA) in improving patient survival when traditional treatments failed.
- * In both cases, REBOA was used as an emergency procedure—one during air transfer and the other in an ambulance—to control severe bleeding and stabilize patients before they underwent hysterectomy.
Anesthetic Considerations and Outcomes in Amniotic Fluid Embolism: A Retrospective Study over a 15-Year Period.
J Clin Med
May 2024
Clinical and Surgical Department, Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University, 800216 Galati, Romania.
Article Synopsis
- * Conducted in three Romanian hospitals over several years, the retrospective study identified 11 AFE patients, with the majority experiencing AFE either during labor or soon after childbirth.
- * The study found that AFE is associated with significant maternal mortality (36.3%) and challenges in neonatal outcomes, highlighting the need for a multidisciplinary care approach and advanced life support techniques during management.
Amniotic fluid embolism rescued using venoarterial extracorporeal membrane oxygenation without initial anticoagulation: A case report and literature review.
Medicine (Baltimore)
May 2024
Department of Anesthesiology and Intensive Care Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Article Synopsis
- Amniotic fluid embolism (AFE) is a serious condition that can cause respiratory and circulatory failure during pregnancy, complicating treatment with issues like bleeding tendencies due to disseminated intravascular coagulation (DIC).
- A 39-year-old patient with AFE underwent emergency cesarean section and required massive blood transfusions; when she developed critical respiratory and circulatory failure, venoarterial extracorporeal membrane oxygenation (VA-ECMO) was implemented without initial anticoagulation.
- The patient's condition stabilized after five days on VA-ECMO, allowing her to be weaned off the machine and ultimately discharged home in good health, highlighting the importance of managing bleeding tendencies effectively in such cases.
A Case of Consumptive Coagulopathy Before Cardiopulmonary Failure in Amniotic Fluid Embolism and Review of Literature: A Perspective of the Latent Onset and Progression of Coagulopathy.
Cureus
March 2024
Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Hamamatsu, JPN.
Article Synopsis
- * A case study describes a 42-year-old woman experiencing urgent cesarean delivery due to abnormal fetal heart rates, where signs of coagulopathy were present before she exhibited breathing difficulties or low blood pressure.
- * The findings suggest that monitoring for AFE-related coagulopathy should be initiated earlier, especially when there are changes in fetal heart patterns and uterine activity, to improve patient outcomes.
Indicated vs universal third-trimester ultrasound examination in low-risk pregnancies: a pre-post-intervention study.
Am J Obstet Gynecol MFM
May 2024
Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School at The University of Texas Health Science Center, Houston, TX (Dr Roberts, Mr Hotra, Drs Soto, Sibai, Blackwell, and Chauhan).
Article Synopsis
- In low-risk pregnancies, third-trimester ultrasounds are typically done when fundal height and gestational age discrepancies arise; previous studies show that universal ultrasounds don't significantly improve neonatal or maternal outcomes compared to indicated ones.
- The study aimed to see if universal third-trimester ultrasounds could reduce adverse neonatal outcomes and whether they could better detect issues with fetal growth or amniotic fluid.
- Conducted at nine locations, the study compared results from a pre-implementation period with indicated ultrasounds to a post-implementation period where all low-risk pregnancies received ultrasounds at 36-37.6 weeks, allowing clinicians to act on any abnormalities found.
Amniotic Fluid Embolism Coagulopathy Guided by the Point-of-Care Quantra QStat® Hemostasis System: A Case Report.
Cureus
March 2024
Department of Hematology/Laboratories, University Hospital of Orleans, Orleans, FRA.
Article Synopsis
- Amniotic fluid embolism (AFE) is a serious and uncommon complication that can happen during labor or shortly after delivery, with a high risk of maternal death.
- Diagnosing AFE is tough because its symptoms overlap with other pregnancy issues, making early identification crucial for effective treatment and improving survival rates.
- This case study highlights a 31-year-old woman with placenta previa who showed AFE symptoms post-Cesarean section and emphasizes the use of the Quantra QStat system for quick assessment of bleeding disorders to guide treatment.
Management and outcomes of women with low fibrinogen concentration during pregnancy or immediately postpartum: A UK national population-based cohort study.
Acta Obstet Gynecol Scand
July 2024
National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Article Synopsis
- Pregnant women with fibrinogen levels below 2 g/L are at high risk for severe postpartum hemorrhage and related complications, yet the criteria for identifying those needing fibrinogen therapy are unclear.
- A UK study identified 124 cases of low fibrinogen in pregnant women, mainly linked to postpartum hemorrhage from events like placental abruption or trauma, with a low incidence of inherited conditions.
- The study found high maternal and perinatal mortality rates, including 27 stillbirths and two maternal deaths due to massive hemorrhage, indicating the seriousness of low fibrinogen levels in this population.*
Post-mortem diagnosis of amniotic fluid embolism.
Autops Case Rep
February 2024
Università degli Studi di Milano, Dipartimento di Scienze Biomediche per la Salute, Laboratorio di Istopatologia e Microbiologia Forense, Istituto di Medicina Legale, Milano, Italia.