Erratum to "The importance of sleep studies in improving the health indices of a nation" [Sleep Med: X 4 (2022) 100049].

[This corrects the article DOI: 10.1016/j.sleepx.

In-silico identification of small molecule benzofuran-1,2,3-triazole hybrids as potential inhibitors targeting EGFR in lung cancer via ligand-based pharmacophore modeling and molecular docking studies.

Unlabelled: Lung cancer is one of the most common and deadly types of cancer worldwide, and the epidermal growth factor receptor (EGFR) has emerged as a promising therapeutic target for the treatment of this disease. In this study, we designed a library of 1840 benzofuran-1,2,3-triazole hybrids and conducted pharmacophore-based screening to identify potential EGFR inhibitors. The 20 identified compounds were further evaluated using molecular docking and molecular dynamics simulations to understand their binding interactions with the EGFR receptor.

Targeting monocarboxylate transporters (MCTs) in cancer: How close are we to the clinics?

As a result of metabolic reprogramming, cancer cells display high rates of glycolysis, causing an excess production of lactate along with an increase in extracellular acidity. Proton-linked monocarboxylate transporters (MCTs) are crucial in the maintenance of this metabolic phenotype, by mediating the proton-coupled lactate flux across cell membranes, also contributing to cancer cell pH regulation. Among the proteins codified by the SLC16 gene family, MCT1 and MCT4 isoforms are the most explored in cancers, being overexpressed in many cancer types, from solid tumours to haematological malignancies.

Current understanding of biological interactions and processing of DNA origami nanostructures: Role of machine learning and implications in drug delivery.

DNA origami has emerged as an exciting avenue that provides a versatile two and three-dimensional DNA-based platform for nanomedicine and drug delivery applications. Their incredible programmability, custom synthesis, efficiency, biocompatibility, and physio-chemical nature make DNA origami ideal for biomedical applications. Several recent studies demonstrated the potential of DNA origami for different technological applications, especially in drug delivery.

A study on structural, optical, and electrical characteristics of perovskite CsPbBr QD/2D-TiSe nanosheet based nanocomposites for optoelectronic applications.

Lead halide perovskite (CsPbBr) quantum dots (QDs) and two-dimensional (2D) layered transition metal dichalcogenides have a significant application in solution-processed optoelectronic devices. Here, we report the oleylamine-assisted exfoliation of TiSe nanosheets (NSs) in dichlorobenzene with high concentration and stable dispersion. The functionalized TiSe NSs were used to synthesize the solution-processed perovskite CsPbBr QD/TiSe NS-based nanocomposite.

Cervical Spinal Lesion, Completeness of Injury, Stress, and Depression Reduce the Efficiency of Mental Imagery in People With Spinal Cord Injury.

Objectives: The aims of this study were to assess the relationships of (1) clinical variables (age, level of injury, time since injury [TSI], and completeness of injury) and (2) psychological variables (stress and depression) with mental imagery ability in individuals with spinal cord injury.

Study Design: This was a cross-sectional study. Participants with spinal cord injury (N = 130) were requested to fill the Kinesthetic and Visual Imagery Questionnaire and Vividness of Motor Imagery Questionnaire.

Pharmacological and Therapeutic Approaches in the Treatment of Epilepsy.

Epilepsy affects around 50 million people across the globe and is the third most common chronic brain disorder. It is a non-communicable disease of the brain that affects people of all ages. It is accompanied by depression, anxiety, and substantially increased morbidity and mortality.

Role of Phytomolecules in the Treatment of Obesity: Targets, Mechanisms and Limitations.

Obesity has become a worldwide health problem. It triggers additional co-morbidities like cardiovascular diseases, cancer, depression, sleep disorders, gastrointestinal problems and many more. Excess accumulation of fat in obesity could be caused by many factors like sedentary lifestyle, consumption of high-fat diet, genetic predisposition, etc.

Current Status of Drug Targets and Emerging Therapeutic Strategies in the Management of Alzheimer's Disease.

Alzheimer's disease (AD) is a chronic neurodegenerative disease affecting the elderly. AD is associated with a progressive decline in memory and cognitive abilities, drastic changes in behavioural patterns and other psychiatric manifestations. It leads to a significant decline in the quality of life at personal, household as well as national level.

Mental imagery training for treatment of central neuropathic pain: a narrative review.

Mental imagery is a quasi-perceptual experience in the absence of external stimuli. This concept has intrigued psychologists, sportspersons, neurologists and other scientists for over a decade now. Imagery has been used in rehabilitation and the results have been promising.

In situ soft x-ray absorption spectroscopic study of polycrystalline Fe/MgO interfaces.

Interfacial interactions between a layer of iron and MgO hold the key to various phenomena like tunnel magnetoresistance, perpendicular magnetic anisotropy, interlayer exchange coupling, observed in the system. Interface structure has been studied in situ during deposition of iron on MgO surface, using soft x-ray absorption spectroscopy (SXAS). Sub-monolayer sensitivity of SXAS, combined with in situ measurements as a function of iron layer thickness, allowed one to study the evolution of interface with film thickness.

Increased stress and altered expression of histone modifying enzymes in brain are associated with aberrant behaviour in vitamin B12 deficient female mice.

A sub-optimal nutritional environment from early life can be envisaged as a stressor that translates into mental health problems in adulthood. After considering (a) the widespread prevalence of vitamin B12 deficiency especially amongst women in developing countries and (b) the importance of vitamin B12 in normal brain function, in this study we have elucidated the behavioural correlates of chronic severe and moderate vitamin B12 deficiency in C57BL/6 mice. Female weanling mice were assigned to three dietary groups: (a) control AIN-76A diet with cellulose as dietary fibre (b) vitamin B12 restricted AIN-76A diet with pectin as dietary fibre (severe deficiency group) and (c) vitamin B12 restricted AIN-76A diet with cellulose as dietary fibre (moderate deficiency group).

Cancer treatment with nano-diamonds.

Diamond nano-particles find new and far-reaching applications in modern biomedical science and biotechnologies. Due to its excellent biocompatibility, nano-diamonds serve as versatile platforms that can be embedded within polymer-based microfilm devices. Nano-diamonds are complexed with a chemotherapeutic that enables sustained/slow release of the drug for a minimum of one month, with a significant amount of drug in reserve.

Nutraceuticals for geriatrics.

Geriatrics is a medical practice that addresses the complex needs of older patients and emphasizes maintaining functional independence even in the presence of chronic disease. Treatment of geriatric patients requires a different strategy and is very complex. Geriatric medicines aim to promote health by preventing and treating diseases and disabilities in older adults.

Assessment of phytochemical composition and antioxidant potential in some indigenous chilli genotypes from North East India.

Twenty five chilli genotypes from North East region of India evaluated showed variation for capsaicin from 0.27% (CHF-CA-1) to 3.03% (CHF-CA-21), oleoresin content from 2.

Glucosinolates: the phytochemicals of nutraceutical importance.

Glucosinolates (thioglucoside-N-hydroxysulphates) constitute a homogeneous class of naturally occurring thiosaccharidic compounds mainly found in the botanical order Brassicales. They can be hydrolyzed by myrosinase to produce D-glucose and various other degradation products like isothiocyanates (ITCs)-depending on the aglycon part. The exact function of glucosinolates (GLSs) in the plant is unclear, however their potent odour and taste suggests a role in herbivore and microbial defense.

Antioxidant and free radical scavenging activities of some fruits.

Phenols, a major group of antioxidant phytochemicals, have profound importance due to their biological and free radical scavenging activities. To identify their potential sources extracts of some fruits and their different parts were studied for total phenolic contents (TPC), antioxidant (AOA) and free radical scavenging activities (FRSA). The amount of TPC varied from 10.