3,070 results match your criteria: "Amenorrhea Secondary"

Diagnostic and therapeutic hysteroscopy in Ethiopia: a retrospective study on practice and outcomes.

BMC Womens Health

December 2024

Department of Obstetrics and Gynecology, School of Medicine, Debre Markos University, Debre Markos, Amhara Region, Ethiopia.

Background: Hysteroscopy is considered the standard for evaluating the uterine cavity. Limited data exists regarding hysteroscopy in Ethiopia. Therefore, the objective of the study was to describe the diagnostic and operative hysteroscopic procedures at St.

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Objective: Sheehan syndrome (SS), or postpartum pituitary necrosis occurs due to reduced vascular supply following postpartum hemorrhage, often linked to coagulation abnormalities, and pituitary antibodies. A smaller sella turcica volume is a risk factor for SS, consequent to compressive effects on the pituitary stalk. Hypopituitarism in SS increases the risk of metabolic liver and bone diseases.

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Chemotherapeutic agents result in the loss of growing follicles, which can manifest as amenorrhoea. Alkylating chemotherapy (AC) is known to be more gonadotoxic than non-alkylating chemotherapy (NAC). Anti-Mullerian Hormone (AMH), an indirect marker of ovarian reserve, and age have been investigated as predictors of ovarian function after chemotherapy, however little is known about the time to return of menses.

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Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) is a rare congenital disorder characterized by agenesis of the uterus and upper two-thirds of the vagina. It affects around 1 in 4000-5000 females and is of two types: type 1, also known as isolated Müllerian aplasia or Rokitansky, which involves only uterovaginal agenesis, and type 2, presents as uterovaginal agenesis along with renal, cardiac, and other organ anomalies. Despite the absence of vaginal and uterine structures, individuals with MRKHS typically present with normal secondary sexual characteristics and ovarian functions.

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Osseous metaplasia of the endometrium is a rare condition involving the bone tissue in the endometrial cavity. Its presence along with haematometra is an infrequent condition and is not reported until now. We present a case of a woman in her mid-30s with primary infertility and secondary amenorrhoea.

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Coronavirus disease 2019 (COVID-19) caused unprecedented disruptions in the lives of people, inducing a change in social behavior because of quarantine and physical distancing measures for health safety. It greatly affected not only the general population but also the healthcare system, forcing healthcare providers and consumers to adjust from the traditional mode of in-person consultation to telemedicine to enable safe and prompt delivery of adequate and efficient patient care. A 35-year-old female was diagnosed with acromegaly secondary to pituitary macroadenoma, presenting as a 10-year history of weight gain, amenorrhea, hand and feet enlargement, coarse facial features, and bilateral vision loss.

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Article Synopsis
  • Cervical tuberculosis is rare, constituting only 0.1-0.65% of all tuberculosis cases, and presents primarily with symptoms like infertility, abnormal bleeding, pelvic pain, and amenorrhea, without any specific visible changes to the cervix.
  • A 45-year-old woman was misdiagnosed with cervical cancer, but further examination revealed she actually had tuberculosis of the cervix, highlighting the importance of proper diagnosis.
  • Tuberculosis can cause chronic pelvic inflammation and infertility, and clinicians should consider it as a potential diagnosis in cases of unexplained lower genital tract symptoms, since it can mimic more common conditions like cervical cancer.
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Frequency, clinical presentation and management of primary amenorrhea in a tertiary care setting.

Pak J Med Sci

December 2024

Riffat Jaleel, FCPS, Department of Obstetrics and Gynaecology Unit II, D. Ruth K. M. Pfau Civil Hospital Karachi and, Dow University of Health Sciences, Karachi, Pakistan.

Article Synopsis
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Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a congenital disorder affecting the female reproductive system, primarily characterized by the absence or underdevelopment of the uterus and upper two-thirds of the vagina, with preserved ovarian function and normal secondary sexual characteristics. It is a rare disease though prevalence may vary based on genetic and environmental factors. This report details a case of a 26-year-old female patient with a history of smoking, alcohol use, and prior inguinal hernioplasty, presenting with primary amenorrhea and inability to engage in vaginal intercourse.

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Background: Globally, approximately 19.4% of women of reproductive age use intrauterine contraception, encompassing both copper intrauterine devices (Cu-IUDs) and levonorgestrel intrauterine devices (LNG-IUDs). Despite current guidelines endorsing intrauterine contraception as a primary method, there remains debate regarding device selection.

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Article Synopsis
  • Secondary amenorrhea is defined as the absence of menstrual cycles for over 3 months in women with previously regular periods, or over 6 months in those with irregular cycles, requiring lab tests to check for pituitary function.
  • A case study of a 31-year-old woman with Diamond-Blackfan anemia and type 2 diabetes showed she experienced amenorrhea for a year after IUD removal, leading to lab tests revealing low levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH).
  • An MRI of her pituitary gland showed no signal, indicating pituitary dysfunction likely caused by iron overload from her frequent blood transfusions, resulting in her treatment with an iron chelator and oral contraception.
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  • - The case study presents a 35-year-old woman who experienced health issues linked to chronic electronic cigarette use, including secondary amenorrhea and symptoms of hyperandrogenism like acne and hirsutism.
  • - Initial tests suggested a condition called 11β-hydroxylase deficiency, but genetic analysis showed no mutations to support this diagnosis.
  • - The patient's symptoms were ultimately attributed to disrupted steroid production caused by chemicals in electronic cigarette oil, highlighting the importance of understanding pharmacology for accurate diagnosis.
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  • Cushing's disease (CD) co-occurring with chronic kidney disease (CKD) is rare and makes diagnosis challenging due to CKD-induced hypercortisolism; this report presents three female cases to improve understanding of diagnosis in such contexts.
  • Each patient, aged between 12 and 16, had various CKD-related conditions and presented symptoms typical of CD, which were confirmed through clinical and biochemical evaluations; surgical interventions led to remission, but some patients developed pituitary deficiencies.
  • These cases highlight the need for careful clinical assessment in diagnosing CD among CKD patients, as clear diagnostic criteria are currently lacking.
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Article Synopsis
  • - Perrault syndrome (PRLTS) is a rare genetic disorder leading to hearing loss in both men and women, and ovarian dysfunction specifically in females with a 46, XX karyotype.
  • - A 26-year-old woman with symptoms like congenital deafness, ovarian failure, and high FSH levels was misdiagnosed multiple times before genetic testing confirmed her condition as PRLTS.
  • - This case highlights the need for genetic testing and a multidisciplinary approach for better diagnosis and management of PRLTS, which poses significant diagnostic challenges due to its rarity.
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Introduction And Importance: Laparoscopic gonadectomy for nonpalpable glands in the inguinal canal, particularly in patients with Complete Androgen Insensitivity Syndrome (CAIS), presents technical challenges and is infrequently reported. While laparoscopic surgery in young women is minimally invasive and offers cosmetic advantages, it may require an additional inguinal incision depending on gonad location.

Case Presentation: A 16-year-old phenotypic female with a chief complaint of primary amenorrhea was diagnosed with 46, XY karyotype and CAIS.

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Overview of hyperprolactinemia: General approach and reproductive health implications.

Arch Med Res

October 2024

Unidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico. Electronic address:

Article Synopsis
  • Prolactin (PRL) is a hormone from the anterior pituitary that primarily regulates breast development and milk production.
  • Hyperprolactinemia, or elevated PRL levels, is a common issue in medical settings, often caused by medications like antipsychotics, though it can also stem from tumors or other health conditions.
  • This condition is significant for reproductive health, contributing to infertility in about 15-20% of women and causing issues like secondary amenorrhea, while also leading to hypogonadism in men.
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Acromegaly due to ectopic secretion of growth hormone-releasing hormone (GHRH) is a rare disorder. The signs and symptoms of ectopic acromegaly are indistinguishable from acromegaly due to a somatotroph adenoma. A 35-year-old female presented with secondary amenorrhea for 10 years, intermittent headache, and reduced vision in both eyes for 4 years, which worsened over 4 months before presentation.

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Article Synopsis
  • - A genetic condition known as Gordon Holmes syndrome combines symptoms like hypogonadotropic hypogonadism, cerebellar ataxia, chorea, and cognitive impairment, linked to biallelic pathogenic variants.
  • - A case study involves two siblings, a 17-year-old brother with delayed puberty and gynecomastia, and a 15-year-old sister with primary amenorrhea, leading to clinical investigations that revealed reproductive and neurological issues.
  • - Whole-exome sequencing confirmed a homozygous pathogenic variant in both siblings, with parents identified as heterozygous carriers, emphasizing that early signs of hypogonadism can indicate this complex neuroendocrine disorder.
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Article Synopsis
  • - A 25-year-old woman with type II diabetes experienced severe nausea and vomiting, along with significant weight loss over 5 weeks, despite normal vital signs and extensive gastrointestinal testing.
  • - Further investigation revealed panhypopituitarism, a rare condition causing deficiencies in multiple pituitary hormones, particularly adrenocorticotropic hormone and cortisol, which were linked to her symptoms.
  • - After starting treatment for panhypopituitarism, her symptoms resolved within 24 hours, underscoring the importance of thorough medical history and examination in diagnosing rare conditions.
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Primary ovarian insufficiency: update on clinical and genetic findings.

Front Endocrinol (Lausanne)

October 2024

Department of Medical Biotechnologies and Translational Medicine, University of Milan, Milan, Italy.

Article Synopsis
  • Primary ovarian insufficiency (POI) affects about 3.7% of women under 40, leading to fertility challenges and impacting overall health and quality of life.
  • The causes of POI can be unclear, but there is a significant genetic factor involved, particularly linked to defects on the X chromosome.
  • This review discusses the clinical features of POI, associated genetic factors, and management strategies for preserving fertility in those at risk.
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Article Synopsis
  • A woman in her 30s experienced primary infertility and secondary amenorrhoea, with signs of virilisation and a solid mass found on her right ovary, leading to concerns about an ovarian tumor.
  • Tests indicated the likely presence of an androgen-producing tumor called a Sertoli-Leydig cell tumour (SLCT), which was confirmed through histopathology after a fertility-sparing surgery.
  • Following the surgery, the patient’s testosterone levels dropped significantly, and her menstrual cycle resumed, highlighting the importance of recognizing SLCTs in similar cases and considering fertility-preserving options in young women with such conditions.
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