15,463 results match your criteria: "Amebiasis"
PHARMACOKINETICS OF METRONIDAZOLE IN GREEN (), LOGGERHEAD (), AND KEMP'S RIDLEY () SEA TURTLES AFTER SINGLE ORAL AND INTRAVENOUS DOSES.
J Zoo Wildl Med
December 2024
Florida Atlantic University, Harbor Branch Oceanographic Institute, Fort Pierce, FL 34936, USA.
Currently there are few antibacterial dosage regimens established to be safe and effective for sea turtles. Pharmacokinetic evaluation of antibiotics is an essential step in establishing accurate dosage guidelines for a particular species. Metronidazole is an antibiotic that is effective against anaerobic bacteria and some protozoa.
View Article and Find Full Text PDF-induced NETs are highly cytotoxic on hepatic and colonic cells due to serine proteases and myeloperoxidase activities.
Front Immunol
December 2024
Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, Mexico.
During intestinal and liver invasion by the protozoan parasite , extensive tissue destruction linked to large neutrophil infiltrates is observed. It has been proposed that microbicidal components of neutrophils are responsible for the damage, however, the mechanism by which they are released and act in the extracellular space remains unknown. In previous studies, we have shown that trophozoites induce NET formation, leading to the release of neutrophil granule content into extruded DNA.
View Article and Find Full Text PDFSymptomatic Infections Among Men Who Have Sex With Men, New York City, 2018.
Open Forum Infect Dis
December 2024
Parasitology Laboratory, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
is considered the primary species causing the parasitic gastrointestinal infection amebiasis. A cluster of amebiasis infections was identified in 2018 among men who have sex with men in New York City and was likely caused by , traditionally considered to be nonpathogenic.
View Article and Find Full Text PDFAmeboma, a rare cause of intestinal obstruction in bariatric surgery patients: a case report.
J Surg Case Rep
December 2024
Bariatric Surgery, Obesity Goodbye Center, Tijuana 22000, Mexico.
Article Synopsis
- - Ameboma is a rare complication from invasive amebiasis caused by a specific intestinal protozoan, leading to tumor-like inflammatory masses in the lower right abdomen.
- - Symptoms can vary but often include intestinal obstruction and gastrointestinal bleeding, and while imaging techniques like CT and ultrasound can reveal colonic masses, biopsy remains the most reliable way to diagnose ameboma.
- - Treatment generally involves targeting the protozoan causing the infection, with surgery being necessary for severe cases like intestinal obstruction or other serious complications.
Article Synopsis
- Entamoeba histolytica is a parasite causing intestinal amebiasis, particularly prevalent in tropical areas and a major health issue in developing countries. Traditional diagnostic methods can cause delays in treatment, exacerbating patient conditions.
- A case involving a 59-year-old HIV-positive man revealed how initial testing misdiagnosed his illness, but advanced diagnostics using the FilmArray GI Panel quickly identified E. histolytica in under an hour.
- The successful and prompt treatment with antiamoebic drugs significantly improved the patient's health, highlighting the importance of rapid diagnosis in managing gastrointestinal infections effectively.
[Balamuthia mandrillaris amebic encephalitis: report of a case].
Zhonghua Bing Li Xue Za Zhi
December 2024
Department of Pathology, Affiliated Hospital of Hebei University, Baoding071000, China.
A Synthetic View on Acanthamoeba Keratitis Host Immune Response: Potential Factors Influencing the Development of Chronic Inflammation.
Cornea
January 2025
Laboratório de Imunoquímica, Departamento de Patologia Básica, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil; and.
Article Synopsis
Understanding the pathogenicity of Naegleria fowleri in association with N. fowleri antigen-1 (Nfa1).
Parasites Hosts Dis
November 2024
Department of Clinical Laboratory Sciences, Arkansas State University, PO Box 910, State University, AR 72467, USA.
Article Synopsis
Amoebicidal and cysticidal in vitro activity of cationic dendritic molecules against Acanthamoeba polyphaga and Acanthamoeba griffini.
Parasitol Res
November 2024
University of Alcala, Department of Biomedicine and Biotechnology, 28805, Madrid, Spain.
Article Synopsis
Cutaneous amoebiasis: a dermatological rarity.
An Bras Dermatol
November 2024
Clinic of Dermatology, Santa Casa de São Paulo Hospital, São Paulo, SP, Brazil; Laboratory of Pathology, Santa Casa de São Paulo Hospital, São Paulo, SP, Brazil.
Exploring the Interactome of the Queuine Salvage Protein DUF2419 in .
Cells
November 2024
Department of Molecular Microbiology, Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3525433, Israel.
Article Synopsis
Fulminant amoebic colitis: a challenging diagnosis for the surgeon.
J Surg Case Rep
November 2024
Department of General and Endoscopic Surgery, Dr. Manuel Gea González General Hospital, Calzada de Tlalpan 4800, Belisario Domínguez Sección XVI, Mexico City 14080, Mexico.
Article Synopsis
Difficulty Confirming the Diagnosis of Amoebic Enteritis.
Tokai J Exp Clin Med
December 2024
Department of Gastroenterology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
Article Synopsis
- Amoebic dysentery is a serious disease in Japan, classified as Category 5, with around 1,000 annual cases, and about 10% are invasive strains.
- Most invasive cases show no symptoms, making them hard to detect, especially since a key blood test was discontinued in 2017.
- Proper diagnosis and treatment are crucial to avoid severe complications, such as ulceration and liver abscesses, which can occur with delayed care.
Discharges of Wastewater Treatment Plants Needed Further Monitoring to Minimize Potential Risk of and for Public Health.
Environ Health (Wash)
November 2024
Department of Environmental Engineering, Middle East Technical University, 06800 Ankara, Turkey.
Article Synopsis
- * A study in Ankara, Turkey, evaluated the ability of five different WWTPs to remove these parasites over a year, measuring specific genes using quantitative polymerase chain reaction (qPCR).
- * Results showed that removal capacity, expressed as log reduction values, varied with treatment processes, with membrane bioreactor systems being the most effective, highlighting the need for improved monitoring of other systems to protect public health.
Diloxanide in amoebiasis management: Unravelling the mechanism of action and effectiveness.
Basic Clin Pharmacol Toxicol
January 2025
Department of Pharmacy, Faculty of Pharmacy, Universitas Borneo Lestari, Banjarbaru, Indonesia.
Article Synopsis
- Diloxanide is an effective treatment for asymptomatic amoebiasis, but its exact mechanism of action is not well understood despite its structural similarities to chloramphenicol.
- It operates by inhibiting protein synthesis in the E. histolytica parasite, preventing the formation of more virulent cysts, and achieving a parasite clearance rate of 81-96%.
- The study calls for further research into diloxanide's structure-activity relationship and suggests exploring new drug formulations and improved diagnostic methods to enhance treatment efficacy and reduce the risk of relapse.
AGC family kinase of Entamoeba histolytica: Decoding the members biochemically.
PLoS Pathog
November 2024
Multidisciplinary Centre for Advanced Research and Studies, Jamia Millia Islamia, New Delhi, India.
Article Synopsis
- Entamoeba histolytica is a protozoan parasite that causes amoebiasis, a major global health issue, with complex mechanisms of virulence including endocytic processes and motility.
- Two kinases from the AGCK family, EhAGCK1 and EhAGCK2, have been studied, revealing that EhAGCK1 is specifically involved in trogocytosis while EhAGCK2 is engaged in all actin-dependent endocytic processes.
- The research highlights the distinct biochemical properties of these kinases, including their ion dependency and substrate specificity, and emphasizes their unique roles in related endocytic processes such as trogocytosis and phagocytosis.
Autochthonous amebiasis in Spain.
Rev Esp Enferm Dig
November 2024
Gastroenterología y Hepatología, Hospital Universitario Fundación Jiménez Díaz.
Article Synopsis
- Amoebiasis is an infection caused by the protozoan Entamoeba histolytica, typically transmitted through the faecal-oral route and affecting the intestines and liver, especially in tropical areas.
- A case study details a 56-year-old Spanish man who presented with abdominal pain and fever, leading to imaging studies that revealed significant intestinal and liver abnormalities.
- Treatment involved ultrasound-guided drainage of a liver abscess and antibiotic therapy, resulting in a positive response.
Rare occurrence of Blastocystis in sea turtles and insects (cockroaches, houseflies, and crickets) from several states in Peninsular Malaysia.
Trop Biomed
September 2024
School of Biological Sciences, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia.
Article Synopsis
- Blastocystis is a single-celled protist that lives in the intestines of various hosts, including humans, and may cause a range of health issues from gastrointestinal problems to skin disorders.
- The study investigated the prevalence of Blastocystis in insects like cockroaches, houseflies, and crickets, as well as in sea turtles, using microscopic and molecular techniques.
- Results showed low infection rates (4.44% in insects, 7.7% in sea turtles), but highlighted the importance of understanding Blastocystis's genetic diversity and potential reservoirs to improve public health measures.
Hypoxia and collagen deposition in the kidneys infected with Acanthamoeba sp.
Sci Rep
November 2024
Department of Biology, Parasitology, and Pharmaceutical Botany, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Article Synopsis
Plants of the family Lamiaceae as a source of therapeutic agents against Acanthamoeba infections.
Mem Inst Oswaldo Cruz
November 2024
Comenius University in Bratislava, Faculty of Natural Sciences, Department of Zoology, Bratislava, Slovakia.
Article Synopsis
EhRacM differentially regulates macropinocytosis and motility in the enteric protozoan parasite Entamoeba histolytica.
PLoS Pathog
November 2024
Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Article Synopsis
- Macropinocytosis is a key endocytic process that allows cells to take in fluids and particles, playing an essential role in various cell functions like nutrient uptake and signaling.
- While mostly studied in immune and cancer cells, the role of macropinocytosis in pathogens like Entamoeba histolytica, which causes amebiasis, is less understood.
- This study investigates the role of Rho small GTPase proteins in macropinocytosis of E. histolytica, revealing that the protein EhRacM enhances macropinocytosis and influences cell migration, highlighting its importance in understanding pathogen behaviors.
Extracellular Vesicles Derived From Have an Immunomodulatory Effect on THP-1 Macrophages.
J Parasitol Res
October 2024
Division of Infectious Diseases, Stanford University School of Medicine, Stanford, California 94305, USA.
Article Synopsis
- * The research introduces the impact of these EVs on THP-1 differentiated macrophages, revealing that they are taken up by the cells and alter the expression of key cytokines linked to immune responses.
- * Additionally, the EVs cause macrophages to lower their energy production by inhibiting processes like oxidative phosphorylation, suggesting that parasite-derived EVs play a significant role in shaping the immune response and could influence the course of infection.
Correlation between notifiable infectious diseases and transportation passenger traffic from 2013 to 2019 in mainland China.
BMC Public Health
October 2024
Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Article Synopsis
- Population mobility plays a crucial role in the spread of infectious diseases, affecting public health and sustainable development globally.
- The study analyzed data from China between 2013 and 2019, discovering that intestinal diseases had the highest incidence, while sexually transmitted diseases had the highest mortality rate.
- A strong correlation was found between passenger traffic (commercial and public) and various infectious diseases, highlighting transportation's impact on disease prevalence.
High rates of Dientamoeba fragilis and Blastocystis species in children's stool but minor clinical significance.
J Infect
December 2024
Head Office, Medical Division, Meuhedet Health Services, Tel Aviv, Israel; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Article Synopsis
- The study focused on understanding the prevalence and clinical implications of Dientamoeba fragilis (DF) and Blastocystis (Bs) in the stool samples of children under 18 years old.
- Out of 36,008 children tested, 32.5% had DF and 7.9% had Bs, but these infections didn't lead to significantly more health issues compared to those with negative results, except for some abdominal pain in DF-positive cases.
- The findings suggest that while DF and Bs are common in children's stool, they likely have limited clinical importance, especially when compared to known pathogenic microorganisms.
Immunological and cytokine profile (IL-25 and IL-35) in patients with infection in Southern Iraq.
Arch Razi Inst
April 2024
Department of Microbiology, College of Medicine, University of Thi-qar, Thi-qar, Iraq.
Article Synopsis
- The study investigates the cytokine profile of IL-25 and IL-35 in patients with amoebiasis, an intestinal disease caused by a parasite, in southern Iraq.
- Conducted from August 2022 to May 2023, it included 80 participants, 50 with amoebiasis confirmed by PCR and 30 healthy controls.
- Results showed that IL-25 levels were significantly higher in patients with the infection compared to controls, suggesting it could serve as a diagnostic marker for amoebiasis, while IL-35 levels did not differ significantly.