56 results match your criteria: "Amazonas State University (UEA)[Affiliation]"

Introduction: This study aimed to systematically analyze and describe the main challenges of congenital heart diseases (CHDs) in the countries in the Amazon region.

Methods: The methodology followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews checklist utilizing the Medline, Embase, Lilacs, and Google Scholar databases. The inclusion criteria were articles addressing any topic involving CHD in the Amazon region.

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Background: Congenital heart disease (CHD) is the leading cause of death from malformations in infants and has a significant psychological impact on families. This scoping review explored the role of spirituality in supporting families of children with CHD. It also sought to identify gaps in the existing literature and suggest directions for future research.

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R.E. Fries is an Amazonian species known as 'envira-bobó' and 'envira-fofa' and is common in the states of Amazonas, Acre, and Pará.

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Background: The rising prevalence of fungal infections and challenges such as adverse effects and resistance against existing antifungal agents have driven the exploration of new antifungal substances.

Methods: We specifically investigated naphthoquinones, known for their broad biological activities and promising antifungal capabilities. It specifically examined the effects of a particular naphthoquinone on the cellular components of Candida albicans ATCC 60193.

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Article Synopsis
  • - The study explores how changing the conditions in a biotechnological process can lead to the production of new natural aromas, specifically focusing on converting limonene into limonene-1,2-diol using the fungus Pestalotiopsis mangiferae LaBMicrA-505 from the Brazilian Amazon.
  • - Researchers optimized conditions for this biotransformation in shake flasks, discovering that the best biomass yield came from cultures grown in a specific liquid medium for 72 hours.
  • - By applying a central composite design for modeling, they established optimal parameters (4 g/l biomass, 2% substrate, 24°C, 120 rpm, pH 6.0) that resulted in a significant production of lim
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Nanocapsules provide selective delivery and increase the bioavailability of bioactive compounds. In this study, we examined the anticancer and immunomodulatory potential of (crajiru) extract encapsulated in nanocapsules targeting myeloid leukemias. Nanocapsules containing crajiru (nanocapsules-CRJ) were prepared via interfacial polymer deposition and solvent displacement.

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Objective Isotretinoin, also known as 13-cis-retinoic acid, is an isomer of tretinoin, the oxidized form of Vitamin A. Orthodontic tooth movement (OTM) is the result of a cascade of inflammatory responses stimulated by a physical element that is the force generated by orthodontic appliances. Isotretinoin is mainly used among adolescents and young adults, and coincidentally it is this age group that also undergoes orthodontic treatment.

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Constriction of the fetal ductus arteriosus is a condition that narrows the ductus arteriosus and can lead to death, so the importance of prior diagnosis. Citronella, due to its anti-inflammatory properties, should be avoided during pregnancy as it may cause constriction of the fetal duct.

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To investigate the biocatalytic potential of Amazonian actinomycetes for monoterpenes biotransformation. To carry out the present study, eleven actinomycetes of the genus isolated from inga-cipó ( Mart.) rhizospheres were tested for their ability to bioconvert the substrates -(+)-limonene, -(-)-limonene, 1-(-)-α-pinene, and (-)-β-pinene as sole carbon and energy source.

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Software teams increasingly adopt different tools and communication channels to aid the software collaborative development model and coordinate tasks. Among such resources, software development forums have become widely used by developers. Such environments enable developers to get and share technical information quickly.

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Article Synopsis
  • * A total of 260 individuals were monitored for 12 months, revealing that Zika virus RNA was detectable for long periods, especially in semen, and various factors influenced how quickly the virus cleared from different fluids.
  • * The research highlighted the potential for recurrent detection of Zika virus even after it was cleared, underscoring the importance of ongoing monitoring and prevention strategies to manage its transmission.
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Background: Plasmodium vivax is the main species responsible for human malaria in Brazil, and one of its manifestations is splenic malaria, though there are still challenges in its diagnosis. The present study aimed to standardize Plasmodium sp. DNA extraction from histological slices of spleen and diagnosis using real-time qPCR.

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Congenital heart disease (CHD) is the leading cause of death from malformations in the first year of life and carries a significant burden to the family when the diagnosis is made in the prenatal period. We recognize the significance of family counseling following a fetal CHD diagnosis. However, we have observed that most research focuses on assessing the emotional state of family members rather than examining the counseling process itself.

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Article Synopsis
  • Trichoderma is a fungi known for producing nonribosomal peptides called peptaibols, which have strong antimicrobial and anticancer properties, and can help plants resist pathogens.
  • Researchers analyzed peptaibols from a newly identified marine strain of Trichoderma using advanced mass spectrometry, identifying it as a unique species not previously seen in marine environments.
  • The study highlighted the discovery of various biosynthetic gene clusters related to these peptides, leading to the identification of two new series of peptaibols called "endophytins," showcasing the effective use of genome mining and mass spectrometry in natural product research.
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The emergence of multidrug resistance in bacterial pathogens is a growing public health concern requiring solutions including the discovery of new antimicrobial drugs. Fungi have been used for decades as a source of antimicrobials. Ongoing screenings for newly characterized fungal strains producing antimicrobials include environments that are difficult to access like the deep sea, glaciers, wastewaters and environments polluted due to human activity.

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In the Brazilian Amazon, the snake is the primary cause of snakebites. (BaV) venom can cause systemic pathophysiological changes such as acute kidney injury (AKI), which leads to the production of chemokines and cytokines in response to the envenomation. These soluble immunological molecules act by modulating the inflammatory response; however, the mechanisms associated with the development of AKI are still poorly understood.

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Duguetia pycnastera Sandwith (Annonaceae) is a tropical tree that can be found in the Guyanas, Bolivia, Venezuela, and Brazil. In Brazil, it is popularly known as “ata”, “envira”, “envira-preta”, and “envira-surucucu”. In the present work, we investigated the in vitro and in vivo HepG2 cell growth inhibition capacity of D.

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An increase in global energy demand has caused oil prices to reach record levels in recent times. High oil prices together with concerns over CO emissions have resulted in renewed interest in renewable energy. Nowadays, ethanol is the principal renewable biofuel.

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Article Synopsis
  • R. E. Fries, a tree native to the Brazilian Amazon, has its essential oil (EO) evaluated for its cytotoxic and antitumor effects against liver cancer using HepG2 cells as a model.
  • The EO, characterized through hydrodistillation and analyzed by GC-MS and GC-FID, was found to contain key compounds such as germacrene D and caryophyllene oxide.
  • The study demonstrated that the EO exhibited significant anti-liver cancer properties in vitro and in vivo, decreasing tumor mass by 32.8-57.9% and increasing apoptotic cells in HepG2 cells.
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The Amazon rainforest has a rich biodiversity, and studies of Basidiomycete fungi that have biomolecules of biotechnological interest are relevant. The use of lignocellulosic biomass in biotechnological processes proposes an alternative use, and also adds value to the material when employed in the bioconversion of agro-industrial waste. In this context, this study evaluate the production of lignocellulolytic enzymes (carboxymethylcellulases (CMCase), xylanase, pectinase, laccase) as well as phenolic compounds and proteases by solid-state fermentation (SSF) using the fungus Lentinus strigosus isolated from Amazon.

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Introduction: Foreign body ingestion is a common clinical scenario found in clinical practice. Perforations related to foreign bodies are rare, but they can present as a serious condition in emergency surgery services. The most common sites of perforation are angled areas, such as: ileocecal valve, sigmoid colon, duodenojejunal flexure and small intestine.

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Acute myeloid leukemia (AML) is the most lethal form of leukemia. Standard anti-AML treatment remains almost unchanged for decades. Tingenone (TG) and 22-hydroxytingenone (22-HTG) are quinonemethide triterpenes found in the Amazonian plant Salacia impressifolia (Celastraceae), with cytotoxic properties in different histological types of cancer cells.

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