Optimization of adsorption performance by mesoporous materials developed from local clays and zeolite. Application in the treatment of real pharmaceutical effluents.

The treatment of effluents from the pharmaceutical industry currently remains a major challenge due to their impact on the environment and public health along with the cost of treatments. Considering these issues, our work focused on the development of materials with effective adsorption properties to treat industrial effluents based on locally available and inexpensive clays and zeolite. Local Algerian kaolin (Djebel Debbagh), palygorskite (Ghoufi) and zeolite (Tinbdar) were treated thermally and chemically prior to synthesis into mesoporous materials of hexagonal structure using pluronic P123 as surfactant.

Fatty acid composition and antioxidant capacity of defatted, non-defatted and oils extracts of fruit from Algeria.

Background: The nutritional value and health-promoting properties cause the fruits (acorns) of to have great potential for use in the food industry as functional ingredients and antioxidants source.

Objective: In this study, the amount of total phenolic compounds, flavonoids in different extracts (defatted, non-defatted) and composition of fatty acids in the fruits oils of were investigated. Besides, antioxidant activity was determined.

Exploring the anticancer potential of new 3-cyanopyridine derivatives bearing N-acylhydrazone motif: Synthesis, DFT calculations, cytotoxic evaluation, molecular modeling, and antioxidant properties.

3-Cyanopyridine derivatives are known for exhibiting excellent anticancer activity due to their strong capability to inhibit various biological targets, including Pim-1 kinase, survivin, and tubulin polymerization. On the other hand, N-acylhydrazones (NAH) are known to be a very versatile motif in medicinal chemistry and drug design. Based on these data, we report in this paper, the synthesis of novel 3-cyanopyridines incorporating N-acyl hydrazine scaffold, the evaluation of their cytotoxicity on the breast (MCF-7) and ovarian (A-2780) cancer cell lines and their antioxidant properties.

Exploring the Anti-Cancer Potential of Hispidin: A Comprehensive in Silico and in Vitro Study on Human Osteosarcoma Saos2 Cells.

Hispidin was initially discovered in basidiomycete Inonotus hispidus (Bull.) P. Karst and this extraordinary compound possesses immense potency and can be extracted from the wild mushroom through specialized bioreactor cultivation techniques.

HPLC-DAD-MS Characterization, Antioxidant Activity, α-amylase Inhibition, Molecular Docking, and ADMET of Flavonoids from Fenugreek Seeds.

Fenugreek () has a great beneficial health effect; it has been used in traditional medicine by many cultures. Likewise, the α-amylase inhibitors are potential compounds in the development of drugs for the treatment of diabetes. The beneficial health effects of fenugreek lead us to explore the chemical composition of the seeds and their antioxidant and α-amylase inhibition activities.

analysis of identified molecules using LC-HR/MS of L. ethyl acetate fraction against three monkeypox virus targets.

Monkeypox virus is a viral disease transmitted to humans through contact with infected animals, such as monkeys and rodents, or through direct contact with the bodily fluids or lesions of infected humans. The aim of this study is to evaluate the inhibition effect of eight L. ethyl acetate fraction identified molecules using LC-MS on three monkeypox targets such as the vaccinia virus thymidylate kinase (VTK), the viral profilin-like protein (VPP), and the viral RNA polymerase (VRP).

In vitro study of biogenic amine production and gastrointestinal stress tolerance by some enterococci strains.

Background: Owing to the toxic effects of enterococci, their biogenic amine production is a negative aspect of safe strain selection and unfavourable activity in food. Additionally, the ability to tolerate acid and bile are two important traits for the selection of probiotic strains since they show the probiotic bacteria's capacity to survive throughout gastrointestinal transit. In the present work, six enterococci strains belonging to Enterococcus gallinarum and Enterococcus hirae were subjected to in vitro evaluation of their ability to produce biogenic amines and to tolerate gastrointestinal stress in order to investigate their possibility for future intended use as probiotics.

Assessment of hybrid machine learning algorithms using TRMM rainfall data for daily inflow forecasting in Três Marias Reservoir, eastern Brazil.

This study investigates the application of the Gaussian Radial Basis Function Neural Network (GRNN), Gaussian Process Regression (GPR), and Multilayer Perceptron Optimized by Particle Swarm Optimization (MLP-PSO) models in analyzing the relationship between rainfall and runoff and in predicting runoff discharge. These models utilize autoregressive input vectors based on daily-observed TRMM rainfall and TMR inflow data. The performance evaluation of each model is conducted using statistical measures to compare their effectiveness in capturing the complex relationships between input and output variables.

Artificial intelligent systems optimized by metaheuristic algorithms and teleconnection indices for rainfall modeling: The case of a humid region in the mediterranean basin.

Characterized by their high spatiotemporal variability, rainfalls are difficult to predict, especially under climate change. This study proposes a multilayer perceptron (MLP) network optimized by Genetic Algorithm (GA), Particle Swarm Optimization (PSO), Firefly Algorithm (FFA), and Teleconnection Pattern Indices - such as North Atlantic Oscillation (NAO), Southern Oscillations (SOI), Western Mediterranean Oscillation (WeMO), and Mediterranean Oscillation (MO) - to model monthly rainfalls at the Sebaou River basin (Northern Algeria). Afterward, we compared the best-optimized MLP to the application of the Extreme Learning Machine optimized by the Bat algorithm (Bat-ELM).

A Safety-Aware Location Privacy-Preserving IoV Scheme with Road Congestion-Estimation in Mobile Edge Computing.

By leveraging the conventional Vehicular Ad-hoc Networks (VANETs), the Internet of Vehicles (IoV) paradigm has attracted the attention of different research and development bodies. However, IoV deployment is still at stake as many security and privacy issues are looming; location tracking using overheard safety messages is a good example of such issues. In the context of location privacy, many schemes have been deployed to mitigate the adversary's exploiting abilities.

Repurposing antibiotics as potent multi-drug candidates for SARS-CoV-2 delta and omicron variants: molecular docking and dynamics.

There is a daunting public health emergency due to the emergence and rapid global spread of the new omicron variants of SARS-CoV-2. The variants differ in many characteristics, such as transmissibility, antigenicity and the immune system of the human hosts' shifting responses. This change in characteristics raises concern, as it leads to unknown consequences and also raises doubts about the efficacy of the currently available vaccines.

Insight into the control of nodule immunity and senescence during Medicago truncatula symbiosis.

Medicago (Medicago truncatula) establishes a symbiosis with the rhizobia Sinorhizobium sp, resulting in the formation of nodules where the bacteria fix atmospheric nitrogen. The loss of immunity repression or early senescence activation compromises symbiont survival and leads to the formation of nonfunctional nodules (fix-). Despite many studies exploring an overlap between immunity and senescence responses outside the nodule context, the relationship between these processes in the nodule remains poorly understood.

L. flavonoids as potent inhibitors to xanthine oxidase: in vitro, molecular docking, ADMET and PASS studies.

Excessive intake of purine-rich foods such as seafood and red meat leads to excess xanthine oxidase activity and provokes gout attacks. The aim of this paper is to evaluate and , the inhibition effect of plant extracts (flavonoids (Cae) and alkaloids (CaK)) and its six derivative compounds on bovine xanthine oxidase (BXO). The study consists of molecular docking with GOLD v4.

Quinic and Digallic acids from Desf. Leaves Extracts as Potent Dual Effect Inhibitors against main Protease and RNA-dependent RNA Polymerase of SARS-CoV-2.

Background: Through this study, the Chemical composition realized by UHPLC-DADESI- MSn allowed the detection of different phenolic compound groups from Pistacia atlantica Desf. leaves extracts. We studied the inhibition of main protease (CL3 M) and RNA-dependent RNA polymerase (RdRp) of the SARS-CoV-2 by the identified molecules through molecular docking.

Hourly solar irradiation forecast using hybrid local gravitational clustering and group method of data handling methods.

The foundation for many solar energy uses as well as economic and environmental concerns is global solar irradiation information. However, due to solar irradiation and measurement variations, reliable worldwide statistics on solar irradiation are frequently impossible or challenging to acquire. In addition, more precise forecasts of solar irradiation play an increasingly important role in electric energy planning and management due to integrating photovoltaic solar systems into power networks.

The inhibitory kinetics of vitamins B9, C, E, and D3 on bovine xanthine oxidase: Gout treatment.

Background: Over-consumption of foods high in purines like seafood, red meat, and alcoholic beverages leads to hyperuricemia causing gout attacks. Xanthine oxidase was reported responsible for the overproduction of uric acid.

Material And Methods: We intend to test in silico and in vitro, the inhibition effect of four vitamins against bovine milk xanthine oxidase (BXO).

Exploring Structural Mechanism of COVID-19 Treatment with Glutathione as a Potential Peptide Inhibitor to the Main Protease: Molecular Dynamics Simulation and MM/PBSA Free Energy Calculations Study.

The 2019-novel coronavirus has unfolded everywhere in the world and obliged a billion human beings in open confinement, whereas many treatments, and vaccines have been proposed towards this pandemic. The main protease (M) is an attractive drug target due to the fact that it is the essential protein for virus invasion. This research tests in silico the effect of five vitamins towards M, by employing molecular docking (MD), molecular dynamics simulation (MDS) with molecular mechanics-Poisson-Boltzmann surface area (MM-PBSA) studies.

An updated checklist of the mosquitoes (Diptera: Culicidae) present in Algeria, with assessments of doubtful records and problematic species.

An updated checklist of the mosquitoes (Diptera: Culicidae) of Algeria based on records published from 1903 to 2021 is presented. Fifty-three species belonging to seven genera are known with reasonable confidence to occur in the country, including Aedes (15 species), Anopheles (15), Coquillettidia (2), Culex (14), Culiseta (5), Orthopodomyia (1) and Uranotaenia (1). Two additional species, Culex simpsoni Theobald, 1905 and Uranotaenia balfouri Theobald, 1904, are provisionally regarded as present in Algeria.

Hispidin, Harmaline, and Harmine as potent inhibitors of bovine xanthine oxidase: Gout treatment, in vitro, ADMET prediction, and SAR studies.

Alkaloids and phenols are potent inhibitors family for many enzymes used in many therapies. We aim to evaluate in vitro and in silico, the inhibition effect of Hispidin, Harmaline, and Harmine as pure molecules to bovine milk xanthine oxidase (BXO), Molecular docking and SAR study with GOLD was done to explain the mechanism of action related to its inhibition, ADMET parameters were checked to confirm their pharmacokinetics (PK) using preADMET 2.0 server, we classified our inhibitors by applying five drug-likeness rules, the best-ranked inhibitors were chosen based on the approved ADMET properties, drug-likeness qualifications, and the best PLPchem score generated by GOLD.

Perception of seismic design by architects in Algeria.

The purpose of this article is to analyse the results of a survey towards the architects and engineers of construction in order to estimate the perception of the anti-seismic protection amongst these professionals. It focuses more on the architects who design buildings and, in many cases, monitor their implementation. The main result is the observation of inadequacies and gaps in seismic culture amongst the professionals, especially architects.

In Silico and In Vitro Studies of the Inhibitory Effect of Antihistamine Drug Cyproheptadine Hydrochloride on Human Salivary Alpha Amylase.

Background: For the first time, the inhibitory effects on the human salivary alpha-amylase activity of the anti-inflammatory drugs indomethacin, diclofenac sodium, ketoprofen, diclofenac potassium, diclofenac, triamcinolone acetonide, and the antihistamine drugs levocetirizine dihydrochloride, desloratadine, cycloheptadine hydrochloride, have been investigated to confirm the other properties of these drugs.

Objective: This study aimed to determine the effect of nine known drugs on human salivary α-amylase in vitro and the nature of interactions with structure-activity relationship using molecular docking experiments.

Methods: The inhibition of human salivary alpha amylase by the six anti-inflammatory and three antihistamine drugs has been carried out using the new method that has been proved in our previous work.

A novel comprehensive framework for analyzing and assessing water quality and failure consequences based on Bayesian networks.

The study of the effects of mixing potable water with wastewater is a complex and difficult research area. This difficulty is because water and sewage networks are subject to various physical, environmental, and operational factors. The main objective of the study was to propose a new comprehensive framework for analyzing and assessing water quality based on Bayesian networks.

Occurrence and molecular characterization of Giardia duodenalis in lambs in Djelfa, the central steppe of Algeria.

Little is known of the prevalence and genetic identity of Giardia duodenalis in sheep in Algeria. The present study aimed at characterizing G. duodenalis in lambs up to 6 months of age in Djelfa, Algeria.

Identification, Quantification, and Antioxidant Activity of Hydroalcoholic Extract of from Algeria.

Objectives: Our study aimed to investigate the chemical profile of hydroalcoholic extract of Algerian and its antioxidant activity.

Materials And Methods: The hydroalcoholic extract of Algerian was investigated for its phenolic constituents using high performance liquid chromatography (HPLC)-diode array detection (DAD)-electrospray ionization (ESI)-mass spectrometer (MS)/MS. The antioxidant activity and total phenolic content were also evaluated via oxygen radical absorbance capacity and Folin-Ciocalteu assays, respectively.