An Enhanced Computational Approach Using Multi-kernel Positive Unlabeled Learning for Predicting Drug-target Interactions.

Background: In recent years, analyzing complex biological networks to predict future links in such networks has attracted the attention of many medical and computer science researchers. The discovery of new drugs is one of the application cases for predicting future connections in biological networks. The operation of drug-target interactions prediction (DTIP) can be considered a fundamental step in identifying potential interactions between drug and target to identify new drugs.

What About My Weight? Insufficient Weight Loss or Weight Regain After Bariatric Metabolic Surgery.

Context: This review study aimed to investigate the definition, etiology, risk factors (RFs), management strategy, and prevention of insufficient weight loss (IWL) and weight regain (WR) following bariatric metabolic surgery (BMS).

Evidence Acquisition: Electronic databases were searched to retrieve relevant articles. The inclusion criteria were English articles with adult participants assessing the definition, prevalence, etiology, RFs, management strategy, and prevention of IWL/WR.

Multiple objective energy optimization of a trade center building based on genetic algorithm using ecological materials.

It is crucial to optimize energy consumption in buildings while considering thermal comfort. The first step here involved an EnergyPlus simulation on a trade center building located in Tehran, Bandar Abbas, and Tabriz, Iran. A multi-objective optimization was then performed based on non-dominated sorting genetic algorithm II (NSGA-II) in jEPlus + EA to establish the building in the selected city where would benefit the most from implementing the radiant ceiling cooling system.

Coumarin derivative-functionalized nanoporous silica as an on-off fluorescent sensor for detecting Fe and Hg ions: a circuit logic gate.

A highly efficient fluorescent sensor (S-DAC) was easily created by functionalizing the SBA-15 surface with N-(2-Aminoethyl)-3-Aminopropyltrimethoxysilane followed by the covalent attachment of 7-diethylamino 3-acetyl coumarin (DAC). This chemosensor (S-DAC) demonstrates selective and sensitive recognition of Fe and Hg in water-based solutions, with detection limits of 0.28 × 10 M and 0.

MnFeO-NH-HKUST-1, MOF magnetic composite, as a novel sorbent for efficient dye removal: fabrication, characterization and isotherm studies.

Dye in industrial wastewater is one of the most serious environmental concerns due to its potentially harmful effects on human health. Many industrial dyes are carcinogenic, toxic and teratogenic. Removal and recovery of hazardous dyes from the effluents requires efficient adsorbents.

Transforming leisure time physical activity into a habit through social institutions.

Physical activity is a positive health behavior that has been shown to reduce the risk of physical and mental illnesses; There's strong evidence suggesting that Physical activity, as one of the components of a healthy lifestyle, if transformed into a consistent behavior or habit early in life, becomes easier to sustain throughout the lifecycle and leads to valuable outcomes for the society's health in various physical, mental, and social dimensions. Each social institution, considering its unique role and characteristics, can contribute to shaping individuals' behaviors in societies. Consequently, identifying the role of social institutions in the development of leisure-time physical activity (LTPA) as a regular activity and a behavioral habit can result in the selection and implementation of highly effective intervention strategies.

Efficacy of high-intensity interval and continuous endurance trainings on cecal microbiota metabolites and inflammatory factors in diabetic rats induced by high-fat diet.

Physical exercise is known to modulate the intestinal microbiota composition and control the symptoms of metabolic syndrome. In this research, we intend to investigate and compare the effect of high-intensity interval and continuous endurance trainings (HIIT and CET) on cecal microbiota metabolites and inflammatory factors in diabetic rats. A number of Wistar rats were made diabetic by a high-fat diet and trained under two types of exercise protocols, HIIT and CET.

Optimizing Wound Healing: Examining the Influence of Biopolymers Through a Comprehensive Review of Nanohydrogel-Embedded Nanoparticles in Advancing Regenerative Medicine.

Nanohydrogel wound healing refers to the use of nanotechnology-based hydrogel materials to promote the healing of wounds. Hydrogel dressings are made up of a three-dimensional network of hydrophilic polymers that can absorb and retain large amounts of water or other fluids. Nanohydrogels take this concept further by incorporating nanoscale particles or structures into the hydrogel matrix.

Therapeutic potential of exosomes in spermatogenesis regulation and male infertility.

Background: Spermatogenesis is a fundamental process crucial for male reproductive health and fertility. Exosomes, small membranous vesicles released by various cell types, have recently garnered attention for their role in intercellular communication.

Objective: This review aims to comprehensively explore the role of exosomes in regulating spermatogenesis, focusing on their involvement in testicular development and cell-to-cell communication.

Increased V-ATPase activity can lead to chemo-resistance in oral squamous cell carcinoma via autophagy induction: new insights.

Oral squamous cell carcinoma (OSCC) is a cancer type with a high rate of recurrence and a poor prognosis. Tumor chemo-resistance remains an issue for OSCC patients despite the availability of multimodal therapy options, which causes an increase in tumor invasiveness. Vacuolar ATPase (V-ATPase), appears to be one of the most significant molecules implicated in MDR in tumors like OSCC.

Synthesis, theoretical analysis, and biological properties of a novel tridentate Schiff base palladium (II) complex.

Schiff base complexes play a crucial role in bioinorganic chemistry. A novel curcumin/phenylalanine tridentate Schiff base ligand and its palladium (II) complex were synthesized so that they were stable in aqueous buffer. The structure of the complex was investigated using a variety of methods, including DFT, NBO analysis, FMOs, and MESP.

Living-loss: A narrative synthesis review of the grief process in parents of children with autism spectrum disorder.

Problem: Realizing that a child has a lifelong developmental condition like Autism Spectrum Disorder (ASD) can create feelings of sadness and grief for the parents. It remains unclear, however, how parents deal with and understand these emotions. The purpose of this narrative review was to explore the grief process of parents of children with ASD.

Celebrity Worship Among Adolescents is Driven by Neuroticism, Avoidant Identity Style, and Need to Belong.

Media celebrities can exert significant influence on societal change, and adolescents are the most vulnerable population to such influence given that this is a period when personal identity-seeking starts to become increasingly important. However, there is a lack of research examining the factors that contribute to adolescents' vulnerability to celebrity worship. The present study investigated the relationship between neuroticism, avoidant identity style, and celebrity worship among adolescents with a particular focus on mediating the role of the need to belong among a convenience sample of Iranian adolescents ( = 396; girls = 68%; age = 15.

A dynamic study of VEGF-A siDOX-EVs trafficking through the insert co-culture blood-brain barrier model by digital holographic microscopy.

Introduction: Modeling the blood-brain barrier has long been a challenge for pharmacological studies. Up to the present, numerous attempts have been devoted to recapitulating the endothelial barrier to assess drug delivery vehicles' efficiency for brain disorders. In the current work, we presented a new approach for analyzing the morphometric parameters of the cells of an insert co-culture blood-brain barrier model using rat brain astrocytes, rat brain microvascular endothelial cells, and rat brain pericytes.

Repurposing of Compounds from Streptomyces spp. as Potential Inhibitors of Aminoacyltransferase FemA: An Essential Drug Target against Drug-resistant Staphylococcus aureus.

Background: Drug-resistant Staphylococcus aureus represents a substantial healthcare challenge worldwide, and its range of available therapeutic options continues to diminish progressively. Thus, this study aimed to identify potential inhibitors against FemA, a crucial protein involved in the cell wall biosynthesis of S. aureus.

Extracellular vesicles derived from dendritic cells loaded with VEGF-A siRNA and doxorubicin reduce glioma angiogenesis in vitro.

Background: Numerous attempts have been devoted to designing anti-angiogenic agents as a strategy to slow tumor growth and progression. Clinical applications of conventional anti-angiogenic agents face some challenges, e.g.

Smartphone-based device for point-of-care diagnostics of pulmonary inflammation using convolutional neural networks (CNNs).

In pulmonary inflammation diseases, like COVID-19, lung involvement and inflammation determine the treatment regime. Respiratory inflammation is typically arisen due to the cytokine storm and the leakage of the vessels for immune cells recruitment. Currently, such a situation is detected by the clinical judgment of a specialist or precisely by a chest CT scan.

Facile Cu-MOF-derived CoO mesoporous-structure as a cooperative catalyst for the reduction nitroarenes and dyes.

The present study describes the environmentally friendly and cost-effective synthesis of magnetic, mesoporous structure-CoO nanoparticles (m-CoO) utilizing almond peel as a biotemplate. This straightforward method yields a material with high surface area, as confirmed by various characterization techniques. Subsequently, the utilization of m-CoO, graphene oxide (GO), Cu(II)acetate (Cu), and asparagine enabled the successful synthesis of a novel magnetic MOF, namely GO-Cu-ASP-m-CoO MOF.

Insight into the activation mechanism of carbonic anhydrase(II) through 2-(2-aminoethyl)-pyridine: a promising pathway for enhanced enzymatic activity.

Activation of human carbonic anhydrase II (hCA II) holds great promise for treating memory loss symptoms associated with Alzheimer's disease. Despite its importance, the activation mechanism of hCA II has been largely overlooked in favor of the well-studied inhibition mechanism. To address this unexplored realm, we use first-principles calculations to tease out the activation mechanism of hCA II using 2-(2-aminoethyl)-pyridine (2-2AEPy), a promising activator.

The relationships between parental attachment, peer attachment, automatic thoughts, and mindfulness skills among Iranian adolescents.

This study aimed to examine the relationship between parental attachment, peer attachments, and automatic thoughts with adolescent mindfulness skills in Iranian adolescents, drawing on internal working models and social cognitive theory. The data was collected from a sample of Iranian adolescents in Tehran using standardized measurement instruments previously developed by researchers. The collected data was analyzed using both simple and multiple regression analyses.

Cobalt sulfide flower-like derived from metal organic frameworks on nickel foam as an electrode for fabrication of asymmetric supercapacitors.

Metal-organic frameworks, as a kind of advanced nanoporous materials with metal centers and organic linkers, have been applied as promising electrode materials in energy storage devices. In this study, we are successfully prepared cobalt sulfide nanosheets (CoS) derived from the metal-organic framework on nickel foam (NF). The prepared electrodes are characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, energy-dispersive X-ray spectroscopy, Brunauer-Emmett-Teller and Barrett-Joyner-Halenda and electrochemical methods like voltammetry, galvanostatic charge-discharge curve and electrochemical impedance spectroscopy.

Three-Component Reaction between 3-Acetylcoumarins, Amines, and Elemental Sulfur: A Designed Approach to 3-Amino-4-thieno[3,2-]coumarins.

In this work, a series of novel 3-amino-4-thieno[3,2-]coumarins were designed and synthesized by a one-pot, catalyst-free, and three-component reaction of 3-acetylcoumarins with amines and elemental sulfur. Readily available starting materials, simple heating conditions, facile installation of a sulfur atom into the molecule using S as a sulfur source, acceptable functional group tolerance, and synthetically useful yields are some highlighted benefits of this process.

Testicular niche repair after gonadotoxic treatments: Current knowledge and future directions.

The testicular niche, which includes the germ cells, somatic cells, and extracellular matrix, plays a crucial role in maintaining the proper functions of the testis. Gonadotoxic treatments, such as chemotherapy and radiation therapy, have significantly improved the survival rates of cancer patients but have also been shown to have adverse effects on the testicular microenvironment. Therefore, repairing the testicular niche after gonadotoxic treatments is essential to restore its function.

Sulfonic acid-functionalized chitosan-metal-organic framework composite for efficient and rapid conversion of fructose to 5-hydroxymethylfurfural.

In pursuit of designing a bio-based catalyst for the dehydration of biomass (i.e., fructose) to 5-hydroxymethylfurfural, a novel catalytic composite was prepared by in-situ formation of an Al-based metal-organic framework in the presence of chitosan.

The Relationship Between Childhood Traumatic Experiences and Bodily Distress Syndrome: The Mediating Role of Somatoform Dissociation.

This research aimed to investigate the relationship between childhood traumatic experiences and bodily distress syndrome, and the mediating role of somatoform dissociation. A total of 241 individuals living in Iran aged 20-40 years ( = 26.41 years,  = 6.