Association of Prehospital Plasma Transfusion With Survival in Trauma Patients With Hemorrhagic Shock When Transport Times Are Longer Than 20 Minutes: A Post Hoc Analysis of the PAMPer and COMBAT Clinical Trials.

Importance: Both military and civilian clinical practice guidelines include early plasma transfusion to achieve a plasma to red cell ratio approaching 1:1 to 1:2. However, it was not known how early plasma should be given for optimal benefit. Two recent randomized clinical trials were published, with apparently contradictory results.

Prehospital Blood Product and Crystalloid Resuscitation in the Severely Injured Patient: A Secondary Analysis of the Prehospital Air Medical Plasma Trial.

Objective: The aim of this study was to determine whether prehospital blood products reduce 30-day mortality in patients at risk for hemorrhagic shock compared with crystalloid only resuscitation.

Summary Of Background Data: Hemorrhage is the primary cause of preventable death after injury. Large volume crystalloid resuscitation can be deleterious.

Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock.

Background: After a person has been injured, prehospital administration of plasma in addition to the initiation of standard resuscitation procedures in the prehospital environment may reduce the risk of downstream complications from hemorrhage and shock. Data from large clinical trials are lacking to show either the efficacy or the risks associated with plasma transfusion in the prehospital setting.

Methods: To determine the efficacy and safety of prehospital administration of thawed plasma in injured patients who are at risk for hemorrhagic shock, we conducted a pragmatic, multicenter, cluster-randomized, phase 3 superiority trial that compared the administration of thawed plasma with standard-care resuscitation during air medical transport.

Clinical Implications of CD30 Expression in Aggressive B-Cell Lymphomas.

Background: US Food and Drug Administration approval of brentuximab vedotin for treatment of CD30-positive relapsed/refractory lymphomas, including classical Hodgkin lymphoma and anaplastic large cell lymphoma, initiated significant interest in researching CD30 expression in other therapy-resistant or relapsed lymphomas. We evaluated CD30 expression in 116 cases of aggressive B-cell lymphomas diagnosed at Penn State Milton S. Hershey Medical Center between 2000 and 2012 with the purpose of assessing the benefit of treatment with brentuximab.

Oral contraceptive use as a risk factor for premenopausal breast cancer: a meta-analysis.

Objective: To perform a meta-analysis of case-control studies that addressed whether prior oral contraceptive (OC) use is associated with premenopausal breast cancer.

Methods: We searched the MEDLINE and PubMed databases and bibliography reviews to identify case-control studies of OCs and premenopausal breast cancer published in or after 1980. Search terms used included breast neoplasms, oral contraceptives, contraceptive agents, and case-control studies.

Prevalence and cost savings of therapeutic interchange among U.S. hospitals.

The prevalence and cost savings of therapeutic interchange (TI) among teaching, nonteaching, and investor-owned hospitals in the United States was studied. A survey was sent to all directors of pharmacy at hospitals listed in the 1999 American Hospital Association directory as having more than 100 beds; 463 (29.8%) hospitals responded.

Postfertilization effect of hormonal emergency contraception.

Objective: To assess the possibility of a postfertilization effect in regard to the most common types of hormonal emergency contraception (EC) used in the US and to explore the ethical impact of this possibility.

Data Sources And Study Selection: A MEDLINE search (1966-November 2001) was done to identify all pertinent English-language journal articles. A review of reference sections of the major review articles was performed to identify additional articles.

How to expand a facility's reach through a dedicated pediatric unit.

Instead of combining pediatric outpatients with adults to balance patient census, one hospital incorporated outpatient pediatric care into the inpatient unit. The change enabled nurses to provide specialized care in a dedicated area and expanded the hospital's scope of services.

You can have a dedicated pediatric unit.

Instead of combining pediatric outpatients with adults to balance patient census, one hospital incorporated outpatient pediatric care in the inpatient unit. The change enables nurses to provide specialized care in a dedicated area and expands the hospital's scope of services.

Brain-mapping abnormalities in a family with three obsessive compulsive children.

Brain electrical activity mapping (BEAM) and personality disorder assessment (Millon Clinical Multiaxial Inventory-II) were performed on a married couple and their four children. Three of the children had previously been identified as having obsessive compulsive disorder (OCD). Temporal lobe abnormalities were found in all four children but in neither parent.