[How to help a patient with abacterial prostatitis?].

Introduction: Despite all the achievements of modern medicine, chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) remains a difficult disorder to treat. Patients are often dissatisfied with the treatment outcomes, since the main symptoms, namely pain and urination disorders, usually decrease, but do not completely resolve.

Aim: To study the efficiency of the combined drug Prostatex Plus in the treatment of patients with CPPS (IIIb).

[Use of the drug Prostatex plus in patients with chronic abacterial prostatitis and BPH].

Aim: To evaluate the efficiency of therapy with Prostatex plus rectal suppositories in the treatment of patients with chronic abacterial prostatitis and benign prostatic hyperplasia (BPH).

Materials And Methods: A total of 50 men with chronic abacterial prostatitis of category III A, occurring in combination with BPH, were included in the study. All patients received Prostatex plus (rectal suppositories) 1 suppository 1 time per day.

[Erectile dysfunction in railway station workers: principles of treatment (prospective randomized study)].

Introduction: Erectile dysfunction is often a consequence of stressful situations, lack of adequate sleep and rest, and sedentary lifestyles. The profession of locomotive engineer implies the presence of these negative factors, which in addition provoke high blood pressure and the development of hypertension.

Materials And Methods: A total of 85 patients of the urological and therapeutic departments of the "Clinical Hospital "Russian Railways Medicine" in the city of Barnaul", working as locomotive drivers or assistant drivers, were examined.

[Onto-phylogenetic prerequisites for development of chronic cystitis in women].

Introduction: Urinary tract infections (UTIs) are among the most common bacterial infections. At the request "cystitis", there are 12,067 publications in the RSCI system (e.library) as of 10/08/2023 and 16,332 articles were screened in the Pubmed.

[Chronic cystitis: how to prolong the relapse-free period?].

Introduction: Chronic cystitis predominates in the structure of urinary tract infections (UTIs). International guidelines are mainly focused on the treatment of acute uncomplicated cystitis; the approaches for managing patients with chronic cystitis has not been sufficiently developed.

Material And Methods: A total of 91 patients were included in prospective multicenter randomized comparative controlled study.

[Spermoprotective properties of Prostatex in patients with chronic abacterial prostatitis].

Aim: To study the effect of Prostatex therapy on spermatogenesis in patients with infertility that developed due to chronic abacterial prostatitis.

Materials And Methods: A total of 60 men with infertility in marriage and chronic abacterial prostatitis were included in the study. All patients received therapy with Prostatex rectal suppositories 10 mg 1 time per day.

[Combined therapy of patients with recurrent cystitis using a complex of natural antimicrobial peptides and cytokines: first results].

Introduction: Urinary tract infections (UTIs) remain an important problem in urology due to their high prevalence and tendency to relapse. The improvement of the treatment outcomes in chronic cystitis is still relevant.

Material And Methods: A total of 91 patients were included in prospective, multicenter, randomized, comparative, controlled study.

[Spontaneous rupture of kidney tumor. Successful surgical treatment].

A clinical case of spontaneous rupture of the kidney lesion that occurred after physical exercise is presented in the article. During the examination (ultrasound, multi-slice computed tomography of the kidneys), the diagnosis was unclear, and therefore, the patient underwent surgical treatment. Given the risks of complications and impossibility to exclude the malignancy, a decision was made to perform nephrectomy.

[Possibilities of monotherapy with Prostatex in patients with chronic abacterial prostatitis].

Aim: To study the efficiency of the treatment of patients with chronic abacterial prostatitis using the drug Prostatex.

Materials And Methods: A total of 72 patients aged 22 to 43 years with chronic abacterial prostatitis were included in the study. All patients received Prostatex in the form of suppositories 10 mg QD within 20 days.

[Management of lower urinary tract symptoms in patients with benign prostatic hyperplasia during COVID-19. results of an all-russian observational study ATLANT].

Background: COVID-19 aggravates lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH). The optimal treatment regimen for patients with this disease during the COVID-19 pandemic is still under question.

Objectives: The aim of the All-Russian observational study of Afalaza in the Treatment of LUTS in pAtieNTs with BPH during COVID-19 (ATLANT) was to obtain additional data on the efficacy and safety of Afalaza in this patient group.

[Treatment and prevention of chronic cystitis in women].

Aim: to evaluate the efficiency of the dietary supplement NefroBest in women with chronic cystitis.

Materials And Methods: On the basis of the Department of Urology and Nephrology of the Altai State Medical University and the urological department of the NUZ CH "RJD Medicine", Barnaul, from September 2019 to August 2020 a total of 40 women with chronic cystitis were treaeted. Depending on the type of treatment, all women were divided into the main and control groups, each of 20 people.

[Possibilities of using sildenafil in patients with cardiovascular comorbidities who underwent transurethral resection of the prostate].

Aim: To study the efficacy and safety of using sildenafil in patients with erectile dysfunction (ED) and concomitant cardiovascular diseases (CVD) who underwent transurethral resection of the prostate (TURP).

Material And Methods: A total of 59 patients (age from 50 to 75 years) with a diagnosis of benign prostatic hyperplasia (BPH), requiring surgical treatment due to inefficiency of drug therapy, I-PSS score more than 20 points), who were sexually active, but had erectile dysfunction (IIEF score < 21), coronary heart disease (NYHA class I) and stage 1-2 hypertension with stable blood pressure. All patients underwent bipolar TURP.

[The efficiency of combination therapy of non-gonococcal urethritis in men].

Aim: To carry out a comparative assessment of the efficiency of combination therapy for non-gonococcal urethritis (NGU) in men.

Materials And Methods: a total of 124 patients with NGU and laboratory-confirmed urogenital infection were included in the study. The diagnostic methods included microscopy of urethral smear, real-time polymerase chain reaction (PCR) for the detection of uropathogens and laser Doppler flowmetry for evaluating the urethral microcirculation.

[Clinical, morphological and microcirculatory criteria of local recurrence of the prostate cancer after HIFU therapy].

Aim: to study the clinical, morphological and microcirculatory criteria for treatment efficiency and prognosis of local recurrence after HIFU.

Materials And Methods: On the basis of the urological department of Clinical Hospital "Russian Railways - Medicine" in Barnaul (the clinical base of the Department of Urology and Andrology with a course of Specialized Surgery of FGBOU VO "Altai State Medical University") for the period 2011-2018, a comprehensive examination and treatment of 240 patients with prostate cancer (PCa) by means of HIFU using "Ablatherm" was performed following transurethral resection of the prostate (TURP). The indication for HIFU was morphologically-proven PCa (stage T2a-cN0M0) in patients with contraindications due to comorbidities or those who refused from radical prostatectomy.

[Current approaches to the diagnosis of acute cystitis and to evaluation of treatment efficiency].

Introduction: Lower urinary tract infections are common infectious diseases. Although there are international valid questionnaires for evaluating a number of urological diseases (prostatitis, BPH, erectile dysfunction), a unified questionnaire for cystitis was absent until recently. Our aim was to evaluate the efficiency and ease of use of the Acute Cystitis Symptom Score (ACSS) in the daily urological practice.

[Gastroesophageal reflux after laparoscopic hiatal hernia repair in patients with axial hiatal hernia].

Objective: To find out significance of the main locking mechanisms of lower esophageal sphincter in the relapse of GERD in patients with axial hiatal hernia after previous antireflux laparoscopic surgery.

Material And Methods: There were 103 patients with GERD and axial hiatal hernia who underwent original circular laparoscopic esophagofundoplication with correction of hiatal opening dimensions by crural and hiatal repair. Depending on generalized DeMeester index (within the normal range or its excess), all patients were divided into two groups - without relapse (group 1, =88) and with recurrent GERD (group 2, =15).

[Retroperitoneoscopic approach for treatment of acute obstructive calculous pyelonephritis. Alternative or a method of choice?].

Aim: to compare the results of treatment of patients with acute obstructive calculous pyelonephritis, who underwent to retroperitoneoscopic procedure, with patients, who underwent to drainage of the collecting system by means of ureteral stent or nephrostomy tube as the first stage.

Materials And Methods: A total of 121 patients were treated from 2011 to 2019. Of these, 78 patients were included in the main group.

[Actualization of assessment of morphologic features of incisions and chop wounds of 'barrier' tissues of the head].

Aim of this study is to determine the influence of the basic conditions of the traumatic interaction of cutting and chopping objects with 'barrier' tissues of the scalp on the formation of morphological signs of damage. It was suggested to perform the comparative analysis of the morphological signs of incised and chopped scalp tissue wounds obtained by changing one given parameter in experimental damage modeling. The influence of the basic conditions of the traumatic interaction of cutting and chopping objects with the 'barrier' tissues of the scalp on the formation of morphological signs of the resulting damage was determined.

[The influence of proteolytic enzymes on the antioxidant defensive system in infertile married men].

The causes of male infertility remain unclear in 30-75% cases and are considered idiopathic. The study of influence of free oxygen radicals on the male reproductive function is of outmost interest. Given the important role of hyaluronidase in the penetration of sperm into the egg, we decided to evaluate the drug Longidaza, which has long-acting enzymatic (proteolytic) activity.

Hypercapnic hypoxia as a potential means to extend life expectancy and improve physiological activity in mice.

The application of combined hypoxia and hypercapnia (hypercapnic hypoxia) during respiratory exercises results in a maximum increase in resistance to acute hypoxia and ischemic tolerance of the brain. The results of those researches allow the assumption that hypercapnic hypoxia is a promising method for prophylaxis, treatment, and rehabilitation, as well as a means to increase life expectancy. The study was conducted to verify the hypothesis that it is possible to extend the life span through regular courses of respiratory exercises with hypercapnic hypoxia.

[Acute uncomplicated cysititis: do we follow the guidelines?].

Introduction: Lower urinary tract infection are a common urologic disease, but a therapy is not always optimal.

Aim: to evaluate the compliance of prescriptions made by urologists in treatment of patients with lower urinary tract infection, in particular with acute uncomplicated cystitis.

Materials And Methods: A specially designed questionnaire was filled out by 161 urologists from Novosibirsk, Barnaul and Krasnoyarsk, as well as participants of VII Congress of urologists of Siberia.

[The role of presepsin in the estimation of disease severity and assesment the treatment efficiency in patients purulent pyelonephritis].

Aim: to determine the importance of a presepsin plasma level for early identification of urosepsis, assessment the severity and efficiency of therapy.

Material And Methods: From 2017 to 2018 . a prospective controlled randomized cohort study with 32 patients (6 men, 26 women) aged from 20 to 60 years was conducted.

[The preparation of patients with urinary stone disease to extracorporeal shock-wave lithotripsy].

Unlabelled: The treatment of urinary stone disease is one of the most urgent and complex issue in modern urology. Citrate is one of the most important natural urinary inhibitors of stone formation. In this regard, the drugs containing citrate sodium and potassium are being actively used.

[The features of the pathologic changes in chronic oxalate stone disease after 16 week of experimental phase].

Aim: to study the pathologic features of chronic oxalate stone disease.

Materials And Methods: a model of the experimental oxalate stone disease was done in rats that drank the 1% ethylene glycol solution for 16 weeks. The pathologic analysis of the rats kidneys was done.