Doubly Metathetic NiCl-Catalyzed Coupling Between Bis(2-oxazolines) and Aldehydes: A Novel Access to Bis(ester-imine) Derivatives.

The coupling between bis(2-oxazolines) and two equivalents of aromatic aldehydes in the presence of catalytic amounts of NiCl affords an ester-imine product in synthetically useful yields. This virtually unknown, 100% atom-economic transformation involves the formal metathesis between the C=N double bond of the bis(2-oxazoline) moiety, which undergoes ring-opening, and the C=O double bond of the aldehyde. The scope of this transformation is studied, and a mechanism is proposed based on DFT calculations.

Bio-Valorization of Spent Coffee Grounds and Potato Peel as Substrates for Growth.

, due to its saprophytic nature, can extract nutrients and bioactive compounds from the substrate on which it is grown. This study aimed to assess the effect of adding spent coffee grounds (SCG) and potato peel (PPW) in the wheat straw substrate formulation to grow over the production indicators, physicochemical, techno-functional, total chemical compounds, and antioxidant properties. Treatments were described as follows: T1, wheat straw at 100%; T2, wheat straw at 80% + 10% of SCG + 10% of PPW; T3, wheat straw at 70% + 15% of SCG + 15% of PPW; T4, wheat straw at 60% + 20% of SCG + 20% of PPW.

Effect of vitamin K1 supplementation on coronary calcifications in hemodialysis patients: a randomized controlled trial.

Background: Chronic kidney disease (CKD) is associated with several adverse cardiovascular outcomes, including coronary heart disease, heart failure, and arrhythmias. The severity of arterial calcifications predicts the risk of coronary heart disease and increases the risk of premature cardiovascular death. In experimental models, vitamin K1 supplementation appears to reduce coronary artery calcifications.

Comparing the Management Recommendations of Large Language Model and Colorectal Cancer Multidisciplinary Team: A Pilot Study.

Background: Management of anorectal cancers requires a multidisciplinary team approach. Recently, large language models have been suggested as potential tools for various applications in health care.

Objective: Assess suggested management recommendations provided by a generative artificial intelligence chatbot with those of a colorectal cancer multidisciplinary team to evaluate applicability in clinical settings.

Effect of dietary protein on serum hepcidin and iron in adults with obesity and insulin resistance: A randomized single blind clinical trial.

Background And Aims: Both obesity and iron deficiency are public health problems. The association between the two problems could be explained by chronic low-grade inflammation in obesity, which could stimulate hepcidin expression and modify iron concentration that the consumption of high-protein diets could prevent. Thus, this study aimed to compare the effects of high-protein diets with a predominance of animal or vegetable protein on serum hepcidin and iron concentrations in adults with obesity.

Chiral plasmonic Au@Pt nanoparticles for detection of HO and Hg and enantiomeric differentiation.

Chiral Au@Pt nanoparticles (NPs) with optically plasmonic and catalytic active surfaces were sustainably prepared to serve as label-free surface enhanced Raman scattering (SERS) platform to distinguish D- and L-enantiomers of alanine and tartaric acid. Surface morphologies were characterized by high-angle annular dark-field imaging-scanning transmission electron microscopy (HADDF-STEM) and selected area energy diffraction (SAED) patterns. The amounts of Pt on chiral Au NPs were estimated by the inductively coupled plasma-optical emission spectrometer (ICP-OES) and X-ray diffraction (XRD).

[Living with psychotropic drugs: A community photovoice study in people with high treatment adherence in Southeastern Spain].

Adherence to psychopharmacological treatment essentially involves a process of meaning-making. The objective of this study was to explore the experience of people undergoing chronic psychiatric treatment from the patients' perspective. In 2018, using the photovoice methodology, four sessions were conducted with the participation of 11 individuals from a community school in a socially marginalized neighborhood of a southeastern Spanish city, some of whom were also users of a social rehabilitation and integration center and a day center.

Factores sociodemográficos-sanitarios sobre la decisión de interrupción del embarazo, Chile: un análisis de clases latentes.

Objetivo: identificar las características sociodemográficas y/o sociosanitarias comunes de quienes solicitaron prestaciones para la interrupción voluntaria del embarazo (IVE) en Chile mediante un análisis de clases latentes, con el fin de examinar la relación entre estos patrones y la decisión de interrumpir el embarazo.

MÉtodos: análisis de clases latentes a partir de una cohorte retrospectiva basada en registros anonimizados a nivel nacional. Gestantes que solicitaron las prestaciones contempladas en la Ley 21.

Merging mixed reality and computational modeling for enhanced visualization of cardiac biomechanics.

Mixed reality (MR) has the potential to complement numerical simulations for enhanced post-processing and integrate digital models into the daily clinical practice of healthcare professionals. In complex cardiac anatomies, the decision-making process for bioprosthesis implantation involves the challenging analysis of heart valve distribution, positioning, and sealing. This study proposes a framework to visualize computational modeling results in an immersive environment for comprehensive analysis of the geometric implications of implanted devices on human heart function.

Complications of cerebrospinal fluid drainage in thoracoabdominal aortic procedures.

Background: Cerebrospinal fluid (CSF) drainage is used to reduce spinal cord ischemia (SCI) in patients undergoing thoracoabdominal aortic procedures. Recent literature has found high rates of complication associated with CSF drainage, which has led to changes in practice. The aim of this study was to investigate rates of CSF drain-related complications in patients undergoing a thoracoabdominal aortic procedure with perioperative placement of a CSF drain.

Extension patellar engagement index: a new measurement of patellar height.

Introduction: Patellar instability is a multifactorial pathology requiring precise evaluation of its contributing factors, particularly patella alta. Patellotibial height measurement indexes, such as the Caton-Deschamps index, have the disadvantage of being referenced to the tibia. Patellotrochlear indexes are more appropriate but fail to account for variable knee flexion during magnetic resonance imaging (MRI).

PITX2 expression and Neanderthal introgression in HS3ST3A1 contribute to variation in tooth dimensions in modern humans.

Dental morphology varies greatly throughout evolution, including in the human lineage, but little is known about the biology of this variation. Here, we use multiomics analyses to examine the genetics of variation in tooth crown dimensions. In a human cohort with mixed continental ancestry, we detected genome-wide significant associations at 18 genome regions.

Comprehensive analysis of the bacterial spectrum for enhanced clinical insight in microbial ureteral stent colonization, uncomplicated urinary tract infections and catheter-associated urinary tract infections: a principal component analysis-based literature review.

Purpose: Controversies exist regarding the prevailing spectrum of microorganisms in microbial ureteral stent colonization (MUSC) and their clinical significance. The aim of this comprehensive review is to determine the predominant microbial spectrum in patients with an indwelling ureteral stent in comparison to catheter-associated urinary tract infections (CAUTI) and uncomplicated urinary tract infections (UTI).

Methods: Google scholar, PubMed, Embase, Medline, and Cochrane literature databases were searched from inception to April 2022 to identify manuscripts on MUSC, uncomplicated UTI and CAUTI.

Uncommon presentation of an acute appendicitis caused by Enterobius vermicularis in an adult.

Enterobius vermicularis is the most common parasitic infection in temperate and cold climates, affecting populations in both developing and developed countries. Although typically asymptomatic, it can lead to acute appendicitis, a relationship that has been a subject of debate. Therefore, we present a case of acute appendicitis induced by E.

[High blood pressure and associated lifestyles in an urban population in Argentina].

Introduction: The American Heart Association (AHA/ACC) sets as a goal for blood pressure (BP) control not to exceed values of 130/80 mmHg, both in individuals with and without a diagnosis of hypertension (HT), standards not evaluated so far in the Argentine population. The objective was to determine the prevalence of high BP (HBP) in individuals with and without a diagnosis of HT taking into account the AHA/ACC criteria and to evaluate its association with sociodemographic and lifestyle factors.

Materials And Methods: Cross-sectional populationbased study in 911 persons >18 years of age in Córdoba, Argentina (period 2020-2022).

Comparing Patellofemoral Kinematics Assessed With a Novel Muscle Actuator System and an Oxford Rig Using Noncadaveric Knees.

Total knee replacement (TKR) failure, low patient satisfaction and high revision surgery rates may stem from insufficient preclinical testing. Conventional joint motion simulators for preclinical testing of TKR implants manipulate a knee joint in force, displacement, or simulated muscle control. However, a rig capable of using all three control modes has yet to be described in literature.

Recent Plasmonic Gold- and Silver-Assisted Raman Spectra for Advanced SARS-CoV-2 Detection.

COVID-19 has become one of the deadliest epidemics in the past years. In efforts to combat the deadly disease besides vaccines, drug therapies, and facemasks, significant focus has been on designing specific methods for the sensitive and accurate detection of SARS-CoV-2. Of these, surface-enhanced Raman scattering (SERS) is an attractive analytical tool for the identification of SARS-CoV-2.

and analyses of a novel variant in 6 identified in a family with postlingual non-syndromic hearing loss from Argentina.

Hereditary hearing loss stands as the most prevalent sensory disorder, with over 124 non-syndromic genes and approximately 400 syndromic forms of deafness identified in humans. The clinical presentation of these conditions spans a spectrum, ranging from mild to profound hearing loss. The aim of this study was to identify the genetic cause of hearing loss in a family and functionally validate a novel variant identified in the 6 gene.

Imlunestrant with or without Abemaciclib in Advanced Breast Cancer.

Background: Imlunestrant is a next-generation, brain-penetrant, oral selective estrogen-receptor (ER) degrader that delivers continuous ER inhibition, even in cancers with mutations in the gene encoding ERα ().

Methods: In a phase 3, open-label trial, we enrolled patients with ER-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer that recurred or progressed during or after aromatase inhibitor therapy, administered alone or with a cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor. Patients were assigned in a 1:1:1 ratio to receive imlunestrant, standard endocrine monotherapy, or imlunestrant-abemaciclib.

Synthesis, characterization, biological activities, and computational studies of pyrazolyl-thiazole derivatives of thiophene.

This study reports the synthesis, characterization, and biological evaluation of a series of pyrazolyl-thiazole derivatives of thiophene. Seven compounds were synthesized and characterized using NMR spectroscopy and mass spectrometry. The antimicrobial activities of these derivatives were evaluated against various bacterial (, , , ) and fungal strains (, , , ), demonstrating significant inhibition zones and low minimum inhibitory concentrations (MIC).