4,203 results match your criteria: "Alloimmunization From Transfusions"
BMC Pregnancy Childbirth
December 2024
Immunology LATAM, Janssen, Mendoza, Buenos Aires, CP (1428), 1259, Argentina.
Background: Hemolytic disease of the fetus and newborn (HDFN) is a condition due to maternal blood group antibodies targeting antigens in fetal red blood cells, with significant prenatal/perinatal morbidity and mortality. Severe HDFN cases are often associated with alloimmunization against Rhesus D (RhD) or Kell antigens. Information about HDFN epidemiology and treatment in Latin American countries is limited.
View Article and Find Full Text PDFInt J Hematol Oncol Stem Cell Res
October 2024
Department of Immunology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Human platelet antigens (HPAs) play a clinically significant role in alloimmunization and the development of immune-mediated disorders such as immune thrombocytopenia (ITP), fetal and neonatal alloimmune thrombocytopenia (FNAIT), and post-transfusion purpura (PTP). Understanding the genetic profiles of HPAs is critical for preventing and treating these conditions. Given the limitations of serological methods in determining HPA genotypes, this study aims to investigate the association between the genotypes of HPA1, HPA2, HPA3, HPA4, and HPA15 antigens and autoimmune thrombocytopenia in Lorestan Province, utilizing the PCR-SSP method.
View Article and Find Full Text PDFTransfusion
December 2024
Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Background: In 2010, Denmark was the first country to implement a targeted routine antenatal anti-D prophylaxis (tRAADP) program, offering fetal RHD genotyping to all nonimmunized D negative pregnant women. The program represented a shift from only postnatal prophylaxis to a combined antenatal and postnatal prophylaxis. This study aimed to evaluate the clinical effect of tRAADP in Denmark.
View Article and Find Full Text PDFAm J Transplant
December 2024
Centre for Inflammatory Disease, Department of Immunology and Inflammation, Imperial College London, Hammersmith Campus, Du Cane Road, LondonW12 0NN; Imperial College Renal and Transplant Centre, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, W12 0HS. Electronic address:
It is widely accepted that blood transfusions can cause allosensitisation, but it is often reported that new HLA antibodies are non-specific and transient. This study explores the effect of blood transfusion on allosensitisation in waitlisted transplant patients including the development of transfusion specific antibodies (TSAs), whilst they remain on the waiting list and longitudinally following subsequent transplantation. A total of 105 blood donors of transfusions received by 50 patients on the transplant waiting list were HLA typed.
View Article and Find Full Text PDFCureus
November 2024
Pathology and Laboratory Medicine, University of South Alabama College of Medicine, Mobile, USA.
The anti-M antibody is a cold, naturally occurring immunoglobulin M (IgM) antibody that is generally considered clinically insignificant and often overlooked in transfusion practices and assessments of patients at risk for hemolytic disease of the fetus and newborn (HDFN). However, the presence of an IgG component in this case renders the antibody clinically significant, underscoring the necessity for proper serologic testing during prenatal evaluations. We present a case involving an anti-M antibody with an IgG component to highlight the critical importance of thorough serologic testing during prenatal testing.
View Article and Find Full Text PDFFront Immunol
December 2024
Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Exposure to allogenic red blood cells (RBCs), either through pregnancy or transfusion, can result in alloimmunization, which can lead to severe hemolytic transfusion reactions and pregnancy complications. Passively administered antibodies can be used to prevent alloimmunization, where steric hindrance of allogeneic epitopes has been postulated as one mechanism whereby antibody engagement may prevent RBC alloimmunization. However, the dynamics of antibody engagement on the RBC surface has remained difficult to study.
View Article and Find Full Text PDFTransfus Med Hemother
December 2024
Department of Blood Transfusion, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Background: Erythrocyte alloantibodies and autoantibodies complicate transfusion. However, the prevalence of erythrocyte alloimmunization and autoimmunization has not been estimated in the Chinese pediatric population. Therefore, we investigated the prevalence of erythrocyte alloimmunization and autoimmunization in the Chinese pediatric population with the aim of developing a reasonable transfusion management policy in children from China.
View Article and Find Full Text PDFBackground: The ABO, Rh, and Kell blood groups are the most immunogenic and clinically important blood antigens. These antigens can trigger strong immune responses after blood transfusions, leading to alloimmunization and post-hemolytic transfusion reactions. The aim of this study was to determine prevalence of ABO, Rh, and Kell blood group antigens at the Al-Qurayyat Regional Laboratory and Blood Bank Center, Al-Qurayyat region, Saudi Arabia.
View Article and Find Full Text PDFTrauma Surg Acute Care Open
December 2024
Donald D Trunkey Center for Civilian and Combat Casualty Care, Oregon Health and Science University, Portland, Oregon, USA.
J Perinatol
December 2024
Women and Children's Services, Providence Health and Services, Portland, OR, USA.
Maternal alloimmunization to paternal blood group antigens is the underlying cause of hemolytic disease of the fetus and newborn. Alloantibodies to the major, clinically significant blood group antigens are readily identified by the blood bank which, in turn, allows for appropriate monitoring of the maternal-fetal unit. However, uncommon blood group antibodies, particularly those directed against low and high prevalence antigens, present a more formidable challenge for obstetricians, neonatologists, and transfusion medicine specialists.
View Article and Find Full Text PDFTransfus Apher Sci
December 2024
Department of Hematology, Shanghai Sixth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine, China.
Background: Patients with myelodysplastic syndrome (MDS) are characterized by chronic anemia and most of them require transfusion making them prone to developing transfusion dependence (TD) and inducing red blood cell (RBC) alloimmunization. Little information is available regarding the status of transfusions of MDS patients in China.
Materials And Methods: Clinical history and transfusion information of MDS transfusion patients from 2004 to 2023 were collected from electronic medical and laboratory records.
Transfus Med
December 2024
Department of Immunology and Transfusion Medicine, Oslo University Hospital, Oslo, Norway.
Transfusion
December 2024
Transfusion Medicine, Héma-Québec, Montréal, Québec, Canada.
Br J Haematol
December 2024
Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Transfusion
November 2024
Institute of Transfusion Medicine, University Hospital Schleswig-Holstein, Lübeck/Kiel, Germany.
Vaccines (Basel)
October 2024
Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
J Pers Med
November 2024
Department of Pediatric Oncology and Hematology, Institute of Pediatrics, Jagiellonian University Medical College, 30-663 Krakow, Poland.
Ann Hematol
November 2024
Center for Postgraduate Education and Training, National Center for Child Health and Development (NCCHD), 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.
Int J Gen Med
November 2024
Consultant Molecular Biologist, Bristol, UK.
Anaesthesiologie
December 2024
Klinik und Poliklinik für Anästhesiologie, Intensivmedizin, Notfallmedizin und Schmerztherapie, Universitätsklinikum Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Deutschland.
Br J Haematol
November 2024
NHS Blood and Transplant, Oxford, UK.
Am J Perinatol
November 2024
Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California.
Neonatology
November 2024
Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada.
Rev Colomb Obstet Ginecol
September 2024
Unidad de Medicina Materno Fetal, Clínica Del Prado, Universidad CES. Medellín (Colombia); Fundared Materna. Bogotá (Colombia).