2 results match your criteria: "Allegheny University of the Health Sciences Pittsburgh[Affiliation]"

Gabapentin. Antiepileptic mechanism of action.

Neuropsychobiology

October 1998

Center for Neurosciences Research, Allegheny University of the Health Sciences Pittsburgh, PA 15212-4772, USA.

Gabapentin is an antiepileptic drug used in the treatment of partial and generalized tonic-clonic seizures. Its antiepileptic mechanism of action is not known. The transport of gabapentin across membranes and its demonstrated effects on voltage-gated ion channels (sodium, calcium), presynaptic mechanisms that can enhance GABAergic inhibition, and ligand-gated ion channels (GABA receptors and glutamate receptors) are reviewed.

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