3,313 results match your criteria: "Allegheny General Hospital[Affiliation]"

Social media provides platforms for transplant infectious diseases (TIDs) clinicians to network, exchange ideas, and educate each other and the broader public. A #TxIDChat on the social media platform X was conducted on the perceptions of social media in TID by the account @TxID_Fellows. This article examines the current usage of social media by TID clinicians, and its role in education, patient outreach, and networking.

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Human granulocytic anaplasmosis (HGA) is transmitted by the black-legged tick and presents with fever, thrombocytopenia, leukocytopenia, and elevated transaminases. If left untreated, HGA can progress to hemophagocytic lymphohistiocytosis (HLH), which can be fatal. Here, we discuss a case of a woman diagnosed with anaplasmosis who was treated promptly.

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Uniportal video-assisted lung resection versus robotic-assisted lung resection, is there a difference?

J Thorac Dis

November 2024

Department of Thoracic and Cardiovascular Surgery, Division of Thoracic and Esophageal Surgery, Allegheny General Hospital, Pittsburgh, PA, USA.

Background: There has been increasing adoption of robot-assisted thoracic surgery (RATS) and uniportal video-assisted thoracic surgery (uVATS) for lung resection. We undertook a single-institution retrospective study, comparing these approaches.

Methods: An analysis was performed of patients who underwent lung resection by either uVATS or RATS.

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Introduction: Rupture of the flexor carpi radialis (FCR) tendon is a rare phenomenon that is often described in the setting of rheumatoid arthritis or following trauma. Pseudotendon formation is seen commonly among extensor tendons of the antebrachium, typically as a sequelae of traumatic injury, spontaneous rupture in rheumatism, or postoperatively. Less frequent is the presence of pseudotendon in flexor tendons of the forearm.

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Introduction: Bone Marrow Lesions (BMLs) have a strong correlation to patient reported pain, functional limitations, joint deterioration, and rapid progression to total knee arthroplasty. The Subchondroplasty® (SCP) Procedure uses AccuFill®, a calcium phosphate bone substitute material (BSM), to treat bone defects such as microtrabecular fractures and BML.

Methods: This observational, prospective, multicenter, cohort study evaluated the effect of the SCP Procedure at two-year follow-up for 70 patients with knee BML.

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Hypertrophy of the Annular Ligament as a Cause of Painful Elbow Snapping: Case Report and Literature Review.

Orthop Nurs

December 2024

Tommy Pan, MD, Department of Orthopaedics, Allegheny General Hospital, Allegheny Health Network Medical Education Consortium, Pittsburgh, PA.

Article Synopsis
  • * A case study of a 37-year-old male showed that after 5 years of persistent elbow pain and an MRI confirming the condition, the patient underwent surgery for both the hypertrophied ligament and lateral epicondylitis, resulting in complete symptom relief.
  • * The text underscores the importance of recognizing this condition to facilitate early surgical intervention, preventing further joint damage, and aims to enhance awareness among nurses and hand surgeons regarding its diagnosis and treatment.
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Background Context: Cervical Disc Arthroplasty (CDA) has been shown to be an effective and safe alternative to Anterior Cervical Discectomy and Fusion (ACDF), with randomized controlled trials (RCTs) reporting non-inferior or even favorable outcomes to ACDF. However, the current literature of large RCTs reporting long-term outcomes of CDA primarily comprises of the industry sponsored Food and Drug Administration (FDA) Investigational Device Exemption (IDE) trials. As a result, CDA has yet to be universally accepted by surgeons due to concerns of bias in the current literature.

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  • Systemic Epstein-Barr virus-positive T-cell lymphoma (TCL) in children is rare and often follows an EBV infection, leading to a hyperinflammatory state and poor outcomes, often presenting with hemophagocytic lymphohistiocytosis (HLH) syndrome.
  • The disorder involves a hyperactive immune response and may be linked to genetic alterations on chromosome 22q11.2, increasing the risk of non-Hodgkin lymphoma later in life.
  • A case study of a 21-year-old male who developed HLH from an EBV infection ultimately resulted in a diagnosis of systemic EBV TCL, and despite treatment, he did not survive before receiving a stem cell transplant, highlighting the need for awareness
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Article Synopsis
  • - The patient, a cardiac transplant recipient, experienced symptoms of right eye pain and blurry vision.
  • - Upon investigation, she was diagnosed with intracardiac aspergilloma that affected her pericardium, alongside complications like endogenous endophthalmitis and an acute heart attack.
  • - Treatment included a mechanical debulking procedure using the Angiovac system to address the aspergilloma.
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Pharmacogenetics promises to optimize treatment-related outcomes by informing optimal drug selection and dosing based on an individual's genotype in conjunction with other important clinical factors. Despite significant evidence of genetic associations with drug response, pharmacogenetic testing has not been widely implemented into clinical practice. Among the barriers to broad implementation are limited guidance for how to successfully integrate testing into clinical workflows and limited data on outcomes with pharmacogenetic implementation in clinical practice.

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Background: () is associated with the development of gastrointestinal disorders ranging from gastritis to gastric cancer. The evidence of the association between metabolic dysfunction-associated steatohepatitis (MASH) and infection in the literature is scarce. Therefore, we aim to evaluate the risk of developing MASH in patients who have had a diagnosis of infection independently of any confounding variables.

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  • A study called PEERLESS compared two catheter methods, large-bore mechanical thrombectomy (LBMT) and catheter-directed thrombolysis (CDT), for treating intermediate-risk pulmonary embolism (PE) in 550 patients, focusing on various health outcomes.
  • The results showed that LBMT led to fewer complications and less need for intensive care compared to CDT, including lower rates of clinical deterioration and ICU admissions.
  • Although LBMT had better short-term outcomes, there were no significant differences in mortality or major bleeding between the two treatment methods after 30 days.
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Introduction: An abdominal aortic aneurysm (AAA) is a dilation localized in the infrarenal segment of the abdominal aorta that can expand continuously and rupture if left untreated. Computational methods such as finite element analysis (FEA) are widely used with in silico models to calculate biomechanical predictors of rupture risk while choosing constitutive material properties for the AAA wall and intraluminal thrombus (ILT).

Methods: In the present work, we investigated the effect of different constitutive material properties for the wall and ILT on 21 idealized and 10 unruptured patient-specific AAA geometries.

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Article Synopsis
  • - The study analyzed the OXYGEN trial, which compared high levels of oxygen (80% FiO2) vs. lower levels (30% FiO2) for preventing infections in patients with specific types of fractures and aimed to see if using an "as-treated" approach changed the results compared to the "intention-to-treat" method.
  • - Conducted at 29 trauma centers, 1,231 patients with tibial plateau, tibial pilon, or calcaneus fractures were randomly assigned to either oxygen treatment; adherence was evaluated using two specific criteria based on the percentage of surgery time at different oxygen levels.
  • - Results showed no significant differences in primary and deep infection rates, but the treatment group had fewer
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Background: Microscopic colitis is a relatively new diagnosis that was first described in the 1980s. Patients usually present with chronic watery and non-bloody diarrhea and are typically characterized by an unremarkable gross appearance of the colon on lower endoscopy while having evidence of lymphocytic infiltration of the lamina propria and the epithelium on histology. Two subtypes have been described in the literature: Collagenous colitis, with marked thickening of the subepithelial layer, and Lymphocytic colitis.

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The objective of this analysis was to compare clinician-based and formally calculated risk assessments by REVEAL Lite 2 and COMPERA 2.0 and to characterize parenteral prostacyclin utilization within 90 days of baseline in high-risk patients. A multisite, double-blind, retrospective chart review of patients with pulmonary arterial hypertension (PAH) was conducted with an index period of January 2014-March 2017.

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  • Incidental durotomy (ID) is a common issue in spine surgeries that can lead to longer hospital stays and complications like pseudomeningocele formation, prompting a study comparing traditional open vs. minimally invasive (MIS) microdiscectomy techniques.
  • The study included 192 MIS patients and 2902 open surgery patients, ultimately analyzing 156 matched patients from both groups for ID occurrences and complications.
  • Results showed a similar incidence rate of ID in both methods (3.1% total), with one re-operation in the open cohort for pseudomeningocele, but no significant difference in re-operation rates between the two groups, highlighting the need for more extensive future research.
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Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) is a rare hematologic cancer, accounting for less than 1% of acute leukemias in the U.S. Diagnosis involves detecting markers like CD123, CD4, CD56, TCL1, and TCF4.

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  • Historically, women with aortic stenosis have been underdiagnosed and faced worse outcomes compared to men, leading to the need for better treatment recognition and participation in clinical trials.
  • The SMART trial aimed to compare the clinical and hemodynamic outcomes of women with small aortic annuli receiving either self-expanding valves (SEVs) or balloon-expandable valves (BEVs) during transcatheter aortic valve replacement.
  • In a study of 621 women, no significant differences were observed in the main clinical outcomes between the SEV and BEV groups after 12 months, but SEVs showed a lower rate of bioprosthetic valve dysfunction.
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  • Proximal femoral replacement (PFR) is a surgical technique used after tumor removal or failed hip replacements, but the risk of prosthetic instability is higher when there’s significant bone or soft tissue loss.
  • This study analyzed the outcomes of PFR among 106 patients over 15 years, categorizing them by the type of implant used: bipolar, constrained, or dual mobility.
  • Results showed that dual mobility implants had a longer time to dislocation and that smoking history and BMI differed among the groups, but all types had similar rates of early dislocation overall.
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P-15 is a 15-amino-acid-long biomimetic peptide widely demonstrated to enhance osteogenesis in vivo. Despite the prevalence of polyether-ether-ketone (PEEK) in interbody device manufacturing, a growing body of evidence suggests it may produce an unfavorable immune response. The purpose of this preliminary study was to characterize the immune response and new bone growth surrounding PEEK implants with and without a P-15 peptide-based osteobiologic.

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Dual-frame transcatheter mitral valve replacement has emerged over the last decade as an alternative to mitral valve surgery in patients with severe mitral regurgitation, especially in the presence of prohibitive operative risk. This paper presents a case of massive superinfected thrombosis of the Tendyne valve tether along with its risk factors, diagnosis, and management.

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Article Synopsis
  • The study investigates the link between hospital volumes for aortic valve replacement (AVR) surgeries—either transcatheter (TAVR) or surgical (SAVR)—and patient outcomes, specifically in-hospital mortality and 30-day readmission rates.
  • It classified hospitals based on their procedural volumes and analyzed data from over 72,000 patients across 400 U.S. hospitals, finding that higher hospital volumes are associated with lower in-hospital mortality but do not affect 30-day readmissions.
  • The conclusions suggest that patients with aortic stenosis have better outcomes when treated in high-volume hospitals that perform both TAVR and SAVR procedures frequently.
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