Stomach and duodenal ulcer as a cause of death in patients with cancer: a cohort study.

Introduction: Non-cancer deaths are now becoming a significant threat to the health of cancer patients. Death from stomach and duodenal ulcer is linked to cancer due to the side effects of treatment and its pathogenesis. However, guidelines for identifying cancer patients at the highest risk of death from stomach and duodenal ulcer remain unclear.

Cataract surgical coverage in Indian population aged 50 years and above.

Objectives: The objectives of the study were to obtain the current estimates of cataract surgical coverage (CSC) at varying thresholds of vision and gender variations across districts in diverse Indian populations aged ≥50 years.

Methods: Data collected from the national blindness survey from 31 Indian districts between 2015 and 2019 were analyzed. CSC at varying thresholds of presenting visual acuity <3/60, <6/60, and <6/18 were estimated along with gender variations across districts in population ≥50 years of age.

"Chasing Rainbows" Beyond Kaposi Sarcoma's Dermoscopy: A Mini-Review.

The dermoscopic rainbow pattern (RP), also known as polychromatic pattern, is characterized by a multicolored appearance, resulting from the dispersion of polarized light as it penetrates various tissue components. Its separation into different wavelengths occurs according to the physics principles of scattering, absorption, and interference of light, creating the optical effect of RP. Even though the RP is regarded as a highly specific dermoscopic indicator of Kaposi's sarcoma, in the medical literature, it has also been documented as an atypical dermoscopic finding of other non-Kaposi skin entities.

DEEP LEARNING-BASED FRAMEWORK TO DETERMINE THE DEGREE OF COVID-19 INFECTIONS FROM CHEST X-RAY.

The corona virus disease-19 (COVID-19) epidemic, the whole globe is suffering from a medical condition catastrophe that is unprecedented in scale. As the coronavirus spreads, scientists are worried about offering or helping in the supply of remedies to preserve lives and end the epidemic. Artificial intelligence (AI), for example, has occurred altered to deal with the difficulties raised by pandemics.

Micronutrient status and associated factors of anemia among undernourished children of 5-18 years: First study from Himalayan foothills.

Purpose: Undernutrition in children is a critical worldwide concern that hampers both their physical and cognitive growth. The nutritional status of school-going children and adolescents remains insufficiently addressed with no comprehensive data. This is the first study from the Himalayan foothills that aims to assess the clinical and laboratory aspects of anemia with micronutrient status in undernourished children above the age of five along with association of clinical features with anemia severity.

Correlating symptom severity index, clinical diagnostic criteria of CTS-6 and timed Phalen's test in clinical evaluation of carpal tunnel syndrome.

Background: Carpal Tunnel Syndrome (CTS) poses significant diagnostic challenges, especially in resource-limited settings. Reliable tools such as the 6-item Symptom Severity Index, Timed Phalen's Test (TPT) and CTS-6 are promising but under investigated. Correlation between these tools and symptom severity remains underexplored.

A study of clinical profile and outcome of patients with snake bite-induced acute kidney injury.

Background: Snake bite is a well-known occupational hazard amongst farmers, plantation workers, and other outdoor workers and results in much morbidity and mortality throughout the world. The complications related to kidneys are observed in most patients with snake bites admitted to a hospital. The current study aimed to study the renal involvement in patients with snake bites with reference to clinical features and the time of onset of acute renal failure.

Neuropsychiatric complications in chronic kidney disease: Role of gender, clinical, and sociodemographic factors.

Introduction: Patients with chronic kidney disease (CKD) frequently experience neuropsychiatric conditions, such as depression, anxiety, and cognitive impairment, which not only significantly diminish their quality of life, but also contribute to longer hospitalizations, poor treatment adherence, and increased mortality. This hospital-based cross-sectional study aimed to investigate neuropsychiatric complications in CKD patients, focusing on gender differences, and clinical and other sociodemographic factors.

Materials And Methods: Diagnosis of CKD was based on the Kidney Disease: Improving Global Outcomes (KDIGO) criteria, and patients aged 18 years or above were included.

Which antidiabetic drugs do patients of T2DM prefer in India and why? A discrete choice experiment.

Background: Uncontrolled diabetes persists despite guideline-based treatment, partly attributed to inadequate patient involvement. This research addresses shared decision-making by eliciting patient preferences in Type 2 Diabetes Mellitus (T2DM) treatment based on certain key attributes and explores their correlation with socio-demographic-clinical profiles.

Methods: A discrete choice experiment (DCE) was conducted among T2DM outpatients in an Indian tertiary care center.

Dermoscopy of syphilitic chancre: Report of five cases.

Dermoscopy is a non-invasive tool which helps in the visualization of skin structures and patterns not visible to the naked eye. This study evaluates the effectiveness of dermoscopy in diagnosing primary syphilis, which typically presents as a painless ulcer at the site of inoculation. In this study, dermoscopic patterns such as vascular structures and background colour changes were analyzed in patients with confirmed primary syphilis.

Comparison of Phenylephrine Bolus and Infusion Regimens on Maternal and Fetal Outcomes During Cesarean Delivery: A Systematic Review and Meta-Analysis.

Background: A systematic review and meta-analysis was conducted to compare phenylephrine boluses versus prophylactic infusion in parturients undergoing cesarean delivery under spinal or combined spinal-epidural anesthesia on feto-maternal outcomes.

Methods: Medline, Embase, Cochrane, and US Clinical registry databases were searched. Studies comparing phenylephrine boluses (both therapeutic and prophylactic) with infusion (both fixed- and variable-rate) assessing various feto-maternal outcomes were included.

Disruption of Molecular Interactions between the G3BP1 Stress Granule Host Protein and the Nucleocapsid (NTD-N) Protein Impedes SARS-CoV-2 Virus Replication.

The Ras GTPase-activating protein SH3-domain-binding protein 1 (G3BP1) serves as a formidable barrier to viral replication by generating stress granules (SGs) in response to viral infections. Interestingly, viruses, including SARS-CoV-2, have evolved defensive mechanisms to hijack SG proteins like G3BP1 for the dissipation of SGs that lead to the evasion of the host's immune responses. Previous research has demonstrated that the interaction between the NTF2-like domain of G3BP1 (G3BP1) and the intrinsically disordered N-terminal domain (NTD-N) of the N-protein plays a crucial role in regulating viral replication and pathogenicity.

Histopathological changes in various organs in electrocution deaths.

Death due to electrical injuries are a major health concern and has a high rate of morbidity and mortality. Electrocution death is defined as that occurring due to passage of electric current inside the body and is obviously a form of unnatural death. The cause includes ventricular fibrillation, paralysis of respiratory muscles and the central respiratory centre.

Transduction of Human Fetal Liver Hematopoietic CD34+ Stem and Progenitor Cells into a Cell Line by Enhancing Telomerase Activity.

: Human fetal liver hematopoietic stem cells have proven potential as therapeutics but lack extensive research due to their limited supply. Even expanded fetal liver hematopoietic stem cells enter senescence or lose their self-renewal capacity after a few days in culture. The present study aimed to obtain a homogeneous and persistent supply of hematopoietic stem cells from the fetal liver by establishing a cell line through immortalization of cells by enhancing telomerase activity.

Limb salvage in Christmas disease masquerading as fungating aneurysmal bone cyst.

A boy in middle childhood presented with complaints of swelling and pain in his right forearm for 4 months. He had previously undergone left above-elbow amputation due to a suspected malignant tumour in that arm. Radiological imaging revealed a locally aggressive bone tumour of the right distal radius.

Research trends on AI in breast cancer diagnosis, and treatment over two decades.

Objective: Recently, the integration of Artificial Intelligence (AI) has significantly enhanced the diagnostic accuracy in breast cancer screening. This study aims to deliver an extensive review of the advancements in AI for breast cancer diagnosis and prognosis through a bibliometric analysis.

Methodology: Therefore, this study gathered pertinent peer-reviewed research articles from the Scopus database, spanning the years 2000 to 2024.

Prospective Analytical Case-Control Study of COVID-19 Positive Versus Negative Patients for Subclinical Placental Dysfunction.

Background & Objective: Placenta provides nutrition and protection from various infections and toxins to the baby while they are in the mother's womb. The present study was done to see the effects of coronavirus infection on the placenta of infected mothers and the final pregnancy outcome.

Methods: A total of 50 antenatal women (25 infected with coronavirus and 25 uninfected women) were enrolled and their placentae were examined for any significant histopathological changes.

Determinants of tumor necrosis and its impact on outcome in patients with Localized osteosarcoma uniformly treated with a response adapted regimen without high dose Methotrexate- A retrospective institutional analysis.

Purpose: Response to neoadjuvant chemotherapy in form of tumor necrosis predicts outcome in osteosarcoma; although response-adapted treatment escalation failed to improve outcome among patients treated with high-dose methotrexate-based (HDMTx) chemotherapy. This study aimed to identify factors predicting tumor necrosis and its impact on survival among patients with non-metastatic osteosarcoma treated with a response-adapted non-HDMTx regimen.

Methods: A retrospective single-institutional study was conducted among non-metastatic osteosarcoma patients treated with neoadjuvant therapy between 2004-2019.

Trimethylamine N-oxide in cardiovascular disease: Pathophysiology and the potential role of statins.

Cardiovascular diseases are one of the leading causes of mortality and morbidity worldwide, with the total number of cases increasing to 523 million in 2019. Despite the advent of new drugs, cardiovascular mortality has increased at an alarming rate of 53.7 % from 12.