Celiac Crisis: A Life-Threatening Complication of Celiac Disease.

Celiac disease (CD) is an immune-mediated enteropathy with varied systemic involvement and association with increased morbidity and mortality. Strong clinical suspicion is the key, and diagnosis is made using histopathology and serology. Though the consumption of a strict gluten-free diet can improve symptoms and limit mucosal damage, curative therapy is still lacking.

Pulmonary Aspiration Syndromes: An Imaging-based Review.

The term "aspiration" describes lung injury that results from unintentional passage of contents other than air into the lungs and bronchial tree, commonly from the gastrointestinal and upper respiratory tracts. Only a small proportion of aspiration-related events are symptomatic, especially in predisposed individuals such as patients with diminished consciousness, impaired swallowing, oesophageal motility disorders, and reflux disease. Aspiration-related syndromes can be classified based on the onset of presentation, composition of the aspirated substance, and anatomic site of injury.

Meta-analysis of longitudinal comparison of transcatheter versus surgical aortic valve replacement in patients at low to intermediate surgical risk.

Background: Surgical aortic valve replacement (SAVR) is the commonly used approach for aortic valve replacement (AVR) in patients with aortic stenosis at low or intermediate surgical risk. However, transcatheter aortic valve replacement (TAVR) has emerged as an alternative to SAVR for AVR. This meta-analysis aims to assess the comparative efficacy and safety of TAVR versus SAVR in low-to-intermediate surgical risk patients by analyzing temporal trends in the outcomes of TAVR and SAVR at various follow-up intervals, providing a more detailed understanding.

Trends and disparities in age, sex, ethnoracial background, and urbanization status in adult mortality due to thoracic aortic aneurysm: a retrospective nationwide study in the United States.

Introduction: Thoracic aortic aneurysms (TAA) are a significant health concern, with the true prevalence likely underestimated due to undiagnosed cases. Outcomes in TAA are influenced by factors like age, sex, and comorbidities such as hypertension. This study examines mortality trends and disparities associated with TAA in US adults.

Comparative evaluation of PD-L1 expression and tumor immune microenvironment in molecular subtypes of muscle-invasive bladder cancer and its correlation with survival outcomes.

Objectives: Immune checkpoint inhibitors have revolutionized treatment of platinum-refractory advanced bladder cancer, offering hope where options are limited. Response varies, however, influenced by factors such as the tumor's immune microenvironment and prior therapy. Muscle-invasive bladder cancer (MIBC) is stratified into molecular subtypes, with distinct clinicopathologic features affecting prognosis and treatment.

Optimizing costs and sustainability for gamma knife radiosurgery: A cost and breakeven analysis at India's largest neurosurgery centre.

Background: Establishing and maintaining gamma knife facility incurs significant costs, mandating healthcare institutions to meticulously assess financial implications for sustainability.

Methods: This study explores the financial implications of setting up and operating a Gamma Knife facility, with an aim to ascertain user charges for achieving breakeven. The study was conducted from January to June 2019 at the largest neurosurgery centre of an Institute of National Importance (INI), in Delhi, India.

Pulmonary Dysfunction in Children with Dystrophinopathy: A Cross-Sectional Study.

Objectives: To observe the prevalence of impaired pulmonary function during various phases of the disease course in children aged 5-18 y with dystrophinopathy. The correlation between different parameters of pulmonary dysfunction and motor function was also studied.

Methods: One hundred and thirty-three confirmed cases of Duchenne muscular dystrophy (DMD), fulfilling predefined inclusion and exclusion criteria were evaluated.

Navigating Work and Breastfeeding: A Qualitative Exploration of Breastfeeding Experiences among Nurses and Support Staff in South India.

Objective: The personal experiences of breastfeeding healthcare workers may influence the quality of breastfeeding support provided. This study explored the breastfeeding experiences of nurses and support staff in South India. Materials and Methods: A qualitative exploratory study using focus group discussions (FGDs) was conducted among nurses and support staff of a newly established tertiary care hospital in South India.

Decoding Monogenic Hypertension: A Review of Rare Hypertension Disorders.

Hypertension is a growing concern worldwide, with increasing prevalence rates in both children and adults. Most cases of hypertension are multifactorial, with various genetic, environmental, socioeconomic, and lifestyle influences. However, monogenic hypertension, a blanket term for a group of rare of hypertensive disorders, is caused by single-gene mutations that are typically inherited in an autosomal dominant fashion, and ultimately disrupt normal blood pressure regulation in the kidney or adrenal gland.

Mechanical Thrombectomy for Acute Ischemic Stroke in Nonagenarians: A Dilemma in Treatment Approach.

Stroke is one of the major causes of mortality and morbidity, particularly among the elderly population. As the general population ages, cerebrovascular disease is anticipated to increase in prevalence. Strokes can manifest as either hemorrhagic or ischemic events.

A Phase III, Double-Blind, Randomized, Multicenter, Clinical Trial to Evaluate the Efficacy and Safety of a Fixed-Dose Combination of Metformin Hydrochloride and Myo-Inositol Compared to Metformin in Patients With Polycystic Ovary Syndrome.

Background Polycystic ovary syndrome (PCOS) poses a significant health concern among reproductive-aged women and is characterized by ovarian dysfunction, hyperandrogenism, and insulin resistance. This study aims to assess the efficacy and safety of metformin and myo-inositol combination therapy compared to metformin monotherapy in patients with PCOS. Materials and methods This was a phase III, double-blind, randomized controlled clinical trial.

Turning Your Presentations/Posters to Publications.

A scientific manuscript or paper is invariably the ultimate goal of most scientific endeavors and in a majority of cases, the final manuscript often begins as an abstract submitted to a conference to be presented as either a poster or an oral presentation. It is practically possible for authors to use a conference presentation as a basic template to expand and write a complete manuscript. However, it is imperative for authors to acknowledge the limitations of these abstracts and make attempts to improve the quality of work before embarking on writing a full-length manuscript.

Approach to Publishing a Scientific (Radiology) Book.

In the modern landscape of information technology, the role of books remains pivotal in education and research, especially in scientific fields such as radiology. This article outlines a comprehensive approach to publishing a scientific book in radiology, from the initial concept to distribution and ongoing updates. The process is influenced by factors such as the author's motivation, expertise, and target audience.

Building Credibility with Comprehensive Citation Practices.

Honoring those who paved the way and paving the way for others is an old saying and practice that emphasizes the importance of acknowledging the contributions of others while also guiding and mentoring those who follow in your footsteps. In academic and scientific writings, citations are very important for maintaining the integrity, credibility, and progression of scientific knowledge. This article examines the significance of citations, their various types and methods, and the different styles used.

Peer Review of an Article: Tips, Tricks, and Troubleshooting.

Scientific publications are rapidly increasing in number, placing growing pressure on academics to publish. This study highlights the important tips and tricks for the authors in the context of reviewers' feedback and how to manage the article till the final stage of publication.

Access to timely cancer treatment initiation in India: extent, determinants and trends.

Background: Treatment delays are significantly associated with advanced stage, poor response to treatment, increased mortality risk, poor health outcomes, increased healthcare expenditures among cancer patients. However, factors associated with these delays have not yet been robustly evaluated. In order to bridge this gap, we determined the delayed time to treatment initiation (TTI) among cancer patients in India, ascertained its determinants, and assessed the trends of delayed TTI.

Snow White's tale in nephrology: the emerging threat of skin-whitening creams on kidney health.

The timeless tale of Snow White, with its emphasis on fair skin as a beauty ideal, mirrors a contemporary issue in nephrology: the harmful impact of skin-whitening creams on kidney health. Fairness creams have deeply embedded themselves in global society, driven by a pervasive obsession with lighter skin tones as a symbol of beauty. This widespread use reflects deeply rooted cultural beliefs and social norms, despite the significant health risks associated with these products.

Bleeding From Unintentional Portal Vein Stenting During Endoscopic Retrograde Cholangiopancreatography Managed With Portal Vein Stent Graft Placement-A Case Report With a Detailed Review of the Literature.

Suspicion of vascular injury during endoscopic retrograde cholangiopancreatography (ERCP) should be raised in the event of intraprocedural bleeding, persistent hyperbilirubinemia, and sepsis despite biliary stenting. Most inadvertent portal vein (PV) cannulations during ERCP are innocuous, and mere withdrawal of guidewire and catheter suffices. However, unintentional PV stenting, particularly with larger metallic stents, increases the likelihood of significant bleeding.

Critical Insights into Novel Immunomodulatory Therapy for Sepsis: Evaluating Promise Amidst Limitations.

Angadi VM, Kambagiri P, Jindal A. Critical Insights into Novel Immunomodulatory Therapy for Sepsis: Evaluating Promise Amidst Limitations. Indian J Crit Care Med 2025;29(1):90.

In Light of the LANDI-SEP Trial: New Evidence or Double Jeopardy?

Datta PK, Sathe P, Bhattacharjee A, Kundu R. In Light of the LANDI-SEP Trial: New Evidence or Double Jeopardy? Indian J Crit Care Med 2025;29(1):84-85.

Prevention of Delirium in the Intensive Care Unit through Nonpharmacological Interventions: An Umbrella Review.

Introduction: Delirium is a syndrome commonly seen in intensive care unit (ICU) patients. It is characterized by acute changes in mental status, inattention, disorganized thinking, and altered level of consciousness. Due to its higher prevalence in mechanically ventilated ICU patients, it is crucial to recognize it early and implement standardized evidence-based protocols for preventing it in regular practice.

Association of Glycemic Variability with Outcomes in Non-diabetic Sepsis Patients: A Prospective Observational Study.

Background: Glycemic variability (GV) is the third domain of sepsis-induced dysglycemia, after hyperglycemia and hypoglycemia, potentially leading to adverse outcomes. This study analyzed the association of GV with in-hospital mortality and length of stay (LOS) in non-diabetic sepsis patients.

Materials And Methods: In this prospective observational study, non-diabetic sepsis patients were followed till day 14 of hospital stay, and blood glucose levels were assessed by finger-prick method (seven times per day) daily; clinico-laboratory and GV parameters [standard deviation (SD), coefficient of variation (CV), mean amplitude of glycemic excursion (MAGE)] were assessed on days 1, 3, 5, 7, 10, and 14 of admission.

Controlling Glycemic Variability in Non-diabetic Sepsis Patients: A Step toward Precision in Critical Care.

Prakash J, Vaibhaw V, Saran K. Controlling Glycemic Variability in Non-diabetic Sepsis Patients: A Step toward Precision in Critical Care. Indian J Crit Care Med 2025;29(1):6-7.