Onion Peel Ethylacetate Fraction and Its Derived Constituent Quercetin 4'--β-D Glucopyranoside Attenuates Quorum Sensing Regulated Virulence and Biofilm Formation.

The resistance and pathogenesis of bacteria could be related to their ability to sense and respond to population density, termed quorum sensing (QS). Inhibition of the QS system is considered as a novel strategy for the development of antipathogenic agents, especially for combating drug-resistant bacterial infections. In the present study, the anti-QS activity of Onion peel ethylacetate fraction (ONE) was tested against CV12472 and PAO1.

Enhanced Killing and Antibiofilm Activity of Encapsulated Cinnamaldehyde against .

sp. impelled opportunistic infection in immune-compromised patients ensuing from asymptomatic colonization to pathogenic forms. Moreover, slow spread of species inducing refractory mucosal and invasive infections brings acute resistance to antifungal drugs.

Synergistic Effect of Doripenem and Cefotaxime to Inhibit CTX-M-15 Type β-Lactamases: Biophysical and Microbiological Views.

CTX-M-15 type β-lactamase has the ability to hydrolyse cefotaxime, a third generation cephalosporin. The infections caused by multidrug resistant strains, especially CTX-M-15 producing strains are being treated with carbapenem group of β-lactam antibiotics. The objective of the study was to know if cefotaxime in combination with doripenem (carbapemen antibiotic) at very low concentration, inhibits the CTX-M-15 producing bacterial strains.

Exacerbation of -nitrosodiethylamine Induced Hepatotoxicity and DNA Damage in Mice Exposed to Chronic Unpredictable Stress.

Psychological stress contributes to increased susceptibility to a number of diseases including cancer. The present study was designed to assess the effect of chronic unpredictable stress on -nitrosodiethylamine induced liver toxicity in terms of antioxidant status and DNA damage in Swiss albino mice. The animals used in this study were randomized into different groups based on the treatment with -nitrosodiethylamine or chronic unpredictable stress alone and post-stress administration of -nitrosodiethylamine.

Leaf Extracts of L. Inhibit Quorum Sensing - Regulated Production of Virulence Factors and Biofilm in Test Bacteria.

Quorum sensing (QS) is a global gene regulatory mechanism in bacteria for various traits including virulence factors. Disabling QS system with anti-infective agent is considered as a potential strategy to prevent bacterial infection. L.

Ethylene Role in Plant Growth, Development and Senescence: Interaction with Other Phytohormones.

The complex juvenile/maturity transition during a plant's life cycle includes growth, reproduction, and senescence of its fundamental organs: leaves, flowers, and fruits. Growth and senescence of leaves, flowers, and fruits involve several genetic networks where the phytohormone ethylene plays a key role, together with other hormones, integrating different signals and allowing the onset of conditions favorable for stage progression, reproductive success and organ longevity. Changes in ethylene level, its perception, and the hormonal crosstalk directly or indirectly regulate the lifespan of plants.

Scaffold of Selenium Nanovectors and Honey Phytochemicals for Inhibition of Quorum Sensing and Biofilm Formation.

Honey is an excellent source of polyphenolic compounds that are effective in attenuating quorum sensing (QS), a chemical process of cell-to-cell communication system used by the opportunistic pathogen to regulate virulence and biofilm formation. However, lower water solubility and inadequate bioavailability remains major concerns of these therapeutic polyphenols. Its therapeutic index can be improved by using nano-carrier systems to target QS signaling potently.