555 results match your criteria: "Alcoholic Neuropathy"

Article Synopsis
  • The study explores the use of a standardized alcoholic extract of seeds (CPS) from an Indian traditional medicinal plant for treating diabetes-related complications, including neuropathy and cardiac issues in rodents.
  • The research involved administering two doses of CPS to diabetic rats and monitoring their effects on blood glucose levels, body weight, and various health parameters over six weeks, alongside histopathological examinations.
  • Results indicated that CPS treatment significantly improved motor functions, reduced diabetic complications, and normalized blood pressure and other vital signs, suggesting its potential as a therapeutic agent for diabetes management.
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Beyond the Liver: Neurologic Manifestations of Alcohol Use.

Clin Liver Dis

November 2024

Department of Internal Medicine, University of South Dakota Sanford School of Medicine, 1400 West 22nd Street, Sioux Falls, SD 57105, USA; Division of Hepatology, Avera McKennan Hospital & University Health Center, 1315 South Cliff Avenue, Suite 1200 Plaza 3, Sioux Falls, SD 57105, USA. Electronic address:

Article Synopsis
  • Alcohol use not only harms the liver but also significantly affects the nervous system, often mimicking hepatic encephalopathy, making diagnosis challenging.
  • It disrupts neurotransmitter balance, especially between gamma-aminobutyric acid and glutamate, and chronic use, along with thiamine deficiency, leads to long-term neurological issues.
  • Alcohol-related neurological disorders range from acute symptoms like intoxication and withdrawal to chronic conditions such as Korsakoff syndrome, dementia, and peripheral neuropathy, emphasizing the need for careful diagnosis through medical history and exams.
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Background: Peripheral neuropathy (PN) is a common neurological disorder, and circulating plasma proteins with causal genetic evidence are a major source of therapeutic targets. This study identifies several potential plasma proteins that are causally related to PN risk, providing new insights into protein-mediated pathogenesis of PN and potential targets for novel therapies.

Methods: To identify potential therapeutic targets for PN, we employed two-sample Mendelian randomization (MR) to identify plasma proteins associated with six common PN.

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Background And Aims: We examined the impact of a co-diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes (T2D) on patient outcomes.

Methods: Using TriNetX, a global federated research network (n = 114 million), we undertook two retrospective cohort studies, using time-to-event analysis. Analysis 1 compared MASLD with T2D to MASLD alone; analysis 2 compared T2D with MASLD to T2D alone.

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In this editorial, we comment on the article by Liu published in the recent issue of the (Relationship between GCKR gene rs780094 polymorphism and type 2 diabetes with albuminuria). Type 2 diabetes mellitus (T2DM) is a chronic disorder characterized by dysregulated glucose homeostasis. The persistent elevated blood glucose level in T2DM significantly increases the risk of developing severe complications, including cardiovascular disease, re-tinopathy, neuropathy, and nephropathy.

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Background And Study Aims: Nonalcoholic fatty liver disease is the most prevalent chronic liver disease globally and is linked to augmented susceptibility to type 2 diabetes mellitus (DM), cardiovascular disease, and microvascular complications inherent to DM, such as nephropathy, neuropathy, and retinopathy. The fibrosis-4 (FIB-4) scoring system, a noninvasive tool, is useful for predicting the extent of liver fibrosis across diverse pathologies. This study aimed to assess the potential predictive role of FIB-4 scores in microvascular complications associated with diabetes.

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Alcohol overconsumption is well known to cause damage to the peripheral nervous system, affecting both small and large nerve fibers. The aim of this descriptive study was to investigate peripheral nerve damage, and to correlate clinical, epidemiological and neurophysiological findings, in patients diagnosed with Alcohol Use Disorder (AUD). Ninety alcohol-dependent subjects on inpatient basis were enrolled in this prospective study over a 3-year period.

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Article Synopsis
  • Acute pancreatitis is an inflammatory disorder of the pancreas that can lead to multi-organ dysfunction and has systemic inflammatory effects, and rare complications like optic neuropathy can occur, particularly in cases related to alcohol use.
  • A case study of a 51-year-old woman with severe abdominal pain revealed moderate to severe acute pancreatitis and subsequent left optic neuropathy, presenting as peri-orbital pain, lacrimation, and blurry vision after 11 days of illness.
  • Upon diagnosis, high-dose oral steroids were administered, leading to significant improvement in her symptoms and optic disc oedema over follow-up periods, highlighting the need to recognize optic neuropathy as a potential complication of acute pancreatitis.
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Article Synopsis
  • - Wernicke-Korsakoff Syndrome (WKS) is a serious neurological condition mainly caused by a lack of thiamine, often linked to alcohol use, but can also arise from diet issues or other health problems.
  • - A 28-year-old woman developed WKS after surgery for pancreatitis, showing severe cognitive challenges, including poor memory and planning skills, along with physical issues.
  • - Treatment involved high-dose thiamine and therapy, leading to notable improvements in her cognitive and physical conditions within three months, emphasizing the need for quick, coordinated medical care.
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Objective: The aim: To study the peculiarities of diabetic polyneuropathy in patients with type 2 diabetes mellitus and concomitant NAFLD.

Patients And Methods: Materials and methods: We examined 75 patients with type 2 diabetes mellitus, including 31 (41.3%) women and 44 (58.

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Tinospora cordifolia ameliorates paclitaxel-induced neuropathic pain in albino rats.

J Ethnopharmacol

March 2024

Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India. Electronic address:

Article Synopsis
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A 56-year-old man with a medical history of alcoholic cirrhosis presented with acute bilateral loss of vision. On admission, the patient had pale skin and low arterial pressure. Ophthalmic examination demonstrated a visual acuity of 6/9 in the right eye and the absence of light perception in the left.

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Article Synopsis
  • Diabetes and its complications significantly impact quality of life globally, presenting serious public health challenges.
  • C-peptide serves as a key indicator of pancreatic function and plays various roles in cellular processes, with its relationship to diabetic complications being complex and not fully understood.
  • While C-peptide replacement therapy shows promise in animal studies for treating diabetes-related complications, clinical trials have not yielded satisfactory results, highlighting the need for more research on optimal C-peptide levels before and after treatment.
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Sulforaphane: A nutraceutical against diabetes-related complications.

Pharmacol Res

October 2023

Cochrane South Africa, South African Medical Research Council, Tygerberg 7505, South Africa; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa. Electronic address:

Article Synopsis
  • * Sulforaphane has shown promise in combating oxidative stress and inflammation, which are linked to various metabolic issues such as diabetic cardiomyopathy, neuropathy, and nephropathy, through mechanisms like activating specific proteins that help protect against these conditions.
  • * Clinical studies indicate that diets rich in sulforaphane can enhance metabolic health and reduce cardiovascular risks in individuals with type 2 diabetes, highlighting its potential as a therapeutic nutraceutical, along with discussions on its bioavailability and effects on diabetes progression.
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Objective: The aim of this study was to investigate the prevalence of microvascular and macrovascular diabetic complications and the associated comorbidities in newly diagnosed pre-diabetic individuals.

Patients And Methods: This cross-sectional study includes 100 newly diagnosed pre-diabetic individuals. Fasting plasma glucose, HbA1c, and oral glucose tolerance (OGTT) were tested according to the American Diabetes Association's diagnostic criteria for pre-diabetes, besides anthropometric measurements, lipid profiles, and demographic and biochemical parameters.

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Article Synopsis
  • * It works by triggering metabolic and hormonal changes that promote cellular health, particularly through a process called hepatic autophagy, which helps maintain energy balance and protect against damage.
  • * IF influences various molecular pathways and cytokines that can enhance liver health and may offer new treatments for liver-related diseases like fatty liver disease and hepatitis.
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The mammalian target of rapamycin complex 1 syndrome (Tors), paradigm implies an exhaustive cohesive disease entity driven by a hyperactive mTORC1, and which includes obesity, type 2 diabetic hyperglycemia, diabetic dyslipidemia, diabetic cardiomyopathy, diabetic nephropathy, diabetic peripheral neuropathy, hypertension, atherosclerotic cardiovascular disease, non-alcoholic fatty liver disease, some cancers, neurodegeneration, polycystic ovary syndrome, psoriasis and other. The TorS paradigm may account for the efficacy of standard-of-care treatments of type 2 diabetes (T2D) in alleviating the glycaemic and non-glycaemic diseases of TorS in T2D and non-T2D patients. The TorS paradigm may generate novel treatments for TorS diseases.

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Article Synopsis
  • Advanced glycation end products (AGEs) are linked to both microvascular and macrovascular complications in diabetes, primarily due to uncontrolled hyperglycemia leading to their formation. //! -
  • AGEs are produced through non-enzymatic reactions between sugars and biological molecules, accumulating in the body and promoting oxidative stress by activating the receptor for AGEs (RAGE) and generating reactive oxygen species (ROS). //! -
  • Clinical studies show a strong association between levels of AGEs and diabetic complications, suggesting that both endogenous AGEs and those from the diet contribute to conditions like retinopathy, nephropathy, and insulin resistance. //!
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Article Synopsis
  • * Following her abstinence, she developed worsening neurological symptoms, including neuropathy and memory problems, prompting medical evaluation.
  • * MRI results indicated chronic central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM), likely related to alcohol withdrawal, and she was treated with vitamins and scheduled for physical therapy.
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Background: Methanol is a highly toxic, non-potable alcohol. Outbreaks of methanol toxicity occur due to its fraudulent addition to alcoholic beverages as a cheaper substitute for ethanol. Recently, alongside the coronavirus disease 2019 (COVID-19) pandemic, rumors circulated on social media that consuming alcohol can prevent or cure the virus, leading to a COVID-19 and methanol-induced optic neuropathy (MON) syndemic.

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Objective: To investigate the association between non-alcoholic fatty liver disease (NAFLD) and liver enzymes with the incidence of microvascular complications (neuropathy, retinopathy, and nephropathy) in a cohort of Iranian patients with type 2 diabetes.

Methods: For a total population of 3123 patients with type 2 diabetes, a prospective study was designed for 1215 patients with NAFLD and 1908 gender and age-matched control patients without NAFLD. The two groups were followed for a median duration of 5 years for the incidence of microvascular complications.

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Introduction: Nonalcoholic fatty liver disease (NAFLD) is considered a multisystem disease, as it is bidirectionally linked to other cardiometabolic disorders, such as type 2 diabetes (T2D). However, the long-term risk for microvascular outcomes in NAFLD is unclear.

Methods: Using the outpatient part of the nationwide Swedish Patient Register in the time period between 01/01/2002 and 12/31/2019, we identified all individuals with a first NAFLD diagnosis (N = 6785) and matched these (age, sex, and municipality) with up to 10 reference individuals from the general population (N = 61,136).

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Introduction: In countries where alcoholic beverages are legally prohibited, methanol toxicity usually occurs due to ingesting homemade alcoholic drinks. The initial ophthalmologic symptoms of methanol toxicity typically appear 6-48 h after ingestion, and the severity of symptoms varies widely from mild and painless decreased vision to no-light perception vision.

Methods: This prospective study examines 20 patients with acute methanol poisoning within 10 days of use.

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Article Synopsis
  • * A study involving 3,029 adults aged 40-85 revealed that 41.27% had NAFLD, and those with NAFLD had a 1.44 times higher risk of PN after adjusting for other factors.
  • * The association between NAFLD and PN was particularly strong in younger adults (ages 40-64) compared to older adults, indicating a significant public health concern.
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Introduction: COVID-19 emerged as a novel pandemic with serious illness. Acute motor and sensory axonal neuropathy, a Guillain-Barré syndrome variant also results in ventilator support, and bed-ridden state. Presence of COVID-19 along with GBS will cause serious complications if left untreated.

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