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Prevalence and mutation analysis of the spike protein in feline enteric coronavirus and feline infectious peritonitis detected in household and shelter cats in western Canada.
Can J Vet Res
January 2020
Department of Ecosystem and Public Health (McKay, Davies, van der Meer) and Diagnostic Services Unit (Davies), Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta; Department of Veterinary Pathology (Meachem) and Department of Small Animal Clinical Sciences (Snead), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan; Meow Foundation, Calgary, Alberta (Brannen); Fish Creek Pet Hospital, Calgary, Alberta (Mutlow); Wild Rose Cat Clinic, Calgary, Alberta (Ruelle).
Feline infectious peritonitis (FIP) is a fatal disease for which no simple antemortem diagnostic assay is available. A new polymerase chain reaction (PCR) test has recently been developed that targets the spike protein region of the FIP virus (FIPV) and can identify specific mutations (M1030L or S1032A), the presence of which indicates a shift from feline enteric coronavirus (FeCV) to FIPV. This test will only be useful in the geographical region of interest, however, if the FIP viruses contain these mutations.
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