Cardiotoxic Effects Following CAR-T Cell Therapy: A Literature Review.

Purpose Of Review: This paper reviewed the current literature on incidence, clinical manifestations, and risk factors of Chimeric Antigen Receptor T-cell (CAR-T) cardiotoxicity.

Recent Findings: CAR-T therapy has emerged as a groundbreaking treatment for hematological malignancies since FDA approval in 2017. CAR-T therapy is however associated with a few side effects, among which cardiotoxicity is of significant concern.

Deep learning applications to breast cancer detection by magnetic resonance imaging: a literature review.

Deep learning analysis of radiological images has the potential to improve diagnostic accuracy of breast cancer, ultimately leading to better patient outcomes. This paper systematically reviewed the current literature on deep learning detection of breast cancer based on magnetic resonance imaging (MRI). The literature search was performed from 2015 to Dec 31, 2022, using Pubmed.

Clinical and mechanistic insights into the roles of DDX41 in haematological malignancies.

DEAD-box Helicase 41 (DDX41) is a member of the DExD/H-box helicase family that has a variety of cellular functions. Of note, germline and somatic mutations in the DDX41 gene are prevalently found in myeloid malignancies. Here, we present a comprehensive and analytic review covering relevant clinical, translational and basic science findings on DDX41.

Abdominal Contouring: Can the American Society of Anesthesiologists Classification System Help Determine When to Say No?

Background: The purpose of this study was to determine whether the American Society of Anesthesiologists classification system could be used preoperatively to identify patients at high risk for complications after abdominal contouring.

Methods: Using the National Surgical Quality Improvement Program database from 2007 to 2012, patients undergoing abdominal contouring procedures were identified and stratified by American Society of Anesthesiologists class. The primary outcome was any complication within 30 days.

Multimodal Therapy in the Treatment of Prostate Sarcoma: The Johns Hopkins Experience.

Background: The objective of this study was to evaluate the use of neoadjuvant chemoradiation in patients with prostate sarcoma treated at our institution and report oncological outcomes.

Materials And Methods: The records of patients with intermediate- or high-grade prostate sarcoma treated with curative intent at our institution from 1993 to 2013 were reviewed. Patient demographic information, tumor characteristics, and treatment modalities used were assessed.

Cardioprotective effects of verapamil on myocardial structure and function in a murine model of chronic Trypanosoma cruzi infection (Brazil Strain): an echocardiographic study.

Verapamil has been shown to attenuate the extent of myocardial injury in murine models of chronic Trypanosoma cruzi infection. Infected mice treated with verapamil have significantly lower myocardial expression of inducible nitric oxide synthase and cytokines and substantially less inflammatory infiltrate and myocyte necrosis at necropsy. In the present study, we examined the cardiac structural and functional correlates of verapamil treatment in CD1 mice infected with the Brazil strain of T.

Topography of the initial cortical component of the median nerve somatosensory evoked potential. Relationship to central sulcus anatomy.

The initial cortical component of the median nerve somatosensory evoked potential (SSEP), the parietal N20, is generated in the posterior bank of the central sulcus and inverts in polarity across the sulcus. The inversion is used to identify the central sulcus. The precentral P20 is sometimes not identifiable in scalp recordings, and this has been attributed to a dipole orientation that directs the maximum positivity downward, into the brain.

Prevalence of peripheral neuropathy in injection drug users.

Background: Nucleoside analogue reverse transcriptase inhibitors are a critical component of antiretroviral therapy in HIV-infected persons. Several of these medications cause painful, dose-limiting peripheral neuropathy (PN), which may develop earlier and more intensely in persons with preexisting neuropathy. The prevalence of baseline peripheral neuropathy in injection drug users (IDUs), one of the largest populations of HIV-infected persons, has not been described, yet has important implications for the selection of antiretroviral therapy.

Screening infants and young children for hearing loss: examination of the CAST procedure.

A computer-mediated visual reinforcement audiometry (VRA) screening procedure, the Classification of Audiograms by Sequential Testing (CAST), was used with 59 infants and young children who received both CAST screening and conventional audiologic assessment. Approximately one-third of the children had normal hearing, one-third had conductive hearing loss, and the remaining one-third had previously diagnosed sensorineural hearing loss. The sensitivity and specificity of CAST were calculated and the relationship between the predicted CAST pattern and the child's actual audiogram was examined.

1457 years of microsurgical experience.

Microsurgery is a relatively new field of surgery involving various methods and practices that are currently evolving. Our goal was to register the current practices employed by the members of the American Society for Reconstructive Microsurgery. A survey was mailed to the 319 members of the society, resulting in a response rate of 33 percent (106 of 319).